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P46153 (GATA6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor GATA-6
Alternative name(s):
DNA-binding protein GATA-GT2
GATA-binding factor 6
Gene names
Name:Gata6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional activator. Involved in gene regulation specifically in the gastric epithelium.

Subunit structure

Interacts with LMCD1 By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed predominantly in gastric mucosa and at much lower levels in the intestine.

Domain

The GATA-type zinc fingers mediate interaction with LMCD1 By similarity.

Sequence similarities

Contains 2 GATA-type zinc fingers.

Sequence caution

The sequence AAA92577.1 differs from that shown. Reason: Frameshift at positions 430 and 432.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processodontogenesis of dentin-containing tooth

Inferred from expression pattern PubMed 17923110. Source: RGD

positive regulation of BMP signaling pathway

Inferred from direct assay PubMed 12606287. Source: BHF-UCL

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 19628789. Source: RGD

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 15591218. Source: RGD

regulation of transcription, DNA-templated

Inferred from expression pattern Ref.2. Source: RGD

response to cAMP

Inferred from expression pattern PubMed 9188781. Source: RGD

response to drug

Inferred from expression pattern PubMed 19842842. Source: RGD

response to toxic substance

Inferred from expression pattern PubMed 9188781. Source: RGD

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 10851229. Source: RGD

   Molecular_functiondouble-stranded DNA binding

Inferred from direct assay PubMed 10851229. Source: RGD

enhancer sequence-specific DNA binding

Inferred from direct assay PubMed 20855530. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.2. Source: RGD

transcription factor binding

Inferred from physical interaction PubMed 10330176. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from direct assay PubMed 12606287. Source: BHF-UCL

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Transcription factor GATA-6
PRO_0000083426

Regions

Zinc finger384 – 40825GATA-type 1
Zinc finger438 – 46225GATA-type 2
Compositional bias173 – 18311Poly-Ala
Compositional bias322 – 3287Poly-His
Compositional bias443 – 4475Poly-Thr

Amino acid modifications

Modified residue2661Phosphoserine By similarity

Experimental info

Sequence conflict4311S → I in AAA92577. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P46153 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 2D1C1515B66B1BCE

FASTA58759,168
        10         20         30         40         50         60 
MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG DRGPCGASNC 

        70         80         90        100        110        120 
RTPQLDTEAV AGPPGRSLLL SPYTSHPFAA AHGAAAPGVA GPGSALSTWE DLLLFTDLDQ 

       130        140        150        160        170        180 
AATASKLLWS SRGAKLSPFA AEQPEEMYQT LAALSSQGPA AYDGAPGGFV HSAAAAAAAA 

       190        200        210        220        230        240 
AAASSPVYVP TTRVGSMLPG LPYLQGAGSG PSNHAGGAGA HPGWPQASAD SPPYGGGGAA 

       250        260        270        280        290        300 
GGGAAGPGGA GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGAGAGS VSGGGGSLAA 

       310        320        330        340        350        360 
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMGAPLT PAWPAGPFET PVLHSLQSRA 

       370        380        390        400        410        420 
GAPLPVPRGP SADLLEDLSE SRECVNCGSI QTPLWRRDGT GHYLCNACGL YSKMNGLSRP 

       430        440        450        460        470        480 
LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE 

       490        500        510        520        530        540 
GIQTRKRKPK NINKSKACSG NSSVPMTPTS SSSNSDDCTK NTSPPTQSTA SGVGASVMSA 

       550        560        570        580 
VGESANPENS DLKYSGQDGL YIGVSLSSPA EVTSSVRQDS WCALALA 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes."
Tamura S., Wang X.H., Maeda M., Futai M.
Proc. Natl. Acad. Sci. U.S.A. 90:10876-10880(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 108-587.
Strain: Wistar.
Tissue: Stomach.
[3]Erratum
Tamura S., Wang X.H., Maeda M., Futai M.
Proc. Natl. Acad. Sci. U.S.A. 91:4609-4609(1994) [PubMed] [Europe PMC] [Abstract]
[4]"GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut."
Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E., Evans T.
J. Biol. Chem. 269:23177-23184(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF PROBABLE FRAMESHIFTS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR03109887 Genomic DNA. No translation available.
AABR03111467 Genomic DNA. No translation available.
AABR03111603 Genomic DNA. No translation available.
AABR03112401 Genomic DNA. No translation available.
AABR03112926 Genomic DNA. No translation available.
AABR03113211 Genomic DNA. No translation available.
L22760 mRNA. Translation: AAA92577.1. Frameshift.
PIRA49645.
RefSeqNP_062058.1. NM_019185.1.
UniGeneRn.8701.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid247966. 1 interaction.
STRING10116.ENSRNOP00000036967.

Proteomic databases

PaxDbP46153.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29300.
KEGGrno:29300.
UCSCRGD:2666. rat.

Organism-specific databases

CTD2627.
RGD2666. Gata6.

Phylogenomic databases

eggNOGCOG5641.
HOGENOMHOG000047700.
HOVERGENHBG051703.
KOK17897.
PhylomeDBP46153.

Gene expression databases

GenevestigatorP46153.

Family and domain databases

Gene3D3.30.50.10. 2 hits.
InterProIPR008013. GATA_N.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERPTHR10071:SF23. PTHR10071:SF23. 1 hit.
PfamPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PRINTSPR00619. GATAZNFINGER.
SMARTSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio608714.
PROP46153.

Entry information

Entry nameGATA6_RAT
AccessionPrimary (citable) accession number: P46153
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families