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P46153

- GATA6_RAT

UniProt

P46153 - GATA6_RAT

Protein

Transcription factor GATA-6

Gene

Gata6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Transcriptional activator. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri384 – 40825GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 46225GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. double-stranded DNA binding Source: RGD
    2. enhancer sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: RGD
    4. transcription factor binding Source: UniProtKB
    5. transcription regulatory region DNA binding Source: BHF-UCL
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. odontogenesis of dentin-containing tooth Source: RGD
    2. positive regulation of apoptotic process Source: RGD
    3. positive regulation of BMP signaling pathway Source: BHF-UCL
    4. positive regulation of transcription from RNA polymerase II promoter Source: RGD
    5. regulation of transcription, DNA-templated Source: RGD
    6. response to cAMP Source: RGD
    7. response to drug Source: RGD
    8. response to toxic substance Source: RGD
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor GATA-6
    Alternative name(s):
    DNA-binding protein GATA-GT2
    GATA-binding factor 6
    Gene namesi
    Name:Gata6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2666. Gata6.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: RGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 587587Transcription factor GATA-6PRO_0000083426Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei266 – 2661PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP46153.

    Expressioni

    Tissue specificityi

    Expressed predominantly in gastric mucosa and at much lower levels in the intestine.

    Gene expression databases

    GenevestigatoriP46153.

    Interactioni

    Subunit structurei

    Interacts with LMCD1.By similarity

    Protein-protein interaction databases

    BioGridi247966. 1 interaction.
    STRINGi10116.ENSRNOP00000036967.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi173 – 18311Poly-AlaAdd
    BLAST
    Compositional biasi322 – 3287Poly-His
    Compositional biasi443 – 4475Poly-Thr

    Domaini

    The GATA-type zinc fingers mediate interaction with LMCD1.By similarity

    Sequence similaritiesi

    Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri384 – 40825GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 46225GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5641.
    HOGENOMiHOG000047700.
    HOVERGENiHBG051703.
    KOiK17897.
    PhylomeDBiP46153.

    Family and domain databases

    Gene3Di3.30.50.10. 2 hits.
    InterProiIPR008013. GATA_N.
    IPR028437. TF_GATA_6.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PANTHERiPTHR10071:SF23. PTHR10071:SF23. 1 hit.
    PfamiPF00320. GATA. 2 hits.
    PF05349. GATA-N. 1 hit.
    [Graphical view]
    PRINTSiPR00619. GATAZNFINGER.
    SMARTiSM00401. ZnF_GATA. 2 hits.
    [Graphical view]
    PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46153-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG    50
    DRGPCGASNC RTPQLDTEAV AGPPGRSLLL SPYTSHPFAA AHGAAAPGVA 100
    GPGSALSTWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA AEQPEEMYQT 150
    LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLPG 200
    LPYLQGAGSG PSNHAGGAGA HPGWPQASAD SPPYGGGGAA GGGAAGPGGA 250
    GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGAGAGS VSGGGGSLAA 300
    MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMGAPLT PAWPAGPFET 350
    PVLHSLQSRA GAPLPVPRGP SADLLEDLSE SRECVNCGSI QTPLWRRDGT 400
    GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR 450
    RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKACSG 500
    NSSVPMTPTS SSSNSDDCTK NTSPPTQSTA SGVGASVMSA VGESANPENS 550
    DLKYSGQDGL YIGVSLSSPA EVTSSVRQDS WCALALA 587
    Length:587
    Mass (Da):59,168
    Last modified:November 25, 2008 - v2
    Checksum:i2D1C1515B66B1BCE
    GO

    Sequence cautioni

    The sequence AAA92577.1 differs from that shown. Reason: Frameshift at positions 430 and 432.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti431 – 4311S → I in AAA92577. (PubMed:8248184)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03109887 Genomic DNA. No translation available.
    AABR03111467 Genomic DNA. No translation available.
    AABR03111603 Genomic DNA. No translation available.
    AABR03112401 Genomic DNA. No translation available.
    AABR03112926 Genomic DNA. No translation available.
    AABR03113211 Genomic DNA. No translation available.
    L22760 mRNA. Translation: AAA92577.1. Frameshift.
    PIRiA49645.
    RefSeqiNP_062058.1. NM_019185.1.
    UniGeneiRn.8701.

    Genome annotation databases

    GeneIDi29300.
    KEGGirno:29300.
    UCSCiRGD:2666. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03109887 Genomic DNA. No translation available.
    AABR03111467 Genomic DNA. No translation available.
    AABR03111603 Genomic DNA. No translation available.
    AABR03112401 Genomic DNA. No translation available.
    AABR03112926 Genomic DNA. No translation available.
    AABR03113211 Genomic DNA. No translation available.
    L22760 mRNA. Translation: AAA92577.1 . Frameshift.
    PIRi A49645.
    RefSeqi NP_062058.1. NM_019185.1.
    UniGenei Rn.8701.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 247966. 1 interaction.
    STRINGi 10116.ENSRNOP00000036967.

    Proteomic databases

    PaxDbi P46153.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29300.
    KEGGi rno:29300.
    UCSCi RGD:2666. rat.

    Organism-specific databases

    CTDi 2627.
    RGDi 2666. Gata6.

    Phylogenomic databases

    eggNOGi COG5641.
    HOGENOMi HOG000047700.
    HOVERGENi HBG051703.
    KOi K17897.
    PhylomeDBi P46153.

    Miscellaneous databases

    NextBioi 608714.
    PROi P46153.

    Gene expression databases

    Genevestigatori P46153.

    Family and domain databases

    Gene3Di 3.30.50.10. 2 hits.
    InterProi IPR008013. GATA_N.
    IPR028437. TF_GATA_6.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    PANTHERi PTHR10071:SF23. PTHR10071:SF23. 1 hit.
    Pfami PF00320. GATA. 2 hits.
    PF05349. GATA-N. 1 hit.
    [Graphical view ]
    PRINTSi PR00619. GATAZNFINGER.
    SMARTi SM00401. ZnF_GATA. 2 hits.
    [Graphical view ]
    PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes."
      Tamura S., Wang X.H., Maeda M., Futai M.
      Proc. Natl. Acad. Sci. U.S.A. 90:10876-10880(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 108-587.
      Strain: Wistar.
      Tissue: Stomach.
    3. "GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut."
      Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E., Evans T.
      J. Biol. Chem. 269:23177-23184(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF PROBABLE FRAMESHIFTS.

    Entry informationi

    Entry nameiGATA6_RAT
    AccessioniPrimary (citable) accession number: P46153
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3