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P46257

- ALF2_PEA

UniProt

P46257 - ALF2_PEA

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Protein

Fructose-bisphosphate aldolase, cytoplasmic isozyme 2

Gene
N/A
Organism
Pisum sativum (Garden pea)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521SubstrateBy similarity
Binding sitei143 – 1431SubstrateBy similarity
Active sitei184 – 1841Proton acceptorBy similarity
Active sitei226 – 2261Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei359 – 3591Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

SABIO-RKP46257.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase, cytoplasmic isozyme 2 (EC:4.1.2.13)
OrganismiPisum sativum (Garden pea)
Taxonomic identifieri3888 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Fructose-bisphosphate aldolase, cytoplasmic isozyme 2PRO_0000216924Add
BLAST

Proteomic databases

PRIDEiP46257.
ProMEXiP46257.

Structurei

3D structure databases

ProteinModelPortaliP46257.
SMRiP46257. Positions 11-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46257-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHFKSKYHD ELIANAAYIG TPGKGILAAD ESTGTIGKRL SSINVENVES
60 70 80 90 100
NRQALRELLF TASWLFLQYL SGVILFEETL YQKTAAGKPF VDVLNEAGVL
110 120 130 140 150
PGIKVDKGTV ELAGTDGETT TQGLDGLGAR CRKYYEAGAR FAKWRAVLKI
160 170 180 190 200
GANEPSEHSI HENAYGLARY AVICQENGLV PIVEPEILVD GSHDILKCAA
210 220 230 240 250
ITERVLAATY KALSDHHVIL EGTLLKPNMV TPGSDAPKVA PEVIAEHTVR
260 270 280 290 300
ALQRTVPAAV PAVVFLSGGQ SEEEASVNLN AINQIKGKKP WTLSFSFGRA
310 320 330 340 350
LQQSTLKAWG GKTENVKAAQ DALLTRAKAN SEATLGTYKG ASNLGAGASE

SLHVKDYKY
Length:359
Mass (Da):38,491
Last modified:November 1, 1995 - v1
Checksum:iC0CAB16E9CC1B9EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89829 Genomic DNA. Translation: CAA61947.1.
PIRiS58167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89829 Genomic DNA. Translation: CAA61947.1 .
PIRi S58167.

3D structure databases

ProteinModelPortali P46257.
SMRi P46257. Positions 11-359.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P46257.
ProMEXi P46257.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
SABIO-RK P46257.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Pelzer-Reith B., Schnarrenberger C.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leaf.

Entry informationi

Entry nameiALF2_PEA
AccessioniPrimary (citable) accession number: P46257
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3