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Protein

HTH-type transcriptional regulator HexR

Gene

hexR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Represses the expression of the hex regulon (zwf, eda, glp and gap).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi37 – 56H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG12860-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator HexR
Alternative name(s):
Hex regulon repressor
Gene namesi
Name:hexR
Synonyms:yebK
Ordered Locus Names:b1853, JW1842
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12860 hexR

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686231 – 289HTH-type transcriptional regulator HexRAdd BLAST289

Proteomic databases

PaxDbiP46118
PRIDEiP46118

Interactioni

Protein-protein interaction databases

BioGridi4260935, 14 interactors
DIPiDIP-9891N
IntActiP46118, 2 interactors
STRINGi316385.ECDH10B_1994

Structurei

3D structure databases

ProteinModelPortaliP46118
SMRiP46118
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 77HTH rpiR-typePROSITE-ProRule annotationAdd BLAST77
Domaini121 – 260SISPROSITE-ProRule annotationAdd BLAST140

Phylogenomic databases

eggNOGiENOG4106KNT Bacteria
COG1737 LUCA
HOGENOMiHOG000027158
InParanoidiP46118
KOiK19337
OMAiRGPRFRE
PhylomeDBiP46118

Family and domain databases

CDDicd05013 SIS_RpiR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR000281 HTH_RpiR
IPR035472 RpiR-like_SIS
IPR001347 SIS
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01418 HTH_6, 1 hit
PF01380 SIS, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51071 HTH_RPIR, 1 hit
PS51464 SIS, 1 hit

Sequencei

Sequence statusi: Complete.

P46118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMLEKIQSQ LEHLSKSERK VAEVILASPD NAIHSSIAAM ALEANVSEPT
60 70 80 90 100
VNRFCRSMDT RGFPDFKLHL AQSLANGTPY VNRNVNEDDS VESYTGKIFE
110 120 130 140 150
SAMATLDHVR HSLDKSAINR AVDLLTQAKK IAFFGLGSSA AVAHDAMNKF
160 170 180 190 200
FRFNVPVVYS DDIVLQRMSC MNCSDGDVVV LISHTGRTKN LVELAQLARE
210 220 230 240 250
NDAMVIALTS AGTPLAREAT LAITLDVPED TDIYMPMVSR LAQLTVIDVL
260 270 280
ATGFTLRRGA KFRDNLKRVK EALKESRFDK QLLNLSDDR
Length:289
Mass (Da):31,976
Last modified:November 1, 1997 - v2
Checksum:i34F43A9C6FC89EFF
GO

Sequence cautioni

The sequence M55005 differs from that shown. Reason: Frameshift at positions 32 and 63.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82N → Y in AAA68942 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74923.1
AP009048 Genomic DNA Translation: BAA15661.1
M55005 Genomic DNA No translation available.
U27210 Genomic DNA Translation: AAA68942.1
PIRiE64947
RefSeqiNP_416367.1, NC_000913.3
WP_001056706.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74923; AAC74923; b1853
BAA15661; BAA15661; BAA15661
GeneIDi946373
KEGGiecj:JW1842
eco:b1853
PATRICifig|1411691.4.peg.395

Entry informationi

Entry nameiHEXR_ECOLI
AccessioniPrimary (citable) accession number: P46118
Secondary accession number(s): P76282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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