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P46273

- PGK_CANAL

UniProt

P46273 - PGK_CANAL

Protein

Phosphoglycerate kinase

Gene

PGK1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Binding sitei122 – 1221SubstrateBy similarity
    Binding sitei170 – 1701SubstrateBy similarity
    Binding sitei219 – 2191ATPBy similarity
    Binding sitei312 – 3121ATP; via carbonyl oxygenBy similarity
    Binding sitei343 – 3431ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi372 – 3754ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: CGD
    3. protein binding Source: CGD

    GO - Biological processi

    1. glycolytic process Source: CGD
    2. induction by symbiont of host defense response Source: CGD
    3. interaction with host Source: CGD

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Cell wall biogenesis/degradation, Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.2.3. 1096.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:PGK1
    ORF Names:CaO19.11135, CaO19.3651
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000415. PGK1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: CGD
    2. cytoplasm Source: CGD
    3. external side of plasma membrane Source: CGD
    4. extracellular region Source: UniProtKB-KW
    5. fungal-type cell wall Source: CGD
    6. hyphal cell wall Source: CGD
    7. plasma membrane Source: CGD

    Keywords - Cellular componenti

    Cell wall, Cytoplasm, Secreted

    Pathology & Biotechi

    Protein family/group databases

    Allergomei5991. Cand a PGK.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Phosphoglycerate kinasePRO_0000145876Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEP46273.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi1230131. 1 interaction.
    STRINGi5476.CAL0000415.

    Structurei

    3D structure databases

    ProteinModelPortaliP46273.
    SMRiP46273. Positions 2-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingBy similarity
    Regioni63 – 664Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    KOiK00927.
    OrthoDBiEOG71K6D7.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSNKLSVK DLDVAGKRVF IRVDFNVPLD GKTITNNQRI VAALPTIKYV    50
    EEHKPKYIVL ASHLGRPNGE RNDKYSLAPV ATELEKLLGQ KVTFLNDCVG 100
    PEVTKAVENA KDGEIFLLEN LRYHIEEEGS SKDKDGKKVK ADPEAVKKFR 150
    QELTSLADVY INDAFGTAHR AHSSMVGLEV PQRAAGFLMS KELEYFAKAL 200
    ENPERPFLAI LGGAKVSDKI QLIDNLLDKV DMLIVGGGMA FTFKKILNKM 250
    PIGDSLFDEA GAKNVEHLVE KAKKNNVELI LPVDFVTADK FDKDAKTSSA 300
    TDAEGIPDNW MGLDCGPKSV ELFQQAVAKA KTIVWNGPPG VFEFEKFANG 350
    TKSLLDAAVK SAENGNIVII GGGDTATVAK KYGVVEKLSH VSTGGGASLE 400
    LLEGKDLPGV VALSNKN 417
    Length:417
    Mass (Da):45,180
    Last modified:November 1, 1995 - v1
    Checksum:i6F147F640F5EC784
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25180 Genomic DNA. Translation: AAA66523.1.
    AACQ01000203 Genomic DNA. Translation: EAK92092.1.
    AACQ01000201 Genomic DNA. Translation: EAK92141.1.
    RefSeqiXP_711323.1. XM_706231.1.
    XP_711371.1. XM_706279.1.

    Genome annotation databases

    GeneIDi3647038.
    3647081.
    KEGGical:CaO19.11135.
    cal:CaO19.3651.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25180 Genomic DNA. Translation: AAA66523.1 .
    AACQ01000203 Genomic DNA. Translation: EAK92092.1 .
    AACQ01000201 Genomic DNA. Translation: EAK92141.1 .
    RefSeqi XP_711323.1. XM_706231.1.
    XP_711371.1. XM_706279.1.

    3D structure databases

    ProteinModelPortali P46273.
    SMRi P46273. Positions 2-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1230131. 1 interaction.
    STRINGi 5476.CAL0000415.

    Protein family/group databases

    Allergomei 5991. Cand a PGK.

    2D gel databases

    COMPLUYEAST-2DPAGE P46273.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647038.
    3647081.
    KEGGi cal:CaO19.11135.
    cal:CaO19.3651.

    Organism-specific databases

    CGDi CAL0000415. PGK1.

    Phylogenomic databases

    eggNOGi COG0126.
    KOi K00927.
    OrthoDBi EOG71K6D7.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BRENDAi 2.7.2.3. 1096.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "3-phosphoglycerate kinase: a glycolytic enzyme protein present in the cell wall of Candida albicans."
      Alloush H.M., Lopez-Ribot J.L., Masten B.J., Chaffin W.L.
      Microbiology 143:321-330(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 3153A.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiPGK_CANAL
    AccessioniPrimary (citable) accession number: P46273
    Secondary accession number(s): Q59NN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3