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P46157 (GLL1A_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gallinacin-1 alpha

Short name=Gal-1 alpha
Alternative name(s):
Antimicrobial peptide CHP2
Chicken heterophil peptide 2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length65 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans.

Subcellular location

Secreted. Cytoplasmic granule.

Sequence similarities

Belongs to the beta-defensin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 256
PRO_0000007010
Peptide26 – 6439Gallinacin-1 alpha Ref.3
PRO_0000007011

Amino acid modifications

Disulfide bond31 ↔ 59 By similarity
Disulfide bond38 ↔ 53 By similarity
Disulfide bond43 ↔ 60 By similarity

Experimental info

Sequence conflict521K → L AA sequence Ref.4

Sequences

Sequence LengthMass (Da)Tools
P46157 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: BC835B79574F2ECE

FASTA657,286
        10         20         30         40         50         60 
MRIVYLLLPF ILLLAQGAAG SSQALGRKSD CFRKNGFCAF LKCPYLTLIS GKCSRFHLCC 


KRIWG 

« Hide

References

[1]"Gallinacin-3, an inducible epithelial beta-defensin in the chicken."
Zhao C., Nguyen T., Liu L., Sacco R.E., Brogden K.A., Lehrer R.I.
Infect. Immun. 69:2684-2691(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Trachea.
[2]"Chicken beta-defensin in China chicken breeds."
Cao Y., Chen Y., Bi Y., Xie Q., Chen J.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Guangxi Huang and Qingyuan Ma.
[3]"Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes."
Harwig S.S.L., Swiderek K.M., Kokryakov V.N., Tan L., Lee T.D., Panyutich E.A., Aleshina G.M., Shamova O.V., Lehrer R.I.
FEBS Lett. 342:281-285(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-64.
Strain: Cross Broiler-6.
Tissue: Leukocyte.
[4]"Isolation of antimicrobial peptides from avian heterophils."
Evans E.W., Beach G.G., Wunderlich J., Harmon B.G.
J. Leukoc. Biol. 56:661-665(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-59.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF181951 mRNA. Translation: AAG09211.1.
DQ858337 mRNA. Translation: ABI48253.1.
DQ858297 mRNA. Translation: ABI48213.1.
PIRS43282.
UniGeneGga.176.

3D structure databases

ProteinModelPortalP46157.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB1.C.85.3.1. the pore-forming -defensin (-defensin) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004222.

Family and domain databases

InterProIPR001855. Defensin_beta-typ.
[Graphical view]
PfamPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLL1A_CHICK
AccessionPrimary (citable) accession number: P46157
Secondary accession number(s): P80390, Q09MR8, Q9DG59
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 30, 2005
Last modified: January 22, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families