Reviewed,
UniProtKB/Swiss-Prot P46235 (LGUL_VIBPA)
Last modified
June 16, 2009.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Probable lactoylglutathione lyase EC=4.4.1.5 Alternative name(s): Methylglyoxalase Aldoketomutase Glyoxalase I Short name=Glx I Ketone-aldehyde mutase S-D-lactoylglutathione methylglyoxal lyase | ||||
| Gene names |
| ||||
| Organism | Vibrio parahaemolyticus [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 670 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio |
Protein attributes
| Sequence length | 138 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione By similarity. |
| Catalytic activity | (R)-S-lactoylglutathione = glutathione + methylglyoxal. |
| Cofactor | Binds 1 nickel ion per subunit By similarity. |
| Pathway | Secondary metabolite metabolism; methylglyoxal degradation; D-lactate from methylglyoxal: step 1/2. |
| Sequence similarities | Belongs to the glyoxalase I family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Nickel |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | lactoylglutathione lyase activity Inferred from electronic annotation. Source: EC nickel ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 138 | 138 | Probable lactoylglutathione lyase | PRO_0000168098 | |||||
Sites | |||||||||
| Metal binding | 8 | 1 | Nickel By similarity | ||||||
| Metal binding | 59 | 1 | Nickel By similarity | ||||||
| Metal binding | 77 | 1 | Nickel By similarity | ||||||
| Metal binding | 125 | 1 | Nickel By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633 / Serotype O3:K6. |
| [2] | "MotY, a component of the sodium-type flagellar motor." McCarter L.L. J. Bacteriol. 176:4219-4225(1994) [PubMed: 8021208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-138. Strain: BB22. |
Cross-references
Sequence databases | |
|---|---|
| BA000031 Genomic DNA. Translation: BAC60372.1. U06949 Genomic DNA. Translation: AAA21576.1. | |
| RefSeq | NP_798488.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1F9Z based on UniProtKB Q59384. |
| SMR | P46235. Positions 5-128. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1189621. |
| GenomeReviews | Gene locus VP2109 in contig BA000031_GR. |
| KEGG | vpa:VP2109. |
| NMPDR | fig|223926.1.peg.2109. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P46235. |
| OMA | P46235. PGPMKHG. |
Enzyme and pathway databases | |
| BioCyc | VPAR223926:VP2109-MON. |
| BRENDA | 4.4.1.5. 3063. |
Family and domain databases | |
| InterPro | IPR004360. Glyas_bleo-R_dOase. IPR004361. Glyoxalase_1. IPR018146. Glyoxalase_1_CS. [Graphical view] |
| Pfam | PF00903. Glyoxalase. 1 hit. [Graphical view] |
| ProDom | PD002334. Gly_diox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00068. glyox_I. 1 hit. |
| PROSITE | PS00934. GLYOXALASE_I_1. 1 hit. PS00935. GLYOXALASE_I_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LGUL_VIBPA | ||||||||
| Accession | Primary (citable) accession number: P46235 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


