rseC

Functionⁱ

May play a role in reduction of the SoxR iron-sulfur cluster. May work together with the RsxABCDGE complex.1 Publication

Miscellaneous

Part of the rseD-rpoE-rseA-rseB-rseC operon (PubMed:9159522, PubMed:9159523, PubMed:28924029).3 Publications

Caution

Was originally suggested to positively regulate sigma-E activity in vitro.1 Publication

GO - Biological processⁱ

response to oxidative stress
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 24580753

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCycⁱ	EcoCyc:G7347-MONOMER

BioCycⁱ

EcoCyc:G7347-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein RseCCurated
Gene namesⁱ	Name:rseC2 Publications Ordered Locus Names:b2570, JW2554
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG13178 rseC

EcoGeneⁱ

EG13178 rseC

Subcellular locationⁱ

Cell inner membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.8
  "Global topology analysis of the Escherichia coli inner membrane proteome."
  Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
  Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: TOPOLOGY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.
; Multi-pass membrane protein Sequence analysis

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 72	Cytoplasmic1 PublicationAdd BLAST	72
Transmembraneⁱ	73 – 95	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	96 – 98	Periplasmic1 Publication	3
Transmembraneⁱ	99 – 121	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	122 – 159	Cytoplasmic1 PublicationAdd BLAST	38

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

According to PubMed:9159522, insertion mutant shows a modest reduction in sigma-E (rpoE) activity. However, PubMed:9159523 shows that deletion of the gene has no effect on sigma-E activity (PubMed:9159522, PubMed:9159523). Deletion of the gene enhances soxS expression (PubMed:12773378). Mutant shows increased motility and biofilm formation (PubMed:18344336). Deletion mutant is more sensitive than wild-type specifically to hydrogen peroxide exposure, but not other stresses (PubMed:24580753).5 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000097483	1 – 159	Protein RseCAdd BLAST		159

Proteomic databases

PaxDbⁱ	P46187
PRIDEⁱ	P46187

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	426059911 interactors.
STRINGⁱ	316385.ECDH10B_2738

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P46187
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the RseC family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105WMJ Bacteria COG3086 LUCA
HOGENOMⁱ	HOG000272284
InParanoidⁱ	P46187
KEGG Orthology (KO) More...KOⁱ	K03803
OMAⁱ	KSACNHC

Family and domain databases

InterProⁱ	View protein in InterPro IPR026268 RseC IPR007359 SigmaE_reg_RseC_MucC
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04246 RseC_MucC, 1 hit
PIRSFⁱ	PIRSF004923 RseC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P46187-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIKEWATVVS WQNGQALVSC DVKASCSSCA SRAGCGSRVL NKLGPQTTHT 
        60         70         80         90        100
IVVPCDEPLV PGQKVELGIA EGSLLSSALL VYMSPLVGLF LIASLFQLLF 
       110        120        130        140        150
ASDVAALCGA ILGGIGGFLI ARGYSRKFAA RAEWQPIILS VALPPGLVRF 

ETSSEDASQ

Length:159

Mass (Da):16,639

Last modified:November 1, 1995 - v1

Checksum:ⁱBCFD8970DF6277C0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U37089 Genomic DNA Translation: AAC45317.1 U37455 Genomic DNA Translation: AAC45320.1 D64044 Genomic DNA Translation: BAA10917.1 U00096 Genomic DNA Translation: AAC75623.1 AP009048 Genomic DNA Translation: BAE76746.1
PIRⁱ	I83299
NCBI Reference Sequences More...RefSeqⁱ	NP_417065.1, NC_000913.3 WP_000589068.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75623; AAC75623; b2570 BAE76746; BAE76746; BAE76746
GeneIDⁱ	947052
KEGGⁱ	ecj:JW2554 eco:b2570
PATRICⁱ	fig\|1411691.4.peg.4164

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P46187	J7QUC4 V2RKH2 I2SN80 A0A236M3H1 A0A125X0L8 A0A0E1SWJ4 E1J3Q8 A0A070SN97 H4UML2 M9G9J9 +23	Escherichia coli Escherichia coli HVH 50 (4-2593475) Escherichia coli 1.2264 Shigella boydii Escherichia coli 1-110-08_S3_C1 Escherichia coli 53638 Escherichia coli MS 124-1 Escherichia coli 2-210-07_S3_C3 Escherichia coli DEC6A Escherichia coli MP021561.2 And more	159	UniRef100_P46187	Cluster: Protein RseC	34

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P46187	J7QUC4 V2RKH2 I2SN80 A0A236M3H1 A0A125X0L8 A0A0E1SWJ4 E1J3Q8 A0A070SN97 H4UML2 M9G9J9 +374	Escherichia coli Escherichia coli HVH 50 (4-2593475) Escherichia coli 1.2264 Shigella boydii Escherichia coli 1-110-08_S3_C1 Escherichia coli 53638 Escherichia coli MS 124-1 Escherichia coli 2-210-07_S3_C3 Escherichia coli DEC6A Escherichia coli MP021561.2 And more	159	UniRef90_P46187	Cluster: Protein RseC	385

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P46187	J7QUC4 V2RKH2 I2SN80 A0A236M3H1 A0A125X0L8 A0A0E1SWJ4 E1J3Q8 A0A070SN97 H4UML2 M9G9J9 +1162	Escherichia coli Escherichia coli HVH 50 (4-2593475) Escherichia coli 1.2264 Shigella boydii Escherichia coli 1-110-08_S3_C1 Escherichia coli 53638 Escherichia coli MS 124-1 Escherichia coli 2-210-07_S3_C3 Escherichia coli DEC6A Escherichia coli MP021561.2 And more	159	UniRef50_P46187	Cluster: Protein RseC	1,173

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U37089 Genomic DNA Translation: AAC45317.1 U37455 Genomic DNA Translation: AAC45320.1 D64044 Genomic DNA Translation: BAA10917.1 U00096 Genomic DNA Translation: AAC75623.1 AP009048 Genomic DNA Translation: BAE76746.1
PIRⁱ	I83299
NCBI Reference Sequences More...RefSeqⁱ	NP_417065.1, NC_000913.3 WP_000589068.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P46187
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	426059911 interactors.
STRINGⁱ	316385.ECDH10B_2738

Proteomic databases

PaxDbⁱ	P46187
PRIDEⁱ	P46187

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75623; AAC75623; b2570 BAE76746; BAE76746; BAE76746
GeneIDⁱ	947052
KEGGⁱ	ecj:JW2554 eco:b2570
PATRICⁱ	fig\|1411691.4.peg.4164

Organism-specific databases

EchoBASEⁱ	EB2970
EcoGeneⁱ	EG13178 rseC

Phylogenomic databases

eggNOGⁱ	ENOG4105WMJ Bacteria COG3086 LUCA
HOGENOMⁱ	HOG000272284
InParanoidⁱ	P46187
KEGG Orthology (KO) More...KOⁱ	K03803
OMAⁱ	KSACNHC

Enzyme and pathway databases

BioCycⁱ	EcoCyc:G7347-MONOMER

BioCycⁱ

EcoCyc:G7347-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P46187

PROⁱ

PR:P46187

Family and domain databases

InterProⁱ	View protein in InterPro IPR026268 RseC IPR007359 SigmaE_reg_RseC_MucC
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04246 RseC_MucC, 1 hit
PIRSFⁱ	PIRSF004923 RseC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RSEC_ECOLI
Accessionⁱ	P46187Primary (citable) accession number: P46187 Secondary accession number(s): Q2MAG0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	March 28, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P46187 (RSEC_ECOLI)

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Protein RseC

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ