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Protein

HTH-type transcriptional regulator HexR

Gene

hexR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Represses the expression of the hex regulon (zwf, eda, glp and gap).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi37 – 5620H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12860-MONOMER.
ECOL316407:JW1842-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator HexR
Alternative name(s):
Hex regulon repressor
Gene namesi
Name:hexR
Synonyms:yebK
Ordered Locus Names:b1853, JW1842
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12860. hexR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289HTH-type transcriptional regulator HexRPRO_0000068623Add
BLAST

Proteomic databases

PaxDbiP46118.

Interactioni

Protein-protein interaction databases

BioGridi4260935. 12 interactions.
DIPiDIP-9891N.
IntActiP46118. 2 interactions.
STRINGi511145.b1853.

Structurei

3D structure databases

ProteinModelPortaliP46118.
SMRiP46118. Positions 2-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7777HTH rpiR-typePROSITE-ProRule annotationAdd
BLAST
Domaini121 – 260140SISPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH rpiR-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 SIS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4106KNT. Bacteria.
COG1737. LUCA.
HOGENOMiHOG000027158.
InParanoidiP46118.
KOiK19337.
OMAiDRYSPMV.
PhylomeDBiP46118.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMLEKIQSQ LEHLSKSERK VAEVILASPD NAIHSSIAAM ALEANVSEPT
60 70 80 90 100
VNRFCRSMDT RGFPDFKLHL AQSLANGTPY VNRNVNEDDS VESYTGKIFE
110 120 130 140 150
SAMATLDHVR HSLDKSAINR AVDLLTQAKK IAFFGLGSSA AVAHDAMNKF
160 170 180 190 200
FRFNVPVVYS DDIVLQRMSC MNCSDGDVVV LISHTGRTKN LVELAQLARE
210 220 230 240 250
NDAMVIALTS AGTPLAREAT LAITLDVPED TDIYMPMVSR LAQLTVIDVL
260 270 280
ATGFTLRRGA KFRDNLKRVK EALKESRFDK QLLNLSDDR
Length:289
Mass (Da):31,976
Last modified:November 1, 1997 - v2
Checksum:i34F43A9C6FC89EFF
GO

Sequence cautioni

The sequence M55005 differs from that shown. Reason: Frameshift at positions 32 and 63. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821N → Y in AAA68942 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74923.1.
AP009048 Genomic DNA. Translation: BAA15661.1.
M55005 Genomic DNA. No translation available.
U27210 Genomic DNA. Translation: AAA68942.1.
PIRiE64947.
RefSeqiNP_416367.1. NC_000913.3.
WP_001056706.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74923; AAC74923; b1853.
BAA15661; BAA15661; BAA15661.
GeneIDi946373.
KEGGiecj:JW1842.
eco:b1853.
PATRICi32119029. VBIEscCol129921_1932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74923.1.
AP009048 Genomic DNA. Translation: BAA15661.1.
M55005 Genomic DNA. No translation available.
U27210 Genomic DNA. Translation: AAA68942.1.
PIRiE64947.
RefSeqiNP_416367.1. NC_000913.3.
WP_001056706.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP46118.
SMRiP46118. Positions 2-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260935. 12 interactions.
DIPiDIP-9891N.
IntActiP46118. 2 interactions.
STRINGi511145.b1853.

Proteomic databases

PaxDbiP46118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74923; AAC74923; b1853.
BAA15661; BAA15661; BAA15661.
GeneIDi946373.
KEGGiecj:JW1842.
eco:b1853.
PATRICi32119029. VBIEscCol129921_1932.

Organism-specific databases

EchoBASEiEB2702.
EcoGeneiEG12860. hexR.

Phylogenomic databases

eggNOGiENOG4106KNT. Bacteria.
COG1737. LUCA.
HOGENOMiHOG000027158.
InParanoidiP46118.
KOiK19337.
OMAiDRYSPMV.
PhylomeDBiP46118.

Enzyme and pathway databases

BioCyciEcoCyc:EG12860-MONOMER.
ECOL316407:JW1842-MONOMER.

Miscellaneous databases

PROiP46118.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEXR_ECOLI
AccessioniPrimary (citable) accession number: P46118
Secondary accession number(s): P76282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.