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P46195 (KGUA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:GUK1
Synonyms:GUK
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP.

Catalytic activity

ATP + GMP = ADP + GDP.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 198197Guanylate kinase
PRO_0000170650

Regions

Domain4 – 186183Guanylate kinase-like
Nucleotide binding11 – 188ATP By similarity

Sites

Active site441 By similarity
Active site1371 By similarity
Active site1481 By similarity
Binding site1711ATP By similarity
Binding site1721ATP; via carbonyl oxygen By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P46195 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 9A153A0924C1F3AB

FASTA19821,910
        10         20         30         40         50         60 
MSGPRPVVLS GPSGAGKSTL LKKLLQEHGS IFGFSVSHTT RDPRPGEENG KDYYFVTREV 

        70         80         90        100        110        120 
MQRDIAAGDF IEHAEFSGNL YGTSKAAVRA VQAMNRICVL DVDLQGVRNI KKTDLRPIYI 

       130        140        150        160        170        180 
FVQPPSLDVL EQRLRQRNTE TEESLAKRLA AARADMESSK EPGLFDLIIV NDSLDKAYWA 

       190 
LKEALSEEIK KAQGTGQS 

« Hide

References

« Hide 'large scale' references
[1]"Guanylate kinase from bovine retina: isolation, primary structure, and expression in E. coli."
Gaidarov I.O., Suslov O.N., Ovchinnikova T.V., Abdulaev N.G.
Bioorg. Khim. 20:367-381(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.
[3]"Enzymes of the cyclic GMP metabolism in bovine retina. I. Cloning and expression of the gene for guanylate kinase."
Gaidarov I.O., Suslov O.N., Abdulaev N.G.
FEBS Lett. 335:81-84(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 10-17; 24-32; 35-82; 90-97; 121-126; 139-146; 149-154 AND 178-182.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X67029 mRNA. Translation: CAA47423.1.
BC102478 mRNA. Translation: AAI02479.1.
PIRS39447.
RefSeqNP_001152884.1. NM_001159412.1.
NP_001152885.1. NM_001159413.1.
NP_776503.1. NM_174078.3.
XP_005208455.1. XM_005208398.1.
UniGeneBt.4287.

3D structure databases

ProteinModelPortalP46195.
SMRP46195. Positions 5-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000019656.

Proteomic databases

PRIDEP46195.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000036545; ENSBTAP00000036402; ENSBTAG00000014775.
ENSBTAT00000066343; ENSBTAP00000054864; ENSBTAG00000014775.
GeneID281217.
KEGGbta:281217.

Organism-specific databases

CTD2987.

Phylogenomic databases

eggNOGCOG0194.
GeneTreeENSGT00730000110700.
HOGENOMHOG000037640.
HOVERGENHBG003344.
InParanoidP46195.
KOK00942.
OrthoDBEOG7J1814.

Family and domain databases

Gene3D3.40.50.300. 3 hits.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805269.

Entry information

Entry nameKGUA_BOVIN
AccessionPrimary (citable) accession number: P46195
Secondary accession number(s): Q3ZCE9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families