P46250 (SEC14_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SEC14 cytosolic factor

Alternative name(s):
Phosphatidylinositol/phosphatidylcholine transfer protein
Short name=PI/PC TP

Gene names

Name:	SEC14
ORF Names:	CaO19.8556, CaO19.941

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro By similarity.
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein By similarity.
Sequence similarities	Contains 1 CRAL-TRIO domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	CDP-choline pathway Inferred from genetic interaction Ref.1. Source: CGD post-Golgi vesicle-mediated transport Inferred from genetic interaction Ref.1. Source: CGD protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from sequence or structural similarity Ref.2. Source: CGD Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphatidylinositol transporter activity Inferred from sequence or structural similarity Ref.2. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	SEC14 cytosolic factor		PRO_0000210739
Regions
	Domain	99 – 272	174	CRAL-TRIO

Sequences

	Sequence		Length	Mass (Da)
	P46250 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 1F194A8EA8B525BE	FASTA	301	34,709
	10 20 30 40 50 60 MTTMTTEEIL ASYPQITAPT DQTGYTSNLT PEQKTTLDIF RQQLTELGYK DRLDDASLLR 70 80 90 100 110 120 FLRARKFDIQ KAIDMFVACE KWREDFGVNT ILKDFHYEEK PIVAKMYPTY YHKTDKDGRP 130 140 150 160 170 180 VYFEELGKVD LVKMLKITTQ ERMLKNLVWE YEAMCQYRLP ACSRKAGYLV ETSCTVLDLS 190 200 210 220 230 240 GISVTSAYNV IGYVREASKI GQDYYPERMG KFYLINAPFG FSTAFKLFKP FLDPVTVSKI 250 260 270 280 290 300 HILGYSYKKE LLKQIPPQNL PVKFGGMSDV SDDDLLLKDV GPWRDPEFIG PEGECPRAYN I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of Candida albicans SEC14 gene homologue coding for a putative essential function." Monteoliva L., Sanchez M., Pla J., Gil C., Nombela C. Yeast 12:1097-1105(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 64385 / 1001.
[2]	"Two transcripts, differing at their 3' ends, are produced from the Candida albicans SEC14 gene." Riggle P.J., Slobodkin I.V., Brown D.H. Jr., Hanson M.P., Volkert T.L., Kumamoto C.A. Microbiology 143:3527-3535(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: SGY243.
[3]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X81937 Genomic DNA. Translation: CAA57490.1. U61975 mRNA. Translation: AAB41491.1. AACQ01000063 Genomic DNA. Translation: EAK97793.1. AACQ01000062 Genomic DNA. Translation: EAK97854.1.
PIR	S57923.
RefSeq	XP_716780.1. XM_711687.1. XP_716840.1. XM_711747.1.
3D structure databases
ProteinModelPortal	P46250.
SMR	P46250. Positions 7-296.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0003685.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3641491. 3641542.
KEGG	cal:CaO19.8556. cal:CaO19.941.
Organism-specific databases
CGD	CAL0003685. SEC14.
Phylogenomic databases
eggNOG	NOG309458.
Family and domain databases
Gene3D	3.40.525.10. 1 hit.
InterPro	IPR001071. CRAL-bd_toc_tran. IPR001251. CRAL-TRIO_dom. IPR011074. CRAL/TRIO_N_dom. [Graphical view]
Pfam	PF00650. CRAL_TRIO. 1 hit. PF03765. CRAL_TRIO_N. 1 hit. [Graphical view]
PRINTS	PR00180. CRETINALDHBP.
SMART	SM01100. CRAL_TRIO_N. 1 hit. SM00516. SEC14. 1 hit. [Graphical view]
SUPFAM	SSF52087. CRAL_TRIO_C. 1 hit. SSF46938. Sec14p_like_N. 1 hit.
PROSITE	PS50191. CRAL_TRIO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SEC14_CANAL

Accession

Primary (citable) accession number: P46250
Secondary accession number(s): Q5A505

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program