Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetaldehyde dehydrogenase 2

Gene

acoD

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the catabolism of acetoin and ethanol.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei262 – 2621By similarity
Active sitei301 – 3011By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2456NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. acetoin catabolic process Source: UniProtKB-UniPathway
  2. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Acetoin catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-5660-MONOMER.
RETL1328306-WGS:GSTH-3798-MONOMER.
UniPathwayiUPA00040.
UPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2 (EC:1.2.1.3)
Alternative name(s):
Acetaldehyde dehydrogenase II
Short name:
ACDH-II
Gene namesi
Name:acoD
Ordered Locus Names:H16_B1960
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Acetaldehyde dehydrogenase 2PRO_0000056566Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_B1960.

Structurei

3D structure databases

ProteinModelPortaliP46368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00138.
OMAiHLIMEAA.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMAEIAQLG VSNPYKQQYE NYIGGAWVPP AGGEYFESTT PITGKPFTRV
60 70 80 90 100
PRSGQQDVDA ALDAAHAAKA AWARTSTTER ANILNRIADR IEANLKLLAV
110 120 130 140 150
AESIDNGKPV RETTAADLPL AVDHFRYFAG CIRAQEGGIS EIDADTIAYH
160 170 180 190 200
FHEPLGVVGQ IIPWNFPLLM ATWKLAPALA AGNCVVLKPA EQTPASILVL
210 220 230 240 250
MEVIGDLLPP GVVNVINGFG LEAGKPLASS PRISKVAFTG ETTTGRLIMQ
260 270 280 290 300
YASQNLIPVT LELGGKSPNI FFEDVLAADD AFFDKALEGF AMFALNQGEV
310 320 330 340 350
CTCPSRALIQ ESIYDRFMER ALKRVAAIRQ GHPLDTGTMI GAQASAEQLE
360 370 380 390 400
KILSYIDLGR KEGAQCLTGG ERNVLDGDLA GGYYVKPTVF AGHNKMRIFQ
410 420 430 440 450
EEIFGPVVSV TTFKDEEEAL AIANDTLYGL GAGVWTRDGA RAFRMGRGIQ
460 470 480 490 500
AGRVWTNCYH AYPAHAAFGG YKQSGIGREN HRMMLDHYQQ TKNLLVSYSP

NALGFF
Length:506
Mass (Da):54,882
Last modified:November 1, 1995 - v1
Checksum:iA8715BD93B126D4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74003 Genomic DNA. Translation: AAA21943.1.
AM260480 Genomic DNA. Translation: CAJ96742.1.
PIRiA42597.
RefSeqiYP_841472.1. NC_008314.1.

Genome annotation databases

EnsemblBacteriaiCAJ96742; CAJ96742; H16_B1960.
GeneIDi4456449.
KEGGireh:H16_B1960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74003 Genomic DNA. Translation: AAA21943.1.
AM260480 Genomic DNA. Translation: CAJ96742.1.
PIRiA42597.
RefSeqiYP_841472.1. NC_008314.1.

3D structure databases

ProteinModelPortaliP46368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381666.H16_B1960.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ96742; CAJ96742; H16_B1960.
GeneIDi4456449.
KEGGireh:H16_B1960.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00138.
OMAiHLIMEAA.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

UniPathwayiUPA00040.
UPA00780; UER00768.
BioCyciCNEC381666:GJUJ-5660-MONOMER.
RETL1328306-WGS:GSTH-3798-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and molecular characterization of the gene coding for acetaldehyde dehydrogenase II (acoD) of Alcaligenes eutrophus."
    Priefert H., Krueger N., Jendrossek D., Schmidt B., Steinbuechel A.
    J. Bacteriol. 174:899-907(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-20.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiDHA2_CUPNH
AccessioniPrimary (citable) accession number: P46368
Secondary accession number(s): Q0JZT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.