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Protein

Potassium channel toxin alpha-KTx 4.1

Gene
N/A
Organism
Tityus serrulatus (Brazilian scorpion)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potently blocks Kv1.1/KCNA1 (85%), Kv1.2/KCNA2 (91%), Kv1.3/KCNA3 (89%), Kv1.6/KCNA6 (94%), and Shaker (97%).3 Publications

Miscellaneous

Inhibits with low efficiency Kv1.5/KCNA5, Kv2.1/KCNB1, Kv7.1/KCNQ1 and ERG/KCNH2. Does not inhibit Kv1.4/KCNA4, Kv3.1/KCNC1, Kv7.2/KCNQ2 (PubMed:24590385) and ERG1/Kv11.1/KCNH2 (PubMed:18687312).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei27Basic residue of the functional dyadBy similarity1
Sitei36Aromatic residue of the functional dyadBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 4.11 Publication
Alternative name(s):
TSK41 Publication
Tityustoxin K-alpha1 Publication
Short name:
TsTX-K-alpha1 Publication
Short name:
TyKalphaCurated
Toxin II-9
Ts71 Publication
OrganismiTityus serrulatus (Brazilian scorpion)
Taxonomic identifieri6887 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeTityus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27K → A, E or R: Significant loss of affinity for squid Kv1A channel. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449231 – 37Potassium channel toxin alpha-KTx 4.11 PublicationAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 281 Publication
Disulfide bondi13 ↔ 331 Publication
Disulfide bondi17 ↔ 351 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

Secondary structure

137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 20Combined sources11
Beta strandi26 – 29Combined sources4
Beta strandi32 – 35Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HP2NMR-A1-37[»]
ProteinModelPortaliP46114.
SMRiP46114.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46114.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 33Interaction with Ca(2+)-activated K(+) channelsSequence analysis8

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR036574. Scorpion_toxin-like_sf.
IPR001947. Scorpion_toxinS_K_inh.
PfamiView protein in Pfam
PF00451. Toxin_2. 1 hit.
PRINTSiPR00286. CHARYBDTOXIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586. Scorpion_toxinS. 1 hit.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiView protein in PROSITE
PS01138. SCORP_SHORT_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P46114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
VFINAKCRGS PECLPKCKEA IGKAAGKCMN GKCKCYP
Length:37
Mass (Da):3,948
Last modified:November 1, 1995 - v1
Checksum:i639B98A977335929
GO

Mass spectrometryi

Molecular mass is 3942 Da from positions 1 - 37. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiKAX41_TITSE
AccessioniPrimary (citable) accession number: P46114
Secondary accession number(s): P08816
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 22, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families