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P46273 (PGK_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:PGK1
ORF Names:CaO19.11135, CaO19.3651
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Subcellular location

Cytoplasm. Secretedcell wall HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145876

Regions

Nucleotide binding372 – 3754ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1221Substrate By similarity
Binding site1701Substrate By similarity
Binding site2191ATP By similarity
Binding site3121ATP; via carbonyl oxygen By similarity
Binding site3431ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P46273 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6F147F640F5EC784

FASTA41745,180
        10         20         30         40         50         60 
MSLSNKLSVK DLDVAGKRVF IRVDFNVPLD GKTITNNQRI VAALPTIKYV EEHKPKYIVL 

        70         80         90        100        110        120 
ASHLGRPNGE RNDKYSLAPV ATELEKLLGQ KVTFLNDCVG PEVTKAVENA KDGEIFLLEN 

       130        140        150        160        170        180 
LRYHIEEEGS SKDKDGKKVK ADPEAVKKFR QELTSLADVY INDAFGTAHR AHSSMVGLEV 

       190        200        210        220        230        240 
PQRAAGFLMS KELEYFAKAL ENPERPFLAI LGGAKVSDKI QLIDNLLDKV DMLIVGGGMA 

       250        260        270        280        290        300 
FTFKKILNKM PIGDSLFDEA GAKNVEHLVE KAKKNNVELI LPVDFVTADK FDKDAKTSSA 

       310        320        330        340        350        360 
TDAEGIPDNW MGLDCGPKSV ELFQQAVAKA KTIVWNGPPG VFEFEKFANG TKSLLDAAVK 

       370        380        390        400        410 
SAENGNIVII GGGDTATVAK KYGVVEKLSH VSTGGGASLE LLEGKDLPGV VALSNKN 

« Hide

References

« Hide 'large scale' references
[1]"3-phosphoglycerate kinase: a glycolytic enzyme protein present in the cell wall of Candida albicans."
Alloush H.M., Lopez-Ribot J.L., Masten B.J., Chaffin W.L.
Microbiology 143:321-330(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 3153A.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U25180 Genomic DNA. Translation: AAA66523.1.
AACQ01000203 Genomic DNA. Translation: EAK92092.1.
AACQ01000201 Genomic DNA. Translation: EAK92141.1.
RefSeqXP_711323.1. XM_706231.1.
XP_711371.1. XM_706279.1.

3D structure databases

ProteinModelPortalP46273.
SMRP46273. Positions 2-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1230131. 1 interaction.
STRING5476.CAL0000415.

Protein family/group databases

Allergome5991. Cand a PGK.

2D gel databases

COMPLUYEAST-2DPAGEP46273.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3647038.
3647081.
KEGGcal:CaO19.11135.
cal:CaO19.3651.

Organism-specific databases

CGDCAL0000415. PGK1.

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OrthoDBEOG71K6D7.

Enzyme and pathway databases

BRENDA2.7.2.3. 1096.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_CANAL
AccessionPrimary (citable) accession number: P46273
Secondary accession number(s): Q59NN7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names