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Protein

Crk-like protein

Gene

CRKL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate the transduction of intracellular signals.

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • phosphotyrosine residue binding Source: CAFA
  • RNA binding Source: UniProtKB
  • SH3/SH2 adaptor activity Source: ProtInc
  • signal transducer activity Source: ProtInc

GO - Biological processi

  • activation of MAPKK activity Source: Reactome
  • animal organ morphogenesis Source: Ensembl
  • anterior/posterior pattern specification Source: Ensembl
  • blood vessel development Source: Ensembl
  • cytokine-mediated signaling pathway Source: Reactome
  • heart development Source: Ensembl
  • intracellular signal transduction Source: ProtInc
  • JNK cascade Source: ProtInc
  • parathyroid gland development Source: Ensembl
  • positive regulation of cell proliferation Source: CACAO
  • positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  • Ras protein signal transduction Source: ProtInc
  • thymus development Source: Ensembl

Enzyme and pathway databases

ReactomeiR-HSA-170968 Frs2-mediated activation
R-HSA-186763 Downstream signal transduction
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875656 MET receptor recycling
R-HSA-912631 Regulation of signaling by CBL
SignaLinkiP46109
SIGNORiP46109

Names & Taxonomyi

Protein namesi
Recommended name:
Crk-like protein
Gene namesi
Name:CRKL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099942.12
HGNCiHGNC:2363 CRKL
MIMi602007 gene
neXtProtiNX_P46109

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi160W → L: Abolishes interaction with DOCK5. 1 Publication1

Organism-specific databases

DisGeNETi1399
MalaCardsiCRKL
OpenTargetsiENSG00000099942
Orphaneti261330 Distal 22q11.2 microdeletion syndrome
PharmGKBiPA26881

Polymorphism and mutation databases

BioMutaiCRKL
DMDMi1169094

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793471 – 303Crk-like proteinAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphotyrosineCombined sources1
Modified residuei207PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP46109
MaxQBiP46109
PaxDbiP46109
PeptideAtlasiP46109
PRIDEiP46109

2D gel databases

OGPiP46109

PTM databases

iPTMnetiP46109
PhosphoSitePlusiP46109

Expressioni

Gene expression databases

BgeeiENSG00000099942
CleanExiHS_CRKL
GenevisibleiP46109 HS

Organism-specific databases

HPAiHPA000532
HPA001100

Interactioni

Subunit structurei

Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • phosphotyrosine residue binding Source: CAFA
  • SH3/SH2 adaptor activity Source: ProtInc

Protein-protein interaction databases

BioGridi107789, 112 interactors
CORUMiP46109
DIPiDIP-29165N
IntActiP46109, 94 interactors
MINTiP46109
STRINGi9606.ENSP00000346300

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 14Combined sources4
Beta strandi15 – 18Combined sources4
Helixi21 – 28Combined sources8
Beta strandi29 – 31Combined sources3
Beta strandi36 – 40Combined sources5
Beta strandi42 – 46Combined sources5
Beta strandi48 – 54Combined sources7
Beta strandi57 – 66Combined sources10
Turni67 – 69Combined sources3
Beta strandi70 – 73Combined sources4
Beta strandi78 – 80Combined sources3
Helixi81 – 88Combined sources8
Beta strandi93 – 96Combined sources4
Beta strandi105 – 107Combined sources3
Beta strandi119 – 132Combined sources14
Beta strandi138 – 141Combined sources4
Beta strandi146 – 154Combined sources9
Beta strandi157 – 164Combined sources8
Beta strandi170 – 174Combined sources5
Helixi175 – 177Combined sources3
Beta strandi178 – 182Combined sources5
Helixi190 – 192Combined sources3
Helixi203 – 205Combined sources3
Beta strandi238 – 242Combined sources5
Beta strandi248 – 251Combined sources4
Beta strandi253 – 255Combined sources3
Beta strandi263 – 269Combined sources7
Beta strandi271 – 279Combined sources9
Beta strandi282 – 287Combined sources6
Helixi288 – 290Combined sources3
Beta strandi291 – 293Combined sources3
Beta strandi296 – 299Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BZXX-ray2.80A237-303[»]
2BZYX-ray2.50A/B237-303[»]
2DBKNMR-A229-303[»]
2EO3NMR-A1-104[»]
2LQNNMR-A1-303[»]
2LQWNMR-A1-303[»]
ProteinModelPortaliP46109
SMRiP46109
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46109

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 102SH2PROSITE-ProRule annotationAdd BLAST89
Domaini123 – 183SH3 1PROSITE-ProRule annotationAdd BLAST61
Domaini235 – 296SH3 2PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the CRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG4792 Eukaryota
ENOG4110574 LUCA
GeneTreeiENSGT00820000127055
HOGENOMiHOG000236288
HOVERGENiHBG105616
InParanoidiP46109
KOiK04438
OMAiFPGMSRE
OrthoDBiEOG091G0JPQ
PhylomeDBiP46109
TreeFamiTF321436

Family and domain databases

CDDicd11759 SH3_CRK_C, 1 hit
cd11758 SH3_CRK_N, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035458 CRK_SH3_C
IPR035457 CRK_SH3_N
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

P46109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL
60 70 80 90 100
SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE
110 120 130 140 150
PAPRYPSPPM GSVSAPNLPT AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL
160 170 180 190 200
VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI
210 220 230 240 250
PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA KAIQKRVPCA
260 270 280 290 300
YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD

ENE
Length:303
Mass (Da):33,777
Last modified:November 1, 1995 - v1
Checksum:i294CF1EE2CD44B81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59656 mRNA Translation: CAA42199.1
CR456423 mRNA Translation: CAG30309.1
AK292909 mRNA Translation: BAF85598.1
CH471176 Genomic DNA Translation: EAX02932.1
CH471176 Genomic DNA Translation: EAX02933.1
CH471176 Genomic DNA Translation: EAX02934.1
BC043500 mRNA Translation: AAH43500.1
CCDSiCCDS13785.1
PIRiS41754
RefSeqiNP_005198.1, NM_005207.3
UniGeneiHs.5613

Genome annotation databases

EnsembliENST00000354336; ENSP00000346300; ENSG00000099942
ENST00000411769; ENSP00000396646; ENSG00000099942
GeneIDi1399
KEGGihsa:1399
UCSCiuc002ztf.2 human

Similar proteinsi

Entry informationi

Entry nameiCRKL_HUMAN
AccessioniPrimary (citable) accession number: P46109
Secondary accession number(s): A8KA44, D3DX35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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