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P46239 (GUNF_FUSOX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative endoglucanase type F

EC=3.2.1.4
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
OrganismFusarium oxysporum (Fusarium vascular wilt)
Taxonomic identifier5507 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaemitosporic NectriaceaeFusariumFusarium oxysporum species complex

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sequence similarities

Belongs to the glycosyl hydrolase 10 (cellulase F) family.

Contains 1 CBM1 (fungal-type carbohydrate-binding) domain.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncellulase activity

Inferred from electronic annotation. Source: UniProtKB-EC

cellulose binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 385366Putative endoglucanase type F
PRO_0000007961

Regions

Domain23 – 5331CBM1
Region53 – 8432Linker
Region85 – 385301Catalytic

Sites

Active site2101Proton donor By similarity
Active site3211Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P46239 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: B3C3807C07D3C0EC

FASTA38541,225
        10         20         30         40         50         60 
MHTLSVLLAL APVSALAQAP IWGQCGGNGW TGATTCASGL KCEKINDWYY QCVPGSGGSE 

        70         80         90        100        110        120 
PQPSSTQGGG TPQPTGGNSG GTGLDAKFKA KGKQYFGTEI DHYHLNNNPL INIVKAQFGQ 

       130        140        150        160        170        180 
VTCENSMKWD AIEPSRNSFT FSNADKVVDF ATQNGKLIRG HTLLWHSQLP QWVQNINDRS 

       190        200        210        220        230        240 
TLTAVIENHV KTMVTRYKGK ILQWDVVNNE IFAEDGNLRD SVFSRVLGED FVGIAFRAAR 

       250        260        270        280        290        300 
AADPAAKLYI NDYNLDKSDY AKVTRGMVAH VNKWIAAGIP IDGIGSQGHL AAPSGWNPAS 

       310        320        330        340        350        360 
GVPAALRALA ASDAKEIAIT ELDIAGASAN DYLTVMNACL AVPKCVGITV WGVSDKDSWR 

       370        380 
PGDNPLLYDS NYQPKAAFNA LANAL 

« Hide

References

[1]"The use of conserved cellulase family-specific sequences to clone cellulase homologue cDNAs from Fusarium oxysporum."
Sheppard P.O., Grant F.J., Oort P.J., Sprecher C.A., Foster D.C., Hagen F.S., Upshall A., McKnight G.L., O'Hara P.J.
Gene 150:163-167(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L29380 mRNA. Translation: AAA65588.1.

3D structure databases

ProteinModelPortalP46239.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyCBM1. Carbohydrate-Binding Module Family 1.
GH10. Glycoside Hydrolase Family 10.

Proteomic databases

PRIDEP46239.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR000254. Cellulose-bd_dom_fun.
IPR001000. Glyco_hydro_10.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00734. CBM_1. 1 hit.
PF00331. Glyco_hydro_10. 1 hit.
[Graphical view]
PRINTSPR00134. GLHYDRLASE10.
ProDomPD001821. CBD_fun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00236. fCBD. 1 hit.
SM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
SSF57180. SSF57180. 1 hit.
PROSITEPS00562. CBM1_1. 1 hit.
PS51164. CBM1_2. 1 hit.
PS00591. GLYCOSYL_HYDROL_F10. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUNF_FUSOX
AccessionPrimary (citable) accession number: P46239
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries