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P46111 (KAX32_LEIQH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 3.2
Alternative name(s):
Agitoxin-2
Short name=AgTx-2
Short name=AgTx2
OrganismLeiurus quinquestriatus hebraeus (Yellow scorpion)
Taxonomic identifier6884 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeLeiurus

Protein attributes

Sequence length38 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potent inhibitor of shaker potassium channels as well as the mammalian homologs of shaker.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 3 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3838Potassium channel toxin alpha-KTx 3.2
PRO_0000044926

Regions

Region26 – 338Interaction with Ca(2+)-activated K(+) channels Potential

Amino acid modifications

Disulfide bond8 ↔ 28 Ref.2
Disulfide bond14 ↔ 33 Ref.2
Disulfide bond18 ↔ 35 Ref.2

Secondary structure

........ 38
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P46111 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C8BB8513F87B51CD

FASTA384,097
        10         20         30 
GVPINVSCTG SPQCIKPCKD AGMRFGKCMN RKCHCTPK 

« Hide

References

[1]"Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom."
Garcia M.L., Garcia-Calvo M., Hidalgo P., Lee A., Mackinnon R.
Biochemistry 33:6834-6839(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.
[2]"Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry."
Krezel A.M., Kasibhatla C., Hidalgo P., Mackinnon R., Wagner G.
Protein Sci. 4:1478-1489(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

Cross-references

Sequence databases

PIRB54471.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AGTNMR-A1-38[»]
ProteinModelPortalP46111.
SMRP46111. Positions 1-38.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP46111.

Entry information

Entry nameKAX32_LEIQH
AccessionPrimary (citable) accession number: P46111
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references