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P46369

- THCA_RHOER

UniProt

P46369 - THCA_RHOER

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Protein
EPTC-inducible aldehyde dehydrogenase
Gene
thcA
Organism
Rhodococcus erythropolis (Arthrobacter picolinophilus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Degrades all aldehydes potentially generated by N dealkylation of thiocarbamates and may also participate in ethanolamine metabolism and further assimilation of degradation products by thiocarbamate-induced cytochrome P-450.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei263 – 2631 By similarity
Active sitei302 – 3021 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi219 – 2257NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
EPTC-inducible aldehyde dehydrogenase (EC:1.2.1.3)
Gene namesi
Name:thcA
OrganismiRhodococcus erythropolis (Arthrobacter picolinophilus)
Taxonomic identifieri1833 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 506505EPTC-inducible aldehyde dehydrogenase
PRO_0000056453Add
BLAST

Proteomic databases

PRIDEiP46369.

Expressioni

Inductioni

By EPTC (S-ethyl dipropylcarbamothioate).

Structurei

3D structure databases

ProteinModelPortaliP46369.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46369-1 [UniParc]FASTAAdd to Basket

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MTKYARPGTA DAIMSFQSRY DNWIGNEWVA PVKGQYFENP TPVTGQNFCD    50
VARSTAEDIE LALDAAHAAA PAWGKTSVAE RAIILNKIAD RMEENLESIA 100
LAESWDNGKP IRETLNADIP LAIDHFRYFA GAIRAQEGSL SEINSDTVAY 150
HFHEPLGVVG QIIPWNFPIL MAVWKLAPAL AAGNAIVLKP AEQTPVSILH 200
LIGIIGDLLP AGVLNIVNGF GVEAGKPLAS SPRIKKIAFT GETTTGRLIM 250
QYASQNLIPV TLELGGKSPN VFFSDVLASN DDYQDKALEG FTMFALNQGE 300
VCTAPSRALI QEDIFDEFLA MAAIRTKAVR QGDPLDTDTM IGAQASNDQL 350
EKILSYIEIG KAEGAKVITG GERAELGGDL SGGYYVQPTV FTGNNKMRIF 400
QEIFGPVVSV TSFKDYDEAI EIANDTLYGL GAGVWSRDGG VAYRAGRDIQ 450
AGRVWTNTYH QYPAHAAFGG YKQSGIGREN HLMMLSHYQQ TKNLLVSYAQ 500
KAQGFF 506
Length:506
Mass (Da):54,994
Last modified:January 23, 2007 - v2
Checksum:iDDA25B7138B34B37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17129 Genomic DNA. Translation: AAC77472.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17129 Genomic DNA. Translation: AAC77472.1 .

3D structure databases

ProteinModelPortali P46369.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P46369.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Degradation of the thiocarbamate herbicide EPTC (S-ethyl dipropylcarbamothioate) and biosafening by Rhodococcus sp. strain NI86/21 involve an inducible cytochrome P-450 system and aldehyde dehydrogenase."
    Nagy I., Schoofs G., Compernolle F., Proost P., Vanderleyden J., de Mot R.
    J. Bacteriol. 177:676-687(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: NI86/21.

Entry informationi

Entry nameiTHCA_RHOER
AccessioniPrimary (citable) accession number: P46369
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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