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P46273

- PGK_CANAL

UniProt

P46273 - PGK_CANAL

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Protein

Phosphoglycerate kinase

Gene
PGK1, CaO19.11135, CaO19.3651
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate By similarity
Binding sitei122 – 1221Substrate By similarity
Binding sitei170 – 1701Substrate By similarity
Binding sitei219 – 2191ATP By similarity
Binding sitei312 – 3121ATP; via carbonyl oxygen By similarity
Binding sitei343 – 3431ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi372 – 3754ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: CGD
  3. protein binding Source: CGD

GO - Biological processi

  1. glycolytic process Source: CGD
  2. induction by symbiont of host defense response Source: CGD
  3. interaction with host Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Cell wall biogenesis/degradation, Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.2.3. 1096.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK1
ORF Names:CaO19.11135, CaO19.3651
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000415. PGK1.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: CGD
  2. cytoplasm Source: CGD
  3. external side of plasma membrane Source: CGD
  4. extracellular region Source: UniProtKB-KW
  5. fungal-type cell wall Source: CGD
  6. hyphal cell wall Source: CGD
  7. plasma membrane Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Cytoplasm, Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei5991. Cand a PGK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Phosphoglycerate kinaseUniRule annotationPRO_0000145876Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP46273.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi1230131. 1 interaction.
STRINGi5476.CAL0000415.

Structurei

3D structure databases

ProteinModelPortaliP46273.
SMRiP46273. Positions 2-416.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate binding By similarity
Regioni63 – 664Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
KOiK00927.
OrthoDBiEOG71K6D7.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46273-1 [UniParc]FASTAAdd to Basket

« Hide

MSLSNKLSVK DLDVAGKRVF IRVDFNVPLD GKTITNNQRI VAALPTIKYV    50
EEHKPKYIVL ASHLGRPNGE RNDKYSLAPV ATELEKLLGQ KVTFLNDCVG 100
PEVTKAVENA KDGEIFLLEN LRYHIEEEGS SKDKDGKKVK ADPEAVKKFR 150
QELTSLADVY INDAFGTAHR AHSSMVGLEV PQRAAGFLMS KELEYFAKAL 200
ENPERPFLAI LGGAKVSDKI QLIDNLLDKV DMLIVGGGMA FTFKKILNKM 250
PIGDSLFDEA GAKNVEHLVE KAKKNNVELI LPVDFVTADK FDKDAKTSSA 300
TDAEGIPDNW MGLDCGPKSV ELFQQAVAKA KTIVWNGPPG VFEFEKFANG 350
TKSLLDAAVK SAENGNIVII GGGDTATVAK KYGVVEKLSH VSTGGGASLE 400
LLEGKDLPGV VALSNKN 417
Length:417
Mass (Da):45,180
Last modified:November 1, 1995 - v1
Checksum:i6F147F640F5EC784
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25180 Genomic DNA. Translation: AAA66523.1.
AACQ01000203 Genomic DNA. Translation: EAK92092.1.
AACQ01000201 Genomic DNA. Translation: EAK92141.1.
RefSeqiXP_711323.1. XM_706231.1.
XP_711371.1. XM_706279.1.

Genome annotation databases

GeneIDi3647038.
3647081.
KEGGical:CaO19.11135.
cal:CaO19.3651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25180 Genomic DNA. Translation: AAA66523.1 .
AACQ01000203 Genomic DNA. Translation: EAK92092.1 .
AACQ01000201 Genomic DNA. Translation: EAK92141.1 .
RefSeqi XP_711323.1. XM_706231.1.
XP_711371.1. XM_706279.1.

3D structure databases

ProteinModelPortali P46273.
SMRi P46273. Positions 2-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1230131. 1 interaction.
STRINGi 5476.CAL0000415.

Protein family/group databases

Allergomei 5991. Cand a PGK.

2D gel databases

COMPLUYEAST-2DPAGE P46273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647038.
3647081.
KEGGi cal:CaO19.11135.
cal:CaO19.3651.

Organism-specific databases

CGDi CAL0000415. PGK1.

Phylogenomic databases

eggNOGi COG0126.
KOi K00927.
OrthoDBi EOG71K6D7.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BRENDAi 2.7.2.3. 1096.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "3-phosphoglycerate kinase: a glycolytic enzyme protein present in the cell wall of Candida albicans."
    Alloush H.M., Lopez-Ribot J.L., Masten B.J., Chaffin W.L.
    Microbiology 143:321-330(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 3153A.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPGK_CANAL
AccessioniPrimary (citable) accession number: P46273
Secondary accession number(s): Q59NN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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