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P46098

- 5HT3A_HUMAN

UniProt

P46098 - 5HT3A_HUMAN

Protein

5-hydroxytryptamine receptor 3A

Gene

HTR3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.2 Publications

    GO - Molecular functioni

    1. receptor activity Source: ProtInc
    2. serotonin-activated cation-selective channel activity Source: ProtInc
    3. serotonin binding Source: MGI
    4. serotonin receptor activity Source: MGI
    5. voltage-gated potassium channel activity Source: Ensembl

    GO - Biological processi

    1. cation transport Source: GOC
    2. cellular response to growth factor stimulus Source: Ensembl
    3. digestion Source: ProtInc
    4. ion transmembrane transport Source: Reactome
    5. response to cocaine Source: Ensembl
    6. response to ethanol Source: Ensembl
    7. serotonin receptor signaling pathway Source: GOC
    8. synaptic transmission Source: ProtInc
    9. transmembrane transport Source: Reactome
    10. transport Source: ProtInc

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_25387. Ligand-gated ion channel transport.

    Protein family/group databases

    TCDBi1.A.9.2.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 3A
    Short name:
    5-HT3-A
    Short name:
    5-HT3A
    Alternative name(s):
    5-hydroxytryptamine receptor 3
    Short name:
    5-HT-3
    Short name:
    5-HT3R
    Serotonin receptor 3A
    Serotonin-gated ion channel receptor
    Gene namesi
    Name:HTR3A
    Synonyms:5HT3R, HTR3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:5297. HTR3A.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. cytoplasm Source: Ensembl
    4. integral component of plasma membrane Source: ProtInc
    5. neuronal cell body Source: Ensembl
    6. plasma membrane Source: Reactome
    7. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi178 – 1781W → S: Abolished ligand binding to the heteromeric receptor. 1 Publication
    Mutagenesisi432 – 4321R → Q: Little effect on conductance. Massive increase of conductance; when associated with D-436 and A-440. 1 Publication
    Mutagenesisi436 – 4361R → D: Increased conductance. Massive increase of conductance; when associated with Q-432 and A-440. 1 Publication
    Mutagenesisi440 – 4401R → A: Increased conductance. Massive increase of conductance; when associated with Q-432 and D-436. 1 Publication

    Organism-specific databases

    PharmGKBiPA29555.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 4784555-hydroxytryptamine receptor 3APRO_0000000408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi157 ↔ 171By similarity
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP46098.
    PRIDEiP46098.

    PTM databases

    PhosphoSiteiP46098.

    Expressioni

    Tissue specificityi

    Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.1 Publication

    Gene expression databases

    ArrayExpressiP46098.
    BgeeiP46098.
    CleanExiHS_HTR3A.
    GenevestigatoriP46098.

    Interactioni

    Subunit structurei

    Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.4 Publications

    Protein-protein interaction databases

    STRINGi9606.ENSP00000347754.

    Structurei

    3D structure databases

    ProteinModelPortaliP46098.
    SMRiP46098. Positions 37-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 241218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini269 – 2735CytoplasmicSequence Analysis
    Topological domaini293 – 30210ExtracellularSequence Analysis
    Topological domaini322 – 455134CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini476 – 4783ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei242 – 26827Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29219Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32119Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei456 – 47520Helical; Name=4Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni414 – 45037HA-stretchAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302526.
    HOGENOMiHOG000241519.
    HOVERGENiHBG106638.
    KOiK04819.
    OMAiFIVRLVH.
    OrthoDBiEOG7KDF9H.
    PhylomeDBiP46098.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR008132. 5HT3_rcpt.
    IPR008133. 5HT3_rcpt_A.
    IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR01709. 5HT3ARECEPTR.
    PR01708. 5HT3RECEPTOR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P46098-1) [UniParc]FASTAAdd to Basket

    Also known as: 5-HT3R-AS

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR    50
    PVRDWRKPTT VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE 100
    DFDNITKLSI PTDSIWVPDI LINEFVDVGK SPNIPYVYIR HQGEVQNYKP 150
    LQVVTACSLD IYNFPFDVQN CSLTFTSWLH TIQDINISLW RLPEKVKSDR 200
    SVFMNQGEWE LLGVLPYFRE FSMESSNYYA EMKFYVVIRR RPLFYVVSLL 250
    LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI 300
    GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQQPVP AWLRHLVLER 350
    IAWLLCLREQ STSQRPPATS QATKTDDCSA MGNHCSHMGG PQDFEKSPRD 400
    RCSPPPPPRE ASLAVCGLLQ ELSSIRQFLE KRDEIREVAR DWLRVGSVLD 450
    KLLFHIYLLA VLAYSITLVM LWSIWQYA 478
    Length:478
    Mass (Da):55,280
    Last modified:November 1, 1995 - v1
    Checksum:i24CA9A232286FBC9
    GO
    Isoform 2 (identifier: P46098-2) [UniParc]FASTAAdd to Basket

    Also known as: 5-HT3R-AL

    The sequence of this isoform differs from the canonical sequence as follows:
         306-306: G → GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG

    Show »
    Length:510
    Mass (Da):58,388
    Checksum:i3DF54EB0BF54C519
    GO
    Isoform 3 (identifier: P46098-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-22: MLLWVQQALLALLLPTLLAQGE → MHRSFLQ

    Show »
    Length:463
    Mass (Da):53,763
    Checksum:iFA630E3384245F9C
    GO
    Isoform 4 (identifier: P46098-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLGKLAM

    Note: No experimental confirmation available.

    Show »
    Length:484
    Mass (Da):55,894
    Checksum:i74F70567007BCB51
    GO
    Isoform 5 (identifier: P46098-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLGKLAM
         306-306: G → GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG

    Note: No experimental confirmation available.Curated

    Show »
    Length:516
    Mass (Da):59,002
    Checksum:i91E8DBE4B4802BA6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461R → T in AAB37533. (PubMed:8848005)Curated
    Sequence conflicti125 – 1251F → L in AAB37533. (PubMed:8848005)Curated
    Sequence conflicti321 – 3211A → T in AAB37533. (PubMed:8848005)Curated
    Sequence conflicti386 – 3861S → T in AAB37533. (PubMed:8848005)Curated
    Isoform 5 (identifier: P46098-5)
    Sequence conflicti342 – 3421C → W in CD014118. (PubMed:15028279)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331A → T.1 Publication
    Corresponds to variant rs117793058 [ dbSNP | Ensembl ].
    VAR_037398
    Natural varianti253 – 2531S → N.
    Corresponds to variant rs4938063 [ dbSNP | Ensembl ].
    VAR_037399
    Natural varianti344 – 3441R → H.1 Publication
    Corresponds to variant rs35815285 [ dbSNP | Ensembl ].
    VAR_037400
    Natural varianti391 – 3911P → R.1 Publication
    VAR_037401
    Natural varianti409 – 4091R → Q.1 Publication
    VAR_037402

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2222MLLWV…LAQGE → MHRSFLQ in isoform 3. 1 PublicationVSP_042214Add
    BLAST
    Alternative sequencei1 – 11M → MLGKLAM in isoform 4 and isoform 5. 2 PublicationsVSP_043484
    Alternative sequencei306 – 3061G → GKAPPGSRAQSGEKPAPSHL LHVSLASALGCTG in isoform 2 and isoform 5. 2 PublicationsVSP_000078

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49394 mRNA. Translation: BAA08387.1.
    S82612 mRNA. Translation: AAB37533.2.
    AJ003078 mRNA. Translation: CAA05851.1.
    AJ003079 mRNA. Translation: CAA05852.1.
    AJ005205 Genomic DNA. Translation: CAA06442.3.
    AF498984 mRNA. Translation: AAM21131.1.
    BT007204 mRNA. Translation: AAP35868.1.
    CD014118 mRNA. No translation available.
    AK299973 mRNA. Translation: BAG61798.1.
    AP000908 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67238.1.
    CH471065 Genomic DNA. Translation: EAW67240.1.
    BC002354 mRNA. Translation: AAH02354.1.
    BC004453 mRNA. Translation: AAH04453.2.
    CCDSiCCDS53710.1. [P46098-3]
    CCDS8365.2. [P46098-4]
    CCDS8366.2. [P46098-5]
    RefSeqiNP_000860.2. NM_000869.5. [P46098-4]
    NP_001155244.1. NM_001161772.2. [P46098-3]
    NP_998786.2. NM_213621.3. [P46098-5]
    UniGeneiHs.413899.

    Genome annotation databases

    EnsembliENST00000299961; ENSP00000299961; ENSG00000166736. [P46098-3]
    ENST00000355556; ENSP00000347754; ENSG00000166736. [P46098-5]
    ENST00000375498; ENSP00000364648; ENSG00000166736. [P46098-4]
    ENST00000504030; ENSP00000424189; ENSG00000166736. [P46098-1]
    ENST00000506841; ENSP00000424776; ENSG00000166736. [P46098-2]
    GeneIDi3359.
    KEGGihsa:3359.
    UCSCiuc010rxa.2. human. [P46098-4]
    uc010rxb.2. human.
    uc010rxc.2. human. [P46098-3]

    Polymorphism databases

    DMDMi1168222.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49394 mRNA. Translation: BAA08387.1 .
    S82612 mRNA. Translation: AAB37533.2 .
    AJ003078 mRNA. Translation: CAA05851.1 .
    AJ003079 mRNA. Translation: CAA05852.1 .
    AJ005205 Genomic DNA. Translation: CAA06442.3 .
    AF498984 mRNA. Translation: AAM21131.1 .
    BT007204 mRNA. Translation: AAP35868.1 .
    CD014118 mRNA. No translation available.
    AK299973 mRNA. Translation: BAG61798.1 .
    AP000908 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67238.1 .
    CH471065 Genomic DNA. Translation: EAW67240.1 .
    BC002354 mRNA. Translation: AAH02354.1 .
    BC004453 mRNA. Translation: AAH04453.2 .
    CCDSi CCDS53710.1. [P46098-3 ]
    CCDS8365.2. [P46098-4 ]
    CCDS8366.2. [P46098-5 ]
    RefSeqi NP_000860.2. NM_000869.5. [P46098-4 ]
    NP_001155244.1. NM_001161772.2. [P46098-3 ]
    NP_998786.2. NM_213621.3. [P46098-5 ]
    UniGenei Hs.413899.

    3D structure databases

    ProteinModelPortali P46098.
    SMRi P46098. Positions 37-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000347754.

    Chemistry

    BindingDBi P46098.
    ChEMBLi CHEMBL2094132.
    DrugBanki DB00969. Alosetron.
    DB00543. Amoxapine.
    DB01238. Aripiprazole.
    DB01161. Chloroprocaine.
    DB00604. Cisapride.
    DB00363. Clozapine.
    DB00757. Dolasetron.
    DB01049. Ergoloid mesylate.
    DB00889. Granisetron.
    DB00408. Loxapine.
    DB01043. Memantine.
    DB00333. Methadone.
    DB01233. Metoclopramide.
    DB00370. Mirtazapine.
    DB00334. Olanzapine.
    DB00904. Ondansetron.
    DB00377. Palonosetron.
    DB00721. Procaine.
    DB01224. Quetiapine.
    DB00728. Rocuronium.
    DB06204. Tapentadol.
    DB00726. Trimipramine.
    DB01199. Tubocurarine.
    DB00246. Ziprasidone.
    GuidetoPHARMACOLOGYi 373.

    Protein family/group databases

    TCDBi 1.A.9.2.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    PTM databases

    PhosphoSitei P46098.

    Polymorphism databases

    DMDMi 1168222.

    Proteomic databases

    PaxDbi P46098.
    PRIDEi P46098.

    Protocols and materials databases

    DNASUi 3359.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299961 ; ENSP00000299961 ; ENSG00000166736 . [P46098-3 ]
    ENST00000355556 ; ENSP00000347754 ; ENSG00000166736 . [P46098-5 ]
    ENST00000375498 ; ENSP00000364648 ; ENSG00000166736 . [P46098-4 ]
    ENST00000504030 ; ENSP00000424189 ; ENSG00000166736 . [P46098-1 ]
    ENST00000506841 ; ENSP00000424776 ; ENSG00000166736 . [P46098-2 ]
    GeneIDi 3359.
    KEGGi hsa:3359.
    UCSCi uc010rxa.2. human. [P46098-4 ]
    uc010rxb.2. human.
    uc010rxc.2. human. [P46098-3 ]

    Organism-specific databases

    CTDi 3359.
    GeneCardsi GC11P113879.
    HGNCi HGNC:5297. HTR3A.
    MIMi 182139. gene.
    neXtProti NX_P46098.
    PharmGKBi PA29555.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302526.
    HOGENOMi HOG000241519.
    HOVERGENi HBG106638.
    KOi K04819.
    OMAi FIVRLVH.
    OrthoDBi EOG7KDF9H.
    PhylomeDBi P46098.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_25387. Ligand-gated ion channel transport.

    Miscellaneous databases

    GeneWikii HTR3A.
    GenomeRNAii 3359.
    NextBioi 13282.
    PROi P46098.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46098.
    Bgeei P46098.
    CleanExi HS_HTR3A.
    Genevestigatori P46098.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR008132. 5HT3_rcpt.
    IPR008133. 5HT3_rcpt_A.
    IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR01709. 5HT3ARECEPTR.
    PR01708. 5HT3RECEPTOR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species."
      Miyake A., Mochizuki S., Takemoto Y., Akuzawa S.
      Mol. Pharmacol. 48:407-416(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Hippocampus.
    2. "Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit."
      Belelli D., Balcarek J.M., Hope A.G., Peters J.A., Lambert J.J., Blackburn T.P.
      Mol. Pharmacol. 48:1054-1062(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    3. "Molecular cloning of alternatively spliced human 5HT3 receptor cDNAs."
      Bruess M., Goethert M., Hayer M., Bonisch H.
      Ann. N. Y. Acad. Sci. 861:234-235(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Amygdala and Hippocampus.
    4. "Exon-intron organization of the human 5-HT3A receptor gene."
      Bruess M., Eucker T., Goethert M., Bonisch H.
      Neuropharmacology 39:308-315(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    7. "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes."
      Jin P., Fu G.K., Wilson A.D., Yang J., Chien D., Hawkins P.R., Au-Young J., Stuve L.L.
      Genomics 83:566-571(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    12. "The 5-HT3B subunit is a major determinant of serotonin-receptor function."
      Davies P.A., Pistis M., Hanna M.C., Peters J.A., Lambert J.J., Hales T.G., Kirkness E.F.
      Nature 397:359-363(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    13. "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit."
      Dubin A.E., Huvar R., D'Andrea M.R., Pyati J., Zhu J.Y., Joy K.C., Wilson S.J., Galindo J.E., Glass C.A., Luo L., Jackson M.R., Lovenberg T.W., Erlander M.G.
      J. Biol. Chem. 274:30799-30810(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, TISSUE SPECIFICITY.
      Tissue: Small intestine.
    14. "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors."
      Kelley S.P., Dunlop J.I., Kirkness E.F., Lambert J.J., Peters J.A.
      Nature 424:321-324(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, REGION, MUTAGENESIS OF ARG-432; ARG-436 AND ARG-440.
    15. "Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3."
      Cheng A., McDonald N.A., Connolly C.N.
      J. Biol. Chem. 280:22502-22507(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIC3.
    16. "Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E."
      Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M.
      Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, MUTAGENESIS OF TRP-178.
    17. "Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."
      Frank B., Niesler B., Bondy B., Spaeth M., Pongratz D.E., Ackenheil M., Fischer C., Rappold G.
      Clin. Rheumatol. 23:338-344(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT THR-33.
    18. "Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."
      Yamada K., Hattori E., Iwayama Y., Ohnishi T., Ohba H., Toyota T., Takao H., Minabe Y., Nakatani N., Higuchi T., Detera-Wadleigh S.D., Yoshikawa T.
      Biol. Psychiatry 60:192-201(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HIS-344; ARG-391 AND GLN-409.

    Entry informationi

    Entry namei5HT3A_HUMAN
    AccessioniPrimary (citable) accession number: P46098
    Secondary accession number(s): B4DSY6
    , G5E986, O60854, Q7KZM7, Q99918, Q9BSZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 150 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3