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Protein

60S ribosomal protein L11

Gene

RpL11

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • ribosomal large subunit assembly Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L11
Gene namesi
Name:RpL11
Synonyms:RPL11A
ORF Names:CG7726
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0013325 RpL11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001250891 – 18460S ribosomal protein L11Add BLAST184

Proteomic databases

PaxDbiP46222
PRIDEiP46222

Expressioni

Gene expression databases

BgeeiFBgn0013325
ExpressionAtlasiP46222 baseline and differential
GenevisibleiP46222 DM

Interactioni

Subunit structurei

Component of the large ribosomal subunit.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Fmr1Q9NFU05EBI-183104,EBI-422631

Protein-protein interaction databases

BioGridi62897, 11 interactors
DIPiDIP-18297N
IntActiP46222, 4 interactors
MINTiP46222
STRINGi7227.FBpp0085717

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CJ1-184[»]
ProteinModelPortaliP46222
SMRiP46222
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0397 Eukaryota
COG0094 LUCA
GeneTreeiENSGT00910000144211
InParanoidiP46222
KOiK02868
OMAiEDTMAWF
OrthoDBiEOG091G0LSV
PhylomeDBiP46222

Family and domain databases

Gene3Di3.30.1440.10, 1 hit
InterProiView protein in InterPro
IPR002132 Ribosomal_L5
IPR031309 Ribosomal_L5_C
IPR020929 Ribosomal_L5_CS
IPR022803 Ribosomal_L5_dom_sf
IPR031310 Ribosomal_L5_N
PANTHERiPTHR11994 PTHR11994, 1 hit
PfamiView protein in Pfam
PF00281 Ribosomal_L5, 1 hit
PF00673 Ribosomal_L5_C, 1 hit
PIRSFiPIRSF002161 Ribosomal_L5, 1 hit
SUPFAMiSSF55282 SSF55282, 1 hit
PROSITEiView protein in PROSITE
PS00358 RIBOSOMAL_L5, 1 hit

Sequencei

Sequence statusi: Complete.

P46222-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVTKKIKR DPAKNPMRDL HIRKLCLNIC VGESGDRLTR AAKVLEQLTG
60 70 80 90 100
QQPVFSKARY TVRSFGIRRN EKIAVHCTVR GAKAEEILER GLKVREYELR
110 120 130 140 150
RENFSSTGNF GFGIQEHIDL GIKYDPSIGI YGLDFYVVLG RPGYNVNHRK
160 170 180
RKSGTVGFQH RLTKEDAMKW FQQKYDGIIL NTKK
Length:184
Mass (Da):21,112
Last modified:August 31, 2004 - v2
Checksum:iE64EF5568A530C09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14 – 18KNPMR → QEPDE in AAC46585 (PubMed:7893752).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15643 mRNA Translation: AAC46585.1
AE013599 Genomic DNA Translation: AAF57560.1
AY094790 mRNA Translation: AAM11143.1
PIRiS60245
RefSeqiNP_001286614.1, NM_001299685.1
NP_477054.1, NM_057706.5
UniGeneiDm.700

Genome annotation databases

EnsemblMetazoaiFBtr0086533; FBpp0085717; FBgn0013325
FBtr0340533; FBpp0309436; FBgn0013325
GeneIDi37235
KEGGidme:Dmel_CG7726

Similar proteinsi

Entry informationi

Entry nameiRL11_DROME
AccessioniPrimary (citable) accession number: P46222
Secondary accession number(s): Q9V8U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 31, 2004
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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