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P46235

- LGUL_VIBPA

UniProt

P46235 - LGUL_VIBPA

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Protein
Probable lactoylglutathione lyase
Gene
gloA, VP2109
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione By similarity.

Catalytic activityi

(R)-S-lactoylglutathione = glutathione + methylglyoxal.

Cofactori

Binds 1 nickel ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Nickel; via tele nitrogen By similarity
Binding sitei12 – 121Substrate By similarity
Metal bindingi59 – 591Nickel By similarity
Binding sitei63 – 631Substrate By similarity
Metal bindingi77 – 771Nickel; via tele nitrogen By similarity
Binding sitei77 – 771Substrate By similarity
Active sitei125 – 1251Proton donor/acceptor By similarity
Metal bindingi125 – 1251Nickel By similarity

GO - Molecular functioni

  1. lactoylglutathione lyase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-2165-MONOMER.
UniPathwayiUPA00619; UER00675.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lactoylglutathione lyase (EC:4.4.1.5)
Alternative name(s):
Aldoketomutase
Glyoxalase I
Short name:
Glx I
Ketone-aldehyde mutase
Methylglyoxalase
S-D-lactoylglutathione methylglyoxal lyase
Gene namesi
Name:gloA
Ordered Locus Names:VP2109
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002493: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Probable lactoylglutathione lyase
PRO_0000168098Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223926.VP2109.

Structurei

3D structure databases

ProteinModelPortaliP46235.
SMRiP46235. Positions 5-128.

Family & Domainsi

Sequence similaritiesi

Belongs to the glyoxalase I family.

Phylogenomic databases

eggNOGiCOG0346.
HOGENOMiHOG000232011.
KOiK01759.
OMAiIGEEDIY.
OrthoDBiEOG6DVJXX.

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
IPR004361. Glyoxalase_1.
IPR018146. Glyoxalase_1_CS.
[Graphical view]
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR00068. glyox_I. 1 hit.
PROSITEiPS00934. GLYOXALASE_I_1. 1 hit.
PS00935. GLYOXALASE_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46235-1 [UniParc]FASTAAdd to Basket

« Hide

MSNGRILHTM LRVGDLDKSI KFYTEVMGMQ LLRTNENKEY EYTLAFVGYG    50
DESQGAVIEL TYNWGKTEYD LGTAFGHIAI GVDDIYATCD AIKAAGGNVT 100
REAGPVKGGT THIAFVKDPD GYMIELIQNK QASAGLEG 138
Length:138
Mass (Da):15,034
Last modified:April 4, 2003 - v2
Checksum:i5738D502E3CA35FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000031 Genomic DNA. Translation: BAC60372.1.
U06949 Genomic DNA. Translation: AAA21576.1.
RefSeqiNP_798488.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC60372; BAC60372; BAC60372.
GeneIDi1189621.
KEGGivpa:VP2109.
PATRICi20142378. VBIVibPar50997_2019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000031 Genomic DNA. Translation: BAC60372.1 .
U06949 Genomic DNA. Translation: AAA21576.1 .
RefSeqi NP_798488.1. NC_004603.1.

3D structure databases

ProteinModelPortali P46235.
SMRi P46235. Positions 5-128.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223926.VP2109.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC60372 ; BAC60372 ; BAC60372 .
GeneIDi 1189621.
KEGGi vpa:VP2109.
PATRICi 20142378. VBIVibPar50997_2019.

Phylogenomic databases

eggNOGi COG0346.
HOGENOMi HOG000232011.
KOi K01759.
OMAi IGEEDIY.
OrthoDBi EOG6DVJXX.

Enzyme and pathway databases

UniPathwayi UPA00619 ; UER00675 .
BioCyci VPAR223926:GHK4-2165-MONOMER.

Family and domain databases

Gene3Di 3.10.180.10. 1 hit.
InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
IPR004361. Glyoxalase_1.
IPR018146. Glyoxalase_1_CS.
[Graphical view ]
Pfami PF00903. Glyoxalase. 1 hit.
[Graphical view ]
SUPFAMi SSF54593. SSF54593. 1 hit.
TIGRFAMsi TIGR00068. glyox_I. 1 hit.
PROSITEi PS00934. GLYOXALASE_I_1. 1 hit.
PS00935. GLYOXALASE_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.
  2. "MotY, a component of the sodium-type flagellar motor."
    McCarter L.L.
    J. Bacteriol. 176:4219-4225(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-138.
    Strain: BB22.

Entry informationi

Entry nameiLGUL_VIBPA
AccessioniPrimary (citable) accession number: P46235
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 4, 2003
Last modified: June 11, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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