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P46195

- KGUA_BOVIN

UniProt

P46195 - KGUA_BOVIN

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Protein

Guanylate kinase

Gene
GUK1, GUK
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for recycling GMP and indirectly, cGMP.

Catalytic activityi

ATP + GMP = ADP + GDP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441 By similarity
Active sitei137 – 1371 By similarity
Active sitei148 – 1481 By similarity
Binding sitei171 – 1711ATP By similarity
Binding sitei172 – 1721ATP; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. guanylate kinase activity Source: UniProtKB

GO - Biological processi

  1. nucleotide phosphorylation Source: GOC
  2. purine nucleotide metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_222543. Abacavir metabolism.
REACT_223832. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:GUK1
Synonyms:GUK
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 198197Guanylate kinasePRO_0000170650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP46195.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019656.

Structurei

3D structure databases

ProteinModelPortaliP46195.
SMRiP46195. Positions 5-194.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 186183Guanylate kinase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.

Phylogenomic databases

eggNOGiCOG0194.
GeneTreeiENSGT00730000110700.
HOGENOMiHOG000037640.
HOVERGENiHBG003344.
InParanoidiP46195.
KOiK00942.
OrthoDBiEOG7J1814.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46195-1 [UniParc]FASTAAdd to Basket

« Hide

MSGPRPVVLS GPSGAGKSTL LKKLLQEHGS IFGFSVSHTT RDPRPGEENG    50
KDYYFVTREV MQRDIAAGDF IEHAEFSGNL YGTSKAAVRA VQAMNRICVL 100
DVDLQGVRNI KKTDLRPIYI FVQPPSLDVL EQRLRQRNTE TEESLAKRLA 150
AARADMESSK EPGLFDLIIV NDSLDKAYWA LKEALSEEIK KAQGTGQS 198
Length:198
Mass (Da):21,910
Last modified:January 23, 2007 - v2
Checksum:i9A153A0924C1F3AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67029 mRNA. Translation: CAA47423.1.
BC102478 mRNA. Translation: AAI02479.1.
PIRiS39447.
RefSeqiNP_001152884.1. NM_001159412.1.
NP_001152885.1. NM_001159413.1.
NP_776503.1. NM_174078.3.
XP_005208455.1. XM_005208398.1.
UniGeneiBt.4287.

Genome annotation databases

EnsembliENSBTAT00000036545; ENSBTAP00000036402; ENSBTAG00000014775.
ENSBTAT00000066343; ENSBTAP00000054864; ENSBTAG00000014775.
GeneIDi281217.
KEGGibta:281217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67029 mRNA. Translation: CAA47423.1 .
BC102478 mRNA. Translation: AAI02479.1 .
PIRi S39447.
RefSeqi NP_001152884.1. NM_001159412.1.
NP_001152885.1. NM_001159413.1.
NP_776503.1. NM_174078.3.
XP_005208455.1. XM_005208398.1.
UniGenei Bt.4287.

3D structure databases

ProteinModelPortali P46195.
SMRi P46195. Positions 5-194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000019656.

Proteomic databases

PRIDEi P46195.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000036545 ; ENSBTAP00000036402 ; ENSBTAG00000014775 .
ENSBTAT00000066343 ; ENSBTAP00000054864 ; ENSBTAG00000014775 .
GeneIDi 281217.
KEGGi bta:281217.

Organism-specific databases

CTDi 2987.

Phylogenomic databases

eggNOGi COG0194.
GeneTreei ENSGT00730000110700.
HOGENOMi HOG000037640.
HOVERGENi HBG003344.
InParanoidi P46195.
KOi K00942.
OrthoDBi EOG7J1814.

Enzyme and pathway databases

Reactomei REACT_222543. Abacavir metabolism.
REACT_223832. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

NextBioi 20805269.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Guanylate kinase from bovine retina: isolation, primary structure, and expression in E. coli."
    Gaidarov I.O., Suslov O.N., Ovchinnikova T.V., Abdulaev N.G.
    Bioorg. Khim. 20:367-381(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  3. "Enzymes of the cyclic GMP metabolism in bovine retina. I. Cloning and expression of the gene for guanylate kinase."
    Gaidarov I.O., Suslov O.N., Abdulaev N.G.
    FEBS Lett. 335:81-84(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 10-17; 24-32; 35-82; 90-97; 121-126; 139-146; 149-154 AND 178-182.

Entry informationi

Entry nameiKGUA_BOVIN
AccessioniPrimary (citable) accession number: P46195
Secondary accession number(s): Q3ZCE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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