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Protein

Fructose-bisphosphate aldolase, cytoplasmic isozyme 2

Gene
N/A
Organism
Pisum sativum (Garden pea)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase, cytoplasmic isozyme 1, Fructose-bisphosphate aldolase, cytoplasmic isozyme 2, Fructose-bisphosphate aldolase 1, chloroplastic, Fructose-bisphosphate aldolase 2, chloroplastic
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52SubstrateBy similarity1
Binding sitei143SubstrateBy similarity1
Active sitei184Proton acceptorBy similarity1
Active sitei226Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei359Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

SABIO-RKP46257.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase, cytoplasmic isozyme 2 (EC:4.1.2.13)
OrganismiPisum sativum (Garden pea)
Taxonomic identifieri3888 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169241 – 359Fructose-bisphosphate aldolase, cytoplasmic isozyme 2Add BLAST359

Proteomic databases

PRIDEiP46257.

Structurei

3D structure databases

ProteinModelPortaliP46257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHFKSKYHD ELIANAAYIG TPGKGILAAD ESTGTIGKRL SSINVENVES
60 70 80 90 100
NRQALRELLF TASWLFLQYL SGVILFEETL YQKTAAGKPF VDVLNEAGVL
110 120 130 140 150
PGIKVDKGTV ELAGTDGETT TQGLDGLGAR CRKYYEAGAR FAKWRAVLKI
160 170 180 190 200
GANEPSEHSI HENAYGLARY AVICQENGLV PIVEPEILVD GSHDILKCAA
210 220 230 240 250
ITERVLAATY KALSDHHVIL EGTLLKPNMV TPGSDAPKVA PEVIAEHTVR
260 270 280 290 300
ALQRTVPAAV PAVVFLSGGQ SEEEASVNLN AINQIKGKKP WTLSFSFGRA
310 320 330 340 350
LQQSTLKAWG GKTENVKAAQ DALLTRAKAN SEATLGTYKG ASNLGAGASE

SLHVKDYKY
Length:359
Mass (Da):38,491
Last modified:November 1, 1995 - v1
Checksum:iC0CAB16E9CC1B9EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89829 Genomic DNA. Translation: CAA61947.1.
PIRiS58167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89829 Genomic DNA. Translation: CAA61947.1.
PIRiS58167.

3D structure databases

ProteinModelPortaliP46257.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP46257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
SABIO-RKP46257.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALF2_PEA
AccessioniPrimary (citable) accession number: P46257
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.