P46098 (5HT3A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 3A
Short name=5-HT3-A
Short name=5-HT3A

Alternative name(s):
5-hydroxytryptamine receptor 3
Short name=5-HT-3
Short name=5-HT3R
Serotonin receptor 3A
Serotonin-gated ion channel receptor

Gene names

Name:	HTR3A
Synonyms:	5HT3R, HTR3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Ref.12 Ref.14
Subunit structure	Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3. Ref.12 Ref.13 Ref.15 Ref.16
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. Ref.13
Miscellaneous	The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	digestion Traceable author statement Ref.1. Source: ProtInc synaptic transmission Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serotonin binding Inferred from direct assay Ref.1. Source: MGI serotonin receptor activity Non-traceable author statement. Source: UniProtKB serotonin-activated cation-selective channel activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P46098-1)

Also known as: 5-HT3R-AS;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P46098-2)

Also known as: 5-HT3R-AL;

The sequence of this isoform differs from the canonical sequence as follows:
     306-306: G → GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG

Isoform 3 (identifier: P46098-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MLLWVQQALLALLLPTLLAQGE → MHRSFLQ

Isoform 4 (identifier: P46098-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLGKLAM

Note: No experimental confirmation available.

Isoform 5 (identifier: P46098-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLGKLAM
     306-306: G → GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 478	455	5-hydroxytryptamine receptor 3A		PRO_0000000408
Regions
	Topological domain	24 – 241	218	Extracellular Potential
	Transmembrane	242 – 268	27	Helical; Name=1; Potential
	Topological domain	269 – 273	5	Cytoplasmic Potential
	Transmembrane	274 – 292	19	Helical; Name=2; Potential
	Topological domain	293 – 302	10	Extracellular Potential
	Transmembrane	303 – 321	19	Helical; Name=3; Potential
	Topological domain	322 – 455	134	Cytoplasmic Potential
	Transmembrane	456 – 475	20	Helical; Name=4; Potential
	Topological domain	476 – 478	3	Extracellular Potential
	Region	414 – 450	37	HA-stretch
Amino acid modifications
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	170	1	N-linked (GlcNAc...) Potential
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Disulfide bond	157 ↔ 171		By similarity
Natural variations
	Alternative sequence	1 – 22	22	MLLWV…LAQGE → MHRSFLQ in isoform 3.		VSP_042214
	Alternative sequence	1	1	M → MLGKLAM in isoform 4 and isoform 5.		VSP_043484
	Alternative sequence	306	1	G → GKAPPGSRAQSGEKPAPSHL LHVSLASALGCTG in isoform 2 and isoform 5.		VSP_000078
	Natural variant	33	1	A → T. Ref.17		VAR_037398
	Natural variant	253	1	S → N. Corresponds to variant rs4938063 [ dbSNP | Ensembl ].		VAR_037399
	Natural variant	344	1	R → H. Ref.18 Corresponds to variant rs35815285 [ dbSNP | Ensembl ].		VAR_037400
	Natural variant	391	1	P → R. Ref.18		VAR_037401
	Natural variant	409	1	R → Q. Ref.18		VAR_037402
Experimental info
	Mutagenesis	178	1	W → S: Abolished ligand binding to the heteromeric receptor. Ref.16
	Mutagenesis	432	1	R → Q: Little effect on conductance. Massive increase of conductance; when associated with D-436 and A-440. Ref.14
	Mutagenesis	436	1	R → D: Increased conductance. Massive increase of conductance; when associated with Q-432 and A-440. Ref.14
	Mutagenesis	440	1	R → A: Increased conductance. Massive increase of conductance; when associated with Q-432 and D-436. Ref.14
	Sequence conflict	46	1	R → T in AAB37533. Ref.2
	Sequence conflict	125	1	F → L in AAB37533. Ref.2
	Sequence conflict	321	1	A → T in AAB37533. Ref.2
	Sequence conflict	386	1	S → T in AAB37533. Ref.2
Isoform 5:
	Sequence conflict	342	1	C → W in CD014118. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (5-HT3R-AS) [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 24CA9A232286FBC9	FASTA	478	55,280
	10 20 30 40 50 60 MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR PVRDWRKPTT 70 80 90 100 110 120 VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE DFDNITKLSI PTDSIWVPDI 130 140 150 160 170 180 LINEFVDVGK SPNIPYVYIR HQGEVQNYKP LQVVTACSLD IYNFPFDVQN CSLTFTSWLH 190 200 210 220 230 240 TIQDINISLW RLPEKVKSDR SVFMNQGEWE LLGVLPYFRE FSMESSNYYA EMKFYVVIRR 250 260 270 280 290 300 RPLFYVVSLL LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI 310 320 330 340 350 360 GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQQPVP AWLRHLVLER IAWLLCLREQ 370 380 390 400 410 420 STSQRPPATS QATKTDDCSA MGNHCSHMGG PQDFEKSPRD RCSPPPPPRE ASLAVCGLLQ 430 440 450 460 470 ELSSIRQFLE KRDEIREVAR DWLRVGSVLD KLLFHIYLLA VLAYSITLVM LWSIWQYA
	Isoform 2 (5-HT3R-AL) [UniParc]. Checksum: 3DF54EB0BF54C519	FASTA	510	58,388
	10 20 30 40 50 60 MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR PVRDWRKPTT 70 80 90 100 110 120 VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE DFDNITKLSI PTDSIWVPDI 130 140 150 160 170 180 LINEFVDVGK SPNIPYVYIR HQGEVQNYKP LQVVTACSLD IYNFPFDVQN CSLTFTSWLH 190 200 210 220 230 240 TIQDINISLW RLPEKVKSDR SVFMNQGEWE LLGVLPYFRE FSMESSNYYA EMKFYVVIRR 250 260 270 280 290 300 RPLFYVVSLL LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI 310 320 330 340 350 360 GTPLIGKAPP GSRAQSGEKP APSHLLHVSL ASALGCTGVY FVVCMALLVI SLAETIFIVR 370 380 390 400 410 420 LVHKQDLQQP VPAWLRHLVL ERIAWLLCLR EQSTSQRPPA TSQATKTDDC SAMGNHCSHM 430 440 450 460 470 480 GGPQDFEKSP RDRCSPPPPP REASLAVCGL LQELSSIRQF LEKRDEIREV ARDWLRVGSV 490 500 510 LDKLLFHIYL LAVLAYSITL VMLWSIWQYA
	Isoform 3 [UniParc]. Checksum: FA630E3384245F9C	FASTA	463	53,763
	10 20 30 40 50 60 MHRSFLQARR SRNTTRPALL RLSDYLLTNY RKGVRPVRDW RKPTTVSIDV IVYAILNVDE 70 80 90 100 110 120 KNQVLTTYIW YRQYWTDEFL QWNPEDFDNI TKLSIPTDSI WVPDILINEF VDVGKSPNIP 130 140 150 160 170 180 YVYIRHQGEV QNYKPLQVVT ACSLDIYNFP FDVQNCSLTF TSWLHTIQDI NISLWRLPEK 190 200 210 220 230 240 VKSDRSVFMN QGEWELLGVL PYFREFSMES SNYYAEMKFY VVIRRRPLFY VVSLLLPSIF 250 260 270 280 290 300 LMVMDIVGFY LPPNSGERVS FKITLLLGYS VFLIIVSDTL PATAIGTPLI GVYFVVCMAL 310 320 330 340 350 360 LVISLAETIF IVRLVHKQDL QQPVPAWLRH LVLERIAWLL CLREQSTSQR PPATSQATKT 370 380 390 400 410 420 DDCSAMGNHC SHMGGPQDFE KSPRDRCSPP PPPREASLAV CGLLQELSSI RQFLEKRDEI 430 440 450 460 REVARDWLRV GSVLDKLLFH IYLLAVLAYS ITLVMLWSIW QYA
	Isoform 4 [UniParc]. Checksum: 74F70567007BCB51	FASTA	484	55,894
	10 20 30 40 50 60 MLGKLAMLLW VQQALLALLL PTLLAQGEAR RSRNTTRPAL LRLSDYLLTN YRKGVRPVRD 70 80 90 100 110 120 WRKPTTVSID VIVYAILNVD EKNQVLTTYI WYRQYWTDEF LQWNPEDFDN ITKLSIPTDS 130 140 150 160 170 180 IWVPDILINE FVDVGKSPNI PYVYIRHQGE VQNYKPLQVV TACSLDIYNF PFDVQNCSLT 190 200 210 220 230 240 FTSWLHTIQD INISLWRLPE KVKSDRSVFM NQGEWELLGV LPYFREFSME SSNYYAEMKF 250 260 270 280 290 300 YVVIRRRPLF YVVSLLLPSI FLMVMDIVGF YLPPNSGERV SFKITLLLGY SVFLIIVSDT 310 320 330 340 350 360 LPATAIGTPL IGVYFVVCMA LLVISLAETI FIVRLVHKQD LQQPVPAWLR HLVLERIAWL 370 380 390 400 410 420 LCLREQSTSQ RPPATSQATK TDDCSAMGNH CSHMGGPQDF EKSPRDRCSP PPPPREASLA 430 440 450 460 470 480 VCGLLQELSS IRQFLEKRDE IREVARDWLR VGSVLDKLLF HIYLLAVLAY SITLVMLWSI WQYA
	Isoform 5 [UniParc]. Checksum: 91E8DBE4B4802BA6	FASTA	516	59,002
	10 20 30 40 50 60 MLGKLAMLLW VQQALLALLL PTLLAQGEAR RSRNTTRPAL LRLSDYLLTN YRKGVRPVRD 70 80 90 100 110 120 WRKPTTVSID VIVYAILNVD EKNQVLTTYI WYRQYWTDEF LQWNPEDFDN ITKLSIPTDS 130 140 150 160 170 180 IWVPDILINE FVDVGKSPNI PYVYIRHQGE VQNYKPLQVV TACSLDIYNF PFDVQNCSLT 190 200 210 220 230 240 FTSWLHTIQD INISLWRLPE KVKSDRSVFM NQGEWELLGV LPYFREFSME SSNYYAEMKF 250 260 270 280 290 300 YVVIRRRPLF YVVSLLLPSI FLMVMDIVGF YLPPNSGERV SFKITLLLGY SVFLIIVSDT 310 320 330 340 350 360 LPATAIGTPL IGKAPPGSRA QSGEKPAPSH LLHVSLASAL GCTGVYFVVC MALLVISLAE 370 380 390 400 410 420 TIFIVRLVHK QDLQQPVPAW LRHLVLERIA WLLCLREQST SQRPPATSQA TKTDDCSAMG 430 440 450 460 470 480 NHCSHMGGPQ DFEKSPRDRC SPPPPPREAS LAVCGLLQEL SSIRQFLEKR DEIREVARDW 490 500 510 LRVGSVLDKL LFHIYLLAVL AYSITLVMLW SIWQYA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species." Miyake A., Mochizuki S., Takemoto Y., Akuzawa S. Mol. Pharmacol. 48:407-416(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Hippocampus.
[2]	"Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit." Belelli D., Balcarek J.M., Hope A.G., Peters J.A., Lambert J.J., Blackburn T.P. Mol. Pharmacol. 48:1054-1062(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Amygdala.
[3]	"Molecular cloning of alternatively spliced human 5HT3 receptor cDNAs." Bruess M., Goethert M., Hayer M., Bonisch H. Ann. N. Y. Acad. Sci. 861:234-235(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Amygdala and Hippocampus.
[4]	"Exon-intron organization of the human 5-HT3A receptor gene." Bruess M., Eucker T., Goethert M., Bonisch H. Neuropharmacology 39:308-315(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[5]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[7]	"PCR isolation and cloning of novel splice variant mRNAs from known drug target genes." Jin P., Fu G.K., Wilson A.D., Yang J., Chien D., Hawkins P.R., Au-Young J., Stuve L.L. Genomics 83:566-571(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[9]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[12]	"The 5-HT3B subunit is a major determinant of serotonin-receptor function." Davies P.A., Pistis M., Hanna M.C., Peters J.A., Lambert J.J., Hales T.G., Kirkness E.F. Nature 397:359-363(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT.
[13]	"The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit." Dubin A.E., Huvar R., D'Andrea M.R., Pyati J., Zhu J.Y., Joy K.C., Wilson S.J., Galindo J.E., Glass C.A., Luo L., Jackson M.R., Lovenberg T.W., Erlander M.G. J. Biol. Chem. 274:30799-30810(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, TISSUE SPECIFICITY. Tissue: Small intestine.
[14]	"A cytoplasmic region determines single-channel conductance in 5-HT3 receptors." Kelley S.P., Dunlop J.I., Kirkness E.F., Lambert J.J., Peters J.A. Nature 424:321-324(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, REGION, MUTAGENESIS OF ARG-432; ARG-436 AND ARG-440.
[15]	"Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3." Cheng A., McDonald N.A., Connolly C.N. J. Biol. Chem. 280:22502-22507(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RIC3.
[16]	"Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E." Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M. Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, MUTAGENESIS OF TRP-178.
[17]	"Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients." Frank B., Niesler B., Bondy B., Spaeth M., Pongratz D.E., Ackenheil M., Fischer C., Rappold G. Clin. Rheumatol. 23:338-344(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT THR-33.
[18]	"Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression." Yamada K., Hattori E., Iwayama Y., Ohnishi T., Ohba H., Toyota T., Takao H., Minabe Y., Nakatani N., Higuchi T., Detera-Wadleigh S.D., Yoshikawa T. Biol. Psychiatry 60:192-201(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS HIS-344; ARG-391 AND GLN-409.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D49394 mRNA. Translation: BAA08387.1. S82612 mRNA. Translation: AAB37533.2. AJ003078 mRNA. Translation: CAA05851.1. AJ003079 mRNA. Translation: CAA05852.1. AJ005205 Genomic DNA. Translation: CAA06442.3. AF498984 mRNA. Translation: AAM21131.1. BT007204 mRNA. Translation: AAP35868.1. CD014118 mRNA. No translation available. AK299973 mRNA. Translation: BAG61798.1. AP000908 Genomic DNA. No translation available. CH471065 Genomic DNA. Translation: EAW67238.1. CH471065 Genomic DNA. Translation: EAW67240.1. BC002354 mRNA. Translation: AAH02354.1. BC004453 mRNA. Translation: AAH04453.2.
IPI	IPI00179555. IPI00465351. IPI00748737.
RefSeq	NP_000860.2. NM_000869.5. NP_001155244.1. NM_001161772.2. NP_998786.2. NM_213621.3.
UniGene	Hs.413899.
3D structure databases
ProteinModelPortal	P46098.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000347754.
Protein family/group databases
TCDB	1.A.9.2.1. neurotransmitter receptor, cys loop, ligand-gated ion channel (LIC) family.
PTM databases
PhosphoSite	P46098.
Polymorphism databases
DMDM	1168222.
Proteomic databases
PaxDb	P46098.
PRIDE	P46098.
Protocols and materials databases
DNASU	3359.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299961; ENSP00000299961; ENSG00000166736. ENST00000355556; ENSP00000347754; ENSG00000166736. ENST00000375498; ENSP00000364648; ENSG00000166736. ENST00000504030; ENSP00000424189; ENSG00000166736. ENST00000506841; ENSP00000424776; ENSG00000166736.
GeneID	3359.
KEGG	hsa:3359.
UCSC	uc010rxb.2. human.
Organism-specific databases
CTD	3359.
GeneCards	GC11P113879.
HGNC	HGNC:5297. HTR3A.
MIM	182139. gene.
neXtProt	NX_P46098.
PharmGKB	PA29555.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302526.
HOGENOM	HOG000241519.
HOVERGEN	HBG106638.
KO	K04819.
OMA	GKSPNIP.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	P46098.
Bgee	P46098.
CleanEx	HS_HTR3A.
Genevestigator	P46098.
GermOnline	ENSG00000166736. Homo sapiens.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR008132. 5HT3_rcpt. IPR008133. 5HT3_rcpt_A. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR01709. 5HT3ARECEPTR. PR01708. 5HT3RECEPTOR. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P46098.
ChEMBL	CHEMBL1899.
DrugBank	DB00969. Alosetron. DB01161. Chloroprocaine. DB00604. Cisapride. DB00757. Dolasetron. DB00889. Granisetron. DB00370. Mirtazapine. DB00904. Ondansetron. DB00377. Palonosetron. DB00721. Procaine. DB01199. Tubocurarine.
GenomeRNAi	3359.
NextBio	13282.
SOURCE	Search...

Entry information

Entry name

5HT3A_HUMAN

Accession

Primary (citable) accession number: P46098
Secondary accession number(s): B4DSY6 , G5E986, O60854, Q7KZM7, Q99918, Q9BSZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 134 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.