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P46329

- ALDH3_BACSU

UniProt

P46329 - ALDH3_BACSU

Protein

Probable aldehyde dehydrogenase AldX

Gene

aldX

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei214 – 2141By similarity
    Active sitei248 – 2481By similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
    2. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBSUB:BSU39860-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable aldehyde dehydrogenase AldX (EC:1.2.1.3)
    Gene namesi
    Name:aldX
    Synonyms:yxaS, yxbE
    Ordered Locus Names:BSU39860
    ORF Names:VE7FR
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU39860. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Probable aldehyde dehydrogenase AldXPRO_0000056446Add
    BLAST

    Proteomic databases

    PaxDbiP46329.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU39860.

    Structurei

    3D structure databases

    ProteinModelPortaliP46329.
    SMRiP46329. Positions 3-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271515.
    KOiK00128.
    OrthoDBiEOG6BS8QW.
    PhylomeDBiP46329.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036492. ALDH. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46329-1 [UniParc]FASTAAdd to Basket

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    MEQQVKDDIQ RVFQLQKKQQ KALRASTAEQ RREKLQRFLD SVIAHEEEII    50
    EAIRKDVRKP YHEVKKAEIE GTKKAIRDNM NNLEQWMAPK EVGSSLSPDA 100
    NGILMYEPKG VTLILGPWNY PFMLTMAPLA ASLAAGNSAI VKLSDFTMNT 150
    SNIAAKVIRD AFDEKEVAIF EGEVEVATEL LDQPFDHIFF TGSTNVGKIV 200
    MTAAAKHLAS VTLELGGKSP TIIDSEYDLM DAAKKIAVGK FVNAGQTCIA 250
    PDYLFIKKDV QDRFAGILQT VVNAGFMEDD HTPDRSKFTQ IVNDRNFNRV 300
    KDLFDDAIER GAEVVFGGVF DASDRTISPT VLKNVTPDMK IMQEEIFASI 350
    LPMMNYEDID EVIDYVNDRD KPLALYVFSK NQDLIDNVLQ HTTSGNAAIN 400
    DVVVHFSDVN LPFGGVNTSG IGSYHGVYGF KEFSHEKGVF IQAAE 445
    Length:445
    Mass (Da):49,571
    Last modified:July 28, 2009 - v2
    Checksum:iB705ABD3EFF43A2E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631D → N in BAA21599. (PubMed:7584049)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005554 Genomic DNA. Translation: BAA21599.1.
    AL009126 Genomic DNA. Translation: CAB16022.2.
    PIRiB69584.
    RefSeqiNP_391865.2. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB16022; CAB16022; BSU39860.
    GeneIDi937653.
    KEGGibsu:BSU39860.
    PATRICi18980040. VBIBacSub10457_4182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005554 Genomic DNA. Translation: BAA21599.1 .
    AL009126 Genomic DNA. Translation: CAB16022.2 .
    PIRi B69584.
    RefSeqi NP_391865.2. NC_000964.3.

    3D structure databases

    ProteinModelPortali P46329.
    SMRi P46329. Positions 3-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU39860.

    Proteomic databases

    PaxDbi P46329.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB16022 ; CAB16022 ; BSU39860 .
    GeneIDi 937653.
    KEGGi bsu:BSU39860.
    PATRICi 18980040. VBIBacSub10457_4182.

    Organism-specific databases

    GenoListi BSU39860. [Micado ]

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271515.
    KOi K00128.
    OrthoDBi EOG6BS8QW.
    PhylomeDBi P46329.

    Enzyme and pathway databases

    BioCyci BSUB:BSU39860-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036492. ALDH. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a 36-kb region of the Bacillus subtilis genome between the gnt and iol operons."
      Yoshida K., Seki S., Fujimura M., Miwa Y., Fujita Y.
      DNA Res. 2:61-69(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168 / BGSC1A1.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
      Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
      Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 163.

    Entry informationi

    Entry nameiALDH3_BACSU
    AccessioniPrimary (citable) accession number: P46329
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3