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P46194

- CP19A_BOVIN

UniProt

P46194 - CP19A_BOVIN

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Protein

Aromatase

Gene

CYP19A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091SubstrateBy similarity
Binding sitei374 – 3741Substrate; via amide nitrogenBy similarity
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503AromatasePRO_0000051950Add
BLAST

Proteomic databases

PRIDEiP46194.

Structurei

3D structure databases

ProteinModelPortaliP46194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiP46194.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46194-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLEVLNPRH YNVTSMVSEV VPIASIAILL LTGFLLLVWN YEDTSSIPGP
60 70 80 90 100
SYFLGIGPLI SHCRFLWMGI GSACNYYNKM YGEFMRVWVC GEETLIISKS
110 120 130 140 150
SSMFHVMKHS HYISRFGSKL GLQFIGMHEK GIIFNNNPAL WKAVRPFFTK
160 170 180 190 200
ALSGPGLVRM VTICADSITK HLDRLEEVCN DLGYVDVLTL MRRIMLDTSN
210 220 230 240 250
MLFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL CRKYEKSVKD
260 270 280 290 300
LKDAMEILIE EKRHRISTAE KLEDSIDFAT ELIFAEKRGE LTRENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AIIREIQTVV GERDIRIDDM
360 370 380 390 400
QKLKVVENFI NESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNLGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YITMVMMKVV
460 470 480 490 500
LVTLLRRFHV QTLQGRCVEK MQKKNDLSLH PDETRDRLEM IFTPRNSDKC

LER
Length:503
Mass (Da):58,090
Last modified:August 29, 2001 - v3
Checksum:i47C70292D21AFF97
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161K → N in AAA62244. (PubMed:8404644)Curated
Sequence conflicti260 – 2601E → A in AAA62244. (PubMed:8404644)Curated
Sequence conflicti436 – 4361A → G in AAA62244. (PubMed:8404644)Curated
Sequence conflicti443 – 4431T → A in AAA62244. (PubMed:8404644)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18447 mRNA. Translation: AAA62244.1.
Z32741 mRNA. Translation: CAA83651.1.
Z69242
, Z69243, Z69244, Z69245, Z69246, Z69247, Z69248, Z69249, Z69250 Genomic DNA. Translation: CAC12940.1.
PIRiI46015.
RefSeqiNP_776730.1. NM_174305.1.
UniGeneiBt.4447.

Genome annotation databases

GeneIDi281740.
KEGGibta:281740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18447 mRNA. Translation: AAA62244.1 .
Z32741 mRNA. Translation: CAA83651.1 .
Z69242
, Z69243 , Z69244 , Z69245 , Z69246 , Z69247 , Z69248 , Z69249 , Z69250 Genomic DNA. Translation: CAC12940.1 .
PIRi I46015.
RefSeqi NP_776730.1. NM_174305.1.
UniGenei Bt.4447.

3D structure databases

ProteinModelPortali P46194.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P46194.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281740.
KEGGi bta:281740.

Organism-specific databases

CTDi 1588.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000111912.
HOVERGENi HBG050750.
InParanoidi P46194.
KOi K07434.

Miscellaneous databases

NextBioi 20805660.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450."
    Hinshelwood M.M., Corbin C.J., Tsang P.C., Simpson E.R.
    Endocrinology 133:1971-1977(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "Novel aromatase transcripts from bovine placenta contain repeated sequence motifs."
    Vanselow J., Furbass R.
    Gene 154:281-286(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "Tissue-specific expression of the bovine aromatase-encoding gene uses multiple transcriptional start sites and alternative first exons."
    Furbass R., Kalbe C., Vanselow J.
    Endocrinology 138:2813-2819(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Furbass R.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 443.

Entry informationi

Entry nameiCP19A_BOVIN
AccessioniPrimary (citable) accession number: P46194
Secondary accession number(s): Q29445, Q29453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 29, 2001
Last modified: November 26, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3