Reviewed,
UniProtKB/Swiss-Prot P46169 (BD11_BOVIN)
Last modified
July 22, 2008.
Version 43.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Beta-defensin 11 Alternative name(s): BNDB-11 BNBD-11 Neutrophil beta-defensin 11 | ||||
| Gene names |
| ||||
| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 60 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A. |
| Subcellular location | |
| Tissue specificity | Neutrophilic granules. |
| Sequence similarities | Belongs to the beta-defensin family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Antibiotic Antimicrobial Defensin |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
Sequences
References
| [1] | "Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue." Roosen S., Exner K., Paul S., Schroder J.M., Kalm E., Looft C. Mamm. Genome 15:834-842(2004) [PubMed: 15520886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils." Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J., Smith W., Henschen A.H., Cullor J.S. J. Biol. Chem. 268:6641-6648(1993) [PubMed: 8454635] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-60. Strain: Hereford. Tissue: Neutrophil. |
Cross-references
Sequence databases | |
|---|---|
| AJ567992, AJ567993 Genomic DNA. Translation: CAD99423.1. | |
| PIR | B47753. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BNB based on UniProtKB P46170. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000033540. Bos taurus. [Contig view] |
Phylogenomic databases | |
| HOVERGEN | P46169. |
Family and domain databases | |
| InterPro | IPR001855. Defensin_beta. IPR006080. Defensin_mammal. [Graphical view] |
| Pfam | PF00711. Defensin_beta. 1 hit. [Graphical view] |
| SMART | SM00048. DEFSN. 1 hit. [Graphical view] |
| ProDom | P46169. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | BD11_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P46169 Secondary accession number(s): Q5W5G7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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