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Protein

Phosphoglycerate kinase

Gene

PGK1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (TDH3)
  2. Phosphoglycerate kinase (PGK1)
  3. Phosphoglycerate mutase (GPM2), Phosphoglycerate mutase (GPM1)
  4. Enolase 1 (ENO1)
  5. Pyruvate kinase (CDC19)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei170SubstrateBy similarity1
Binding sitei219ATPBy similarity1
Binding sitei312ATP; via carbonyl oxygenBy similarity1
Binding sitei343ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi372 – 375ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • cell wall organization Source: UniProtKB-KW
  • glycolytic process Source: UniProtKB-UniPathway
  • induction by symbiont of host defense response Source: CGD
  • interaction with host Source: CGD

Keywordsi

Molecular functionKinase, Transferase
Biological processCell wall biogenesis/degradation, Glycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.2.3 1096
UniPathwayiUPA00109; UER00185

Protein family/group databases

MoonProtiP46273

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK1
Ordered Locus Names:CAALFM_C600750CA
ORF Names:CaO19.11135, CaO19.3651
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 6

Organism-specific databases

CGDiCAL0000184891 PGK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Cytoplasm, Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei5991 Cand a PGK

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458761 – 417Phosphoglycerate kinaseAdd BLAST417

Proteomic databases

PRIDEiP46273

2D gel databases

COMPLUYEAST-2DPAGEiP46273

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi1230131, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP46273
SMRiP46273
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni63 – 66Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

InParanoidiP46273
KOiK00927
OMAiDMIFDIG
OrthoDBiEOG092C2GKC

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 4 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P46273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSNKLSVK DLDVAGKRVF IRVDFNVPLD GKTITNNQRI VAALPTIKYV
60 70 80 90 100
EEHKPKYIVL ASHLGRPNGE RNDKYSLAPV ATELEKLLGQ KVTFLNDCVG
110 120 130 140 150
PEVTKAVENA KDGEIFLLEN LRYHIEEEGS SKDKDGKKVK ADPEAVKKFR
160 170 180 190 200
QELTSLADVY INDAFGTAHR AHSSMVGLEV PQRAAGFLMS KELEYFAKAL
210 220 230 240 250
ENPERPFLAI LGGAKVSDKI QLIDNLLDKV DMLIVGGGMA FTFKKILNKM
260 270 280 290 300
PIGDSLFDEA GAKNVEHLVE KAKKNNVELI LPVDFVTADK FDKDAKTSSA
310 320 330 340 350
TDAEGIPDNW MGLDCGPKSV ELFQQAVAKA KTIVWNGPPG VFEFEKFANG
360 370 380 390 400
TKSLLDAAVK SAENGNIVII GGGDTATVAK KYGVVEKLSH VSTGGGASLE
410
LLEGKDLPGV VALSNKN
Length:417
Mass (Da):45,180
Last modified:November 1, 1995 - v1
Checksum:i6F147F640F5EC784
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25180 Genomic DNA Translation: AAA66523.1
CP017628 Genomic DNA Translation: AOW30021.1
RefSeqiXP_711323.1, XM_706231.2

Genome annotation databases

EnsemblFungiiAOW30021; AOW30021; CAALFM_C600750CA
GeneIDi3647081
KEGGical:CAALFM_C600750CA

Similar proteinsi

Entry informationi

Entry nameiPGK_CANAL
AccessioniPrimary (citable) accession number: P46273
Secondary accession number(s): A0A1D8PPF5, Q59NN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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