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P46095 (GPR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor 6
Alternative name(s):
Sphingosine 1-phosphate receptor GPR6
Gene names
Name:GPR6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons By similarity. Ref.5 Ref.7

Subcellular location

Cell membrane; Multi-pass membrane protein Probable. Note: Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor. Ref.6

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Was originally (Ref.5) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case (Ref.7).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362G-protein coupled receptor 6
PRO_0000069514

Regions

Topological domain1 – 7474Extracellular Potential
Transmembrane75 – 9420Helical; Name=1; Potential
Topological domain95 – 10612Cytoplasmic Potential
Transmembrane107 – 13024Helical; Name=2; Potential
Topological domain131 – 14212Extracellular Potential
Transmembrane143 – 16422Helical; Name=3; Potential
Topological domain165 – 18521Cytoplasmic Potential
Transmembrane186 – 20520Helical; Name=4; Potential
Topological domain206 – 23025Extracellular Potential
Transmembrane231 – 24919Helical; Name=5; Potential
Topological domain250 – 27728Cytoplasmic Potential
Transmembrane278 – 30427Helical; Name=6; Potential
Topological domain305 – 3095Extracellular Potential
Transmembrane310 – 33122Helical; Name=7; Potential
Topological domain332 – 36231Cytoplasmic Potential
Compositional bias13 – 164Poly-Val
Compositional bias21 – 288Poly-Ala
Compositional bias40 – 434Poly-Ala

Amino acid modifications

Modified residue3561Phosphoserine Potential
Modified residue3581Phosphoserine Potential
Modified residue3601Phosphoserine Potential
Lipidation3451S-palmitoyl cysteine By similarity
Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation511N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P46095 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: AF8C6075603337AD

FASTA36237,881
        10         20         30         40         50         60 
MNASAASLND SQVVVVAAEG AAAAATAAGG PDTGEWGPPA AAALGAGGGA NGSLELSSQL 

        70         80         90        100        110        120 
SAGPPGLLLP AVNPWDVLLC VSGTVIAGEN ALVVALIAST PALRTPMFVL VGSLATADLL 

       130        140        150        160        170        180 
AGCGLILHFV FQYLVPSETV SLLTVGFLVA SFAASVSSLL AITVDRYLSL YNALTYYSRR 

       190        200        210        220        230        240 
TLLGVHLLLA ATWTVSLGLG LLPVLGWNCL AERAACSVVR PLARSHVALL SAAFFMVFGI 

       250        260        270        280        290        300 
MLHLYVRICQ VVWRHAHQIA LQQHCLAPPH LAATRKGVGT LAVVLGTFGA SWLPFAIYCV 

       310        320        330        340        350        360 
VGSHEDPAVY TYATLLPATY NSMINPIIYA FRNQEIQRAL WLLLCGCFQS KVPFRSRSPS 


EV 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of three novel human genes encoding G protein-coupled receptors."
Heiber M., Docherty J.M., Shah G., Nguyen T., Cheng R., Heng H.H.Q., Marchese A., Tsui L.-C., Shi X., George S.R., O'Dowd B.F.
DNA Cell Biol. 14:25-35(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors."
Song Z.-H., Modi W., Bonner T.I.
Genomics 28:347-349(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors."
Uhlenbrock K., Gassenhuber J., Kostenis E.
Cell. Signal. 14:941-953(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY FUNCTION.
[6]"Constitutively active GPR6 is located in the intracellular compartments."
Padmanabhan S., Myers A.G., Prasad B.M.
FEBS Lett. 583:107-112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay."
Yin H., Chu A., Li W., Wang B., Shelton F., Otero F., Nguyen D.G., Caldwell J.S., Chen Y.A.
J. Biol. Chem. 284:12328-12338(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: LACK OF FUNCTION AS A SPHINGOSINE 1-PHOSPHATE RECEPTOR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L36150 Genomic DNA. Translation: AAA63181.1.
U18549 Genomic DNA. Translation: AAA91631.1.
AL591076 Genomic DNA. Translation: CAI17125.1.
BC043414 mRNA. Translation: AAH43414.1.
BC117298 mRNA. Translation: AAI17299.1.
BC126301 mRNA. Translation: AAI26302.1.
PIRI65990.
RefSeqNP_001273028.1. NM_001286099.1.
NP_005275.1. NM_005284.4.
UniGeneHs.46332.

3D structure databases

ProteinModelPortalP46095.
SMRP46095. Positions 56-344.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000275169.

Chemistry

GuidetoPHARMACOLOGY85.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM1170009.

Proteomic databases

PaxDbP46095.
PRIDEP46095.

Protocols and materials databases

DNASU2830.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000275169; ENSP00000275169; ENSG00000146360.
GeneID2830.
KEGGhsa:2830.
UCSCuc003ptu.3. human.

Organism-specific databases

CTD2830.
GeneCardsGC06P110345.
HGNCHGNC:4515. GPR6.
MIM600553. gene.
neXtProtNX_P46095.
PharmGKBPA28904.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327877.
HOGENOMHOG000294075.
HOVERGENHBG079561.
InParanoidP46095.
KOK04313.
PhylomeDBP46095.
TreeFamTF330052.

Gene expression databases

ArrayExpressP46095.
BgeeP46095.
CleanExHS_GPR6.
GenevestigatorP46095.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001151. GPR6.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00649. GPR6ORPHANR.
PR00644. GPRORPHANR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR6.
GenomeRNAi2830.
NextBio11169.
PROP46095.
SOURCESearch...

Entry information

Entry nameGPR6_HUMAN
AccessionPrimary (citable) accession number: P46095
Secondary accession number(s): Q17RJ7, Q5SYL0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries