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P46098 (5HT3A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 148. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 3A

Short name=5-HT3-A
Short name=5-HT3A
Alternative name(s):
5-hydroxytryptamine receptor 3
Short name=5-HT-3
Short name=5-HT3R
Serotonin receptor 3A
Serotonin-gated ion channel receptor
Gene names
Name:HTR3A
Synonyms:5HT3R, HTR3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Ref.12 Ref.14

Subunit structure

Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3. Ref.12 Ref.13 Ref.15 Ref.16

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. Ref.13

Miscellaneous

The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionIon channel
Ligand-gated ion channel
Receptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcation transport

Traceable author statement Ref.1. Source: GOC

cellular response to growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

digestion

Traceable author statement Ref.1. Source: ProtInc

ion transmembrane transport

Traceable author statement. Source: Reactome

response to cocaine

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

serotonin receptor signaling pathway

Inferred from direct assay Ref.1. Source: GOC

synaptic transmission

Traceable author statement Ref.1. Source: ProtInc

transmembrane transport

Traceable author statement. Source: Reactome

transport

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentaxon

Inferred from electronic annotation. Source: Ensembl

cell junction

Inferred from electronic annotation. Source: UniProtKB-KW

cytoplasm

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement. Source: Reactome

postsynaptic membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionreceptor activity

Traceable author statement Ref.12. Source: ProtInc

serotonin binding

Inferred from direct assay Ref.1. Source: MGI

serotonin receptor activity

Inferred from direct assay Ref.1. Source: MGI

serotonin-activated cation-selective channel activity

Traceable author statement Ref.1. Source: ProtInc

voltage-gated potassium channel activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P46098-1)

Also known as: 5-HT3R-AS;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P46098-2)

Also known as: 5-HT3R-AL;

The sequence of this isoform differs from the canonical sequence as follows:
     306-306: G → GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG
Isoform 3 (identifier: P46098-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MLLWVQQALLALLLPTLLAQGE → MHRSFLQ
Isoform 4 (identifier: P46098-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLGKLAM
Note: No experimental confirmation available.
Isoform 5 (identifier: P46098-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLGKLAM
     306-306: G → GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 4784555-hydroxytryptamine receptor 3A
PRO_0000000408

Regions

Topological domain24 – 241218Extracellular Potential
Transmembrane242 – 26827Helical; Name=1; Potential
Topological domain269 – 2735Cytoplasmic Potential
Transmembrane274 – 29219Helical; Name=2; Potential
Topological domain293 – 30210Extracellular Potential
Transmembrane303 – 32119Helical; Name=3; Potential
Topological domain322 – 455134Cytoplasmic Potential
Transmembrane456 – 47520Helical; Name=4; Potential
Topological domain476 – 4783Extracellular Potential
Region414 – 45037HA-stretch

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation1861N-linked (GlcNAc...) Potential
Disulfide bond157 ↔ 171 By similarity

Natural variations

Alternative sequence1 – 2222MLLWV…LAQGE → MHRSFLQ in isoform 3.
VSP_042214
Alternative sequence11M → MLGKLAM in isoform 4 and isoform 5.
VSP_043484
Alternative sequence3061G → GKAPPGSRAQSGEKPAPSHL LHVSLASALGCTG in isoform 2 and isoform 5.
VSP_000078
Natural variant331A → T. Ref.17
Corresponds to variant rs117793058 [ dbSNP | Ensembl ].
VAR_037398
Natural variant2531S → N.
Corresponds to variant rs4938063 [ dbSNP | Ensembl ].
VAR_037399
Natural variant3441R → H. Ref.18
Corresponds to variant rs35815285 [ dbSNP | Ensembl ].
VAR_037400
Natural variant3911P → R. Ref.18
VAR_037401
Natural variant4091R → Q. Ref.18
VAR_037402

Experimental info

Mutagenesis1781W → S: Abolished ligand binding to the heteromeric receptor. Ref.16
Mutagenesis4321R → Q: Little effect on conductance. Massive increase of conductance; when associated with D-436 and A-440. Ref.14
Mutagenesis4361R → D: Increased conductance. Massive increase of conductance; when associated with Q-432 and A-440. Ref.14
Mutagenesis4401R → A: Increased conductance. Massive increase of conductance; when associated with Q-432 and D-436. Ref.14
Sequence conflict461R → T in AAB37533. Ref.2
Sequence conflict1251F → L in AAB37533. Ref.2
Sequence conflict3211A → T in AAB37533. Ref.2
Sequence conflict3861S → T in AAB37533. Ref.2
Isoform 5:
Sequence conflict3421C → W in CD014118. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (5-HT3R-AS) [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 24CA9A232286FBC9

FASTA47855,280
        10         20         30         40         50         60 
MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR PVRDWRKPTT 

        70         80         90        100        110        120 
VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE DFDNITKLSI PTDSIWVPDI 

       130        140        150        160        170        180 
LINEFVDVGK SPNIPYVYIR HQGEVQNYKP LQVVTACSLD IYNFPFDVQN CSLTFTSWLH 

       190        200        210        220        230        240 
TIQDINISLW RLPEKVKSDR SVFMNQGEWE LLGVLPYFRE FSMESSNYYA EMKFYVVIRR 

       250        260        270        280        290        300 
RPLFYVVSLL LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI 

       310        320        330        340        350        360 
GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQQPVP AWLRHLVLER IAWLLCLREQ 

       370        380        390        400        410        420 
STSQRPPATS QATKTDDCSA MGNHCSHMGG PQDFEKSPRD RCSPPPPPRE ASLAVCGLLQ 

       430        440        450        460        470 
ELSSIRQFLE KRDEIREVAR DWLRVGSVLD KLLFHIYLLA VLAYSITLVM LWSIWQYA 

« Hide

Isoform 2 (5-HT3R-AL) [UniParc].

Checksum: 3DF54EB0BF54C519
Show »

FASTA51058,388
Isoform 3 [UniParc].

Checksum: FA630E3384245F9C
Show »

FASTA46353,763
Isoform 4 [UniParc].

Checksum: 74F70567007BCB51
Show »

FASTA48455,894
Isoform 5 [UniParc].

Checksum: 91E8DBE4B4802BA6
Show »

FASTA51659,002

References

« Hide 'large scale' references
[1]"Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species."
Miyake A., Mochizuki S., Takemoto Y., Akuzawa S.
Mol. Pharmacol. 48:407-416(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Hippocampus.
[2]"Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit."
Belelli D., Balcarek J.M., Hope A.G., Peters J.A., Lambert J.J., Blackburn T.P.
Mol. Pharmacol. 48:1054-1062(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Amygdala.
[3]"Molecular cloning of alternatively spliced human 5HT3 receptor cDNAs."
Bruess M., Goethert M., Hayer M., Bonisch H.
Ann. N. Y. Acad. Sci. 861:234-235(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Amygdala and Hippocampus.
[4]"Exon-intron organization of the human 5-HT3A receptor gene."
Bruess M., Eucker T., Goethert M., Bonisch H.
Neuropharmacology 39:308-315(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[7]"PCR isolation and cloning of novel splice variant mRNAs from known drug target genes."
Jin P., Fu G.K., Wilson A.D., Yang J., Chien D., Hawkins P.R., Au-Young J., Stuve L.L.
Genomics 83:566-571(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[8]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[9]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[12]"The 5-HT3B subunit is a major determinant of serotonin-receptor function."
Davies P.A., Pistis M., Hanna M.C., Peters J.A., Lambert J.J., Hales T.G., Kirkness E.F.
Nature 397:359-363(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[13]"The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit."
Dubin A.E., Huvar R., D'Andrea M.R., Pyati J., Zhu J.Y., Joy K.C., Wilson S.J., Galindo J.E., Glass C.A., Luo L., Jackson M.R., Lovenberg T.W., Erlander M.G.
J. Biol. Chem. 274:30799-30810(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, TISSUE SPECIFICITY.
Tissue: Small intestine.
[14]"A cytoplasmic region determines single-channel conductance in 5-HT3 receptors."
Kelley S.P., Dunlop J.I., Kirkness E.F., Lambert J.J., Peters J.A.
Nature 424:321-324(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, REGION, MUTAGENESIS OF ARG-432; ARG-436 AND ARG-440.
[15]"Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3."
Cheng A., McDonald N.A., Connolly C.N.
J. Biol. Chem. 280:22502-22507(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RIC3.
[16]"Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E."
Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J., Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M.
Mol. Pharmacol. 72:8-17(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, MUTAGENESIS OF TRP-178.
[17]"Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."
Frank B., Niesler B., Bondy B., Spaeth M., Pongratz D.E., Ackenheil M., Fischer C., Rappold G.
Clin. Rheumatol. 23:338-344(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT THR-33.
[18]"Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."
Yamada K., Hattori E., Iwayama Y., Ohnishi T., Ohba H., Toyota T., Takao H., Minabe Y., Nakatani N., Higuchi T., Detera-Wadleigh S.D., Yoshikawa T.
Biol. Psychiatry 60:192-201(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS HIS-344; ARG-391 AND GLN-409.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49394 mRNA. Translation: BAA08387.1.
S82612 mRNA. Translation: AAB37533.2.
AJ003078 mRNA. Translation: CAA05851.1.
AJ003079 mRNA. Translation: CAA05852.1.
AJ005205 Genomic DNA. Translation: CAA06442.3.
AF498984 mRNA. Translation: AAM21131.1.
BT007204 mRNA. Translation: AAP35868.1.
CD014118 mRNA. No translation available.
AK299973 mRNA. Translation: BAG61798.1.
AP000908 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67238.1.
CH471065 Genomic DNA. Translation: EAW67240.1.
BC002354 mRNA. Translation: AAH02354.1.
BC004453 mRNA. Translation: AAH04453.2.
CCDSCCDS53710.1. [P46098-3]
CCDS8365.2. [P46098-4]
CCDS8366.2. [P46098-5]
RefSeqNP_000860.2. NM_000869.5. [P46098-4]
NP_001155244.1. NM_001161772.2. [P46098-3]
NP_998786.2. NM_213621.3. [P46098-5]
UniGeneHs.413899.

3D structure databases

ProteinModelPortalP46098.
SMRP46098. Positions 37-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000347754.

Chemistry

BindingDBP46098.
ChEMBLCHEMBL2094132.
DrugBankDB00969. Alosetron.
DB01161. Chloroprocaine.
DB00604. Cisapride.
DB00757. Dolasetron.
DB00889. Granisetron.
DB00370. Mirtazapine.
DB00904. Ondansetron.
DB00377. Palonosetron.
DB00721. Procaine.
DB01199. Tubocurarine.
GuidetoPHARMACOLOGY373.

Protein family/group databases

TCDB1.A.9.2.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

PTM databases

PhosphoSiteP46098.

Polymorphism databases

DMDM1168222.

Proteomic databases

PaxDbP46098.
PRIDEP46098.

Protocols and materials databases

DNASU3359.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299961; ENSP00000299961; ENSG00000166736. [P46098-3]
ENST00000355556; ENSP00000347754; ENSG00000166736. [P46098-5]
ENST00000375498; ENSP00000364648; ENSG00000166736. [P46098-4]
ENST00000504030; ENSP00000424189; ENSG00000166736. [P46098-1]
ENST00000506841; ENSP00000424776; ENSG00000166736. [P46098-2]
GeneID3359.
KEGGhsa:3359.
UCSCuc010rxa.2. human. [P46098-4]
uc010rxb.2. human.
uc010rxc.2. human. [P46098-3]

Organism-specific databases

CTD3359.
GeneCardsGC11P113879.
HGNCHGNC:5297. HTR3A.
MIM182139. gene.
neXtProtNX_P46098.
PharmGKBPA29555.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302526.
HOGENOMHOG000241519.
HOVERGENHBG106638.
KOK04819.
OMAFIVRLVH.
OrthoDBEOG7KDF9H.
PhylomeDBP46098.
TreeFamTF315605.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressP46098.
BgeeP46098.
CleanExHS_HTR3A.
GenevestigatorP46098.

Family and domain databases

Gene3D1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProIPR008132. 5HT3_rcpt.
IPR008133. 5HT3_rcpt_A.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR01709. 5HT3ARECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHTR3A.
GenomeRNAi3359.
NextBio13282.
PROP46098.
SOURCESearch...

Entry information

Entry name5HT3A_HUMAN
AccessionPrimary (citable) accession number: P46098
Secondary accession number(s): B4DSY6 expand/collapse secondary AC list , G5E986, O60854, Q7KZM7, Q99918, Q9BSZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM