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Protein

Electron transport regulator A

Gene

etrA

Organism
Shewanella oneidensis (strain MR-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regulates anaerobic growth on fumarate, nitrite, Fe3+, TMAO, DMSO, thiosulfate and sulfite, but not on nitrate nor Mn4+.

Miscellaneous

Possesses 4 cysteines which may bind a metal ion (possibly iron).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi197 – 216H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TIGR

GO - Biological processi

  • anaerobic respiration Source: TIGR
  • regulation of transcription, DNA-templated Source: TIGR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transport regulator A
Gene namesi
Name:etrA
Ordered Locus Names:SO_2356
OrganismiShewanella oneidensis (strain MR-1)
Taxonomic identifieri211586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000008186 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001551 – 250Electron transport regulator AAdd BLAST250

Proteomic databases

PaxDbiP46148.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi211586.SO_2356.

Structurei

3D structure databases

ProteinModelPortaliP46148.
SMRiP46148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 237HTH crp-typePROSITE-ProRule annotationAdd BLAST74

Phylogenomic databases

eggNOGiENOG4105DS0. Bacteria.
COG0664. LUCA.
HOGENOMiHOG000186461.
KOiK01420.
OMAiTLPMSKK.
OrthoDBiPOG091H0447.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
PRINTSiPR00034. HTHCRP.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P46148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIEQNKNRR SAASGCAIHC HDCSMGTLCI PFTLNANELD QLDDIIERKK
60 70 80 90 100
PIQKGEQIFK SGDPLKSLFA IRSGTIKSYT ITEQGDEQIT GFHLAGDVIG
110 120 130 140 150
FDGIHAQSHQ SFAQALETSM VCEIPFNILD ELSGTMPKLR QQIMRLMSNE
160 170 180 190 200
IMSDQEMILL LSKKNAEERL AAFISNLANR FGNRGFSAKE FRLTMTRGDI
210 220 230 240 250
GNYLGLTVET ISRLLGRFQK SGLIEVKGKY IIIVDHHELN LLAGNARIAR
Length:250
Mass (Da):27,889
Last modified:November 25, 2002 - v2
Checksum:i24C82E3C8C3E5743
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30I → M in AAA71987 (PubMed:8253682).Curated1
Sequence conflicti64P → L in AAA71987 (PubMed:8253682).Curated1
Sequence conflicti72R → P in AAA71987 (PubMed:8253682).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13868 Unassigned DNA. Translation: AAA71987.1.
AE014299 Genomic DNA. Translation: AAN55390.2.
PIRiA49910.
RefSeqiNP_717946.2. NC_004347.2.
WP_011072343.1. NC_004347.2.

Genome annotation databases

EnsemblBacteriaiAAN55390; AAN55390; SO_2356.
GeneIDi1170077.
KEGGison:SO_2356.
PATRICifig|211586.12.peg.2267.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiETRA_SHEON
AccessioniPrimary (citable) accession number: P46148
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 25, 2002
Last modified: June 7, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome