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P46153

- GATA6_RAT

UniProt

P46153 - GATA6_RAT

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Protein

Transcription factor GATA-6

Gene

Gata6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri384 – 40825GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46225GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. double-stranded DNA binding Source: RGD
  2. enhancer sequence-specific DNA binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: RGD
  4. transcription factor binding Source: UniProtKB
  5. transcription regulatory region DNA binding Source: BHF-UCL
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. odontogenesis of dentin-containing tooth Source: RGD
  2. positive regulation of apoptotic process Source: RGD
  3. positive regulation of BMP signaling pathway Source: BHF-UCL
  4. positive regulation of transcription from RNA polymerase II promoter Source: RGD
  5. regulation of transcription, DNA-templated Source: RGD
  6. response to cAMP Source: RGD
  7. response to drug Source: RGD
  8. response to toxic substance Source: RGD
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-6
Alternative name(s):
DNA-binding protein GATA-GT2
GATA-binding factor 6
Gene namesi
Name:Gata6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2666. Gata6.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Transcription factor GATA-6PRO_0000083426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP46153.

Expressioni

Tissue specificityi

Expressed predominantly in gastric mucosa and at much lower levels in the intestine.

Gene expression databases

GenevestigatoriP46153.

Interactioni

Subunit structurei

Interacts with LMCD1.By similarity

Protein-protein interaction databases

BioGridi247966. 1 interaction.
STRINGi10116.ENSRNOP00000036967.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi173 – 18311Poly-AlaAdd
BLAST
Compositional biasi322 – 3287Poly-His
Compositional biasi443 – 4475Poly-Thr

Domaini

The GATA-type zinc fingers mediate interaction with LMCD1.By similarity

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri384 – 40825GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46225GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiP46153.
KOiK17897.
PhylomeDBiP46153.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF23. PTHR10071:SF23. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46153-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG
60 70 80 90 100
DRGPCGASNC RTPQLDTEAV AGPPGRSLLL SPYTSHPFAA AHGAAAPGVA
110 120 130 140 150
GPGSALSTWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA AEQPEEMYQT
160 170 180 190 200
LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLPG
210 220 230 240 250
LPYLQGAGSG PSNHAGGAGA HPGWPQASAD SPPYGGGGAA GGGAAGPGGA
260 270 280 290 300
GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGAGAGS VSGGGGSLAA
310 320 330 340 350
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMGAPLT PAWPAGPFET
360 370 380 390 400
PVLHSLQSRA GAPLPVPRGP SADLLEDLSE SRECVNCGSI QTPLWRRDGT
410 420 430 440 450
GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR
460 470 480 490 500
RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKACSG
510 520 530 540 550
NSSVPMTPTS SSSNSDDCTK NTSPPTQSTA SGVGASVMSA VGESANPENS
560 570 580
DLKYSGQDGL YIGVSLSSPA EVTSSVRQDS WCALALA
Length:587
Mass (Da):59,168
Last modified:November 25, 2008 - v2
Checksum:i2D1C1515B66B1BCE
GO

Sequence cautioni

The sequence AAA92577.1 differs from that shown. Reason: Frameshift at positions 430 and 432.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti431 – 4311S → I in AAA92577. (PubMed:8248184)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03109887 Genomic DNA. No translation available.
AABR03111467 Genomic DNA. No translation available.
AABR03111603 Genomic DNA. No translation available.
AABR03112401 Genomic DNA. No translation available.
AABR03112926 Genomic DNA. No translation available.
AABR03113211 Genomic DNA. No translation available.
L22760 mRNA. Translation: AAA92577.1. Frameshift.
PIRiA49645.
RefSeqiNP_062058.1. NM_019185.1.
UniGeneiRn.8701.

Genome annotation databases

GeneIDi29300.
KEGGirno:29300.
UCSCiRGD:2666. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03109887 Genomic DNA. No translation available.
AABR03111467 Genomic DNA. No translation available.
AABR03111603 Genomic DNA. No translation available.
AABR03112401 Genomic DNA. No translation available.
AABR03112926 Genomic DNA. No translation available.
AABR03113211 Genomic DNA. No translation available.
L22760 mRNA. Translation: AAA92577.1 . Frameshift.
PIRi A49645.
RefSeqi NP_062058.1. NM_019185.1.
UniGenei Rn.8701.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 247966. 1 interaction.
STRINGi 10116.ENSRNOP00000036967.

Proteomic databases

PaxDbi P46153.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29300.
KEGGi rno:29300.
UCSCi RGD:2666. rat.

Organism-specific databases

CTDi 2627.
RGDi 2666. Gata6.

Phylogenomic databases

eggNOGi COG5641.
HOGENOMi HOG000047700.
HOVERGENi HBG051703.
InParanoidi P46153.
KOi K17897.
PhylomeDBi P46153.

Miscellaneous databases

NextBioi 608714.
PROi P46153.

Gene expression databases

Genevestigatori P46153.

Family and domain databases

Gene3Di 3.30.50.10. 2 hits.
InterProi IPR008013. GATA_N.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
PANTHERi PTHR10071:SF23. PTHR10071:SF23. 1 hit.
Pfami PF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view ]
PRINTSi PR00619. GATAZNFINGER.
SMARTi SM00401. ZnF_GATA. 2 hits.
[Graphical view ]
PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes."
    Tamura S., Wang X.H., Maeda M., Futai M.
    Proc. Natl. Acad. Sci. U.S.A. 90:10876-10880(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 108-587.
    Strain: Wistar.
    Tissue: Stomach.
  3. "GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut."
    Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E., Evans T.
    J. Biol. Chem. 269:23177-23184(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE FRAMESHIFTS.

Entry informationi

Entry nameiGATA6_RAT
AccessioniPrimary (citable) accession number: P46153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3