Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium-activated aldehyde dehydrogenase, mitochondrial

Gene

ALD4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potassium-activated aldehyde dehydrogenase involved in acetate formation during anaerobic growth on glucose.1 Publication

Miscellaneous

Present with 22200 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei192Transition state stabilizerBy similarity1
Active sitei290Proton acceptorPROSITE-ProRule annotation1
Active sitei324NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi268 – 273NADBy similarity6

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: SGD
  • aldehyde dehydrogenase [NAD(P)+] activity Source: SGD

GO - Biological processi

  • acetate biosynthetic process Source: SGD
  • ethanol metabolic process Source: SGD
  • NADPH regeneration Source: SGD
  • pyruvate metabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciYEAST:MONOMER-13666
ReactomeiR-SCE-196757 Metabolism of folate and pterines
R-SCE-380612 Metabolism of serotonin
R-SCE-5365859 RA biosynthesis pathway
R-SCE-6798163 Choline catabolism
R-SCE-70350 Fructose catabolism
R-SCE-71064 Lysine catabolism
R-SCE-71262 Carnitine synthesis
R-SCE-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-activated aldehyde dehydrogenase, mitochondrial (EC:1.2.1.5)
Alternative name(s):
K(+)-activated acetaldehyde dehydrogenase
Short name:
K(+)-ACDH
Gene namesi
Name:ALD4
Synonyms:ALD7, ALDH2
Ordered Locus Names:YOR374W
ORF Names:O6730
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR374W
SGDiS000005901 ALD4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24Mitochondrion2 PublicationsAdd BLAST24
ChainiPRO_000000716525 – 519Potassium-activated aldehyde dehydrogenase, mitochondrialAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96PhosphoserineCombined sources1
Modified residuei216PhosphothreonineCombined sources1
Modified residuei500PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP46367
PaxDbiP46367
PRIDEiP46367
TopDownProteomicsiP46367

PTM databases

iPTMnetiP46367

Interactioni

Protein-protein interaction databases

BioGridi34757, 62 interactors
DIPiDIP-4053N
IntActiP46367, 43 interactors
MINTiP46367
STRINGi4932.YOR374W

Structurei

3D structure databases

ProteinModelPortaliP46367
SMRiP46367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00760000118999
HOGENOMiHOG000271505
InParanoidiP46367
KOiK00128
OMAiCHEALFF
OrthoDBiEOG092C1LLH

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSRSTLCLK TSASSIGRLQ LRYFSHLPMT VPIKLPNGLE YEQPTGLFIN
60 70 80 90 100
NKFVPSKQNK TFEVINPSTE EEICHIYEGR EDDVEEAVQA ADRAFSNGSW
110 120 130 140 150
NGIDPIDRGK ALYRLAELIE QDKDVIASIE TLDNGKAISS SRGDVDLVIN
160 170 180 190 200
YLKSSAGFAD KIDGRMIDTG RTHFSYTKRQ PLGVCGQIIP WNFPLLMWAW
210 220 230 240 250
KIAPALVTGN TVVLKTAEST PLSALYVSKY IPQAGIPPGV INIVSGFGKI
260 270 280 290 300
VGEAITNHPK IKKVAFTGST ATGRHIYQSA AAGLKKVTLE LGGKSPNIVF
310 320 330 340 350
ADAELKKAVQ NIILGIYYNS GEVCCAGSRV YVEESIYDKF IEEFKAASES
360 370 380 390 400
IKVGDPFDES TFQGAQTSQM QLNKILKYVD IGKNEGATLI TGGERLGSKG
410 420 430 440 450
YFIKPTVFGD VKEDMRIVKE EIFGPVVTVT KFKSADEVIN MANDSEYGLA
460 470 480 490 500
AGIHTSNINT ALKVADRVNA GTVWINTYND FHHAVPFGGF NASGLGREMS
510
VDALQNYLQV KAVRAKLDE
Length:519
Mass (Da):56,724
Last modified:November 1, 1997 - v2
Checksum:iE7D9944EA25F948E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51N → NN AA sequence (PubMed:1989592).Curated1
Sequence conflicti63E → V AA sequence (PubMed:1989592).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75282 Genomic DNA Translation: CAA99705.1
BK006948 Genomic DNA Translation: DAA11133.1
PIRiS67286
RefSeqiNP_015019.1, NM_001183794.1

Genome annotation databases

EnsemblFungiiYOR374W; YOR374W; YOR374W
GeneIDi854556
KEGGisce:YOR374W

Similar proteinsi

Entry informationi

Entry nameiALDH4_YEAST
AccessioniPrimary (citable) accession number: P46367
Secondary accession number(s): D6W367, Q08898
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health