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P46240

- AROE_BUCAP

UniProt

P46240 - AROE_BUCAP

Protein

Shikimate dehydrogenase

Gene

aroE

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (30 Aug 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Shikimate + NADP+ = 3-dehydroshikimate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei70 – 701Proton acceptorSequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi131 – 1355NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway
    3. shikimate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-502-MONOMER.
    UniPathwayiUPA00053; UER00087.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shikimate dehydrogenase (EC:1.1.1.25)
    Gene namesi
    Name:aroE
    Ordered Locus Names:BUsg_474
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Shikimate dehydrogenasePRO_0000135996Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg474.

    Structurei

    3D structure databases

    ProteinModelPortaliP46240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0169.
    KOiK00014.
    OMAiPFKEDAY.
    OrthoDBiEOG6RRKMV.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00222. Shikimate_DH_AroE.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR011342. Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view]
    PfamiPF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00507. aroE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P46240-1 [UniParc]FASTAAdd to Basket

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    MCKLEKFNYA LFGNPIDHSQ SPKIHNFFAT QTGILHIYKA INIPLDQFSS    50
    VVSDFFKKNI KGANVTAPFK KEAYFFSDKL TERAKIAQSV NTLKKISDKC 100
    ILGDNTDGIG LLSDLVRLNF IKKNFSILIL GAGGAVKGVL LPLLSLGCSV 150
    YILNRTILNA KILVKQFNKY GKIFVFDRQN FKQQNFDLVI NAMSRNTEKK 200
    NFLPLSLITS KTFFYDMNYS TRNTPFINWC SKAGGSFISN GIGMLVFQAA 250
    YSFLEWHNVL PEINYIINIL NIK 273
    Length:273
    Mass (Da):30,885
    Last modified:August 30, 2002 - v2
    Checksum:i50507AF854774AF6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti203 – 2042LP → T in AAD09433. (PubMed:7535281)Curated
    Sequence conflicti206 – 2061S → I in AAD09433. (PubMed:7535281)Curated
    Sequence conflicti212 – 2121T → R in AAD09433. (PubMed:7535281)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09230 Genomic DNA. Translation: AAD09433.1.
    AE013218 Genomic DNA. Translation: AAM68017.1.
    RefSeqiNP_660806.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM68017; AAM68017; BUsg_474.
    GeneIDi1005693.
    KEGGibas:BUsg474.
    PATRICi21247812. VBIBucAph100086_0501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09230 Genomic DNA. Translation: AAD09433.1 .
    AE013218 Genomic DNA. Translation: AAM68017.1 .
    RefSeqi NP_660806.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali P46240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg474.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM68017 ; AAM68017 ; BUsg_474 .
    GeneIDi 1005693.
    KEGGi bas:BUsg474.
    PATRICi 21247812. VBIBucAph100086_0501.

    Phylogenomic databases

    eggNOGi COG0169.
    KOi K00014.
    OMAi PFKEDAY.
    OrthoDBi EOG6RRKMV.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00087 .
    BioCyci BAPH198804:GHMG-502-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00222. Shikimate_DH_AroE.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR011342. Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view ]
    Pfami PF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00507. aroE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a putative 23S-5S rRNA operon of Buchnera aphidicola (endosymbiont of aphids) unlinked to the 16S rRNA-encoding gene."
      Rouhbakhsh D., Baumann P.
      Gene 155:107-112(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiAROE_BUCAP
    AccessioniPrimary (citable) accession number: P46240
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: August 30, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3