P46148 (ETRA_SHEON) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Electron transport regulator A

Gene names

Name:	etrA
Ordered Locus Names:	SO_2356

Organism

Shewanella oneidensis (strain MR-1) [Reference proteome] [HAMAP]

Taxonomic identifier

211586 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella › Shewanella oneidensis

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Regulates anaerobic growth on fumarate, nitrite, Fe3+, TMAO, DMSO, thiosulfate and sulfite, but not on nitrate nor Mn4+.
Subunit structure	Monomer By similarity.
Miscellaneous	Possesses 4 cysteines which may bind a metal ion (possibly iron).
Sequence similarities	Contains 1 cyclic nucleotide-binding domain. Contains 1 HTH crp-type DNA-binding domain.
Sequence caution	The sequence AAN55390.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anaerobic respiration Inferred from mutant phenotype Ref.1. Source: TIGR transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from mutant phenotype Ref.1. Source: TIGR
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	Electron transport regulator A		PRO_0000100155
Regions
	Domain	164 – 237	74	HTH crp-type
	DNA binding	197 – 216	20	H-T-H motif Potential
Experimental info
	Sequence conflict	30	1	I → M in AAA71987. Ref.1
	Sequence conflict	64	1	P → L in AAA71987. Ref.1
	Sequence conflict	72	1	R → P in AAA71987. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P46148 [UniParc]. Last modified November 25, 2002. Version 2. Checksum: 24C82E3C8C3E5743	FASTA	250	27,889
	10 20 30 40 50 60 MTIEQNKNRR SAASGCAIHC HDCSMGTLCI PFTLNANELD QLDDIIERKK PIQKGEQIFK 70 80 90 100 110 120 SGDPLKSLFA IRSGTIKSYT ITEQGDEQIT GFHLAGDVIG FDGIHAQSHQ SFAQALETSM 130 140 150 160 170 180 VCEIPFNILD ELSGTMPKLR QQIMRLMSNE IMSDQEMILL LSKKNAEERL AAFISNLANR 190 200 210 220 230 240 FGNRGFSAKE FRLTMTRGDI GNYLGLTVET ISRLLGRFQK SGLIEVKGKY IIIVDHHELN 250 LLAGNARIAR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and genetic characterization of etrA, an fnr analog that regulates anaerobic respiration in Shewanella putrefaciens MR-1." Saffarini D.A., Nealson K.H. J. Bacteriol. 175:7938-7944(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MR-1.
[2]	"Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis." Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C., Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A., Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T. , Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R., Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J., Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J., Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V., Smith H.O., Venter J.C., Nealson K.H., Fraser C.M. Nat. Biotechnol. 20:1118-1123(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MR-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L13868 Unassigned DNA. Translation: AAA71987.1. AE014299 Genomic DNA. Translation: AAN55390.1. Different initiation.
PIR	A49910.
RefSeq	NP_717946.2. NC_004347.2.
3D structure databases
ProteinModelPortal	P46148.
ModBase	Search...
Protein-protein interaction databases
STRING	211586.SO_2356.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN55390; AAN55390; SO_2356.
GeneID	1170077.
KEGG	son:SO_2356.
PATRIC	23524333. VBISheOne101494_2267.
Phylogenomic databases
eggNOG	COG0664.
HOGENOM	HOG000186461.
KO	K01420.
OMA	FSANQFR.
ProtClustDB	PRK11161.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 2.60.120.10. 1 hit.
InterPro	IPR018490. cNMP-bd-like. IPR000595. cNMP-bd_dom. IPR012318. HTH_CRP_2. IPR014710. RmlC-like_jellyroll. IPR001808. Tscrpt_reg_HTH_Crp. IPR018335. Tscrpt_reg_HTH_Crp-type_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00027. cNMP_binding. 1 hit. PF00325. Crp. 1 hit. [Graphical view]
PRINTS	PR00034. HTHCRP.
SMART	SM00100. cNMP. 1 hit. SM00419. HTH_CRP. 1 hit. [Graphical view]
SUPFAM	SSF51206. cNMP_binding. 1 hit.
PROSITE	PS50042. CNMP_BINDING_3. 1 hit. PS00042. HTH_CRP_1. 1 hit. PS51063. HTH_CRP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ETRA_SHEON

Accession

Primary (citable) accession number: P46148

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 25, 2002
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program