P46223 (RL7A_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L7a

Gene names

Name:	RpL7A
Synonyms:	SURF-3
ORF Names:	CG3314

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein L7Ae family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	mitotic spindle elongation Inferred from mutant phenotype. Source: FlyBase ribosome biogenesis Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	60S ribosomal protein L7a		PRO_0000136755
Experimental info
	Sequence conflict	112	1	P → A in CAA58023. Ref.1
	Sequence conflict	116 – 117	2	KL → NV in CAA58023. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P46223 [UniParc]. Last modified September 27, 2005. Version 2. Checksum: A31E9735E891E479	FASTA	271	30,732
	10 20 30 40 50 60 MVVKKPRPKK KPVTKKVAPA PLAVKKPVVK KVVNQLFEKR PKNFGIGQNV QPKRDLSRFV 70 80 90 100 110 120 RWPKYIRVQR QKAVLQKRLK VPPPIHQFSQ TLDKTTAVKL FKLLEKYRPE SPLAKKLRLK 130 140 150 160 170 180 KIAEAKAKGK DVEPKKKPSY VSAGTNTVTK LIEQKKAQLV VIAHDVDPLE LVLFLPALCR 190 200 210 220 230 240 KMGVPYCIVK GKARLGRLVR RKTCTTLALT TVDNNDKANF GKVLEAVKTN FNERHEEIRR 250 260 270 HWGGGILGSK SLARISKLER AKARELAQKQ G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genomic organization of the region containing the Drosophila melanogaster rpL7a (Surf-3) gene differs from those of the mammalian and avian Surfeit loci." Armes N., Fried M. Mol. Cell. Biol. 15:2367-2373(1995) [PubMed: 7739520] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Canton-S.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X82782 Genomic DNA. Translation: CAA58023.1. AE014298 Genomic DNA. Translation: AAF46169.1. AE014298 Genomic DNA. Translation: AAN09170.1. AE014298 Genomic DNA. Translation: AAN09172.1. AY089570 mRNA. Translation: AAL90308.1.
PIR	A57416.
RefSeq	NP_511063.1. NM_078508.5. NP_727094.1. NM_167073.2.
UniGene	Dm.7159.
3D structure databases
ProteinModelPortal	P46223.
SMR	P46223. Positions 70-269.
ModBase	Search...
Protein-protein interaction databases
IntAct	P46223. 1 interaction.
MINT	MINT-1546463.
STRING	P46223.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0070915; FBpp0070877; FBgn0014026. FBtr0070916; FBpp0070878; FBgn0014026.
GeneID	31588.
KEGG	dme:Dmel_CG3314.
Organism-specific databases
CTD	6130.
FlyBase	FBgn0014026. RpL7A.
Phylogenomic databases
eggNOG	inNOG06681.
GeneTree	EMGT00050000002347.
InParanoid	P46223.
OMA	HRKTCTS.
OrthoDB	EOG41G1M2.
PhylomeDB	P46223.
Gene expression databases
GermOnline	CG3314. Drosophila melanogaster.
Family and domain databases
InterPro	IPR001921. Ribosomal_L7A/L8. IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45. IPR018492. Ribosomal_L7Ae/L8/Nhp2. IPR004037. Ribosomal_L7Ae_CS. [Graphical view]
KO	K02936.
PANTHER	PTHR23105:SF1. Ribosomal_L7A. 1 hit.
Pfam	PF01248. Ribosomal_L7Ae. 1 hit. [Graphical view]
PRINTS	PR00881. L7ARS6FAMILY. PR00882. RIBOSOMALL7A.
PROSITE	PS01082. RIBOSOMAL_L7AE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	774333.

Entry information

Entry name

RL7A_DROME

Accession

Primary (citable) accession number: P46223
Secondary accession number(s): A4V411, Q9W3Z2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project