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Protein

Chemokine XC receptor 1

Gene

XCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level.

GO - Molecular functioni

  • chemokine receptor activity Source: ProtInc

GO - Biological processi

  • chemokine-mediated signaling pathway Source: GOC
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • inflammatory response Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP46094.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine XC receptor 1
Alternative name(s):
G-protein coupled receptor 5
Lymphotactin receptor
XC chemokine receptor 1
Gene namesi
Name:XCR1
Synonyms:CCXCR1, GPR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1625. XCR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence analysisAdd
BLAST
Transmembranei32 – 5928Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini60 – 6910CytoplasmicSequence analysis
Transmembranei70 – 8920Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini90 – 10314ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12522Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini126 – 14217CytoplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16725Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 19023ExtracellularSequence analysisAdd
BLAST
Transmembranei191 – 20919Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini210 – 22516CytoplasmicSequence analysisAdd
BLAST
Transmembranei226 – 25025Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini251 – 26717ExtracellularSequence analysisAdd
BLAST
Transmembranei268 – 29124Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 33342CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35037.

Chemistry

GuidetoPHARMACOLOGYi75.

Polymorphism and mutation databases

BioMutaiXCR1.
DMDMi1170008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Chemokine XC receptor 1PRO_0000070221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi102 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP46094.
PRIDEiP46094.

PTM databases

iPTMnetiP46094.
PhosphoSiteiP46094.

Expressioni

Gene expression databases

BgeeiP46094.
CleanExiHS_XCR1.
ExpressionAtlasiP46094. baseline and differential.
GenevisibleiP46094. HS.

Organism-specific databases

HPAiHPA013169.

Interactioni

Protein-protein interaction databases

MINTiMINT-1535563.
STRINGi9606.ENSP00000310405.

Structurei

3D structure databases

ProteinModelPortaliP46094.
SMRiP46094. Positions 21-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHYH. Eukaryota.
ENOG410XUKS. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG101128.
InParanoidiP46094.
KOiK04193.
OMAiRNVAFSH.
OrthoDBiEOG7M3J0V.
PhylomeDBiP46094.
TreeFamiTF330966.

Family and domain databases

InterProiIPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS
60 70 80 90 100
LVLWVLVKYE SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF
110 120 130 140 150
LCKLLNMIFS ISLYSSIFFL TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT
160 170 180 190 200
MAVWVASILS SILDTIFHKV LSSGCDYSEL TWYLTSVYQH NLFFLLSLGI
210 220 230 240 250
ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP YNFTLFLQTL
260 270 280 290 300
FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH
310 320 330
VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY
Length:333
Mass (Da):38,508
Last modified:November 1, 1995 - v1
Checksum:iC84E7A3EF919CFA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36149 Genomic DNA. Translation: AAA62837.1.
AY275469 Genomic DNA. Translation: AAP32301.1.
BC069075 mRNA. Translation: AAH69075.1.
BC069589 mRNA. Translation: AAH69589.1.
CCDSiCCDS2736.1.
PIRiI65989.
RefSeqiNP_001019815.1. NM_001024644.1.
NP_005274.1. NM_005283.2.
UniGeneiHs.248116.

Genome annotation databases

EnsembliENST00000309285; ENSP00000310405; ENSG00000173578.
GeneIDi2829.
KEGGihsa:2829.
UCSCiuc003cpd.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36149 Genomic DNA. Translation: AAA62837.1.
AY275469 Genomic DNA. Translation: AAP32301.1.
BC069075 mRNA. Translation: AAH69075.1.
BC069589 mRNA. Translation: AAH69589.1.
CCDSiCCDS2736.1.
PIRiI65989.
RefSeqiNP_001019815.1. NM_001024644.1.
NP_005274.1. NM_005283.2.
UniGeneiHs.248116.

3D structure databases

ProteinModelPortaliP46094.
SMRiP46094. Positions 21-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1535563.
STRINGi9606.ENSP00000310405.

Chemistry

GuidetoPHARMACOLOGYi75.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP46094.
PhosphoSiteiP46094.

Polymorphism and mutation databases

BioMutaiXCR1.
DMDMi1170008.

Proteomic databases

PaxDbiP46094.
PRIDEiP46094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309285; ENSP00000310405; ENSG00000173578.
GeneIDi2829.
KEGGihsa:2829.
UCSCiuc003cpd.2. human.

Organism-specific databases

CTDi2829.
GeneCardsiXCR1.
HGNCiHGNC:1625. XCR1.
HPAiHPA013169.
MIMi600552. gene.
neXtProtiNX_P46094.
PharmGKBiPA35037.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHYH. Eukaryota.
ENOG410XUKS. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG101128.
InParanoidiP46094.
KOiK04193.
OMAiRNVAFSH.
OrthoDBiEOG7M3J0V.
PhylomeDBiP46094.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP46094.

Miscellaneous databases

ChiTaRSiXCR1. human.
GeneWikiiXCR1.
GenomeRNAii2829.
PROiP46094.
SOURCEiSearch...

Gene expression databases

BgeeiP46094.
CleanExiHS_XCR1.
ExpressionAtlasiP46094. baseline and differential.
GenevisibleiP46094. HS.

Family and domain databases

InterProiIPR005393. Chemokine_XCR1.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01568. LYMPHOTACTNR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Identification of single C motif-1/lymphotactin receptor XCR1."
    Yoshida T., Imai T., Kakizaki M., Nishimura M., Takagi S., Yoshie O.
    J. Biol. Chem. 273:16551-16554(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiXCR1_HUMAN
AccessioniPrimary (citable) accession number: P46094
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.