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P46194

- CP19A_BOVIN

UniProt

P46194 - CP19A_BOVIN

Protein

Aromatase

Gene

CYP19A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (29 Aug 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei309 – 3091SubstrateBy similarity
    Binding sitei374 – 3741Substrate; via amide nitrogenBy similarity
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:CYP19A1
    Synonyms:CYP19
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503AromatasePRO_0000051950Add
    BLAST

    Proteomic databases

    PRIDEiP46194.

    Structurei

    3D structure databases

    ProteinModelPortaliP46194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000111912.
    HOVERGENiHBG050750.
    InParanoidiP46194.
    KOiK07434.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46194-1 [UniParc]FASTAAdd to Basket

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    MLLEVLNPRH YNVTSMVSEV VPIASIAILL LTGFLLLVWN YEDTSSIPGP    50
    SYFLGIGPLI SHCRFLWMGI GSACNYYNKM YGEFMRVWVC GEETLIISKS 100
    SSMFHVMKHS HYISRFGSKL GLQFIGMHEK GIIFNNNPAL WKAVRPFFTK 150
    ALSGPGLVRM VTICADSITK HLDRLEEVCN DLGYVDVLTL MRRIMLDTSN 200
    MLFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL CRKYEKSVKD 250
    LKDAMEILIE EKRHRISTAE KLEDSIDFAT ELIFAEKRGE LTRENVNQCI 300
    LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AIIREIQTVV GERDIRIDDM 350
    QKLKVVENFI NESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNLGR 400
    MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YITMVMMKVV 450
    LVTLLRRFHV QTLQGRCVEK MQKKNDLSLH PDETRDRLEM IFTPRNSDKC 500
    LER 503
    Length:503
    Mass (Da):58,090
    Last modified:August 29, 2001 - v3
    Checksum:i47C70292D21AFF97
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti216 – 2161K → N in AAA62244. (PubMed:8404644)Curated
    Sequence conflicti260 – 2601E → A in AAA62244. (PubMed:8404644)Curated
    Sequence conflicti436 – 4361A → G in AAA62244. (PubMed:8404644)Curated
    Sequence conflicti443 – 4431T → A in AAA62244. (PubMed:8404644)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18447 mRNA. Translation: AAA62244.1.
    Z32741 mRNA. Translation: CAA83651.1.
    Z69242
    , Z69243, Z69244, Z69245, Z69246, Z69247, Z69248, Z69249, Z69250 Genomic DNA. Translation: CAC12940.1.
    PIRiI46015.
    RefSeqiNP_776730.1. NM_174305.1.
    UniGeneiBt.4447.

    Genome annotation databases

    GeneIDi281740.
    KEGGibta:281740.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18447 mRNA. Translation: AAA62244.1 .
    Z32741 mRNA. Translation: CAA83651.1 .
    Z69242
    , Z69243 , Z69244 , Z69245 , Z69246 , Z69247 , Z69248 , Z69249 , Z69250 Genomic DNA. Translation: CAC12940.1 .
    PIRi I46015.
    RefSeqi NP_776730.1. NM_174305.1.
    UniGenei Bt.4447.

    3D structure databases

    ProteinModelPortali P46194.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P46194.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281740.
    KEGGi bta:281740.

    Organism-specific databases

    CTDi 1588.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000111912.
    HOVERGENi HBG050750.
    InParanoidi P46194.
    KOi K07434.

    Miscellaneous databases

    NextBioi 20805660.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450."
      Hinshelwood M.M., Corbin C.J., Tsang P.C., Simpson E.R.
      Endocrinology 133:1971-1977(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "Novel aromatase transcripts from bovine placenta contain repeated sequence motifs."
      Vanselow J., Furbass R.
      Gene 154:281-286(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "Tissue-specific expression of the bovine aromatase-encoding gene uses multiple transcriptional start sites and alternative first exons."
      Furbass R., Kalbe C., Vanselow J.
      Endocrinology 138:2813-2819(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Furbass R.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 443.

    Entry informationi

    Entry nameiCP19A_BOVIN
    AccessioniPrimary (citable) accession number: P46194
    Secondary accession number(s): Q29445, Q29453
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: August 29, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3