Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanylate kinase

Gene

GUK1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for recycling GMP and indirectly, cGMP.

Catalytic activityi

ATP + GMP = ADP + GDP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44By similarity1
Active sitei137By similarity1
Active sitei148By similarity1
Binding sitei171ATPBy similarity1
Binding sitei172ATP; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • guanylate kinase activity Source: UniProtKB

GO - Biological processi

  • purine nucleotide metabolic process Source: UniProtKB

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:GUK1
Synonyms:GUK
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001706502 – 198Guanylate kinaseAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP46195.
PRIDEiP46195.

Expressioni

Gene expression databases

BgeeiENSBTAG00000014775.
ExpressionAtlasiP46195. baseline and differential.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019656.

Structurei

3D structure databases

ProteinModelPortaliP46195.
SMRiP46195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 186Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST183

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiKOG0707. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00840000129809.
HOGENOMiHOG000037640.
HOVERGENiHBG003344.
InParanoidiP46195.
KOiK00942.

Family and domain databases

InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGPRPVVLS GPSGAGKSTL LKKLLQEHGS IFGFSVSHTT RDPRPGEENG
60 70 80 90 100
KDYYFVTREV MQRDIAAGDF IEHAEFSGNL YGTSKAAVRA VQAMNRICVL
110 120 130 140 150
DVDLQGVRNI KKTDLRPIYI FVQPPSLDVL EQRLRQRNTE TEESLAKRLA
160 170 180 190
AARADMESSK EPGLFDLIIV NDSLDKAYWA LKEALSEEIK KAQGTGQS
Length:198
Mass (Da):21,910
Last modified:January 23, 2007 - v2
Checksum:i9A153A0924C1F3AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67029 mRNA. Translation: CAA47423.1.
BC102478 mRNA. Translation: AAI02479.1.
PIRiS39447.
RefSeqiNP_001152884.1. NM_001159412.1.
NP_001152885.1. NM_001159413.1.
NP_776503.1. NM_174078.3.
XP_005208455.1. XM_005208398.3.
UniGeneiBt.4287.

Genome annotation databases

EnsembliENSBTAT00000036545; ENSBTAP00000036402; ENSBTAG00000014775.
ENSBTAT00000066343; ENSBTAP00000054864; ENSBTAG00000014775.
GeneIDi281217.
KEGGibta:281217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67029 mRNA. Translation: CAA47423.1.
BC102478 mRNA. Translation: AAI02479.1.
PIRiS39447.
RefSeqiNP_001152884.1. NM_001159412.1.
NP_001152885.1. NM_001159413.1.
NP_776503.1. NM_174078.3.
XP_005208455.1. XM_005208398.3.
UniGeneiBt.4287.

3D structure databases

ProteinModelPortaliP46195.
SMRiP46195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019656.

Proteomic databases

PaxDbiP46195.
PRIDEiP46195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000036545; ENSBTAP00000036402; ENSBTAG00000014775.
ENSBTAT00000066343; ENSBTAP00000054864; ENSBTAG00000014775.
GeneIDi281217.
KEGGibta:281217.

Organism-specific databases

CTDi2987.

Phylogenomic databases

eggNOGiKOG0707. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00840000129809.
HOGENOMiHOG000037640.
HOVERGENiHBG003344.
InParanoidiP46195.
KOiK00942.

Enzyme and pathway databases

ReactomeiR-BTA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Gene expression databases

BgeeiENSBTAG00000014775.
ExpressionAtlasiP46195. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKGUA_BOVIN
AccessioniPrimary (citable) accession number: P46195
Secondary accession number(s): Q3ZCE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: April 12, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.