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Protein

Dipeptidyl aminopeptidase-like protein 6

Gene

Dpp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell surface expression of the potassium channel KCND2 (PubMed:12575952). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:12575952, PubMed:16123112, PubMed:19279261, PubMed:19901547). Has no dipeptidyl aminopeptidase activity (By similarity).By similarity4 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

ESTHERiratno-dpp6. DPP4N_Peptidase_S9.
MEROPSiS09.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl aminopeptidase-like protein 6
Alternative name(s):
DPPX
Dipeptidyl aminopeptidase-related protein
Dipeptidyl peptidase 6
Dipeptidyl peptidase IV-like protein
Dipeptidyl peptidase VI
Short name:
DPP VI
Gene namesi
Name:Dpp6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68402. Dpp6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 89CytoplasmicSequence analysisAdd BLAST89
Transmembranei90 – 110Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini111 – 859ExtracellularSequence analysisAdd BLAST749

GO - Cellular componenti

  • cell surface Source: RGD
  • neuronal cell body Source: RGD
  • voltage-gated potassium channel complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224121 – 859Dipeptidyl aminopeptidase-like protein 6Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi313N-linked (GlcNAc...)Sequence analysis1
Glycosylationi398N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi405 ↔ 412By similarity
Glycosylationi465N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi521 ↔ 524By similarity
Glycosylationi529N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi530 ↔ 548By similarity
Glycosylationi560N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi729 ↔ 840By similarity
Glycosylationi807N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP46101.
PRIDEiP46101.

PTM databases

iPTMnetiP46101.
PhosphoSitePlusiP46101.
UniCarbKBiP46101.

Expressioni

Tissue specificityi

Detected in brain cortex, hippocampus, thalamus and cerebellum granule cells (at protein level) (PubMed:16123112). Isoform DPPX-S is expressed in brain and some peripheral tissues including kidney, ovary, and testis; in contrast isoform DPPX-L is expressed almost exclusively in brain.2 Publications

Interactioni

Subunit structurei

Homodimer (in vitro) (By similarity). Interacts with KCND2 (PubMed:12575952). Identified in a complex with KCND2 and KCNIP2. Forms an octameric complex composed of four DPP6 subunits bound to the KCND2 tetramer.By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043113.

Structurei

3D structure databases

ProteinModelPortaliP46101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
HOGENOMiHOG000231875.
HOVERGENiHBG105877.
InParanoidiP46101.
PhylomeDBiP46101.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform DPPX-L (identifier: P46101-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLYQRFTG KINTSRSFPA PPEASHLLGG QGPEEDAGSK PLGPQAQAVA
60 70 80 90 100
PRERGGAGGR PRFQYQARSD CDEEDELVGS NPPQRNWKGI AIALLVILVI
110 120 130 140 150
CSLIVTSVIL LTPAEDTSLS QKKKVTVEDL FSEDFKIHDP EAKWISDKEF
160 170 180 190 200
IYRERKGSVI LRNVETNNST VLIEGKKIES LRAIRYEISP DKEYALFSYN
210 220 230 240 250
VEPVYQHSHT GYYVLSKIPH GDPQSLDPPE VSNAKLQYAG WGPKGQQLIF
260 270 280 290 300
IFENNIYYCA HVGKQAIRVV STGKEGVIYN GLSDWLYEEE ILKSHIAHWW
310 320 330 340 350
SPDGTRLAYA TINDSRVPLM ELPTYTGSVY PTVKPYHYPK AGSENPSISL
360 370 380 390 400
HVIGLNGPTH DLEMMPPDDP RMREYYITMV KWATSTKVAV TWLNRAQNVS
410 420 430 440 450
ILTLCDATTG VCTKKHEDES EAWLHRQNEE PVFSKDGRKF FFVRAIPQGG
460 470 480 490 500
RGKFYHITVS SSQPNSSNDN IQSITSGDWD VTEILTYDEK RNKLYFLSTE
510 520 530 540 550
DLPRRRHLYS ANTVDDFNRQ CLSCDLVENC TYVSASFSHN MDFFLLKCEG
560 570 580 590 600
PGVPTVTVHN TTDKRRMFDL EANEQVQKAI YDRQMPKIEY RKIEVEDYSL
610 620 630 640 650
PMQILKPATF TDTAHYPLLL VVDGTPGSQS VSERFEVTWE TVLVSSHGAV
660 670 680 690 700
VVKCDGRGSG FQGTKLLHEV RRRLGFLEEK DQMEAVRTML KEQYIDKTRV
710 720 730 740 750
AVFGKDYGGY LSTYILPAKG ENQGQTFTCG SALSPITDFK LYASAFSERY
760 770 780 790 800
LGLHGLDNRA YEMTKLAHRV SALEDQQFLI IHATADEKIH FQHTAELITQ
810 820 830 840 850
LIKGKANYSL QIYPDESHYF HSVALKQHLY RSIIGFFVEC FRIQDKLPTA

TAKEDEEED
Length:859
Mass (Da):97,302
Last modified:November 1, 1995 - v1
Checksum:iCE26856D26ED126B
GO
Isoform DPPX-S (identifier: P46101-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: MASLYQRFTG...QARSDCDEED → MTTAKEPSASGKSVQQQDQ

Show »
Length:803
Mass (Da):91,321
Checksum:i4CB24362576D171D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0053661 – 75MASLY…CDEED → MTTAKEPSASGKSVQQQDQ in isoform DPPX-S. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76426 mRNA. Translation: AAC42061.1.
M76427 mRNA. Translation: AAC42062.1.
RefSeqiNP_074041.1. NM_022850.1. [P46101-1]
UniGeneiRn.10076.

Genome annotation databases

GeneIDi29272.
KEGGirno:29272.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76426 mRNA. Translation: AAC42061.1.
M76427 mRNA. Translation: AAC42062.1.
RefSeqiNP_074041.1. NM_022850.1. [P46101-1]
UniGeneiRn.10076.

3D structure databases

ProteinModelPortaliP46101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043113.

Protein family/group databases

ESTHERiratno-dpp6. DPP4N_Peptidase_S9.
MEROPSiS09.973.

PTM databases

iPTMnetiP46101.
PhosphoSitePlusiP46101.
UniCarbKBiP46101.

Proteomic databases

PaxDbiP46101.
PRIDEiP46101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29272.
KEGGirno:29272.

Organism-specific databases

CTDi1804.
RGDi68402. Dpp6.

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
HOGENOMiHOG000231875.
HOVERGENiHBG105877.
InParanoidiP46101.
PhylomeDBiP46101.

Miscellaneous databases

PROiP46101.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPP6_RAT
AccessioniPrimary (citable) accession number: P46101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.