Reviewed,
UniProtKB/Swiss-Prot P46155 (TOP1_KLEAE)
Last modified
June 16, 2009.
Version 39.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: DNA topoisomerase 1 EC=5.99.1.2 Alternative name(s): DNA topoisomerase I Omega-protein Relaxing enzyme Untwisting enzyme Swivelase | ||
| Gene names |
| ||
| Organism | Klebsiella aerogenes | ||
| Taxonomic identifier | 28451 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella |
Protein attributes
| Sequence length | 18 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. |
| Catalytic activity | ATP-independent breakage of single-stranded DNA, followed by passage and rejoining. |
| Subunit structure | Monomer By similarity. |
| Miscellaneous | When a topoisomerase transiently breaks a DNA backbone bond, it simultaneously forms a protein-DNA link, in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand. |
| Sequence similarities | Belongs to the prokaryotic type I/III topoisomerase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding DNA-binding Nucleotide-binding |
| Molecular function | Isomerase Topoisomerase |
| Gene Ontology (GO) | |
| Biological process | DNA topological change Inferred from electronic annotation. Source: InterPro |
| Cellular component | chromosome Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA topoisomerase (ATP-hydrolyzing) activityInferred from electronic annotation. Source: InterPro DNA topoisomerase type I activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "Characterization of the CysB protein of Klebsiella aerogenes: direct evidence that N-acetylserine rather than O-acetylserine serves as the inducer of the cysteine regulon." Lynch A.S., Tyrrell R., Smerdon S.J., Briggs G.S., Wilkinson A.J. Biochem. J. 299:129-136(1994) [PubMed: 8166630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NCTC 418 / ATCC 15380. |
Cross-references
Sequence databases | |
|---|---|
| X78729 Genomic DNA. No translation available. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1YUA based on UniProtKB P06612. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 5.99.1.2. 366. |
Family and domain databases | |
| InterPro | IPR000380. Topo_IA_core. IPR013263. TopoI_Znr_bac. [Graphical view] |
| Pfam | PF08272. Topo_Zn_Ribbon. 1 hit. [Graphical view] |
| PROSITE | PS00396. TOPOISOMERASE_I_PROK. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TOP1_KLEAE | ||||||||
| Accession | Primary (citable) accession number: P46155 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

Clusters with


