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P46157

- GLL1A_CHICK

UniProt

P46157 - GLL1A_CHICK

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Protein

Gallinacin-1 alpha

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
  2. defense response to fungus Source: UniProtKB-KW
  3. killing of cells of other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin, Fungicide

Protein family/group databases

TCDBi1.C.85.3.1. the pore-forming -defensin (-defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gallinacin-1 alpha
Short name:
Gal-1 alpha
Alternative name(s):
Antimicrobial peptide CHP2
Chicken heterophil peptide 2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 2562 PublicationsPRO_0000007010
Peptidei26 – 6439Gallinacin-1 alphaPRO_0000007011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 59By similarity
Disulfide bondi38 ↔ 53By similarity
Disulfide bondi43 ↔ 60By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP46157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004222.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46157-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIVYLLLPF ILLLAQGAAG SSQALGRKSD CFRKNGFCAF LKCPYLTLIS
60
GKCSRFHLCC KRIWG
Length:65
Mass (Da):7,286
Last modified:August 30, 2005 - v2
Checksum:iBC835B79574F2ECE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521K → L AA sequence (PubMed:7964174)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181951 mRNA. Translation: AAG09211.1.
DQ858337 mRNA. Translation: ABI48253.1.
DQ858297 mRNA. Translation: ABI48213.1.
PIRiS43282.
UniGeneiGga.176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181951 mRNA. Translation: AAG09211.1 .
DQ858337 mRNA. Translation: ABI48253.1 .
DQ858297 mRNA. Translation: ABI48213.1 .
PIRi S43282.
UniGenei Gga.176.

3D structure databases

ProteinModelPortali P46157.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 1.C.85.3.1. the pore-forming -defensin (-defensin) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004222.

Family and domain databases

InterProi IPR001855. Defensin_beta-typ.
[Graphical view ]
Pfami PF00711. Defensin_beta. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gallinacin-3, an inducible epithelial beta-defensin in the chicken."
    Zhao C., Nguyen T., Liu L., Sacco R.E., Brogden K.A., Lehrer R.I.
    Infect. Immun. 69:2684-2691(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Trachea.
  2. "Chicken beta-defensin in China chicken breeds."
    Cao Y., Chen Y., Bi Y., Xie Q., Chen J.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Guangxi Huang and Qingyuan Ma.
  3. Cited for: PROTEIN SEQUENCE OF 26-64.
    Strain: Cross Broiler-6.
    Tissue: Leukocyte.
  4. "Isolation of antimicrobial peptides from avian heterophils."
    Evans E.W., Beach G.G., Wunderlich J., Harmon B.G.
    J. Leukoc. Biol. 56:661-665(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-59.

Entry informationi

Entry nameiGLL1A_CHICK
AccessioniPrimary (citable) accession number: P46157
Secondary accession number(s): P80390, Q09MR8, Q9DG59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 30, 2005
Last modified: November 26, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3