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Protein

5-hydroxytryptamine receptor 3A

Gene

HTR3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.2 Publications

GO - Molecular functioni

  1. receptor activity Source: ProtInc
  2. serotonin-activated cation-selective channel activity Source: ProtInc
  3. serotonin binding Source: MGI
  4. serotonin receptor activity Source: MGI
  5. voltage-gated potassium channel activity Source: Ensembl

GO - Biological processi

  1. cellular response to growth factor stimulus Source: Ensembl
  2. digestion Source: ProtInc
  3. ion transmembrane transport Source: Reactome
  4. response to cocaine Source: Ensembl
  5. response to ethanol Source: Ensembl
  6. serotonin receptor signaling pathway Source: GOC
  7. synaptic transmission Source: ProtInc
  8. transmembrane transport Source: Reactome
  9. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_25387. Ligand-gated ion channel transport.

Protein family/group databases

TCDBi1.A.9.2.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 3A
Short name:
5-HT3-A
Short name:
5-HT3A
Alternative name(s):
5-hydroxytryptamine receptor 3
Short name:
5-HT-3
Short name:
5-HT3R
Serotonin receptor 3A
Serotonin-gated ion channel receptor
Gene namesi
Name:HTR3A
Synonyms:5HT3R, HTR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:5297. HTR3A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 241218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei242 – 26827Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini269 – 2735CytoplasmicSequence Analysis
Transmembranei274 – 29219Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini293 – 30210ExtracellularSequence Analysis
Transmembranei303 – 32119Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini322 – 455134CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei456 – 47520Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini476 – 4783ExtracellularSequence Analysis

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. cytoplasm Source: Ensembl
  4. integral component of plasma membrane Source: ProtInc
  5. neuronal cell body Source: Ensembl
  6. plasma membrane Source: Reactome
  7. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi178 – 1781W → S: Abolished ligand binding to the heteromeric receptor. 1 Publication
Mutagenesisi432 – 4321R → Q: Little effect on conductance. Massive increase of conductance; when associated with D-436 and A-440. 1 Publication
Mutagenesisi436 – 4361R → D: Increased conductance. Massive increase of conductance; when associated with Q-432 and A-440. 1 Publication
Mutagenesisi440 – 4401R → A: Increased conductance. Massive increase of conductance; when associated with Q-432 and D-436. 1 Publication

Organism-specific databases

PharmGKBiPA29555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 4784555-hydroxytryptamine receptor 3APRO_0000000408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi157 ↔ 171By similarity
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP46098.
PRIDEiP46098.

PTM databases

PhosphoSiteiP46098.

Expressioni

Tissue specificityi

Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.1 Publication

Gene expression databases

BgeeiP46098.
CleanExiHS_HTR3A.
ExpressionAtlasiP46098. baseline and differential.
GenevestigatoriP46098.

Interactioni

Subunit structurei

Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.4 Publications

Protein-protein interaction databases

STRINGi9606.ENSP00000347754.

Structurei

3D structure databases

ProteinModelPortaliP46098.
SMRiP46098. Positions 30-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni414 – 45037HA-stretchAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302526.
GeneTreeiENSGT00770000120477.
HOGENOMiHOG000241519.
HOVERGENiHBG106638.
InParanoidiP46098.
KOiK04819.
OMAiFIVRLVH.
OrthoDBiEOG7KDF9H.
PhylomeDBiP46098.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR008132. 5HT3_rcpt.
IPR008133. 5HT3_rcpt_A.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01709. 5HT3ARECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P46098-1) [UniParc]FASTAAdd to Basket

Also known as: 5-HT3R-AS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR
60 70 80 90 100
PVRDWRKPTT VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE
110 120 130 140 150
DFDNITKLSI PTDSIWVPDI LINEFVDVGK SPNIPYVYIR HQGEVQNYKP
160 170 180 190 200
LQVVTACSLD IYNFPFDVQN CSLTFTSWLH TIQDINISLW RLPEKVKSDR
210 220 230 240 250
SVFMNQGEWE LLGVLPYFRE FSMESSNYYA EMKFYVVIRR RPLFYVVSLL
260 270 280 290 300
LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI
310 320 330 340 350
GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQQPVP AWLRHLVLER
360 370 380 390 400
IAWLLCLREQ STSQRPPATS QATKTDDCSA MGNHCSHMGG PQDFEKSPRD
410 420 430 440 450
RCSPPPPPRE ASLAVCGLLQ ELSSIRQFLE KRDEIREVAR DWLRVGSVLD
460 470
KLLFHIYLLA VLAYSITLVM LWSIWQYA
Length:478
Mass (Da):55,280
Last modified:November 1, 1995 - v1
Checksum:i24CA9A232286FBC9
GO
Isoform 2 (identifier: P46098-2) [UniParc]FASTAAdd to Basket

Also known as: 5-HT3R-AL

The sequence of this isoform differs from the canonical sequence as follows:
     306-306: G → GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG

Show »
Length:510
Mass (Da):58,388
Checksum:i3DF54EB0BF54C519
GO
Isoform 3 (identifier: P46098-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MLLWVQQALLALLLPTLLAQGE → MHRSFLQ

Show »
Length:463
Mass (Da):53,763
Checksum:iFA630E3384245F9C
GO
Isoform 4 (identifier: P46098-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLGKLAM

Note: No experimental confirmation available.

Show »
Length:484
Mass (Da):55,894
Checksum:i74F70567007BCB51
GO
Isoform 5 (identifier: P46098-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLGKLAM
     306-306: G → GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG

Note: No experimental confirmation available.Curated

Show »
Length:516
Mass (Da):59,002
Checksum:i91E8DBE4B4802BA6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461R → T in AAB37533. (PubMed:8848005)Curated
Sequence conflicti125 – 1251F → L in AAB37533. (PubMed:8848005)Curated
Sequence conflicti321 – 3211A → T in AAB37533. (PubMed:8848005)Curated
Sequence conflicti386 – 3861S → T in AAB37533. (PubMed:8848005)Curated
Isoform 5 (identifier: P46098-5)
Sequence conflicti342 – 3421C → W in CD014118. (PubMed:15028279)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331A → T.1 Publication
Corresponds to variant rs117793058 [ dbSNP | Ensembl ].
VAR_037398
Natural varianti253 – 2531S → N.
Corresponds to variant rs4938063 [ dbSNP | Ensembl ].
VAR_037399
Natural varianti344 – 3441R → H.1 Publication
Corresponds to variant rs35815285 [ dbSNP | Ensembl ].
VAR_037400
Natural varianti391 – 3911P → R.1 Publication
VAR_037401
Natural varianti409 – 4091R → Q.1 Publication
VAR_037402

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222MLLWV…LAQGE → MHRSFLQ in isoform 3. 1 PublicationVSP_042214Add
BLAST
Alternative sequencei1 – 11M → MLGKLAM in isoform 4 and isoform 5. 2 PublicationsVSP_043484
Alternative sequencei306 – 3061G → GKAPPGSRAQSGEKPAPSHL LHVSLASALGCTG in isoform 2 and isoform 5. 2 PublicationsVSP_000078

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49394 mRNA. Translation: BAA08387.1.
S82612 mRNA. Translation: AAB37533.2.
AJ003078 mRNA. Translation: CAA05851.1.
AJ003079 mRNA. Translation: CAA05852.1.
AJ005205 Genomic DNA. Translation: CAA06442.3.
AF498984 mRNA. Translation: AAM21131.1.
BT007204 mRNA. Translation: AAP35868.1.
CD014118 mRNA. No translation available.
AK299973 mRNA. Translation: BAG61798.1.
AP000908 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67238.1.
CH471065 Genomic DNA. Translation: EAW67240.1.
BC002354 mRNA. Translation: AAH02354.1.
BC004453 mRNA. Translation: AAH04453.2.
CCDSiCCDS53710.1. [P46098-3]
CCDS8365.2. [P46098-4]
CCDS8366.2. [P46098-5]
RefSeqiNP_000860.2. NM_000869.5. [P46098-4]
NP_001155244.1. NM_001161772.2. [P46098-3]
NP_998786.2. NM_213621.3. [P46098-5]
UniGeneiHs.413899.

Genome annotation databases

EnsembliENST00000299961; ENSP00000299961; ENSG00000166736. [P46098-3]
ENST00000355556; ENSP00000347754; ENSG00000166736. [P46098-5]
ENST00000375498; ENSP00000364648; ENSG00000166736. [P46098-4]
ENST00000504030; ENSP00000424189; ENSG00000166736. [P46098-1]
ENST00000506841; ENSP00000424776; ENSG00000166736. [P46098-2]
GeneIDi3359.
KEGGihsa:3359.
UCSCiuc010rxa.2. human. [P46098-4]
uc010rxb.2. human.
uc010rxc.2. human. [P46098-3]

Polymorphism databases

DMDMi1168222.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49394 mRNA. Translation: BAA08387.1.
S82612 mRNA. Translation: AAB37533.2.
AJ003078 mRNA. Translation: CAA05851.1.
AJ003079 mRNA. Translation: CAA05852.1.
AJ005205 Genomic DNA. Translation: CAA06442.3.
AF498984 mRNA. Translation: AAM21131.1.
BT007204 mRNA. Translation: AAP35868.1.
CD014118 mRNA. No translation available.
AK299973 mRNA. Translation: BAG61798.1.
AP000908 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67238.1.
CH471065 Genomic DNA. Translation: EAW67240.1.
BC002354 mRNA. Translation: AAH02354.1.
BC004453 mRNA. Translation: AAH04453.2.
CCDSiCCDS53710.1. [P46098-3]
CCDS8365.2. [P46098-4]
CCDS8366.2. [P46098-5]
RefSeqiNP_000860.2. NM_000869.5. [P46098-4]
NP_001155244.1. NM_001161772.2. [P46098-3]
NP_998786.2. NM_213621.3. [P46098-5]
UniGeneiHs.413899.

3D structure databases

ProteinModelPortaliP46098.
SMRiP46098. Positions 30-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347754.

Chemistry

BindingDBiP46098.
ChEMBLiCHEMBL1899.
DrugBankiDB00969. Alosetron.
DB00543. Amoxapine.
DB01238. Aripiprazole.
DB01161. Chloroprocaine.
DB00604. Cisapride.
DB00363. Clozapine.
DB00757. Dolasetron.
DB01049. Ergoloid mesylate.
DB00889. Granisetron.
DB00408. Loxapine.
DB01043. Memantine.
DB00333. Methadone.
DB01233. Metoclopramide.
DB00370. Mirtazapine.
DB00334. Olanzapine.
DB00904. Ondansetron.
DB00377. Palonosetron.
DB00721. Procaine.
DB01224. Quetiapine.
DB00728. Rocuronium.
DB06204. Tapentadol.
DB00726. Trimipramine.
DB01199. Tubocurarine.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi373.

Protein family/group databases

TCDBi1.A.9.2.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

PTM databases

PhosphoSiteiP46098.

Polymorphism databases

DMDMi1168222.

Proteomic databases

PaxDbiP46098.
PRIDEiP46098.

Protocols and materials databases

DNASUi3359.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299961; ENSP00000299961; ENSG00000166736. [P46098-3]
ENST00000355556; ENSP00000347754; ENSG00000166736. [P46098-5]
ENST00000375498; ENSP00000364648; ENSG00000166736. [P46098-4]
ENST00000504030; ENSP00000424189; ENSG00000166736. [P46098-1]
ENST00000506841; ENSP00000424776; ENSG00000166736. [P46098-2]
GeneIDi3359.
KEGGihsa:3359.
UCSCiuc010rxa.2. human. [P46098-4]
uc010rxb.2. human.
uc010rxc.2. human. [P46098-3]

Organism-specific databases

CTDi3359.
GeneCardsiGC11P113879.
HGNCiHGNC:5297. HTR3A.
MIMi182139. gene.
neXtProtiNX_P46098.
PharmGKBiPA29555.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG302526.
GeneTreeiENSGT00770000120477.
HOGENOMiHOG000241519.
HOVERGENiHBG106638.
InParanoidiP46098.
KOiK04819.
OMAiFIVRLVH.
OrthoDBiEOG7KDF9H.
PhylomeDBiP46098.
TreeFamiTF315605.

Enzyme and pathway databases

ReactomeiREACT_25387. Ligand-gated ion channel transport.

Miscellaneous databases

GeneWikiiHTR3A.
GenomeRNAii3359.
NextBioi13282.
PROiP46098.
SOURCEiSearch...

Gene expression databases

BgeeiP46098.
CleanExiHS_HTR3A.
ExpressionAtlasiP46098. baseline and differential.
GenevestigatoriP46098.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR008132. 5HT3_rcpt.
IPR008133. 5HT3_rcpt_A.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01709. 5HT3ARECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species."
    Miyake A., Mochizuki S., Takemoto Y., Akuzawa S.
    Mol. Pharmacol. 48:407-416(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  2. "Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit."
    Belelli D., Balcarek J.M., Hope A.G., Peters J.A., Lambert J.J., Blackburn T.P.
    Mol. Pharmacol. 48:1054-1062(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  3. "Molecular cloning of alternatively spliced human 5HT3 receptor cDNAs."
    Bruess M., Goethert M., Hayer M., Bonisch H.
    Ann. N. Y. Acad. Sci. 861:234-235(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala and Hippocampus.
  4. "Exon-intron organization of the human 5-HT3A receptor gene."
    Bruess M., Eucker T., Goethert M., Bonisch H.
    Neuropharmacology 39:308-315(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  7. "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes."
    Jin P., Fu G.K., Wilson A.D., Yang J., Chien D., Hawkins P.R., Au-Young J., Stuve L.L.
    Genomics 83:566-571(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  12. "The 5-HT3B subunit is a major determinant of serotonin-receptor function."
    Davies P.A., Pistis M., Hanna M.C., Peters J.A., Lambert J.J., Hales T.G., Kirkness E.F.
    Nature 397:359-363(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  13. "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit."
    Dubin A.E., Huvar R., D'Andrea M.R., Pyati J., Zhu J.Y., Joy K.C., Wilson S.J., Galindo J.E., Glass C.A., Luo L., Jackson M.R., Lovenberg T.W., Erlander M.G.
    J. Biol. Chem. 274:30799-30810(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Small intestine.
  14. "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors."
    Kelley S.P., Dunlop J.I., Kirkness E.F., Lambert J.J., Peters J.A.
    Nature 424:321-324(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, REGION, MUTAGENESIS OF ARG-432; ARG-436 AND ARG-440.
  15. "Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3."
    Cheng A., McDonald N.A., Connolly C.N.
    J. Biol. Chem. 280:22502-22507(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIC3.
  16. "Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E."
    Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M.
    Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, MUTAGENESIS OF TRP-178.
  17. "Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."
    Frank B., Niesler B., Bondy B., Spaeth M., Pongratz D.E., Ackenheil M., Fischer C., Rappold G.
    Clin. Rheumatol. 23:338-344(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT THR-33.
  18. "Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."
    Yamada K., Hattori E., Iwayama Y., Ohnishi T., Ohba H., Toyota T., Takao H., Minabe Y., Nakatani N., Higuchi T., Detera-Wadleigh S.D., Yoshikawa T.
    Biol. Psychiatry 60:192-201(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HIS-344; ARG-391 AND GLN-409.

Entry informationi

Entry namei5HT3A_HUMAN
AccessioniPrimary (citable) accession number: P46098
Secondary accession number(s): B4DSY6
, G5E986, O60854, Q7KZM7, Q99918, Q9BSZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.