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Protein

Aromatic amino acid exporter YddG

Gene

yddG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable efflux pump. Overexpression confers resistance to phenylalanine and increases export of phenylalanine, tyrosine and tryptophan.1 Publication

GO - Molecular functioni

  • L-phenylalanine transmembrane transporter activity Source: EcoCyc
  • L-tryptophan transmembrane transporter activity Source: EcoCyc
  • L-tyrosine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • phenylalanine transport Source: EcoCyc
  • tryptophan transport Source: EcoCyc
  • tyrosine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG12713-MONOMER.
ECOL316407:JW1469-MONOMER.
MetaCyc:EG12713-MONOMER.

Protein family/group databases

TCDBi2.A.7.17.2. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic amino acid exporter YddG
Gene namesi
Name:yddG
Ordered Locus Names:b1473, JW1469
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12713. yddG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST
Topological domaini28 – 336PeriplasmicSequence analysis
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Topological domaini55 – 628CytoplasmicSequence analysis
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Topological domaini84 – 929PeriplasmicSequence analysis
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Topological domaini114 – 1185CytoplasmicSequence analysis
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Topological domaini140 – 15516PeriplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Topological domaini177 – 1826CytoplasmicSequence analysis
Transmembranei183 – 20321HelicalSequence analysisAdd
BLAST
Topological domaini204 – 21815PeriplasmicSequence analysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence analysisAdd
BLAST
Topological domaini240 – 2434CytoplasmicSequence analysis
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Topological domaini265 – 2673PeriplasmicSequence analysis
Transmembranei268 – 28821HelicalSequence analysisAdd
BLAST
Topological domaini289 – 2935CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Aromatic amino acid exporter YddGPRO_0000168943Add
BLAST

Proteomic databases

PaxDbiP46136.

Interactioni

Protein-protein interaction databases

BioGridi4260205. 15 interactions.
STRINGi511145.b1473.

Structurei

3D structure databases

ProteinModelPortaliP46136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 137123EamA 1Add
BLAST
Domaini167 – 285119EamA 2Add
BLAST

Sequence similaritiesi

Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105RPH. Bacteria.
COG0697. LUCA.
HOGENOMiHOG000194714.
InParanoidiP46136.
OMAiVALWFHY.
OrthoDBiEOG6R2GX2.
PhylomeDBiP46136.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRQKATLIG LIAIVLWSTM VGLIRGVSEG LGPVGGAAAI YSLSGLLLIF
60 70 80 90 100
TVGFPRIRQI PKGYLLAGSL LFVSYEICLA LSLGYAATHH QAIEVGMVNY
110 120 130 140 150
LWPSLTILFA ILFNGQKTNW LIVPGLLLAL VGVCWVLGGD NGLHYDEIIN
160 170 180 190 200
NITTSPLSYF LAFIGAFIWA AYCTVTNKYA RGFNGITVFV LLTGASLWVY
210 220 230 240 250
YFLTPQPEMI FSTPVMIKLI SAAFTLGFAY AAWNVGILHG NVTIMAVGSY
260 270 280 290
FTPVLSSALA AVLLSAPLSF SFWQGALMVC GGSLLCWLAT RRG
Length:293
Mass (Da):31,539
Last modified:July 10, 2007 - v3
Checksum:i45E02F367F3E562C
GO

Sequence cautioni

The sequence BAA15122.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAD13437.3.
AP009048 Genomic DNA. Translation: BAA15122.1. Different initiation.
M75029 Genomic DNA. No translation available.
PIRiD64900.
RefSeqiNP_415990.5. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAD13437; AAD13437; b1473.
BAA15122; BAA15122; BAA15122.
GeneIDi945942.
KEGGiecj:JW1469.
eco:b1473.
PATRICi32118238. VBIEscCol129921_1539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAD13437.3.
AP009048 Genomic DNA. Translation: BAA15122.1. Different initiation.
M75029 Genomic DNA. No translation available.
PIRiD64900.
RefSeqiNP_415990.5. NC_000913.3.

3D structure databases

ProteinModelPortaliP46136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260205. 15 interactions.
STRINGi511145.b1473.

Protein family/group databases

TCDBi2.A.7.17.2. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PaxDbiP46136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD13437; AAD13437; b1473.
BAA15122; BAA15122; BAA15122.
GeneIDi945942.
KEGGiecj:JW1469.
eco:b1473.
PATRICi32118238. VBIEscCol129921_1539.

Organism-specific databases

EchoBASEiEB2574.
EcoGeneiEG12713. yddG.

Phylogenomic databases

eggNOGiENOG4105RPH. Bacteria.
COG0697. LUCA.
HOGENOMiHOG000194714.
InParanoidiP46136.
OMAiVALWFHY.
OrthoDBiEOG6R2GX2.
PhylomeDBiP46136.

Enzyme and pathway databases

BioCyciEcoCyc:EG12713-MONOMER.
ECOL316407:JW1469-MONOMER.
MetaCyc:EG12713-MONOMER.

Miscellaneous databases

PROiP46136.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Nitrate-inducible formate dehydrogenase in Escherichia coli K-12. I. Nucleotide sequence of the fdnGHI operon and evidence that opal (UGA) encodes selenocysteine."
    Berg B.L., Li J., Heider J., Stewart V.
    J. Biol. Chem. 266:22380-22385(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-54.
    Strain: K12.
  5. "Detection of new genes in a bacterial genome using Markov models for three gene classes."
    Borodovsky M., McIninch J., Koonin E.V., Rudd K.E., Medigue C., Danchin A.
    Nucleic Acids Res. 23:3554-3562(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.
  7. "YddG from Escherichia coli promotes export of aromatic amino acids."
    Doroshenko V., Airich L., Vitushkina M., Kolokolova A., Livshits V., Mashko S.
    FEMS Microbiol. Lett. 275:312-318(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12 / MG1655 / ATCC 47076.
  8. "Membrane topology analysis of the Escherichia coli aromatic amino acid efflux protein YddG."
    Airich L.G., Tsyrenzhapova I.S., Vorontsova O.V., Feofanov A.V., Doroshenko V.G., Mashko S.V.
    J. Mol. Microbiol. Biotechnol. 19:189-197(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY.
    Strain: K12.

Entry informationi

Entry nameiYDDG_ECOLI
AccessioniPrimary (citable) accession number: P46136
Secondary accession number(s): P76124, P77342
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 10, 2007
Last modified: January 20, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.