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P46240

- AROE_BUCAP

UniProt

P46240 - AROE_BUCAP

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Protein

Shikimate dehydrogenase

Gene

aroE

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Proton acceptorSequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi131 – 1355NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
  3. shikimate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-502-MONOMER.
UniPathwayiUPA00053; UER00087.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (EC:1.1.1.25)
Gene namesi
Name:aroE
Ordered Locus Names:BUsg_474
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Shikimate dehydrogenasePRO_0000135996Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg474.

Structurei

3D structure databases

ProteinModelPortaliP46240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0169.
KOiK00014.
OMAiPFKEDAY.
OrthoDBiEOG6RRKMV.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00222. Shikimate_DH_AroE.
InterProiIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamiPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00507. aroE. 1 hit.

Sequencei

Sequence statusi: Complete.

P46240-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCKLEKFNYA LFGNPIDHSQ SPKIHNFFAT QTGILHIYKA INIPLDQFSS
60 70 80 90 100
VVSDFFKKNI KGANVTAPFK KEAYFFSDKL TERAKIAQSV NTLKKISDKC
110 120 130 140 150
ILGDNTDGIG LLSDLVRLNF IKKNFSILIL GAGGAVKGVL LPLLSLGCSV
160 170 180 190 200
YILNRTILNA KILVKQFNKY GKIFVFDRQN FKQQNFDLVI NAMSRNTEKK
210 220 230 240 250
NFLPLSLITS KTFFYDMNYS TRNTPFINWC SKAGGSFISN GIGMLVFQAA
260 270
YSFLEWHNVL PEINYIINIL NIK
Length:273
Mass (Da):30,885
Last modified:August 30, 2002 - v2
Checksum:i50507AF854774AF6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2042LP → T in AAD09433. (PubMed:7535281)Curated
Sequence conflicti206 – 2061S → I in AAD09433. (PubMed:7535281)Curated
Sequence conflicti212 – 2121T → R in AAD09433. (PubMed:7535281)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09230 Genomic DNA. Translation: AAD09433.1.
AE013218 Genomic DNA. Translation: AAM68017.1.
RefSeqiNP_660806.1. NC_004061.1.
WP_011053983.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM68017; AAM68017; BUsg_474.
GeneIDi1005693.
KEGGibas:BUsg474.
PATRICi21247812. VBIBucAph100086_0501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09230 Genomic DNA. Translation: AAD09433.1 .
AE013218 Genomic DNA. Translation: AAM68017.1 .
RefSeqi NP_660806.1. NC_004061.1.
WP_011053983.1. NC_004061.1.

3D structure databases

ProteinModelPortali P46240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg474.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM68017 ; AAM68017 ; BUsg_474 .
GeneIDi 1005693.
KEGGi bas:BUsg474.
PATRICi 21247812. VBIBucAph100086_0501.

Phylogenomic databases

eggNOGi COG0169.
KOi K00014.
OMAi PFKEDAY.
OrthoDBi EOG6RRKMV.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00087 .
BioCyci BAPH198804:GHMG-502-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00222. Shikimate_DH_AroE.
InterProi IPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view ]
Pfami PF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00507. aroE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a putative 23S-5S rRNA operon of Buchnera aphidicola (endosymbiont of aphids) unlinked to the 16S rRNA-encoding gene."
    Rouhbakhsh D., Baumann P.
    Gene 155:107-112(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiAROE_BUCAP
AccessioniPrimary (citable) accession number: P46240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 30, 2002
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3