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Protein

Fructose-bisphosphate aldolase, cytoplasmic isozyme 1

Gene
N/A
Organism
Pisum sativum (Garden pea)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase, cytoplasmic isozyme 1, Fructose-bisphosphate aldolase, cytoplasmic isozyme 2, Fructose-bisphosphate aldolase 1, chloroplastic, Fructose-bisphosphate aldolase 2, chloroplastic
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Active sitei183Proton acceptorBy similarity1
Active sitei225Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei357Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

SABIO-RKP46256.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase, cytoplasmic isozyme 1 (EC:4.1.2.13)
OrganismiPisum sativum (Garden pea)
Taxonomic identifieri3888 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169231 – 357Fructose-bisphosphate aldolase, cytoplasmic isozyme 1Add BLAST357

Proteomic databases

PRIDEiP46256.

Structurei

3D structure databases

ProteinModelPortaliP46256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFVGKYAD ELIKNAKYIA TPGKGILAAD ESTGTIGKRL ASINVENIEA
60 70 80 90 100
NRQALRELLF TSPNALQYLS GVILFEETLY QKSSEGKPFV EILQENNVIP
110 120 130 140 150
GIKVDKGVVE LAGTDGETTT QGFDSLGARC QQYYKAGARF AKWRAVLKIG
160 170 180 190 200
PNEPSELSIQ QNAQGLARYA IICQENGLVL FVEPEILTDG SHDIAKCAAV
210 220 230 240 250
TETVLAACYK ALNDQHVLLE GTLLKPNMVT PGSDSPKVSP EVIGEYTVNA
260 270 280 290 300
LRRTVPAAVP GIVFLSGGQS EEQATLNLNA MNKFDVVKPW TLSFSFGRAL
310 320 330 340 350
QQSTLKTWSG KKENVGKAQD VFLARCKANS EATLGKYGGG SGTGLASESL

HVKDYKY
Length:357
Mass (Da):38,446
Last modified:November 1, 1995 - v1
Checksum:iBB30E70BA0401D61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89828 mRNA. Translation: CAA61946.1.
PIRiS58168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89828 mRNA. Translation: CAA61946.1.
PIRiS58168.

3D structure databases

ProteinModelPortaliP46256.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP46256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
SABIO-RKP46256.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALF1_PEA
AccessioniPrimary (citable) accession number: P46256
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.