P46169 (DFB11_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 11

Alternative name(s):
BNBD-11
BNDB-11
Neutrophil beta-defensin 11

Gene names

Name:	DEFB11
Synonyms:	BNBD11

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	60 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
Subcellular location	Secreted.
Tissue specificity	Neutrophilic granules.
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.2
	Peptide	23 – 60	38	Beta-defensin 11 Ref.2		PRO_0000044726
Amino acid modifications
	Disulfide bond	27 ↔ 56		By similarity
	Disulfide bond	34 ↔ 49		By similarity
	Disulfide bond	39 ↔ 57		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46169 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 25D05BF218C166DE	FASTA	60	6,507
	10 20 30 40 50 60 MRLHHLLLAL LFLVLSAGSG ISGPLSCRRN GGVCIPIRCP GPMRQIGTCF GRPVKCCRSW

References

[1]	"Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue." Roosen S., Exner K., Paul S., Schroder J.M., Kalm E., Looft C. Mamm. Genome 15:834-842(2004) [PubMed: 15520886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J., Smith W., Henschen A.H., Cullor J.S. J. Biol. Chem. 268:6641-6648(1993) [PubMed: 8454635] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-60. Strain: Hereford. Tissue: Neutrophil.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ567992, AJ567993 Genomic DNA. Translation: CAD99423.1.
IPI	IPI00705689.
PIR	B47753.
3D structure databases
ProteinModelPortal	P46169.
SMR	P46169. Positions 23-60.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004834.
InParanoid	P46169.
OrthoDB	EOG4WM4WG.
Family and domain databases
InterPro	IPR001855. Defensin_beta-typ. IPR006080. Defensin_beta/neutrophil. [Graphical view]
Pfam	PF00711. Defensin_beta. 1 hit. [Graphical view]
SMART	SM00048. DEFSN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DFB11_BOVIN

Accession

Primary (citable) accession number: P46169
Secondary accession number(s): Q5W5G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	June 27, 2006
Last modified:	September 21, 2011
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program