ID   UTMP_BOVIN              Reviewed;         459 AA.
AC   P46201;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   08-NOV-2023, entry version 107.
DE   RecName: Full=Uterine milk protein;
DE            Short=UTMP;
DE   Flags: Precursor;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Endometrium;
RX   PubMed=8942989; DOI=10.1073/pnas.93.24.13653;
RA   Mathialagan N., Hansen T.R.;
RT   "Pepsin-inhibitory activity of the uterine serpins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:13653-13658(1996).
CC   -!- SIMILARITY: Belongs to the serpin family. UTMP subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L22095; AAB61677.1; -; mRNA.
DR   RefSeq; NP_777222.1; NM_174797.3.
DR   AlphaFoldDB; P46201; -.
DR   SMR; P46201; -.
DR   STRING; 9913.ENSBTAP00000009718; -.
DR   MEROPS; I04.981; -.
DR   PaxDb; 9913-ENSBTAP00000009718; -.
DR   GeneID; 286871; -.
DR   KEGG; bta:286871; -.
DR   CTD; 612383; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   HOGENOM; CLU_023330_2_1_1; -.
DR   InParanoid; P46201; -.
DR   OrthoDB; 5165967at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; IEA:UniProtKB-KW.
DR   CDD; cd19559; serpinA14_UTMP_UABP-2; 1.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   Gene3D; 2.10.310.10; Serpins superfamily; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   PANTHER; PTHR11461:SF164; UTEROFERRIN-ASSOCIATED PROTEIN; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Pregnancy; Protease inhibitor; Reference proteome;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..459
FT                   /note="Uterine milk protein"
FT                   /id="PRO_0000032531"
FT   SITE            420..421
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        268
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   459 AA;  52366 MW;  4B2EAA6365418244 CRC64;
     MSHGRMNLAL SLVFILCGLF NSIFCEKQQH SQKHMNLVLL KKISALSQKM EAHPKDFAQE
     LFKALIIEDP RKNIIFSPMA MTTTLATLSL GIKSTMRTHH PEDLKLEPKL LDVHKYLQPL
     VHVGRELVKQ KVLKHQHILF INRKMMVNQM LLQQISKLQG MDIQMIDFTD IEKAKKTISH
     HVAEKTHTKI TNLITDLNPE TILCLVNHIF FKGILKRAFQ PKLTQKEVFF VNDQTKVQVD
     MMRKTERMLY SRSEELHATM VKMPCKGNVS LTLMLPDAGQ FDTDLKKMTA KRAKLQKISD
     FRLVRLILPK LKISFKINFK HLLPKIDPKH ILTATAISQA ITSKAPLPNL EALHQAEIEL
     SEHALTVDTA IHTDNLLKVP VKAKEVPAVV KVPMKAKEVP AVVKVPMNTK EVPVVVKVPM
     NTKEVPVVVK VNRPFLLFVE DEKTQRDLFV GKVLNPQVE
//