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P46235

- LGUL_VIBPA

UniProt

P46235 - LGUL_VIBPA

Protein

Probable lactoylglutathione lyase

Gene

gloA

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (04 Apr 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.By similarity

    Catalytic activityi

    (R)-S-lactoylglutathione = glutathione + methylglyoxal.

    Cofactori

    Binds 1 nickel ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81Nickel; via tele nitrogenBy similarity
    Binding sitei12 – 121SubstrateBy similarity
    Metal bindingi59 – 591NickelBy similarity
    Binding sitei63 – 631SubstrateBy similarity
    Metal bindingi77 – 771Nickel; via tele nitrogenBy similarity
    Binding sitei77 – 771SubstrateBy similarity
    Active sitei125 – 1251Proton donor/acceptorBy similarity
    Metal bindingi125 – 1251NickelBy similarity

    GO - Molecular functioni

    1. lactoylglutathione lyase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Metal-binding, Nickel

    Enzyme and pathway databases

    BioCyciVPAR223926:GHK4-2165-MONOMER.
    UniPathwayiUPA00619; UER00675.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable lactoylglutathione lyase (EC:4.4.1.5)
    Alternative name(s):
    Aldoketomutase
    Glyoxalase I
    Short name:
    Glx I
    Ketone-aldehyde mutase
    Methylglyoxalase
    S-D-lactoylglutathione methylglyoxal lyase
    Gene namesi
    Name:gloA
    Ordered Locus Names:VP2109
    OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
    Taxonomic identifieri223926 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002493: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Probable lactoylglutathione lyasePRO_0000168098Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi223926.VP2109.

    Structurei

    3D structure databases

    ProteinModelPortaliP46235.
    SMRiP46235. Positions 5-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glyoxalase I family.Curated

    Phylogenomic databases

    eggNOGiCOG0346.
    HOGENOMiHOG000232011.
    KOiK01759.
    OMAiIGEEDIY.
    OrthoDBiEOG6DVJXX.

    Family and domain databases

    Gene3Di3.10.180.10. 1 hit.
    InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    IPR004361. Glyoxalase_1.
    IPR018146. Glyoxalase_1_CS.
    [Graphical view]
    PfamiPF00903. Glyoxalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF54593. SSF54593. 1 hit.
    TIGRFAMsiTIGR00068. glyox_I. 1 hit.
    PROSITEiPS00934. GLYOXALASE_I_1. 1 hit.
    PS00935. GLYOXALASE_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46235-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNGRILHTM LRVGDLDKSI KFYTEVMGMQ LLRTNENKEY EYTLAFVGYG    50
    DESQGAVIEL TYNWGKTEYD LGTAFGHIAI GVDDIYATCD AIKAAGGNVT 100
    REAGPVKGGT THIAFVKDPD GYMIELIQNK QASAGLEG 138
    Length:138
    Mass (Da):15,034
    Last modified:April 4, 2003 - v2
    Checksum:i5738D502E3CA35FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000031 Genomic DNA. Translation: BAC60372.1.
    U06949 Genomic DNA. Translation: AAA21576.1.
    RefSeqiNP_798488.1. NC_004603.1.

    Genome annotation databases

    EnsemblBacteriaiBAC60372; BAC60372; BAC60372.
    GeneIDi1189621.
    KEGGivpa:VP2109.
    PATRICi20142378. VBIVibPar50997_2019.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000031 Genomic DNA. Translation: BAC60372.1 .
    U06949 Genomic DNA. Translation: AAA21576.1 .
    RefSeqi NP_798488.1. NC_004603.1.

    3D structure databases

    ProteinModelPortali P46235.
    SMRi P46235. Positions 5-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223926.VP2109.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC60372 ; BAC60372 ; BAC60372 .
    GeneIDi 1189621.
    KEGGi vpa:VP2109.
    PATRICi 20142378. VBIVibPar50997_2019.

    Phylogenomic databases

    eggNOGi COG0346.
    HOGENOMi HOG000232011.
    KOi K01759.
    OMAi IGEEDIY.
    OrthoDBi EOG6DVJXX.

    Enzyme and pathway databases

    UniPathwayi UPA00619 ; UER00675 .
    BioCyci VPAR223926:GHK4-2165-MONOMER.

    Family and domain databases

    Gene3Di 3.10.180.10. 1 hit.
    InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    IPR004361. Glyoxalase_1.
    IPR018146. Glyoxalase_1_CS.
    [Graphical view ]
    Pfami PF00903. Glyoxalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54593. SSF54593. 1 hit.
    TIGRFAMsi TIGR00068. glyox_I. 1 hit.
    PROSITEi PS00934. GLYOXALASE_I_1. 1 hit.
    PS00935. GLYOXALASE_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
      Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
      Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RIMD 2210633.
    2. "MotY, a component of the sodium-type flagellar motor."
      McCarter L.L.
      J. Bacteriol. 176:4219-4225(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-138.
      Strain: BB22.

    Entry informationi

    Entry nameiLGUL_VIBPA
    AccessioniPrimary (citable) accession number: P46235
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: April 4, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3