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P46369

- THCA_RHOER

UniProt

P46369 - THCA_RHOER

Protein

EPTC-inducible aldehyde dehydrogenase

Gene

thcA

Organism
Rhodococcus erythropolis (Arthrobacter picolinophilus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Degrades all aldehydes potentially generated by N dealkylation of thiocarbamates and may also participate in ethanolamine metabolism and further assimilation of degradation products by thiocarbamate-induced cytochrome P-450.

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei263 – 2631By similarity
    Active sitei302 – 3021By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi219 – 2257NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EPTC-inducible aldehyde dehydrogenase (EC:1.2.1.3)
    Gene namesi
    Name:thcA
    OrganismiRhodococcus erythropolis (Arthrobacter picolinophilus)
    Taxonomic identifieri1833 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 506505EPTC-inducible aldehyde dehydrogenasePRO_0000056453Add
    BLAST

    Proteomic databases

    PRIDEiP46369.

    Expressioni

    Inductioni

    By EPTC (S-ethyl dipropylcarbamothioate).

    Structurei

    3D structure databases

    ProteinModelPortaliP46369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46369-1 [UniParc]FASTAAdd to Basket

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    MTKYARPGTA DAIMSFQSRY DNWIGNEWVA PVKGQYFENP TPVTGQNFCD    50
    VARSTAEDIE LALDAAHAAA PAWGKTSVAE RAIILNKIAD RMEENLESIA 100
    LAESWDNGKP IRETLNADIP LAIDHFRYFA GAIRAQEGSL SEINSDTVAY 150
    HFHEPLGVVG QIIPWNFPIL MAVWKLAPAL AAGNAIVLKP AEQTPVSILH 200
    LIGIIGDLLP AGVLNIVNGF GVEAGKPLAS SPRIKKIAFT GETTTGRLIM 250
    QYASQNLIPV TLELGGKSPN VFFSDVLASN DDYQDKALEG FTMFALNQGE 300
    VCTAPSRALI QEDIFDEFLA MAAIRTKAVR QGDPLDTDTM IGAQASNDQL 350
    EKILSYIEIG KAEGAKVITG GERAELGGDL SGGYYVQPTV FTGNNKMRIF 400
    QEIFGPVVSV TSFKDYDEAI EIANDTLYGL GAGVWSRDGG VAYRAGRDIQ 450
    AGRVWTNTYH QYPAHAAFGG YKQSGIGREN HLMMLSHYQQ TKNLLVSYAQ 500
    KAQGFF 506
    Length:506
    Mass (Da):54,994
    Last modified:January 23, 2007 - v2
    Checksum:iDDA25B7138B34B37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17129 Genomic DNA. Translation: AAC77472.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17129 Genomic DNA. Translation: AAC77472.1 .

    3D structure databases

    ProteinModelPortali P46369.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P46369.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Degradation of the thiocarbamate herbicide EPTC (S-ethyl dipropylcarbamothioate) and biosafening by Rhodococcus sp. strain NI86/21 involve an inducible cytochrome P-450 system and aldehyde dehydrogenase."
      Nagy I., Schoofs G., Compernolle F., Proost P., Vanderleyden J., de Mot R.
      J. Bacteriol. 177:676-687(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
      Strain: NI86/21.

    Entry informationi

    Entry nameiTHCA_RHOER
    AccessioniPrimary (citable) accession number: P46369
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3