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P46273

- PGK_CANAL

UniProt

P46273 - PGK_CANAL

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Protein

Phosphoglycerate kinase

Gene

PGK1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Binding sitei122 – 1221SubstrateBy similarity
Binding sitei170 – 1701SubstrateBy similarity
Binding sitei219 – 2191ATPBy similarity
Binding sitei312 – 3121ATP; via carbonyl oxygenBy similarity
Binding sitei343 – 3431ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi372 – 3754ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: CGD

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. glycolytic process Source: CGD
  3. induction by symbiont of host defense response Source: CGD
  4. interaction with host Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Cell wall biogenesis/degradation, Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.2.3. 1096.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK1
ORF Names:CaO19.11135, CaO19.3651
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000415. PGK1.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: CGD
  2. cytoplasm Source: CGD
  3. external side of plasma membrane Source: CGD
  4. extracellular region Source: UniProtKB-KW
  5. fungal-type cell wall Source: CGD
  6. hyphal cell wall Source: CGD
  7. plasma membrane Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Cytoplasm, Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei5991. Cand a PGK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Phosphoglycerate kinasePRO_0000145876Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP46273.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi1230131. 1 interaction.
STRINGi5476.CAL0000415.

Structurei

3D structure databases

ProteinModelPortaliP46273.
SMRiP46273. Positions 2-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni63 – 664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
InParanoidiP46273.
KOiK00927.
OrthoDBiEOG71K6D7.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46273-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSNKLSVK DLDVAGKRVF IRVDFNVPLD GKTITNNQRI VAALPTIKYV
60 70 80 90 100
EEHKPKYIVL ASHLGRPNGE RNDKYSLAPV ATELEKLLGQ KVTFLNDCVG
110 120 130 140 150
PEVTKAVENA KDGEIFLLEN LRYHIEEEGS SKDKDGKKVK ADPEAVKKFR
160 170 180 190 200
QELTSLADVY INDAFGTAHR AHSSMVGLEV PQRAAGFLMS KELEYFAKAL
210 220 230 240 250
ENPERPFLAI LGGAKVSDKI QLIDNLLDKV DMLIVGGGMA FTFKKILNKM
260 270 280 290 300
PIGDSLFDEA GAKNVEHLVE KAKKNNVELI LPVDFVTADK FDKDAKTSSA
310 320 330 340 350
TDAEGIPDNW MGLDCGPKSV ELFQQAVAKA KTIVWNGPPG VFEFEKFANG
360 370 380 390 400
TKSLLDAAVK SAENGNIVII GGGDTATVAK KYGVVEKLSH VSTGGGASLE
410
LLEGKDLPGV VALSNKN
Length:417
Mass (Da):45,180
Last modified:November 1, 1995 - v1
Checksum:i6F147F640F5EC784
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25180 Genomic DNA. Translation: AAA66523.1.
AACQ01000203 Genomic DNA. Translation: EAK92092.1.
AACQ01000201 Genomic DNA. Translation: EAK92141.1.
RefSeqiXP_711323.1. XM_706231.1.
XP_711371.1. XM_706279.1.

Genome annotation databases

GeneIDi3647038.
3647081.
KEGGical:CaO19.11135.
cal:CaO19.3651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25180 Genomic DNA. Translation: AAA66523.1 .
AACQ01000203 Genomic DNA. Translation: EAK92092.1 .
AACQ01000201 Genomic DNA. Translation: EAK92141.1 .
RefSeqi XP_711323.1. XM_706231.1.
XP_711371.1. XM_706279.1.

3D structure databases

ProteinModelPortali P46273.
SMRi P46273. Positions 2-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1230131. 1 interaction.
STRINGi 5476.CAL0000415.

Protein family/group databases

Allergomei 5991. Cand a PGK.

2D gel databases

COMPLUYEAST-2DPAGE P46273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3647038.
3647081.
KEGGi cal:CaO19.11135.
cal:CaO19.3651.

Organism-specific databases

CGDi CAL0000415. PGK1.

Phylogenomic databases

eggNOGi COG0126.
InParanoidi P46273.
KOi K00927.
OrthoDBi EOG71K6D7.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BRENDAi 2.7.2.3. 1096.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "3-phosphoglycerate kinase: a glycolytic enzyme protein present in the cell wall of Candida albicans."
    Alloush H.M., Lopez-Ribot J.L., Masten B.J., Chaffin W.L.
    Microbiology 143:321-330(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 3153A.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPGK_CANAL
AccessioniPrimary (citable) accession number: P46273
Secondary accession number(s): Q59NN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3