Aminobenzoyl-glutamate transport protein - Escherichia coli (strain K12)

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P46133 (ABGT_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Aminobenzoyl-glutamate transport protein

Gene names

Name:	abgT
Synonyms:	ydaH
Ordered Locus Names:	b1336, JW5822
ORF Names:	ECK1332

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for aminobenzoyl-glutamate utilization. May transport aminobenzoyl-glutamate into the cell. Seems also to increase the sensitivity to low levels of aminobenzoyl-glutamate. Sufficient to confer aminobenzoyl-glutamate utilization phenotype.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Ref.7.
Miscellaneous	It is suggested that in wild-type strain abgT would normally be cryptic or not expressed under conditions of growth on minimal medium. Altering the expression of abgT from its wild-type context appears to be the mechanism for obtaining the growth phenotype.

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	p-aminobenzoyl-glutamate uptake transmembrane transporter activity Inferred from mutant phenotype Ref.1. Source: EcoCyc secondary active transmembrane transporter activity Inferred from direct assay. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 508

508

Aminobenzoyl-glutamate transport protein

PRO_0000064422

Regions

Transmembrane

30 – 50

Helical; Potential

Transmembrane

85 – 105

Helical; Potential

Transmembrane

121 – 139

Helical; Potential

Transmembrane

140 – 159

Helical; Potential

Transmembrane

164 – 184

Helical; Potential

Transmembrane

211 – 231

Helical; Potential

Transmembrane

261 – 281

Helical; Potential

Transmembrane

303 – 323

Helical; Potential

Transmembrane

343 – 363

Helical; Potential

Transmembrane

382 – 402

Helical; Potential

Transmembrane

405 – 425

Helical; Potential

Transmembrane

439 – 459

Helical; Potential

Transmembrane

479 – 499

Helical; Potential

Experimental info

Sequence conflict

504

Y → S Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P46133 [UniParc].

Last modified January 15, 2008. Version 3.
Checksum: C33CBCBE7A39E951
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FASTA

508

54,886

        10         20         30         40         50         60 
MSMSSIPSSS QSGKLYGWVE RIGNKVPHPF LLFIYLIIVL MVTTAILSAF GVSAKNPTDG 

        70         80         90        100        110        120 
TPVVVKNLLS VEGLHWFLPN VIKNFSGFAP LGAILALVLG AGLAERVGLL PALMVKMASH 

       130        140        150        160        170        180 
VNARYASYMV LFIAFFSHIS SDAALVIMPP MGALIFLAVG RHPVAGLLAA IAGVGCGFTA 

       190        200        210        220        230        240 
NLLIVTTDVL LSGISTEAAA AFNPQMHVSV IDNWYFMASS VVVLTIVGGL ITDKIIEPRL 

       250        260        270        280        290        300 
GQWQGNSDEK LQTLTESQRF GLRIAGVVSL LFIAAIALMV IPQNGILRDP INHTVMPSPF 

       310        320        330        340        350        360 
IKGIVPLIIL FFFVVSLAYG IATRTIRRQA DLPHLMIEPM KEMAGFIVMV FPLAQFVAMF 

       370        380        390        400        410        420 
NWSNMGKFIA VGLTDILESS GLSGIPAFVG LALLSSFLCM FIASGSAIWS ILAPIFVPMF 

       430        440        450        460        470        480 
MLLGFHPAFA QILFRIADSS VLPLAPVSPF VPLFLGFLQR YKPDAKLGTY YSLVLPYPLI 

       490        500 
FLVVWLLMLL AWYLVGLPIG PGIYPRLS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of mutations that allow p-aminobenzoyl-glutamate utilization by Escherichia coli." Hussein M.J., Green J.M., Nichols B.P. J. Bacteriol. 180:6260-6268(1998) [PubMed: 9829935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: BN1001 and BN1003.
[2]	"A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K. Horiuchi T. DNA Res. 3:363-377(1996) [PubMed: 9097039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 504. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli." Potter P.M., Wilkinson M.C., Fitton J., Carr F.J., Brennand J., Cooper D.P., Margison G.P. Nucleic Acids Res. 15:9177-9193(1987) [PubMed: 2825131] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 452-508.
[6]	"Detection of new genes in a bacterial genome using Markov models for three gene classes." Borodovsky M., McIninch J., Koonin E.V., Rudd K.E., Medigue C., Danchin A. Nucleic Acids Res. 23:3554-3562(1995) [PubMed: 7567469] [Abstract] Cited for: IDENTIFICATION.
[7]	"Global topology analysis of the Escherichia coli inner membrane proteome." Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G. Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: AAC74418.2. AP009048 Genomic DNA. Translation: BAA14929.2. Y00495 Genomic DNA. No translation available.
PIR	C64883.
RefSeq	NP_415852.2. NC_000913.2.
3D structure databases
ProteinModelPortal	P46133.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-9031N.
IntAct	P46133. 1 interaction.
Protein family/group databases
TCDB	2.A.68.1.1. p-aminobenzoyl-glutamate transporter (AbgT) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000001487; EBESCP00000001487; EBESCG00000001238. EBESCT00000015776; EBESCP00000015067; EBESCG00000014836.
GeneID	945912.
GenomeReviews	Gene locus JW5822 in contig AP009048_GR. Gene locus b1336 in contig U00096_GR.
KEGG	ecj:JW5822. eco:b1336.
PATRIC	32117948. VBIEscCol129921_1394.
Organism-specific databases
EchoBASE	EB2697.
EcoGene	EG12853. abgT.
Phylogenomic databases
eggNOG	COG2978.
GeneTree	EBGT00050000008854.
HOGENOM	HBG683698.
OMA	CAFRIGD.
PhylomeDB	P46133.
ProtClustDB	PRK11339.
Enzyme and pathway databases
BioCyc	EcoCyc:ABGT-MONOMER.
Gene expression databases
Genevestigator	P46133.
Family and domain databases
InterPro	IPR004697. Put_transpt_AbgT. IPR011540. YdaH_transpt. [Graphical view]
KO	K12942.
Pfam	PF03806. ABG_transport. 1 hit. [Graphical view]
TIGRFAMs	TIGR00819. YdaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ABGT_ECOLI

Accession

Primary (citable) accession number: P46133
Secondary accession number(s): P76051, P76843, P76845

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 95 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents