Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P46093

- GPR4_HUMAN

UniProt

P46093 - GPR4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

G-protein coupled receptor 4

Gene

GPR4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.2 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 4
Alternative name(s):
G-protein coupled receptor 19
Gene namesi
Name:GPR4
Synonyms:GPR19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:4497. GPR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717ExtracellularSequence AnalysisAdd
BLAST
Transmembranei18 – 4225Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini43 – 5412CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei55 – 7622Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 9115ExtracellularSequence AnalysisAdd
BLAST
Transmembranei92 – 11322Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini114 – 13219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei133 – 15422Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini155 – 17925ExtracellularSequence AnalysisAdd
BLAST
Transmembranei180 – 20122Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini202 – 22423CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei225 – 24521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini246 – 26318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei264 – 28421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini285 – 36278CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362G-protein coupled receptor 4PRO_0000069512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi90 ↔ 168PROSITE-ProRule annotation
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP46093.
PRIDEiP46093.

Expressioni

Gene expression databases

BgeeiP46093.
CleanExiHS_GPR19.
HS_GPR4.
GenevestigatoriP46093.

Organism-specific databases

HPAiHPA014278.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319744.

Structurei

3D structure databases

ProteinModelPortaliP46093.
SMRiP46093. Positions 18-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149070.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
HOVERGENiHBG096696.
InParanoidiP46093.
KOiK04312.
OMAiNHTFCFE.
OrthoDBiEOG7992QK.
PhylomeDBiP46093.
TreeFamiTF331803.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002276. GPR4_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01147. GPR4RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46093-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNHTWEGCH VDSRVDHLFP PSLYIFVIGV GLPTNCLALW AAYRQVQQRN
60 70 80 90 100
ELGVYLMNLS IADLLYICTL PLWVDYFLHH DNWIHGPGSC KLFGFIFYTN
110 120 130 140 150
IYISIAFLCC ISVDRYLAVA HPLRFARLRR VKTAVAVSSV VWATELGANS
160 170 180 190 200
APLFHDELFR DRYNHTFCFE KFPMEGWVAW MNLYRVFVGF LFPWALMLLS
210 220 230 240 250
YRGILRAVRG SVSTERQEKA KIKRLALSLI AIVLVCFAPY HVLLLSRSAI
260 270 280 290 300
YLGRPWDCGF EERVFSAYHS SLAFTSLNCV ADPILYCLVN EGARSDVAKA
310 320 330 340 350
LHNLLRFLAS DKPQEMANAS LTLETPLTSK RNSTAKAMTG SWAATPPSQG
360
DQVQLKMLPP AQ
Length:362
Mass (Da):40,982
Last modified:October 1, 1996 - v2
Checksum:i6C75D97C36204541
GO

Sequence cautioni

The sequence AAA63180.1 differs from that shown. Reason: Frameshift at position 347. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571M → L in AAA79061. (PubMed:7498459)Curated
Sequence conflicti69 – 691T → S in AAA79061. (PubMed:7498459)Curated
Sequence conflicti130 – 1301R → C in AAH67535. (PubMed:15489334)Curated
Sequence conflicti255 – 2551P → L in BAF83387. (PubMed:14702039)Curated
Sequence conflicti337 – 3371A → V in AAA79061. (PubMed:7498459)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti295 – 2951S → N.
Corresponds to variant rs36012326 [ dbSNP | Ensembl ].
VAR_049390

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36148 Genomic DNA. Translation: AAA63180.1. Frameshift.
U21051 Genomic DNA. Translation: AAA98457.1.
U35399 mRNA. Translation: AAA79061.1.
EU432116 mRNA. Translation: ABY87915.1.
AK290698 mRNA. Translation: BAF83387.1.
AC011480 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57368.1.
BC067535 mRNA. Translation: AAH67535.1.
BC067536 mRNA. Translation: AAH67536.1.
CCDSiCCDS12669.1.
PIRiA57641.
I53033.
S68207.
RefSeqiNP_005273.1. NM_005282.2.
UniGeneiHs.17170.

Genome annotation databases

EnsembliENST00000323040; ENSP00000319744; ENSG00000177464.
GeneIDi2828.
KEGGihsa:2828.
UCSCiuc002pcm.3. human.

Polymorphism databases

DMDMi1708027.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36148 Genomic DNA. Translation: AAA63180.1 . Frameshift.
U21051 Genomic DNA. Translation: AAA98457.1 .
U35399 mRNA. Translation: AAA79061.1 .
EU432116 mRNA. Translation: ABY87915.1 .
AK290698 mRNA. Translation: BAF83387.1 .
AC011480 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57368.1 .
BC067535 mRNA. Translation: AAH67535.1 .
BC067536 mRNA. Translation: AAH67536.1 .
CCDSi CCDS12669.1.
PIRi A57641.
I53033.
S68207.
RefSeqi NP_005273.1. NM_005282.2.
UniGenei Hs.17170.

3D structure databases

ProteinModelPortali P46093.
SMRi P46093. Positions 18-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000319744.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 1708027.

Proteomic databases

PaxDbi P46093.
PRIDEi P46093.

Protocols and materials databases

DNASUi 2828.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323040 ; ENSP00000319744 ; ENSG00000177464 .
GeneIDi 2828.
KEGGi hsa:2828.
UCSCi uc002pcm.3. human.

Organism-specific databases

CTDi 2828.
GeneCardsi GC19M046093.
HGNCi HGNC:4497. GPR4.
HPAi HPA014278.
MIMi 600551. gene.
neXtProti NX_P46093.
PharmGKBi PA28886.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149070.
GeneTreei ENSGT00760000119001.
HOGENOMi HOG000004801.
HOVERGENi HBG096696.
InParanoidi P46093.
KOi K04312.
OMAi NHTFCFE.
OrthoDBi EOG7992QK.
PhylomeDBi P46093.
TreeFami TF331803.

Enzyme and pathway databases

Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii GPR4.
GenomeRNAii 2828.
NextBioi 11159.
PROi P46093.
SOURCEi Search...

Gene expression databases

Bgeei P46093.
CleanExi HS_GPR19.
HS_GPR4.
Genevestigatori P46093.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002276. GPR4_orph.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01147. GPR4RECEPTOR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3."
    Mahadevan M.S., Baird S., Bailly J.E., Shutler G.G., Sabourin L.A., Tsilfidis C., Neville C.E., Narang M., Korneluk R.G.
    Genomics 30:84-88(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue."
    An S., Tsai C., Goetzl E.J.
    FEBS Lett. 375:121-124(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4."
    Zhu K., Baudhuin L.M., Hong G., Williams F.S., Cristina K.L., Kabarowski J.H., Witte O.N., Xu Y.
    J. Biol. Chem. 276:41325-41335(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY FUNCTION.
  10. Erratum
    Zhu K., Baudhuin L.M., Hong G., Williams F.S., Cristina K.L., Kabarowski J.H., Witte O.N., Xu Y.
    J. Biol. Chem. 280:43280-43280(2005)
    Cited for: RETRACTION.
  11. Cited for: FUNCTION.
  12. "Previously postulated 'ligand-independent' signaling of GPR4 is mediated through proton-sensing mechanisms."
    Tobo M., Tomura H., Mogi C., Wang J.Q., Liu J.P., Komachi M., Damirin A., Kimura T., Murata N., Kurose H., Sato K., Okajima F.
    Cell. Signal. 19:1745-1753(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGPR4_HUMAN
AccessioniPrimary (citable) accession number: P46093
Secondary accession number(s): A8K3T3, B0M0K1, Q6NWM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3