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P46357

- DAPF_YERPE

UniProt

P46357 - DAPF_YERPE

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Protein
Diaminopimelate epimerase
Gene
dapF, YPO3845, y0385, YP_3202
Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei44 – 441Substrate By similarity
Binding sitei64 – 641Substrate By similarity
Active sitei73 – 731Proton donor/acceptor By similarity
Binding sitei157 – 1571Substrate By similarity
Sitei159 – 1591Important for catalytic activity By similarity
Binding sitei190 – 1901Substrate By similarity
Sitei208 – 2081Important for catalytic activity By similarity
Active sitei217 – 2171Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciYPES214092:GKDD-3816-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:YPO3845, y0385, YP_3202
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Diaminopimelate epimeraseUniRule annotation
PRO_0000149884Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 217UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

IntActiP46357. 1 interaction.
STRINGi214092.YPO3845.

Structurei

3D structure databases

ProteinModelPortaliP46357.
SMRiP46357. Positions 1-274.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 92Substrate binding By similarity
Regioni73 – 753Substrate binding By similarity
Regioni208 – 2092Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiLIVEPPY.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46357-1 [UniParc]FASTAAdd to Basket

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MQFSKMHGLG NDFMVVDAVT QNVYFSPELI RRLADRHTGV GFDQMLVVEP    50
PYDPELDFHY RIFNADGSEV SQCGNGARCF ARFVRLKGLT NKREISVSTQ 100
TGRMILSVTE DEQVCVNMGE PDFEPQTVPF RAAKAEKTYI LRAAEHTVLC 150
GVVSMGNPHC VMQVDDVSVA NVALLGPVLE NHERFPERAN IGFMQVVSRD 200
HIRLRVYERG AGETQACGSG ACAAVAVGVV QDLLNENVHV ELPGGSLHIR 250
WQGPGHPLYM TGPATHVYDG FIHL 274
Length:274
Mass (Da):30,252
Last modified:November 16, 2001 - v2
Checksum:i8B66E79E67EB9FF1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361E → Q in AAC44326. 1 Publication
Sequence conflicti186 – 19813PERAN…MQVVS → LSGQISALCRSSV in AAC44326. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. Translation: CAL22432.1.
AE009952 Genomic DNA. Translation: AAM83974.1.
AE017042 Genomic DNA. Translation: AAS63370.1.
U22968 Genomic DNA. Translation: AAC44326.1.
PIRiAE0468.
RefSeqiNP_667723.1. NC_004088.1.
NP_994493.1. NC_005810.1.
YP_002348723.1. NC_003143.1.

Genome annotation databases

EnsemblBacteriaiAAM83974; AAM83974; y0385.
AAS63370; AAS63370; YP_3202.
GeneIDi