P46094 (XCR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chemokine XC receptor 1

Alternative name(s):
G-protein coupled receptor 5
Lymphotactin receptor
XC chemokine receptor 1

Gene names

Name:	XCR1
Synonyms:	CCXCR1, GPR5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement Ref.4. Source: ProtInc chemotaxis Traceable author statement Ref.4. Source: ProtInc elevation of cytosolic calcium ion concentration Traceable author statement Ref.4. Source: ProtInc inflammatory response Traceable author statement Ref.4. Source: ProtInc release of sequestered calcium ion into cytosol Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Traceable author statement Ref.4. Source: ProtInc
Molecular_function	chemokine receptor activity Traceable author statement PubMed 10679309. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Chemokine XC receptor 1		PRO_0000070221
Regions
	Topological domain	1 – 31	31	Extracellular Potential
	Transmembrane	32 – 59	28	Helical; Name=1; Potential
	Topological domain	60 – 69	10	Cytoplasmic Potential
	Transmembrane	70 – 89	20	Helical; Name=2; Potential
	Topological domain	90 – 103	14	Extracellular Potential
	Transmembrane	104 – 125	22	Helical; Name=3; Potential
	Topological domain	126 – 142	17	Cytoplasmic Potential
	Transmembrane	143 – 167	25	Helical; Name=4; Potential
	Topological domain	168 – 190	23	Extracellular Potential
	Transmembrane	191 – 209	19	Helical; Name=5; Potential
	Topological domain	210 – 225	16	Cytoplasmic Potential
	Transmembrane	226 – 250	25	Helical; Name=6; Potential
	Topological domain	251 – 267	17	Extracellular Potential
	Transmembrane	268 – 291	24	Helical; Name=7; Potential
	Topological domain	292 – 333	42	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	102 ↔ 175		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46094 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: C84E7A3EF919CFA5	FASTA	333	38,508
	10 20 30 40 50 60 MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS LVLWVLVKYE 70 80 90 100 110 120 SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF LCKLLNMIFS ISLYSSIFFL 130 140 150 160 170 180 TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT MAVWVASILS SILDTIFHKV LSSGCDYSEL 190 200 210 220 230 240 TWYLTSVYQH NLFFLLSLGI ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP 250 260 270 280 290 300 YNFTLFLQTL FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH 310 320 330 VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of three novel human genes encoding G protein-coupled receptors." Heiber M., Docherty J.M., Shah G., Nguyen T., Cheng R., Heng H.H.Q., Marchese A., Tsui L.-C., Shi X., George S.R., O'Dowd B.F. DNA Cell Biol. 14:25-35(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Warren C.N., Aronstam R.S., Sharma S.V. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Identification of single C motif-1/lymphotactin receptor XCR1." Yoshida T., Imai T., Kakizaki M., Nishimura M., Takagi S., Yoshie O. J. Biol. Chem. 273:16551-16554(1998) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L36149 Genomic DNA. Translation: AAA62837.1. AY275469 Genomic DNA. Translation: AAP32301.1. BC069075 mRNA. Translation: AAH69075.1. BC069589 mRNA. Translation: AAH69589.1.
IPI	IPI00004349.
PIR	I65989.
RefSeq	NP_001019815.1. NM_001024644.1. NP_005274.1. NM_005283.2.
UniGene	Hs.248116.
3D structure databases
ProteinModelPortal	P46094.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1535563.
STRING	9606.ENSP00000310405.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P46094.
Polymorphism databases
DMDM	1170008.
Proteomic databases
PaxDb	P46094.
PRIDE	P46094.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309285; ENSP00000310405; ENSG00000173578. ENST00000542109; ENSP00000438119; ENSG00000173578.
GeneID	2829.
KEGG	hsa:2829.
UCSC	uc003cpe.3. human.
Organism-specific databases
CTD	2829.
GeneCards	GC03M046037.
HGNC	HGNC:1625. XCR1.
HPA	HPA013169.
MIM	600552. gene.
neXtProt	NX_P46094.
PharmGKB	PA35037.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG151106.
HOGENOM	HOG000234122.
HOVERGEN	HBG101128.
InParanoid	P46094.
KO	K04193.
OMA	APYNLIL.
OrthoDB	EOG4HQDK9.
PhylomeDB	P46094.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P46094.
Bgee	P46094.
CleanEx	HS_XCR1.
Genevestigator	P46094.
GermOnline	ENSG00000173578. Homo sapiens.
Family and domain databases
InterPro	IPR000355. Chemokine_rcpt. IPR005393. Chemokine_XCR1. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24227. PTHR24227. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01568. LYMPHOTACTNR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P46094.
ChEMBL	CHEMBL4339.
GenomeRNAi	2829.
NextBio	11163.
SOURCE	Search...

Entry information

Entry name

XCR1_HUMAN

Accession

Primary (citable) accession number: P46094

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 29, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.