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Protein

p-aminobenzoyl-glutamate transport protein

Gene

abgT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for aminobenzoyl-glutamate utilization. It catalyzes the concentration-dependent uptake of p-aminobenzoyl-glutamate (PABA-GLU) into the cell and allows accumulation of PABA-GLU to a concentration enabling AbgAB to catalyze cleavage into p-aminobenzoate and glutamate. It seems also to increase the sensitivity to low levels of aminobenzoyl-glutamate. May actually serve physiologically as a transporter for some other molecule, perhaps a dipeptide, and that it transports p-aminobenzoyl-glutamate as a secondary activity. The physiological role of abgABT should be clarified.2 Publications

Enzyme regulationi

Completely inhibited by 100 nM of sodium azide and slightly inhibited by 100 mM of potassium fluoride.1 Publication

GO - Molecular functioni

  • p-aminobenzoyl-glutamate uptake transmembrane transporter activity Source: EcoCyc
  • secondary active transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • amino acid transport Source: UniProtKB-KW
  • p-aminobenzoyl-glutamate transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:ABGT-MONOMER.
ECOL316407:JW5822-MONOMER.
MetaCyc:ABGT-MONOMER.

Protein family/group databases

TCDBi2.A.68.1.1. the p-aminobenzoyl-glutamate transporter (abgt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
p-aminobenzoyl-glutamate transport protein
Alternative name(s):
PABA-GLU transport protein
Gene namesi
Name:abgT
Synonyms:ydaH
Ordered Locus Names:b1336, JW5822
ORF Names:ECK1332
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12853. abgT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei121 – 139HelicalSequence analysisAdd BLAST19
Transmembranei140 – 159HelicalSequence analysisAdd BLAST20
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene loss the p-aminobenzoyl-glutamate utilization phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000644221 – 508p-aminobenzoyl-glutamate transport proteinAdd BLAST508

Proteomic databases

PaxDbiP46133.
PRIDEiP46133.

Expressioni

Inductioni

Could be transcriptionally regulated by AbgR.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260156. 183 interactors.
DIPiDIP-9031N.
IntActiP46133. 1 interactor.
STRINGi511145.b1336.

Structurei

3D structure databases

ProteinModelPortaliP46133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CFC. Bacteria.
COG2978. LUCA.
HOGENOMiHOG000285565.
InParanoidiP46133.
KOiK12942.
OMAiPFIQGIV.
PhylomeDBiP46133.

Family and domain databases

InterProiIPR004697. AbgT.
IPR011540. AbgT_Proteobac.
[Graphical view]
PANTHERiPTHR30282:SF0. PTHR30282:SF0. 1 hit.
PfamiPF03806. ABG_transport. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00819. ydaH. 1 hit.

Sequencei

Sequence statusi: Complete.

P46133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMSSIPSSS QSGKLYGWVE RIGNKVPHPF LLFIYLIIVL MVTTAILSAF
60 70 80 90 100
GVSAKNPTDG TPVVVKNLLS VEGLHWFLPN VIKNFSGFAP LGAILALVLG
110 120 130 140 150
AGLAERVGLL PALMVKMASH VNARYASYMV LFIAFFSHIS SDAALVIMPP
160 170 180 190 200
MGALIFLAVG RHPVAGLLAA IAGVGCGFTA NLLIVTTDVL LSGISTEAAA
210 220 230 240 250
AFNPQMHVSV IDNWYFMASS VVVLTIVGGL ITDKIIEPRL GQWQGNSDEK
260 270 280 290 300
LQTLTESQRF GLRIAGVVSL LFIAAIALMV IPQNGILRDP INHTVMPSPF
310 320 330 340 350
IKGIVPLIIL FFFVVSLAYG IATRTIRRQA DLPHLMIEPM KEMAGFIVMV
360 370 380 390 400
FPLAQFVAMF NWSNMGKFIA VGLTDILESS GLSGIPAFVG LALLSSFLCM
410 420 430 440 450
FIASGSAIWS ILAPIFVPMF MLLGFHPAFA QILFRIADSS VLPLAPVSPF
460 470 480 490 500
VPLFLGFLQR YKPDAKLGTY YSLVLPYPLI FLVVWLLMLL AWYLVGLPIG

PGIYPRLS
Length:508
Mass (Da):54,886
Last modified:January 15, 2008 - v3
Checksum:iC33CBCBE7A39E951
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti504Y → S in BAA14929 (PubMed:9097039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74418.2.
AP009048 Genomic DNA. Translation: BAA14929.2.
Y00495 Genomic DNA. No translation available.
PIRiC64883.
RefSeqiNP_415852.2. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC74418; AAC74418; b1336.
BAA14929; BAA14929; BAA14929.
GeneIDi945912.
KEGGiecj:JW5822.
eco:b1336.
PATRICi32117948. VBIEscCol129921_1394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74418.2.
AP009048 Genomic DNA. Translation: BAA14929.2.
Y00495 Genomic DNA. No translation available.
PIRiC64883.
RefSeqiNP_415852.2. NC_000913.3.

3D structure databases

ProteinModelPortaliP46133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260156. 183 interactors.
DIPiDIP-9031N.
IntActiP46133. 1 interactor.
STRINGi511145.b1336.

Protein family/group databases

TCDBi2.A.68.1.1. the p-aminobenzoyl-glutamate transporter (abgt) family.

Proteomic databases

PaxDbiP46133.
PRIDEiP46133.

Protocols and materials databases

DNASUi945912.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74418; AAC74418; b1336.
BAA14929; BAA14929; BAA14929.
GeneIDi945912.
KEGGiecj:JW5822.
eco:b1336.
PATRICi32117948. VBIEscCol129921_1394.

Organism-specific databases

EchoBASEiEB2697.
EcoGeneiEG12853. abgT.

Phylogenomic databases

eggNOGiENOG4105CFC. Bacteria.
COG2978. LUCA.
HOGENOMiHOG000285565.
InParanoidiP46133.
KOiK12942.
OMAiPFIQGIV.
PhylomeDBiP46133.

Enzyme and pathway databases

BioCyciEcoCyc:ABGT-MONOMER.
ECOL316407:JW5822-MONOMER.
MetaCyc:ABGT-MONOMER.

Miscellaneous databases

PROiP46133.

Family and domain databases

InterProiIPR004697. AbgT.
IPR011540. AbgT_Proteobac.
[Graphical view]
PANTHERiPTHR30282:SF0. PTHR30282:SF0. 1 hit.
PfamiPF03806. ABG_transport. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00819. ydaH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABGT_ECOLI
AccessioniPrimary (citable) accession number: P46133
Secondary accession number(s): P76051, P76843, P76845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

It is suggested that in wild-type strain abgT would normally be cryptic or not expressed under conditions of growth on minimal medium. Altering the expression of abgT from its wild-type context appears to be the mechanism for obtaining the growth phenotype (PubMed:9829935).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.