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Protein

Crk-like protein

Gene

CRKL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May mediate the transduction of intracellular signals.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
  • SH3/SH2 adaptor activity Source: ProtInc
  • signal transducer activity Source: ProtInc

GO - Biological processi

  • activation of MAPKK activity Source: Reactome
  • animal organ morphogenesis Source: Ensembl
  • anterior/posterior pattern specification Source: Ensembl
  • blood vessel development Source: Ensembl
  • heart development Source: Ensembl
  • intracellular signal transduction Source: ProtInc
  • JNK cascade Source: ProtInc
  • parathyroid gland development Source: Ensembl
  • positive regulation of cell proliferation Source: CACAO
  • positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  • Ras protein signal transduction Source: ProtInc
  • thymus development Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099942-MONOMER.
ReactomeiR-HSA-170968. Frs2-mediated activation.
R-HSA-186763. Downstream signal transduction.
R-HSA-8875555. MET activates RAP1 and RAC1.
R-HSA-8875656. MET receptor recycling.
R-HSA-912631. Regulation of signaling by CBL.
SignaLinkiP46109.
SIGNORiP46109.

Names & Taxonomyi

Protein namesi
Recommended name:
Crk-like protein
Gene namesi
Name:CRKL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:2363. CRKL.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytosol Source: Reactome
  • endosome Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi160W → L: Abolishes interaction with DOCK5. 1 Publication1

Organism-specific databases

DisGeNETi1399.
MalaCardsiCRKL.
OpenTargetsiENSG00000099942.
Orphaneti261330. Distal 22q11.2 microdeletion syndrome.
PharmGKBiPA26881.

Polymorphism and mutation databases

BioMutaiCRKL.
DMDMi1169094.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793471 – 303Crk-like proteinAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphotyrosineCombined sources1
Modified residuei207PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP46109.
MaxQBiP46109.
PaxDbiP46109.
PeptideAtlasiP46109.
PRIDEiP46109.

2D gel databases

OGPiP46109.

PTM databases

iPTMnetiP46109.
PhosphoSitePlusiP46109.

Expressioni

Gene expression databases

BgeeiENSG00000099942.
CleanExiHS_CRKL.
GenevisibleiP46109. HS.

Organism-specific databases

HPAiHPA000532.
HPA001100.

Interactioni

Subunit structurei

Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005192EBI-910,EBI-375543
CBLP226813EBI-910,EBI-518228
CBLBQ131914EBI-910,EBI-744027
DCBLD2Q96PD23EBI-910,EBI-8536103
EGFRP005333EBI-910,EBI-297353
ERBB2P046262EBI-910,EBI-641062
ERBB3P218603EBI-910,EBI-720706
FLT1P179489EBI-910,EBI-1026718
GAB1Q134804EBI-910,EBI-517684
Kcnma1Q084605EBI-910,EBI-1633915From a different organism.
Kidins220Q9EQG62EBI-910,EBI-976654From a different organism.
MAP4K1Q929185EBI-910,EBI-881
PDGFRAP162343EBI-910,EBI-2861522
PIK3R1P279862EBI-910,EBI-79464
PTK2Q053972EBI-910,EBI-702142
RAPGEF1Q139053EBI-910,EBI-976876
SOS1Q078892EBI-910,EBI-297487

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • SH3/SH2 adaptor activity Source: ProtInc

Protein-protein interaction databases

BioGridi107789. 109 interactors.
DIPiDIP-29165N.
IntActiP46109. 89 interactors.
MINTiMINT-137265.
STRINGi9606.ENSP00000346300.

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 14Combined sources4
Beta strandi15 – 18Combined sources4
Helixi21 – 28Combined sources8
Beta strandi29 – 31Combined sources3
Beta strandi36 – 40Combined sources5
Beta strandi42 – 46Combined sources5
Beta strandi48 – 54Combined sources7
Beta strandi57 – 66Combined sources10
Turni67 – 69Combined sources3
Beta strandi70 – 73Combined sources4
Beta strandi78 – 80Combined sources3
Helixi81 – 88Combined sources8
Beta strandi93 – 96Combined sources4
Beta strandi105 – 107Combined sources3
Beta strandi119 – 132Combined sources14
Beta strandi138 – 141Combined sources4
Beta strandi146 – 154Combined sources9
Beta strandi157 – 164Combined sources8
Beta strandi170 – 174Combined sources5
Helixi175 – 177Combined sources3
Beta strandi178 – 182Combined sources5
Helixi190 – 192Combined sources3
Helixi203 – 205Combined sources3
Beta strandi238 – 242Combined sources5
Beta strandi248 – 251Combined sources4
Beta strandi253 – 255Combined sources3
Beta strandi263 – 269Combined sources7
Beta strandi271 – 279Combined sources9
Beta strandi282 – 287Combined sources6
Helixi288 – 290Combined sources3
Beta strandi291 – 293Combined sources3
Beta strandi296 – 299Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BZXX-ray2.80A237-303[»]
2BZYX-ray2.50A/B237-303[»]
2DBKNMR-A229-303[»]
2EO3NMR-A1-104[»]
2LQNNMR-A1-303[»]
2LQWNMR-A1-303[»]
ProteinModelPortaliP46109.
SMRiP46109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46109.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 102SH2PROSITE-ProRule annotationAdd BLAST89
Domaini123 – 183SH3 1PROSITE-ProRule annotationAdd BLAST61
Domaini235 – 296SH3 2PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the CRK family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG4792. Eukaryota.
ENOG4110574. LUCA.
GeneTreeiENSGT00820000127055.
HOGENOMiHOG000236288.
HOVERGENiHBG105616.
InParanoidiP46109.
KOiK04438.
OMAiTRMNISG.
OrthoDBiEOG091G0JPQ.
PhylomeDBiP46109.
TreeFamiTF321436.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL
60 70 80 90 100
SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE
110 120 130 140 150
PAPRYPSPPM GSVSAPNLPT AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL
160 170 180 190 200
VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI
210 220 230 240 250
PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA KAIQKRVPCA
260 270 280 290 300
YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD

ENE
Length:303
Mass (Da):33,777
Last modified:November 1, 1995 - v1
Checksum:i294CF1EE2CD44B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59656 mRNA. Translation: CAA42199.1.
CR456423 mRNA. Translation: CAG30309.1.
AK292909 mRNA. Translation: BAF85598.1.
CH471176 Genomic DNA. Translation: EAX02932.1.
CH471176 Genomic DNA. Translation: EAX02933.1.
CH471176 Genomic DNA. Translation: EAX02934.1.
BC043500 mRNA. Translation: AAH43500.1.
CCDSiCCDS13785.1.
PIRiS41754.
RefSeqiNP_005198.1. NM_005207.3.
UniGeneiHs.5613.

Genome annotation databases

EnsembliENST00000354336; ENSP00000346300; ENSG00000099942.
ENST00000411769; ENSP00000396646; ENSG00000099942.
GeneIDi1399.
KEGGihsa:1399.
UCSCiuc002ztf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59656 mRNA. Translation: CAA42199.1.
CR456423 mRNA. Translation: CAG30309.1.
AK292909 mRNA. Translation: BAF85598.1.
CH471176 Genomic DNA. Translation: EAX02932.1.
CH471176 Genomic DNA. Translation: EAX02933.1.
CH471176 Genomic DNA. Translation: EAX02934.1.
BC043500 mRNA. Translation: AAH43500.1.
CCDSiCCDS13785.1.
PIRiS41754.
RefSeqiNP_005198.1. NM_005207.3.
UniGeneiHs.5613.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BZXX-ray2.80A237-303[»]
2BZYX-ray2.50A/B237-303[»]
2DBKNMR-A229-303[»]
2EO3NMR-A1-104[»]
2LQNNMR-A1-303[»]
2LQWNMR-A1-303[»]
ProteinModelPortaliP46109.
SMRiP46109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107789. 109 interactors.
DIPiDIP-29165N.
IntActiP46109. 89 interactors.
MINTiMINT-137265.
STRINGi9606.ENSP00000346300.

PTM databases

iPTMnetiP46109.
PhosphoSitePlusiP46109.

Polymorphism and mutation databases

BioMutaiCRKL.
DMDMi1169094.

2D gel databases

OGPiP46109.

Proteomic databases

EPDiP46109.
MaxQBiP46109.
PaxDbiP46109.
PeptideAtlasiP46109.
PRIDEiP46109.

Protocols and materials databases

DNASUi1399.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354336; ENSP00000346300; ENSG00000099942.
ENST00000411769; ENSP00000396646; ENSG00000099942.
GeneIDi1399.
KEGGihsa:1399.
UCSCiuc002ztf.2. human.

Organism-specific databases

CTDi1399.
DisGeNETi1399.
GeneCardsiCRKL.
HGNCiHGNC:2363. CRKL.
HPAiHPA000532.
HPA001100.
MalaCardsiCRKL.
MIMi602007. gene.
neXtProtiNX_P46109.
OpenTargetsiENSG00000099942.
Orphaneti261330. Distal 22q11.2 microdeletion syndrome.
PharmGKBiPA26881.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4792. Eukaryota.
ENOG4110574. LUCA.
GeneTreeiENSGT00820000127055.
HOGENOMiHOG000236288.
HOVERGENiHBG105616.
InParanoidiP46109.
KOiK04438.
OMAiTRMNISG.
OrthoDBiEOG091G0JPQ.
PhylomeDBiP46109.
TreeFamiTF321436.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099942-MONOMER.
ReactomeiR-HSA-170968. Frs2-mediated activation.
R-HSA-186763. Downstream signal transduction.
R-HSA-8875555. MET activates RAP1 and RAC1.
R-HSA-8875656. MET receptor recycling.
R-HSA-912631. Regulation of signaling by CBL.
SignaLinkiP46109.
SIGNORiP46109.

Miscellaneous databases

ChiTaRSiCRKL. human.
EvolutionaryTraceiP46109.
GeneWikiiCRKL.
GenomeRNAii1399.
PROiP46109.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099942.
CleanExiHS_CRKL.
GenevisibleiP46109. HS.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRKL_HUMAN
AccessioniPrimary (citable) accession number: P46109
Secondary accession number(s): A8KA44, D3DX35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.