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Protein

SEC14 cytosolic factor

Gene

SEC14

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro (By similarity).By similarity

GO - Molecular functioni

  1. phosphatidylinositol transporter activity Source: CGD

GO - Biological processi

  1. CDP-choline pathway Source: CGD
  2. cellular response to drug Source: CGD
  3. phospholipid transport Source: GOC
  4. post-Golgi vesicle-mediated transport Source: CGD
  5. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14 cytosolic factor
Alternative name(s):
Phosphatidylinositol/phosphatidylcholine transfer protein
Short name:
PI/PC TP
Gene namesi
Name:SEC14
ORF Names:CaO19.8556, CaO19.941
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003685. SEC14.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: CGD
  2. Golgi membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301SEC14 cytosolic factorPRO_0000210739Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003685.

Structurei

3D structure databases

ProteinModelPortaliP46250.
SMRiP46250. Positions 7-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 272174CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG309458.
InParanoidiP46250.
OrthoDBiEOG761C55.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46250-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTMTTEEIL ASYPQITAPT DQTGYTSNLT PEQKTTLDIF RQQLTELGYK
60 70 80 90 100
DRLDDASLLR FLRARKFDIQ KAIDMFVACE KWREDFGVNT ILKDFHYEEK
110 120 130 140 150
PIVAKMYPTY YHKTDKDGRP VYFEELGKVD LVKMLKITTQ ERMLKNLVWE
160 170 180 190 200
YEAMCQYRLP ACSRKAGYLV ETSCTVLDLS GISVTSAYNV IGYVREASKI
210 220 230 240 250
GQDYYPERMG KFYLINAPFG FSTAFKLFKP FLDPVTVSKI HILGYSYKKE
260 270 280 290 300
LLKQIPPQNL PVKFGGMSDV SDDDLLLKDV GPWRDPEFIG PEGECPRAYN

I
Length:301
Mass (Da):34,709
Last modified:November 1, 1995 - v1
Checksum:i1F194A8EA8B525BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81937 Genomic DNA. Translation: CAA57490.1.
U61975 mRNA. Translation: AAB41491.1.
AACQ01000063 Genomic DNA. Translation: EAK97793.1.
AACQ01000062 Genomic DNA. Translation: EAK97854.1.
PIRiS57923.
RefSeqiXP_716780.1. XM_711687.1.
XP_716840.1. XM_711747.1.

Genome annotation databases

GeneIDi3641491.
3641542.
KEGGical:CaO19.8556.
cal:CaO19.941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81937 Genomic DNA. Translation: CAA57490.1.
U61975 mRNA. Translation: AAB41491.1.
AACQ01000063 Genomic DNA. Translation: EAK97793.1.
AACQ01000062 Genomic DNA. Translation: EAK97854.1.
PIRiS57923.
RefSeqiXP_716780.1. XM_711687.1.
XP_716840.1. XM_711747.1.

3D structure databases

ProteinModelPortaliP46250.
SMRiP46250. Positions 7-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0003685.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3641491.
3641542.
KEGGical:CaO19.8556.
cal:CaO19.941.

Organism-specific databases

CGDiCAL0003685. SEC14.

Phylogenomic databases

eggNOGiNOG309458.
InParanoidiP46250.
OrthoDBiEOG761C55.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of Candida albicans SEC14 gene homologue coding for a putative essential function."
    Monteoliva L., Sanchez M., Pla J., Gil C., Nombela C.
    Yeast 12:1097-1105(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 64385 / 1001.
  2. "Two transcripts, differing at their 3' ends, are produced from the Candida albicans SEC14 gene."
    Riggle P.J., Slobodkin I.V., Brown D.H. Jr., Hanson M.P., Volkert T.L., Kumamoto C.A.
    Microbiology 143:3527-3535(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SGY243.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiSEC14_CANAL
AccessioniPrimary (citable) accession number: P46250
Secondary accession number(s): Q5A505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.