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P46093

- GPR4_HUMAN

UniProt

P46093 - GPR4_HUMAN

Protein

G-protein coupled receptor 4

Gene

GPR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.2 Publications

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 4
    Alternative name(s):
    G-protein coupled receptor 19
    Gene namesi
    Name:GPR4
    Synonyms:GPR19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4497. GPR4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28886.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362G-protein coupled receptor 4PRO_0000069512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi90 ↔ 168PROSITE-ProRule annotation
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP46093.
    PRIDEiP46093.

    Expressioni

    Gene expression databases

    BgeeiP46093.
    CleanExiHS_GPR19.
    HS_GPR4.
    GenevestigatoriP46093.

    Organism-specific databases

    HPAiHPA014278.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000319744.

    Structurei

    3D structure databases

    ProteinModelPortaliP46093.
    SMRiP46093. Positions 18-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini43 – 5412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 9115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini114 – 13219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini155 – 17925ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini202 – 22423CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini246 – 26318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini285 – 36278CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 4225Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7622Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei92 – 11322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei133 – 15422Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei180 – 20122Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149070.
    HOGENOMiHOG000004801.
    HOVERGENiHBG096696.
    InParanoidiP46093.
    KOiK04312.
    OMAiNHTFCFE.
    OrthoDBiEOG7992QK.
    PhylomeDBiP46093.
    TreeFamiTF331803.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002276. GPR4_orph.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01147. GPR4RECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46093-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNHTWEGCH VDSRVDHLFP PSLYIFVIGV GLPTNCLALW AAYRQVQQRN    50
    ELGVYLMNLS IADLLYICTL PLWVDYFLHH DNWIHGPGSC KLFGFIFYTN 100
    IYISIAFLCC ISVDRYLAVA HPLRFARLRR VKTAVAVSSV VWATELGANS 150
    APLFHDELFR DRYNHTFCFE KFPMEGWVAW MNLYRVFVGF LFPWALMLLS 200
    YRGILRAVRG SVSTERQEKA KIKRLALSLI AIVLVCFAPY HVLLLSRSAI 250
    YLGRPWDCGF EERVFSAYHS SLAFTSLNCV ADPILYCLVN EGARSDVAKA 300
    LHNLLRFLAS DKPQEMANAS LTLETPLTSK RNSTAKAMTG SWAATPPSQG 350
    DQVQLKMLPP AQ 362
    Length:362
    Mass (Da):40,982
    Last modified:October 1, 1996 - v2
    Checksum:i6C75D97C36204541
    GO

    Sequence cautioni

    The sequence AAA63180.1 differs from that shown. Reason: Frameshift at position 347.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571M → L in AAA79061. (PubMed:7498459)Curated
    Sequence conflicti69 – 691T → S in AAA79061. (PubMed:7498459)Curated
    Sequence conflicti130 – 1301R → C in AAH67535. (PubMed:15489334)Curated
    Sequence conflicti255 – 2551P → L in BAF83387. (PubMed:14702039)Curated
    Sequence conflicti337 – 3371A → V in AAA79061. (PubMed:7498459)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti295 – 2951S → N.
    Corresponds to variant rs36012326 [ dbSNP | Ensembl ].
    VAR_049390

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36148 Genomic DNA. Translation: AAA63180.1. Frameshift.
    U21051 Genomic DNA. Translation: AAA98457.1.
    U35399 mRNA. Translation: AAA79061.1.
    EU432116 mRNA. Translation: ABY87915.1.
    AK290698 mRNA. Translation: BAF83387.1.
    AC011480 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57368.1.
    BC067535 mRNA. Translation: AAH67535.1.
    BC067536 mRNA. Translation: AAH67536.1.
    CCDSiCCDS12669.1.
    PIRiA57641.
    I53033.
    S68207.
    RefSeqiNP_005273.1. NM_005282.2.
    UniGeneiHs.17170.

    Genome annotation databases

    EnsembliENST00000323040; ENSP00000319744; ENSG00000177464.
    GeneIDi2828.
    KEGGihsa:2828.
    UCSCiuc002pcm.3. human.

    Polymorphism databases

    DMDMi1708027.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36148 Genomic DNA. Translation: AAA63180.1 . Frameshift.
    U21051 Genomic DNA. Translation: AAA98457.1 .
    U35399 mRNA. Translation: AAA79061.1 .
    EU432116 mRNA. Translation: ABY87915.1 .
    AK290698 mRNA. Translation: BAF83387.1 .
    AC011480 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57368.1 .
    BC067535 mRNA. Translation: AAH67535.1 .
    BC067536 mRNA. Translation: AAH67536.1 .
    CCDSi CCDS12669.1.
    PIRi A57641.
    I53033.
    S68207.
    RefSeqi NP_005273.1. NM_005282.2.
    UniGenei Hs.17170.

    3D structure databases

    ProteinModelPortali P46093.
    SMRi P46093. Positions 18-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000319744.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 1708027.

    Proteomic databases

    PaxDbi P46093.
    PRIDEi P46093.

    Protocols and materials databases

    DNASUi 2828.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323040 ; ENSP00000319744 ; ENSG00000177464 .
    GeneIDi 2828.
    KEGGi hsa:2828.
    UCSCi uc002pcm.3. human.

    Organism-specific databases

    CTDi 2828.
    GeneCardsi GC19M046093.
    HGNCi HGNC:4497. GPR4.
    HPAi HPA014278.
    MIMi 600551. gene.
    neXtProti NX_P46093.
    PharmGKBi PA28886.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149070.
    HOGENOMi HOG000004801.
    HOVERGENi HBG096696.
    InParanoidi P46093.
    KOi K04312.
    OMAi NHTFCFE.
    OrthoDBi EOG7992QK.
    PhylomeDBi P46093.
    TreeFami TF331803.

    Enzyme and pathway databases

    Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii GPR4.
    GenomeRNAii 2828.
    NextBioi 11159.
    PROi P46093.
    SOURCEi Search...

    Gene expression databases

    Bgeei P46093.
    CleanExi HS_GPR19.
    HS_GPR4.
    Genevestigatori P46093.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002276. GPR4_orph.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01147. GPR4RECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3."
      Mahadevan M.S., Baird S., Bailly J.E., Shutler G.G., Sabourin L.A., Tsilfidis C., Neville C.E., Narang M., Korneluk R.G.
      Genomics 30:84-88(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue."
      An S., Tsai C., Goetzl E.J.
      FEBS Lett. 375:121-124(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. "Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4."
      Zhu K., Baudhuin L.M., Hong G., Williams F.S., Cristina K.L., Kabarowski J.H., Witte O.N., Xu Y.
      J. Biol. Chem. 276:41325-41335(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY FUNCTION.
    10. Erratum
      Zhu K., Baudhuin L.M., Hong G., Williams F.S., Cristina K.L., Kabarowski J.H., Witte O.N., Xu Y.
      J. Biol. Chem. 280:43280-43280(2005)
      Cited for: RETRACTION.
    11. Cited for: FUNCTION.
    12. "Previously postulated 'ligand-independent' signaling of GPR4 is mediated through proton-sensing mechanisms."
      Tobo M., Tomura H., Mogi C., Wang J.Q., Liu J.P., Komachi M., Damirin A., Kimura T., Murata N., Kurose H., Sato K., Okajima F.
      Cell. Signal. 19:1745-1753(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiGPR4_HUMAN
    AccessioniPrimary (citable) accession number: P46093
    Secondary accession number(s): A8K3T3, B0M0K1, Q6NWM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3