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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 210ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:ML0001
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0001.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142121 – 502Chromosomal replication initiator protein DnaAAdd BLAST502

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0001.

Structurei

3D structure databases

ProteinModelPortaliP46388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235658.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDLSLGFT TVWNAVVSEL NGESNTDDEA TNDSTLVTPL TPQQRAWLNL
60 70 80 90 100
VQPLTIIEGF ALLSVPSSFV QNEIERHLRT PITDALSRRL GQQIQLGVRI
110 120 130 140 150
APPSTDHIDD NSSSADVLLT DDCGTDTDEN YGEPLTGEYQ GLPTYFTERP
160 170 180 190 200
HHTESTVTGG TSLNRRYTFE TFVIGASNRF AHAAALAIAE APARAYNPLF
210 220 230 240 250
IWGESGLGKT HLLHAAGNYA QRLFPGMRVK YVSTEEFTND FINSLRDDRK
260 270 280 290 300
VAFKRSYRDV DVLLVDDIQF IEGKEGIQEE FFHTFNTLHN ANKQIVISSD
310 320 330 340 350
RPPKQLATLE DRLRTRFEWG LITDVQPPEL ETRIAILRKK AQMERLAVPG
360 370 380 390 400
DVLELIASSI ERNIRELEGA LIRVTAFASL NKTAIDKALA EIVLRDLIAD
410 420 430 440 450
ASTMQISAAT IMTATAEYFD TTIEELRGPG KTRALAQSRQ IAMYLCRELT
460 470 480 490 500
DLSLPKIGQA FGRDHTTVMY AQRKILSEMA ERREVFDHVK ELTTRIRQRS

KR
Length:502
Mass (Da):56,314
Last modified:June 1, 2001 - v3
Checksum:i2D45721D99DEDEAE
GO

Sequence cautioni

The sequence AAB53141 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC29509 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183A → R in AAB53141 (PubMed:8969512).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39923 Genomic DNA. Translation: AAB53141.1. Different initiation.
AL583917 Genomic DNA. Translation: CAC29509.1. Different initiation.
PIRiA86909.
RefSeqiWP_010907454.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29509; CAC29509; CAC29509.
PATRICi18050082. VBIMycLep78757_0001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39923 Genomic DNA. Translation: AAB53141.1. Different initiation.
AL583917 Genomic DNA. Translation: CAC29509.1. Different initiation.
PIRiA86909.
RefSeqiWP_010907454.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP46388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29509; CAC29509; CAC29509.
PATRICi18050082. VBIMycLep78757_0001.

Organism-specific databases

LepromaiML0001.

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235658.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_MYCLE
AccessioniPrimary (citable) accession number: P46388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.