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Protein

Protein RseC

Gene

rseC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in reduction of the SoxR iron-sulfur cluster. May work together with the RsxABCDGE complex.1 Publication

Miscellaneous

Part of the rseD-rpoE-rseA-rseB-rseC operon (PubMed:9159522, PubMed:9159523, PubMed:28924029).3 Publications

Caution

Was originally suggested to positively regulate sigma-E activity in vitro.1 Publication

GO - Biological processi

  • response to oxidative stress Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7347-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RseCCurated
Gene namesi
Name:rseC2 Publications
Ordered Locus Names:b2570, JW2554
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13178 rseC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72Cytoplasmic1 PublicationAdd BLAST72
Transmembranei73 – 95HelicalSequence analysisAdd BLAST23
Topological domaini96 – 98Periplasmic1 Publication3
Transmembranei99 – 121HelicalSequence analysisAdd BLAST23
Topological domaini122 – 159Cytoplasmic1 PublicationAdd BLAST38

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

According to PubMed:9159522, insertion mutant shows a modest reduction in sigma-E (rpoE) activity. However, PubMed:9159523 shows that deletion of the gene has no effect on sigma-E activity (PubMed:9159522, PubMed:9159523). Deletion of the gene enhances soxS expression (PubMed:12773378). Mutant shows increased motility and biofilm formation (PubMed:18344336). Deletion mutant is more sensitive than wild-type specifically to hydrogen peroxide exposure, but not other stresses (PubMed:24580753).5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974831 – 159Protein RseCAdd BLAST159

Proteomic databases

PaxDbiP46187
PRIDEiP46187

Interactioni

Protein-protein interaction databases

BioGridi4260599, 11 interactors
STRINGi316385.ECDH10B_2738

Structurei

3D structure databases

ProteinModelPortaliP46187
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RseC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105WMJ Bacteria
COG3086 LUCA
HOGENOMiHOG000272284
InParanoidiP46187
KOiK03803
OMAiKSACNHC

Family and domain databases

InterProiView protein in InterPro
IPR026268 RseC
IPR007359 SigmaE_reg_RseC_MucC
PANTHERiPTHR35867 PTHR35867, 1 hit
PIRSFiPIRSF004923 RseC, 1 hit

Sequencei

Sequence statusi: Complete.

P46187-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKEWATVVS WQNGQALVSC DVKASCSSCA SRAGCGSRVL NKLGPQTTHT
60 70 80 90 100
IVVPCDEPLV PGQKVELGIA EGSLLSSALL VYMSPLVGLF LIASLFQLLF
110 120 130 140 150
ASDVAALCGA ILGGIGGFLI ARGYSRKFAA RAEWQPIILS VALPPGLVRF

ETSSEDASQ
Length:159
Mass (Da):16,639
Last modified:November 1, 1995 - v1
Checksum:iBCFD8970DF6277C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37089 Genomic DNA Translation: AAC45317.1
U37455 Genomic DNA Translation: AAC45320.1
D64044 Genomic DNA Translation: BAA10917.1
U00096 Genomic DNA Translation: AAC75623.1
AP009048 Genomic DNA Translation: BAE76746.1
PIRiI83299
RefSeqiNP_417065.1, NC_000913.3
WP_000589068.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75623; AAC75623; b2570
BAE76746; BAE76746; BAE76746
GeneIDi947052
KEGGiecj:JW2554
eco:b2570
PATRICifig|1411691.4.peg.4164

Similar proteinsi

Entry informationi

Entry nameiRSEC_ECOLI
AccessioniPrimary (citable) accession number: P46187
Secondary accession number(s): Q2MAG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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