true1995-11-012024-03-27163SYI_THEMAEvidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima.Nelson K.E.Clayton R.A.Gill S.R.Gwinn M.L.Dodson R.J.Haft D.H.Hickey E.K.Peterson J.D.Nelson W.C.Ketchum K.A.McDonald L.A.Utterback T.R.Malek J.A.Linher K.D.Garrett M.M.Stewart A.M.Cotton M.D.Pratt M.S.Phillips C.A.Richardson D.L.Heidelberg J.F.Sutton G.G.Fleischmann R.D.Eisen J.A.White O.Salzberg S.L.Smith H.O.Venter J.C.Fraser C.M.doi:10.1038/206011999Nature399323-329NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8Root of the universal tree of life based on ancient aminoacyl-tRNA synthetase gene duplications.Brown J.R.Doolittle W.F.doi:10.1073/pnas.92.7.24411995Proc. Natl. Acad. Sci. U.S.A.922441-2445NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-599BacteriaAnticodon_Ia_Ile_BEmIleRS_coreHUPsIle-tRNA synthetase CP2 domain-likeIle_tRNA_synth_type1aa-tRNA-synth_I_CSaa-tRNA-synth_IaAnticodon_Ile_BEmIle-tRNA-ligaseIle-tRNA-ligase_type1M/V/L/I-tRNA-synth_anticd-bdRossmann-like_a/b/a_foldtRNAsynth_Ia_anticodon-bdVal/Leu/Ile-tRNA-synth_editZnf_FPG/IleRSileSISOLEUCINE--TRNA LIGASE, MITOCHONDRIALSOLEUCYL-TRNA SYNTHETASEAnticodon_1tRNA-synt_1zf-FPG_IleRSTRNASYNTHILEAnticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetasesNucleotidylyl transferaseValRS/IleRS/LeuRS editing domainAA_TRNA_LIGASE_IIsoleucine--tRNA ligase6.1.1.5Isoleucyl-tRNA synthetaseIleRSileSTM_1361Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).Binds 1 zinc ion per subunit.Monomer.IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.Isoleucine--tRNA ligase1071561919'HIGH' region5767'KMSKS' region5945985535978878909079102000-05-30210715632abecf91a8b91ef5bd0bd1768bdac19MEYKNTLNLPKTSFPMKANLVNKEKVFLEEWEKMDLYNYVLEQRKGKPLFVLHDGPPYANGHIHIGTALNKILKDIVVKYKTMRGYRAPYVPGWDTHGLPIEHRVSQELGEKIKEMSPAEIRKKCEEFALRFVDIQREEFKRLGVRGDWENPYITLKPDYEVKILDVFKTLVEQGNVYRSLKPIYWCPRCRTALAEAEIEYHDHKSPSIYVKFRSKEDPNFFIVIWTTTPWTLPANVGIALHPDYEYSVVKVGEEKWVIATDLLDAFSKETGIDCSNVVEKIKGKDLEGKEFVHPIFDDRTSRVILADYVSLETGTGCVHIAPGHGEEDYIYGHVQYGLPIVSPVDEEGRFTEEAGKYKGMFIEDANEVIIEDLKRKGILVHASSITHSYPHCWRCKGPVIFRATEQWFISVDHNNLRQKVLEEIDKVKWIPEWGRNRIRSMVEERPDWCISRQRVWGTPIPAVKCKECGEVVLDPKVIEHFMKIVEKEGTNAWFEKEVEELIPEDFVCPKCGKRSFEKMLDTLDVWIDSGASFEYITTKREDHPFPLDMYLEGSDQHRGWFHSSIFLAVAKRGSAPYKEVLTHGFIKDEQGRKMSKSLGNVVDPMEVVEKYGAEILRLWLASSDYFNDIKISMRIVEQQTEVYRKIRNTFRFLLGNLEDFDPELDRVPHEKLLTIDRWALGRLQEIIKRATEYYDSYEFSKVYNLVVKYCTTELSSLYLDVVKDRLYVEAKDSIYRRSAQTVMHEILISLMKILAPIMTFTMEEVYSHLHEKDRKYKTVQAEYWPEYREEFIDRKLMEDFEKLLSIREDVLKALEEKRQQDVIGHSLDAEVVLVPKNDTIKALLEKYRDILEELFIVSKVSLSDASGELKGELVEVTVKHAEGEKCQRCWKYTTEISASEDFPGVCPRCLAVLKGERKtruetrue