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Protein

Transcription factor GATA-6

Gene

Gata6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 408GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri438 – 462GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • negative regulation of pri-miRNA transcription from RNA polymerase II promoter Source: BHF-UCL
  • odontogenesis of dentin-containing tooth Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of BMP signaling pathway Source: BHF-UCL
  • positive regulation of cardiac muscle cell apoptotic process Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • response to cAMP Source: RGD
  • response to drug Source: RGD
  • response to toxic substance Source: RGD

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-6
Alternative name(s):
DNA-binding protein GATA-GT2
GATA-binding factor 6
Gene namesi
Name:Gata6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2666. Gata6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834261 – 587Transcription factor GATA-6Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei266PhosphoserineCombined sources1
Cross-linki423Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP46153.

PTM databases

iPTMnetiP46153.
PhosphoSitePlusiP46153.

Expressioni

Tissue specificityi

Expressed predominantly in gastric mucosa and at much lower levels in the intestine.

Interactioni

Subunit structurei

Interacts with LMCD1.By similarity

GO - Molecular functioni

  • RNA polymerase II transcription factor binding Source: GO_Central
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi247966. 1 interactor.
STRINGi10116.ENSRNOP00000036967.

Structurei

3D structure databases

SMRiP46153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi173 – 183Poly-AlaAdd BLAST11
Compositional biasi322 – 328Poly-His7
Compositional biasi443 – 447Poly-Thr5

Domaini

The GATA-type zinc fingers mediate interaction with LMCD1.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 408GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri438 – 462GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiP46153.
KOiK17897.
PhylomeDBiP46153.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR008013. GATA_N.
IPR016375. TF_GATA_4/5/6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiView protein in SMART
SM00401. ZnF_GATA. 2 hits.
PROSITEiView protein in PROSITE
PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P46153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG
60 70 80 90 100
DRGPCGASNC RTPQLDTEAV AGPPGRSLLL SPYTSHPFAA AHGAAAPGVA
110 120 130 140 150
GPGSALSTWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA AEQPEEMYQT
160 170 180 190 200
LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLPG
210 220 230 240 250
LPYLQGAGSG PSNHAGGAGA HPGWPQASAD SPPYGGGGAA GGGAAGPGGA
260 270 280 290 300
GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGAGAGS VSGGGGSLAA
310 320 330 340 350
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMGAPLT PAWPAGPFET
360 370 380 390 400
PVLHSLQSRA GAPLPVPRGP SADLLEDLSE SRECVNCGSI QTPLWRRDGT
410 420 430 440 450
GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR
460 470 480 490 500
RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKACSG
510 520 530 540 550
NSSVPMTPTS SSSNSDDCTK NTSPPTQSTA SGVGASVMSA VGESANPENS
560 570 580
DLKYSGQDGL YIGVSLSSPA EVTSSVRQDS WCALALA
Length:587
Mass (Da):59,168
Last modified:November 25, 2008 - v2
Checksum:i2D1C1515B66B1BCE
GO

Sequence cautioni

P46153: The sequence AAA92577 differs from that shown. Reason: Frameshift at positions 430 and 432.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti431S → I in AAA92577 (PubMed:8248184).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109887 Genomic DNA. No translation available.
AABR03111467 Genomic DNA. No translation available.
AABR03111603 Genomic DNA. No translation available.
AABR03112401 Genomic DNA. No translation available.
AABR03112926 Genomic DNA. No translation available.
AABR03113211 Genomic DNA. No translation available.
L22760 mRNA. Translation: AAA92577.1. Frameshift.
PIRiA49645.
RefSeqiNP_062058.2. NM_019185.2.
UniGeneiRn.164914.
Rn.8701.

Genome annotation databases

GeneIDi29300.
KEGGirno:29300.
UCSCiRGD:2666. rat.

Similar proteinsi

Entry informationi

Entry nameiGATA6_RAT
AccessioniPrimary (citable) accession number: P46153
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 25, 2008
Last modified: October 25, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome