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Protein

DNA polymerase III subunit beta

Gene

dnaN

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit beta (EC:2.7.7.7)
Gene namesi
Name:dnaN
Ordered Locus Names:ML0002
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0002.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399DNA polymerase III subunit betaPRO_0000105448Add
BLAST

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi272631.ML0002.

Structurei

3D structure databases

ProteinModelPortaliP46387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CZ8. Bacteria.
COG0592. LUCA.
HOGENOMiHOG000071793.
KOiK02338.
OMAiTHQIRLK.
OrthoDBiEOG65J53F.

Family and domain databases

InterProiIPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
[Graphical view]
PfamiPF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000804. DNA_pol_III_b. 1 hit.
SMARTiSM00480. POL3Bc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00663. dnan. 1 hit.

Sequencei

Sequence statusi: Complete.

P46387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLAKTNVGC SDLKFCLARE SFASAVSWVA KYLPTRPTVP VLSGVLLTGS
60 70 80 90 100
DSGLTISGFD YEVSAEVQVA AEIASSGSVL VSGRLLSDIT RALPNKPVHF
110 120 130 140 150
YVDGNRVALT CGSARFSLPT MAVEDYPTLP TLPDETGTLP SDVFAEAIGQ
160 170 180 190 200
VAIAAGRDYT LPMLTGIRIE ISGDTVVLAA TDRFRLAVRE LKWSVLSSDF
210 220 230 240 250
EASVLVPAKT LVEVAKAGTD GSGVCLSLGA GVGVGKDGLF GISGGGKRST
260 270 280 290 300
TRLLDAEFPK FRQLLPAEHT AVATIDVAEL TEAIKLVALV ADRGAQVRME
310 320 330 340 350
FGDGILRLSA GADDVGRAEE DLAVAFTGEP LTIAFNPNYL TDGLASVHSE
360 370 380 390
RVSFGFTTPS KPALLRPTSN DDVHPTHDGP FPALPTDYVY LLMPVRLPG
Length:399
Mass (Da):41,942
Last modified:November 1, 1995 - v1
Checksum:i48680894EBCB9837
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39923 Genomic DNA. Translation: AAB53142.1.
Z70722 Genomic DNA. Translation: CAA94709.1.
AL583917 Genomic DNA. Translation: CAC29510.1.
PIRiT10002.
RefSeqiNP_301130.1. NC_002677.1.
WP_010907455.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29510; CAC29510; CAC29510.
GeneIDi908144.
KEGGimle:ML0002.
PATRICi18050084. VBIMycLep78757_0002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39923 Genomic DNA. Translation: AAB53142.1.
Z70722 Genomic DNA. Translation: CAA94709.1.
AL583917 Genomic DNA. Translation: CAC29510.1.
PIRiT10002.
RefSeqiNP_301130.1. NC_002677.1.
WP_010907455.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP46387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29510; CAC29510; CAC29510.
GeneIDi908144.
KEGGimle:ML0002.
PATRICi18050084. VBIMycLep78757_0002.

Organism-specific databases

LepromaiML0002.

Phylogenomic databases

eggNOGiENOG4105CZ8. Bacteria.
COG0592. LUCA.
HOGENOMiHOG000071793.
KOiK02338.
OMAiTHQIRLK.
OrthoDBiEOG65J53F.

Family and domain databases

InterProiIPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
[Graphical view]
PfamiPF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000804. DNA_pol_III_b. 1 hit.
SMARTiSM00480. POL3Bc. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00663. dnan. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene arrangement and organization in an approximately 76 kb fragment encompassing the oriC region of the chromosome of Mycobacterium leprae."
    Fsihi H., de Rossi E., Salazar L., Cantoni R., Labo M., Riccardi G., Takiff H.E., Eiglmeier K., Bergh S., Cole S.T.
    Microbiology 142:3147-3161(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Organization of the origins of replication of the chromosomes of Mycobacterium smegmatis, Mycobacterium leprae and Mycobacterium tuberculosis and isolation of a functional origin from M. smegmatis."
    Salazar L., Fsihi H., De Rossi E., Riccardi G., Rios C., Cole S.T., Takiff H.E.
    Mol. Microbiol. 20:283-293(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiDPO3B_MYCLE
AccessioniPrimary (citable) accession number: P46387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 11, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.