SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P46194

- CP19A_BOVIN

UniProt

P46194 - CP19A_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Aromatase

Gene
CYP19A1, CYP19
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091Substrate By similarity
Binding sitei374 – 3741Substrate; via amide nitrogen By similarity
Metal bindingi437 – 4371Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503AromatasePRO_0000051950Add
BLAST

Proteomic databases

PRIDEiP46194.

Structurei

3D structure databases

ProteinModelPortaliP46194.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP46194.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46194-1 [UniParc]FASTAAdd to Basket

« Hide

MLLEVLNPRH YNVTSMVSEV VPIASIAILL LTGFLLLVWN YEDTSSIPGP    50
SYFLGIGPLI SHCRFLWMGI GSACNYYNKM YGEFMRVWVC GEETLIISKS 100
SSMFHVMKHS HYISRFGSKL GLQFIGMHEK GIIFNNNPAL WKAVRPFFTK 150
ALSGPGLVRM VTICADSITK HLDRLEEVCN DLGYVDVLTL MRRIMLDTSN 200
MLFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL CRKYEKSVKD 250
LKDAMEILIE EKRHRISTAE KLEDSIDFAT ELIFAEKRGE LTRENVNQCI 300
LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AIIREIQTVV GERDIRIDDM 350
QKLKVVENFI NESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNLGR 400
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YITMVMMKVV 450
LVTLLRRFHV QTLQGRCVEK MQKKNDLSLH PDETRDRLEM IFTPRNSDKC 500
LER 503
Length:503
Mass (Da):58,090
Last modified:August 29, 2001 - v3
Checksum:i47C70292D21AFF97
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161K → N in AAA62244. 1 Publication
Sequence conflicti260 – 2601E → A in AAA62244. 1 Publication
Sequence conflicti436 – 4361A → G in AAA62244. 1 Publication
Sequence conflicti443 – 4431T → A in AAA62244. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18447 mRNA. Translation: AAA62244.1.
Z32741 mRNA. Translation: CAA83651.1.
Z69242
, Z69243, Z69244, Z69245, Z69246, Z69247, Z69248, Z69249, Z69250 Genomic DNA. Translation: CAC12940.1.
PIRiI46015.
RefSeqiNP_776730.1. NM_174305.1.
UniGeneiBt.4447.

Genome annotation databases

GeneIDi281740.
KEGGibta:281740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18447 mRNA. Translation: AAA62244.1 .
Z32741 mRNA. Translation: CAA83651.1 .
Z69242
, Z69243 , Z69244 , Z69245 , Z69246 , Z69247 , Z69248 , Z69249 , Z69250 Genomic DNA. Translation: CAC12940.1 .
PIRi I46015.
RefSeqi NP_776730.1. NM_174305.1.
UniGenei Bt.4447.

3D structure databases

ProteinModelPortali P46194.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P46194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281740.
KEGGi bta:281740.

Organism-specific databases

CTDi 1588.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000111912.
HOVERGENi HBG050750.
InParanoidi P46194.
KOi K07434.

Miscellaneous databases

NextBioi 20805660.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450."
    Hinshelwood M.M., Corbin C.J., Tsang P.C., Simpson E.R.
    Endocrinology 133:1971-1977(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "Novel aromatase transcripts from bovine placenta contain repeated sequence motifs."
    Vanselow J., Furbass R.
    Gene 154:281-286(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "Tissue-specific expression of the bovine aromatase-encoding gene uses multiple transcriptional start sites and alternative first exons."
    Furbass R., Kalbe C., Vanselow J.
    Endocrinology 138:2813-2819(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Furbass R.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 443.

Entry informationi

Entry nameiCP19A_BOVIN
AccessioniPrimary (citable) accession number: P46194
Secondary accession number(s): Q29445, Q29453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 29, 2001
Last modified: January 22, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi