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Protein

Beta-defensin 12

Gene

DEFB12

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 12
Alternative name(s):
BNBD-12
BNDB-12
Gene namesi
Name:DEFB12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3838Beta-defensin 12PRO_0000044727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 341 Publication
Disulfide bondi12 ↔ 271 Publication
Disulfide bondi17 ↔ 351 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP46170.

Expressioni

Tissue specificityi

Neutrophilic granules.

Structurei

Secondary structure

1
38
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni6 – 94Combined sources
Beta strandi10 – 167Combined sources
Beta strandi21 – 277Combined sources
Turni28 – 314Combined sources
Beta strandi32 – 365Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BNBNMR-A2-38[»]
DisProtiDP00209.
ProteinModelPortaliP46170.
SMRiP46170. Positions 1-38.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46170.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Phylogenomic databases

HOVERGENiHBG004834.
InParanoidiP46170.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
IPR006080. Defensin_beta/alpha.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GPLSCGRNGG VCIPIRCPVP MRQIGTCFGR PVKCCRSW
Length:38
Mass (Da):4,106
Last modified:November 1, 1995 - v1
Checksum:iFD0710704504E3E7
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BNBNMR-A2-38[»]
DisProtiDP00209.
ProteinModelPortaliP46170.
SMRiP46170. Positions 1-38.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP46170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004834.
InParanoidiP46170.

Miscellaneous databases

EvolutionaryTraceiP46170.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
IPR006080. Defensin_beta/alpha.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils."
    Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J., Smith W., Henschen A.H., Cullor J.S.
    J. Biol. Chem. 268:6641-6648(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: Hereford.
    Tissue: Neutrophil.
  2. "Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils."
    Tang Y.-Q., Selsted M.E.
    J. Biol. Chem. 268:6649-6653(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  3. "Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins."
    Zimmermann G.R., Legault P., Selsted M.E., Pardi A.
    Biochemistry 34:13663-13671(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiDFB12_BOVIN
AccessioniPrimary (citable) accession number: P46170
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.