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Protein

Endoglucanase type C

Gene
N/A
Organism
Fusarium oxysporum (Fusarium vascular wilt)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei215NucleophileBy similarity1
Active sitei220Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH7. Glycoside Hydrolase Family 7.
mycoCLAPiEGL7A_FUSOX.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase type C (EC:3.2.1.4)
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Endoglucanase I
Short name:
EG I
OrganismiFusarium oxysporum (Fusarium vascular wilt)
Taxonomic identifieri5507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium oxysporum species complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000000791219 – 429Endoglucanase type CAdd BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1
Disulfide bondi36 ↔ 42
Disulfide bondi66 ↔ 88
Glycosylationi74N-linked (GlcNAc...)1
Disulfide bondi78 ↔ 84
Disulfide bondi156 ↔ 383
Disulfide bondi190 ↔ 213
Disulfide bondi194 ↔ 212
Disulfide bondi233 ↔ 252
Disulfide bondi241 ↔ 246
Disulfide bondi257 ↔ 333
Glycosylationi265N-linked (GlcNAc...)1
Glycosylationi318N-linked (GlcNAc...)1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Structurei

Secondary structure

1429
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 37Combined sources8
Turni38 – 40Combined sources3
Beta strandi41 – 51Combined sources11
Helixi53 – 56Combined sources4
Turni75 – 77Combined sources3
Helixi81 – 87Combined sources7
Helixi95 – 100Combined sources6
Beta strandi103 – 106Combined sources4
Beta strandi109 – 116Combined sources8
Beta strandi124 – 128Combined sources5
Beta strandi132 – 135Combined sources4
Beta strandi144 – 150Combined sources7
Beta strandi158 – 165Combined sources8
Turni169 – 172Combined sources4
Helixi173 – 175Combined sources3
Helixi183 – 185Combined sources3
Beta strandi198 – 200Combined sources3
Beta strandi210 – 212Combined sources3
Beta strandi215 – 221Combined sources7
Beta strandi226 – 231Combined sources6
Beta strandi233 – 235Combined sources3
Beta strandi239 – 241Combined sources3
Helixi243 – 246Combined sources4
Beta strandi250 – 252Combined sources3
Helixi261 – 264Combined sources4
Beta strandi269 – 273Combined sources5
Beta strandi276 – 279Combined sources4
Beta strandi284 – 292Combined sources9
Beta strandi298 – 307Combined sources10
Beta strandi310 – 313Combined sources4
Beta strandi319 – 322Combined sources4
Beta strandi326 – 328Combined sources3
Helixi330 – 335Combined sources6
Helixi339 – 343Combined sources5
Helixi346 – 356Combined sources11
Beta strandi358 – 366Combined sources9
Turni368 – 372Combined sources5
Helixi373 – 376Combined sources4
Helixi378 – 380Combined sources3
Helixi390 – 396Combined sources7
Beta strandi401 – 411Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OVWX-ray2.70A/B/C/D20-416[»]
2OVWX-ray2.30A/B/C/D20-429[»]
3OVWX-ray2.30A/B20-429[»]
4OVWX-ray2.30A/B20-429[»]
ProteinModelPortaliP46237.
SMRiP46237.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46237.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IUY5. Eukaryota.
ENOG410YC82. LUCA.

Family and domain databases

CDDicd07999. GH7_CBH_EG. 1 hit.
Gene3Di2.70.100.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001722. Glyco_hydro_7.
[Graphical view]
PfamiPF00840. Glyco_hydro_7. 1 hit.
[Graphical view]
PRINTSiPR00734. GLHYDRLASE7.
SUPFAMiSSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLSLILSA LAVQVAVAQT PDKAKEQHPK LETYRCTKAS GCKKQTNYIV
60 70 80 90 100
ADAGIHGIRQ KNGAGCGDWG QKPNATACPD EASCAKNCIL SGMDSNAYKN
110 120 130 140 150
AGITTSGNKL RLQQLINNQL VSPRVYLLEE NKKKYEMLHL TGTEFSFDVE
160 170 180 190 200
MEKLPCGMNG ALYLSEMPQD GGKSTSRNSK AGAYYGAGYC DAQCYVTPFI
210 220 230 240 250
NGVGNIKGQG VCCNELDIWE ANSRATHIAP HPCSKPGLYG CTGDECGSSG
260 270 280 290 300
ICDKAGCGWN HNRINVTDFY GRGKQYKVDS TRKFTVTSQF VANKQGDLIE
310 320 330 340 350
LHRHYIQDNK VIESAVVNIS GPPKINFIND KYCAATGANE YMRLGGTKQM
360 370 380 390 400
GDAMSRGMVL AMSVWWSEGD FMAWLDQGVA GPCDATEGDP KNIVKVQPNP
410 420
EVTFSNIRIG EIGSTSSVKA PAYPGPHRL
Length:429
Mass (Da):46,445
Last modified:November 1, 1995 - v1
Checksum:iFAE8A880B1F880F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29378 mRNA. Translation: AAA65586.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29378 mRNA. Translation: AAA65586.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OVWX-ray2.70A/B/C/D20-416[»]
2OVWX-ray2.30A/B/C/D20-429[»]
3OVWX-ray2.30A/B20-429[»]
4OVWX-ray2.30A/B20-429[»]
ProteinModelPortaliP46237.
SMRiP46237.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH7. Glycoside Hydrolase Family 7.
mycoCLAPiEGL7A_FUSOX.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IUY5. Eukaryota.
ENOG410YC82. LUCA.

Miscellaneous databases

EvolutionaryTraceiP46237.

Family and domain databases

CDDicd07999. GH7_CBH_EG. 1 hit.
Gene3Di2.70.100.10. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001722. Glyco_hydro_7.
[Graphical view]
PfamiPF00840. Glyco_hydro_7. 1 hit.
[Graphical view]
PRINTSiPR00734. GLHYDRLASE7.
SUPFAMiSSF49899. SSF49899. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGUNC_FUSOX
AccessioniPrimary (citable) accession number: P46237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.