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P46368

- DHA2_CUPNH

UniProt

P46368 - DHA2_CUPNH

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Protein

Acetaldehyde dehydrogenase 2

Gene
acoD, H16_B1960
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the catabolism of acetoin and ethanol.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei262 – 2621 By similarity
Active sitei301 – 3011 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2456NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. acetoin catabolic process Source: UniProtKB-UniPathway
  2. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Acetoin catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCNEC381666:GJUJ-5660-MONOMER.
RETL1328306-WGS:GSTH-3798-MONOMER.
UniPathwayiUPA00040.
UPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2 (EC:1.2.1.3)
Alternative name(s):
Acetaldehyde dehydrogenase II
Short name:
ACDH-II
Gene namesi
Name:acoD
Ordered Locus Names:H16_B1960
OrganismiCupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Taxonomic identifieri381666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000008210: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Acetaldehyde dehydrogenase 2PRO_0000056566Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381666.H16_B1960.

Structurei

3D structure databases

ProteinModelPortaliP46368.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.
OMAiKGEVCTC.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46368-1 [UniParc]FASTAAdd to Basket

« Hide

MNMAEIAQLG VSNPYKQQYE NYIGGAWVPP AGGEYFESTT PITGKPFTRV    50
PRSGQQDVDA ALDAAHAAKA AWARTSTTER ANILNRIADR IEANLKLLAV 100
AESIDNGKPV RETTAADLPL AVDHFRYFAG CIRAQEGGIS EIDADTIAYH 150
FHEPLGVVGQ IIPWNFPLLM ATWKLAPALA AGNCVVLKPA EQTPASILVL 200
MEVIGDLLPP GVVNVINGFG LEAGKPLASS PRISKVAFTG ETTTGRLIMQ 250
YASQNLIPVT LELGGKSPNI FFEDVLAADD AFFDKALEGF AMFALNQGEV 300
CTCPSRALIQ ESIYDRFMER ALKRVAAIRQ GHPLDTGTMI GAQASAEQLE 350
KILSYIDLGR KEGAQCLTGG ERNVLDGDLA GGYYVKPTVF AGHNKMRIFQ 400
EEIFGPVVSV TTFKDEEEAL AIANDTLYGL GAGVWTRDGA RAFRMGRGIQ 450
AGRVWTNCYH AYPAHAAFGG YKQSGIGREN HRMMLDHYQQ TKNLLVSYSP 500
NALGFF 506
Length:506
Mass (Da):54,882
Last modified:November 1, 1995 - v1
Checksum:iA8715BD93B126D4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74003 Genomic DNA. Translation: AAA21943.1.
AM260480 Genomic DNA. Translation: CAJ96742.1.
PIRiA42597.
RefSeqiYP_841472.1. NC_008314.1.

Genome annotation databases

EnsemblBacteriaiCAJ96742; CAJ96742; H16_B1960.
GeneIDi4456449.
KEGGireh:H16_B1960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74003 Genomic DNA. Translation: AAA21943.1 .
AM260480 Genomic DNA. Translation: CAJ96742.1 .
PIRi A42597.
RefSeqi YP_841472.1. NC_008314.1.

3D structure databases

ProteinModelPortali P46368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381666.H16_B1960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ96742 ; CAJ96742 ; H16_B1960 .
GeneIDi 4456449.
KEGGi reh:H16_B1960.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00128.
OMAi KGEVCTC.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00040 .
UPA00780 ; UER00768 .
BioCyci CNEC381666:GJUJ-5660-MONOMER.
RETL1328306-WGS:GSTH-3798-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and molecular characterization of the gene coding for acetaldehyde dehydrogenase II (acoD) of Alcaligenes eutrophus."
    Priefert H., Krueger N., Jendrossek D., Schmidt B., Steinbuechel A.
    J. Bacteriol. 174:899-907(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-20.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.

Entry informationi

Entry nameiDHA2_CUPNH
AccessioniPrimary (citable) accession number: P46368
Secondary accession number(s): Q0JZT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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