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P46368

- DHA2_CUPNH

UniProt

P46368 - DHA2_CUPNH

Protein

Acetaldehyde dehydrogenase 2

Gene

acoD

Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of acetoin and ethanol.

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei262 – 2621By similarity
    Active sitei301 – 3011By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi240 – 2456NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. acetoin catabolic process Source: UniProtKB-UniPathway
    2. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Acetoin catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCNEC381666:GJUJ-5660-MONOMER.
    RETL1328306-WGS:GSTH-3798-MONOMER.
    UniPathwayiUPA00040.
    UPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 2 (EC:1.2.1.3)
    Alternative name(s):
    Acetaldehyde dehydrogenase II
    Short name:
    ACDH-II
    Gene namesi
    Name:acoD
    Ordered Locus Names:H16_B1960
    OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
    Taxonomic identifieri381666 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000008210: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Acetaldehyde dehydrogenase 2PRO_0000056566Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi381666.H16_B1960.

    Structurei

    3D structure databases

    ProteinModelPortaliP46368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00128.
    OMAiKGEVCTC.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46368-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNMAEIAQLG VSNPYKQQYE NYIGGAWVPP AGGEYFESTT PITGKPFTRV    50
    PRSGQQDVDA ALDAAHAAKA AWARTSTTER ANILNRIADR IEANLKLLAV 100
    AESIDNGKPV RETTAADLPL AVDHFRYFAG CIRAQEGGIS EIDADTIAYH 150
    FHEPLGVVGQ IIPWNFPLLM ATWKLAPALA AGNCVVLKPA EQTPASILVL 200
    MEVIGDLLPP GVVNVINGFG LEAGKPLASS PRISKVAFTG ETTTGRLIMQ 250
    YASQNLIPVT LELGGKSPNI FFEDVLAADD AFFDKALEGF AMFALNQGEV 300
    CTCPSRALIQ ESIYDRFMER ALKRVAAIRQ GHPLDTGTMI GAQASAEQLE 350
    KILSYIDLGR KEGAQCLTGG ERNVLDGDLA GGYYVKPTVF AGHNKMRIFQ 400
    EEIFGPVVSV TTFKDEEEAL AIANDTLYGL GAGVWTRDGA RAFRMGRGIQ 450
    AGRVWTNCYH AYPAHAAFGG YKQSGIGREN HRMMLDHYQQ TKNLLVSYSP 500
    NALGFF 506
    Length:506
    Mass (Da):54,882
    Last modified:November 1, 1995 - v1
    Checksum:iA8715BD93B126D4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74003 Genomic DNA. Translation: AAA21943.1.
    AM260480 Genomic DNA. Translation: CAJ96742.1.
    PIRiA42597.
    RefSeqiYP_841472.1. NC_008314.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ96742; CAJ96742; H16_B1960.
    GeneIDi4456449.
    KEGGireh:H16_B1960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74003 Genomic DNA. Translation: AAA21943.1 .
    AM260480 Genomic DNA. Translation: CAJ96742.1 .
    PIRi A42597.
    RefSeqi YP_841472.1. NC_008314.1.

    3D structure databases

    ProteinModelPortali P46368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381666.H16_B1960.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ96742 ; CAJ96742 ; H16_B1960 .
    GeneIDi 4456449.
    KEGGi reh:H16_B1960.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00128.
    OMAi KGEVCTC.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00040 .
    UPA00780 ; UER00768 .
    BioCyci CNEC381666:GJUJ-5660-MONOMER.
    RETL1328306-WGS:GSTH-3798-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and molecular characterization of the gene coding for acetaldehyde dehydrogenase II (acoD) of Alcaligenes eutrophus."
      Priefert H., Krueger N., Jendrossek D., Schmidt B., Steinbuechel A.
      J. Bacteriol. 174:899-907(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-20.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

    Entry informationi

    Entry nameiDHA2_CUPNH
    AccessioniPrimary (citable) accession number: P46368
    Secondary accession number(s): Q0JZT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3