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Protein

HTH-type transcriptional regulator HexR

Gene

hexR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Represses the expression of the hex regulon (zwf, eda, glp and gap).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi37 – 56H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG12860-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator HexR
Alternative name(s):
Hex regulon repressor
Gene namesi
Name:hexR
Synonyms:yebK
Ordered Locus Names:b1853, JW1842
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12860. hexR.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686231 – 289HTH-type transcriptional regulator HexRAdd BLAST289

Proteomic databases

PaxDbiP46118.
PRIDEiP46118.

Interactioni

Protein-protein interaction databases

BioGridi4260935. 12 interactors.
DIPiDIP-9891N.
IntActiP46118. 2 interactors.
STRINGi316385.ECDH10B_1994.

Structurei

3D structure databases

ProteinModelPortaliP46118.
SMRiP46118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 77HTH rpiR-typePROSITE-ProRule annotationAdd BLAST77
Domaini121 – 260SISPROSITE-ProRule annotationAdd BLAST140

Phylogenomic databases

eggNOGiENOG4106KNT. Bacteria.
COG1737. LUCA.
HOGENOMiHOG000027158.
InParanoidiP46118.
KOiK19337.
PhylomeDBiP46118.

Family and domain databases

CDDicd05013. SIS_RpiR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR000281. HTH_RpiR.
IPR035472. RpiR-like_SIS.
IPR001347. SIS.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.

Sequencei

Sequence statusi: Complete.

P46118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMLEKIQSQ LEHLSKSERK VAEVILASPD NAIHSSIAAM ALEANVSEPT
60 70 80 90 100
VNRFCRSMDT RGFPDFKLHL AQSLANGTPY VNRNVNEDDS VESYTGKIFE
110 120 130 140 150
SAMATLDHVR HSLDKSAINR AVDLLTQAKK IAFFGLGSSA AVAHDAMNKF
160 170 180 190 200
FRFNVPVVYS DDIVLQRMSC MNCSDGDVVV LISHTGRTKN LVELAQLARE
210 220 230 240 250
NDAMVIALTS AGTPLAREAT LAITLDVPED TDIYMPMVSR LAQLTVIDVL
260 270 280
ATGFTLRRGA KFRDNLKRVK EALKESRFDK QLLNLSDDR
Length:289
Mass (Da):31,976
Last modified:November 1, 1997 - v2
Checksum:i34F43A9C6FC89EFF
GO

Sequence cautioni

The sequence M55005 differs from that shown. Reason: Frameshift at positions 32 and 63.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82N → Y in AAA68942 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74923.1.
AP009048 Genomic DNA. Translation: BAA15661.1.
M55005 Genomic DNA. No translation available.
U27210 Genomic DNA. Translation: AAA68942.1.
PIRiE64947.
RefSeqiNP_416367.1. NC_000913.3.
WP_001056706.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74923; AAC74923; b1853.
BAA15661; BAA15661; BAA15661.
GeneIDi946373.
KEGGiecj:JW1842.
eco:b1853.
PATRICifig|1411691.4.peg.395.

Similar proteinsi

Entry informationi

Entry nameiHEXR_ECOLI
AccessioniPrimary (citable) accession number: P46118
Secondary accession number(s): P76282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene