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P46250

- SEC14_CANAL

UniProt

P46250 - SEC14_CANAL

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Protein
SEC14 cytosolic factor
Gene
SEC14, CaO19.8556, CaO19.941
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro By similarity.

GO - Molecular functioni

  1. phosphatidylinositol transporter activity Source: CGD

GO - Biological processi

  1. CDP-choline pathway Source: CGD
  2. cellular response to drug Source: CGD
  3. phospholipid transport Source: GOC
  4. post-Golgi vesicle-mediated transport Source: CGD
  5. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14 cytosolic factor
Alternative name(s):
Phosphatidylinositol/phosphatidylcholine transfer protein
Short name:
PI/PC TP
Gene namesi
Name:SEC14
ORF Names:CaO19.8556, CaO19.941
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003685. SEC14.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: CGD
  2. Golgi membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301SEC14 cytosolic factor
PRO_0000210739Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003685.

Structurei

3D structure databases

ProteinModelPortaliP46250.
SMRiP46250. Positions 7-296.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 272174CRAL-TRIO
Add
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.

Phylogenomic databases

eggNOGiNOG309458.
OrthoDBiEOG761C55.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46250-1 [UniParc]FASTAAdd to Basket

« Hide

MTTMTTEEIL ASYPQITAPT DQTGYTSNLT PEQKTTLDIF RQQLTELGYK    50
DRLDDASLLR FLRARKFDIQ KAIDMFVACE KWREDFGVNT ILKDFHYEEK 100
PIVAKMYPTY YHKTDKDGRP VYFEELGKVD LVKMLKITTQ ERMLKNLVWE 150
YEAMCQYRLP ACSRKAGYLV ETSCTVLDLS GISVTSAYNV IGYVREASKI 200
GQDYYPERMG KFYLINAPFG FSTAFKLFKP FLDPVTVSKI HILGYSYKKE 250
LLKQIPPQNL PVKFGGMSDV SDDDLLLKDV GPWRDPEFIG PEGECPRAYN 300
I 301
Length:301
Mass (Da):34,709
Last modified:November 1, 1995 - v1
Checksum:i1F194A8EA8B525BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81937 Genomic DNA. Translation: CAA57490.1.
U61975 mRNA. Translation: AAB41491.1.
AACQ01000063 Genomic DNA. Translation: EAK97793.1.
AACQ01000062 Genomic DNA. Translation: EAK97854.1.
PIRiS57923.
RefSeqiXP_716780.1. XM_711687.1.
XP_716840.1. XM_711747.1.

Genome annotation databases

GeneIDi3641491.
3641542.
KEGGical:CaO19.8556.
cal:CaO19.941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81937 Genomic DNA. Translation: CAA57490.1 .
U61975 mRNA. Translation: AAB41491.1 .
AACQ01000063 Genomic DNA. Translation: EAK97793.1 .
AACQ01000062 Genomic DNA. Translation: EAK97854.1 .
PIRi S57923.
RefSeqi XP_716780.1. XM_711687.1.
XP_716840.1. XM_711747.1.

3D structure databases

ProteinModelPortali P46250.
SMRi P46250. Positions 7-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003685.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3641491.
3641542.
KEGGi cal:CaO19.8556.
cal:CaO19.941.

Organism-specific databases

CGDi CAL0003685. SEC14.

Phylogenomic databases

eggNOGi NOG309458.
OrthoDBi EOG761C55.

Family and domain databases

Gene3Di 3.40.525.10. 1 hit.
InterProi IPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view ]
Pfami PF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view ]
PRINTSi PR00180. CRETINALDHBP.
SMARTi SM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view ]
SUPFAMi SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of Candida albicans SEC14 gene homologue coding for a putative essential function."
    Monteoliva L., Sanchez M., Pla J., Gil C., Nombela C.
    Yeast 12:1097-1105(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 64385 / 1001.
  2. "Two transcripts, differing at their 3' ends, are produced from the Candida albicans SEC14 gene."
    Riggle P.J., Slobodkin I.V., Brown D.H. Jr., Hanson M.P., Volkert T.L., Kumamoto C.A.
    Microbiology 143:3527-3535(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SGY243.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiSEC14_CANAL
AccessioniPrimary (citable) accession number: P46250
Secondary accession number(s): Q5A505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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