true
1995-11-01
2024-03-27
221
5HT3A_HUMAN
Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.
Miyake A.
Mochizuki S.
Takemoto Y.
Akuzawa S.
1995
Mol. Pharmacol.
48
407-416
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
Hippocampus
Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.
Belelli D.
Balcarek J.M.
Hope A.G.
Peters J.A.
Lambert J.J.
Blackburn T.P.
1995
Mol. Pharmacol.
48
1054-1062
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
Amygdala
Molecular cloning of alternatively spliced human 5HT3 receptor cDNAs.
Bruess M.
Goethert M.
Hayer M.
Bonisch H.
doi:10.1111/j.1749-6632.1998.tb10196.x
1998
Ann. N. Y. Acad. Sci.
861
234-235
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
Exon-intron organization of the human 5-HT3A receptor gene.
Bruess M.
Eucker T.
Goethert M.
Bonisch H.
doi:10.1016/s0028-3908(99)00116-1
2000
Neuropharmacology
39
308-315
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
Blood
cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).
Puhl H.L. III
Ikeda S.R.
Aronstam R.S.
2002-04
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
Kalnine N.
Chen X.
Rolfs A.
Halleck A.
Hines L.
Eisenstein S.
Koundinya M.
Raphael J.
Moreira D.
Kelley T.
LaBaer J.
Lin Y.
Phelan M.
Farmer A.
2003-05
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.
Jin P.
Fu G.K.
Wilson A.D.
Yang J.
Chien D.
Hawkins P.R.
Au-Young J.
Stuve L.L.
doi:10.1016/j.ygeno.2003.09.023
2004
Genomics
83
566-571
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.
Suzuki Y.
Nishikawa T.
Otsuki T.
Sugiyama T.
Irie R.
Wakamatsu A.
Hayashi K.
Sato H.
Nagai K.
Kimura K.
Makita H.
Sekine M.
Obayashi M.
Nishi T.
Shibahara T.
Tanaka T.
Ishii S.
Yamamoto J.
Saito K.
Kawai Y.
Isono Y.
Nakamura Y.
Nagahari K.
Murakami K.
Yasuda T.
Iwayanagi T.
Wagatsuma M.
Shiratori A.
Sudo H.
Hosoiri T.
Kaku Y.
Kodaira H.
Kondo H.
Sugawara M.
Takahashi M.
Kanda K.
Yokoi T.
Furuya T.
Kikkawa E.
Omura Y.
Abe K.
Kamihara K.
Katsuta N.
Sato K.
Tanikawa M.
Yamazaki M.
Ninomiya K.
Ishibashi T.
Yamashita H.
Murakawa K.
Fujimori K.
Tanai H.
Kimata M.
Watanabe M.
Hiraoka S.
Chiba Y.
Ishida S.
Ono Y.
Takiguchi S.
Watanabe S.
Yosida M.
Hotuta T.
Kusano J.
Kanehori K.
Takahashi-Fujii A.
Hara H.
Tanase T.-O.
Nomura Y.
Togiya S.
Komai F.
Hara R.
Takeuchi K.
Arita M.
Imose N.
Musashino K.
Yuuki H.
Oshima A.
Sasaki N.
Aotsuka S.
Yoshikawa Y.
Matsunawa H.
Ichihara T.
Shiohata N.
Sano S.
Moriya S.
Momiyama H.
Satoh N.
Takami S.
Terashima Y.
Suzuki O.
Nakagawa S.
Senoh A.
Mizoguchi H.
Goto Y.
Shimizu F.
Wakebe H.
Hishigaki H.
Watanabe T.
Sugiyama A.
Takemoto M.
Kawakami B.
Yamazaki M.'
Watanabe K.
Kumagai A.
Itakura S.
Fukuzumi Y.
Fujimori Y.
Komiyama M.
Tashiro H.
Tanigami A.
Fujiwara T.
Ono T.
Yamada K.
Fujii Y.
Ozaki K.
Hirao M.
Ohmori Y.
Kawabata A.
Hikiji T.
Kobatake N.
Inagaki H.
Ikema Y.
Okamoto S.
Okitani R.
Kawakami T.
Noguchi S.
Itoh T.
Shigeta K.
Senba T.
Matsumura K.
Nakajima Y.
Mizuno T.
Morinaga M.
Sasaki M.
Togashi T.
Oyama M.
Hata H.
Watanabe M.'
Komatsu T.
Mizushima-Sugano J.
Satoh T.
Shirai Y.
Takahashi Y.
Nakagawa K.
Okumura K.
Nagase T.
Nomura N.
Kikuchi H.
Masuho Y.
Yamashita R.
Nakai K.
Yada T.
Nakamura Y.'
Ohara O.
Isogai T.
Sugano S.
doi:10.1038/ng1285
2004
Nat. Genet.
36
40-45
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor T.D.
Noguchi H.
Totoki Y.
Toyoda A.
Kuroki Y.
Dewar K.
Lloyd C.
Itoh T.
Takeda T.
Kim D.-W.
She X.
Barlow K.F.
Bloom T.
Bruford E.
Chang J.L.
Cuomo C.A.
Eichler E.
FitzGerald M.G.
Jaffe D.B.
LaButti K.
Nicol R.
Park H.-S.
Seaman C.
Sougnez C.
Yang X.
Zimmer A.R.
Zody M.C.
Birren B.W.
Nusbaum C.
Fujiyama A.
Hattori M.
Rogers J.
Lander E.S.
Sakaki Y.
doi:10.1038/nature04632
2006
Nature
440
497-500
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Mural R.J.
Istrail S.
Sutton G.
Florea L.
Halpern A.L.
Mobarry C.M.
Lippert R.
Walenz B.
Shatkay H.
Dew I.
Miller J.R.
Flanigan M.J.
Edwards N.J.
Bolanos R.
Fasulo D.
Halldorsson B.V.
Hannenhalli S.
Turner R.
Yooseph S.
Lu F.
Nusskern D.R.
Shue B.C.
Zheng X.H.
Zhong F.
Delcher A.L.
Huson D.H.
Kravitz S.A.
Mouchard L.
Reinert K.
Remington K.A.
Clark A.G.
Waterman M.S.
Eichler E.E.
Adams M.D.
Hunkapiller M.W.
Myers E.W.
Venter J.C.
2005-07
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
Lung
The 5-HT3B subunit is a major determinant of serotonin-receptor function.
Davies P.A.
Pistis M.
Hanna M.C.
Peters J.A.
Lambert J.J.
Hales T.G.
Kirkness E.F.
doi:10.1038/16941
1999
Nature
397
359-363
FUNCTION
TRANSPORTER ACTIVITY
SUBUNIT
SUBCELLULAR LOCATION
The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit.
Dubin A.E.
Huvar R.
D'Andrea M.R.
Pyati J.
Zhu J.Y.
Joy K.C.
Wilson S.J.
Galindo J.E.
Glass C.A.
Luo L.
Jackson M.R.
Lovenberg T.W.
Erlander M.G.
doi:10.1074/jbc.274.43.30799
1999
J. Biol. Chem.
274
30799-30810
FUNCTION
TRANSPORTER ACTIVITY
SUBUNIT
TISSUE SPECIFICITY
Small intestine
A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.
Kelley S.P.
Dunlop J.I.
Kirkness E.F.
Lambert J.J.
Peters J.A.
doi:10.1038/nature01788
2003
Nature
424
321-324
FUNCTION
DOMAIN
REGION
MUTAGENESIS OF ARG-432; ARG-436 AND ARG-440
Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3.
Cheng A.
McDonald N.A.
Connolly C.N.
doi:10.1074/jbc.m414341200
2005
J. Biol. Chem.
280
22502-22507
INTERACTION WITH RIC3
Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.
Niesler B.
Walstab J.
Combrink S.
Moeller D.
Kapeller J.
Rietdorf J.
Boenisch H.
Goethert M.
Rappold G.
Bruess M.
doi:10.1124/mol.106.032144
2007
Mol. Pharmacol.
72
8-17
FUNCTION
TRANSPORTER ACTIVITY
SUBUNIT
MUTAGENESIS OF TRP-178
Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients.
Frank B.
Niesler B.
Bondy B.
Spaeth M.
Pongratz D.E.
Ackenheil M.
Fischer C.
Rappold G.
doi:10.1007/s10067-004-0927-2
2004
Clin. Rheumatol.
23
338-344
VARIANT THR-33
Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression.
Yamada K.
Hattori E.
Iwayama Y.
Ohnishi T.
Ohba H.
Toyota T.
Takao H.
Minabe Y.
Nakatani N.
Higuchi T.
Detera-Wadleigh S.D.
Yoshikawa T.
doi:10.1016/j.biopsych.2005.11.008
2006
Biol. Psychiatry
60
192-201
VARIANTS HIS-344; ARG-391 AND GLN-409
118
5-hydroxytryptamine-3A receptor complex
5-hydroxytryptamine-3A/B receptor complex
5-hydroxytryptamine-3A/D receptor complex
5-hydroxytryptamine-3A/E receptor complex
5-hydroxytryptamine-3A/C receptor complex
101
Alosetron
Amoxapine
Aripiprazole
Aripiprazole lauroxil
Bupropion
Cannabidiol
Chlorprothixene
Cilansetron
Cisapride
Clozapine
DDP-225
DDP733
Dihydroergocornine
Dihydroergocristine
Dolasetron
Dopamine
Ergoloid mesylate
Ethanol
Gilteritinib
Granisetron
Ketamine
Lamotrigine
Loxapine
Memantine
Methadone
Metoclopramide
Olanzapine
Ondansetron
Palonosetron
Paroxetine
Procaine
Quetiapine
Ramosetron
Renzapride
Rocuronium
Serotonin
Setiptiline
Tapentadol
Tiapride
Ticalopride
Trimipramine
Tropisetron
Tubocurarine
Vortioxetine
Ziprasidone
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family
4 sites, No reported glycans
6 sites
476 antibodies from 36 providers
human
HTR3A
Group enriched (brain, intestine, lymphoid tissue, pancreas, salivary gland)
gene
Eukaryota
Neurotransmitter receptors and postsynaptic signal transmission
7 hits in 1155 CRISPR screens
Tclin
Protein
Expressed in dorsal root ganglion and 94 other cell types or tissues
baseline and differential
LGIC_ECD_5-HT3A
LGIC_TM_5-HT3
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain
5HT3_rcpt
5HT3_rcpt_A
Neur_chan_lig-bd
Neur_chan_lig-bd_sf
Neur_channel
Neuro-gated_channel_TM_sf
Neuro_actylchol_rec
Neurotrans-gated_channel_TM
Neurotransmitter_ion_chnl_CS
LIC
5-HYDROXYTRYPTAMINE RECEPTOR 3A
NEUROTRANSMITTER GATED ION CHANNEL
Neur_chan_LBD
Neur_chan_memb
5HT3ARECEPTR
5HT3RECEPTOR
NRIONCHANNEL
Neurotransmitter-gated ion-channel transmembrane pore
Nicotinic receptor ligand binding domain-like
NEUROTR_ION_CHANNEL
HS
5-hydroxytryptamine receptor 3A
5-HT3-A
5-HT3A
5-hydroxytryptamine receptor 3
5-HT-3
5-HT3R
Serotonin receptor 3A
Serotonin-gated ion channel receptor
HTR3A
5HT3R
HTR3
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Forms homopentameric as well as heteropentameric serotonin-activated cation-selective channel complexes with HTR3B or HTR3C or HTR3D or HTR3E. The homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in vivo (PubMed:15809299, PubMed:10521471, PubMed:17392525, PubMed:9950429). Interacts with RIC3 (PubMed:15809299).
Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.
The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily.
1
23
5-hydroxytryptamine receptor 3A
52792
24
478
Extracellular
241
Helical; Name=1
242
268
Cytoplasmic
269
273
Helical; Name=2
274
292
Extracellular
293
302
Helical; Name=3
303
321
Cytoplasmic
322
455
Helical; Name=4
456
475
Extracellular
476
Disordered
389
408
HA-stretch; determines single-channel conductance in 5-HT3 receptors
414
450
N-linked (GlcNAc...) asparagine
28
N-linked (GlcNAc...) asparagine
104
N-linked (GlcNAc...) asparagine
170
N-linked (GlcNAc...) asparagine
186
157
171
In isoform 3.
MHRSFLQ
22
In isoform 4 and isoform 5.
MLGKLAM
In isoform 2 and isoform 5.
GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG
306
T
33
N
253
H
344
R
391
Q
409
Abolished 5-hydroxytryptamine (serotonin) binding to the heteromeric receptor.
S
178
Little effect on conductance. Massive increase of conductance; when associated with D-436 and A-440.
Q
432
Increased conductance. Massive increase of conductance; when associated with Q-432 and A-440.
D
436
Increased conductance. Massive increase of conductance; when associated with Q-432 and D-436.
A
440
T
46
L
125
T
T
386
W
342
false
5
false
5
false
5
false
3
HTR3C
HTR3D
HTR3E
HTR3E
1995-11-01
1
true
55280
ab1d14528d9a7ae7a6f71756d59e3a1b
1
5-HT3R-AS
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
2
5-HT3R-AL
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
3
MHRSFLQARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
4
MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
5
MLGKLAMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true