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P46157

- GLL1A_CHICK

UniProt

P46157 - GLL1A_CHICK

Protein

Gallinacin-1 alpha

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans.

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW
    2. defense response to fungus Source: UniProtKB-KW
    3. killing of cells of other organism Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin, Fungicide

    Protein family/group databases

    TCDBi1.C.85.3.1. the pore-forming -defensin (-defensin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gallinacin-1 alpha
    Short name:
    Gal-1 alpha
    Alternative name(s):
    Antimicrobial peptide CHP2
    Chicken heterophil peptide 2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 2562 PublicationsPRO_0000007010
    Peptidei26 – 6439Gallinacin-1 alphaPRO_0000007011Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 59By similarity
    Disulfide bondi38 ↔ 53By similarity
    Disulfide bondi43 ↔ 60By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP46157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG004222.

    Family and domain databases

    InterProiIPR001855. Defensin_beta-typ.
    [Graphical view]
    PfamiPF00711. Defensin_beta. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46157-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIVYLLLPF ILLLAQGAAG SSQALGRKSD CFRKNGFCAF LKCPYLTLIS   50
    GKCSRFHLCC KRIWG 65
    Length:65
    Mass (Da):7,286
    Last modified:August 30, 2005 - v2
    Checksum:iBC835B79574F2ECE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521K → L AA sequence (PubMed:7964174)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF181951 mRNA. Translation: AAG09211.1.
    DQ858337 mRNA. Translation: ABI48253.1.
    DQ858297 mRNA. Translation: ABI48213.1.
    PIRiS43282.
    UniGeneiGga.176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF181951 mRNA. Translation: AAG09211.1 .
    DQ858337 mRNA. Translation: ABI48253.1 .
    DQ858297 mRNA. Translation: ABI48213.1 .
    PIRi S43282.
    UniGenei Gga.176.

    3D structure databases

    ProteinModelPortali P46157.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 1.C.85.3.1. the pore-forming -defensin (-defensin) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004222.

    Family and domain databases

    InterProi IPR001855. Defensin_beta-typ.
    [Graphical view ]
    Pfami PF00711. Defensin_beta. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gallinacin-3, an inducible epithelial beta-defensin in the chicken."
      Zhao C., Nguyen T., Liu L., Sacco R.E., Brogden K.A., Lehrer R.I.
      Infect. Immun. 69:2684-2691(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Trachea.
    2. "Chicken beta-defensin in China chicken breeds."
      Cao Y., Chen Y., Bi Y., Xie Q., Chen J.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Guangxi Huang and Qingyuan Ma.
    3. Cited for: PROTEIN SEQUENCE OF 26-64.
      Strain: Cross Broiler-6.
      Tissue: Leukocyte.
    4. "Isolation of antimicrobial peptides from avian heterophils."
      Evans E.W., Beach G.G., Wunderlich J., Harmon B.G.
      J. Leukoc. Biol. 56:661-665(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-59.

    Entry informationi

    Entry nameiGLL1A_CHICK
    AccessioniPrimary (citable) accession number: P46157
    Secondary accession number(s): P80390, Q09MR8, Q9DG59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3