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P46092

- CCR10_HUMAN

UniProt

P46092 - CCR10_HUMAN

Protein

C-C chemokine receptor type 10

Gene

CCR10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 3 (29 Mar 2005)
      Previous versions | rss
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    Functioni

    Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

    GO - Molecular functioni

    1. C-C chemokine receptor activity Source: Ensembl
    2. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. chemotaxis Source: Ensembl
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. immune response Source: InterPro
    4. positive regulation of cytosolic calcium ion concentration Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.
    SignaLinkiP46092.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C chemokine receptor type 10
    Short name:
    C-C CKR-10
    Short name:
    CC-CKR-10
    Short name:
    CCR-10
    Alternative name(s):
    G-protein coupled receptor 2
    Gene namesi
    Name:CCR10
    Synonyms:GPR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:4474. CCR10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28862.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362C-C chemokine receptor type 10PRO_0000069293Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi113 ↔ 191PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiP46092.
    PaxDbiP46092.
    PRIDEiP46092.

    PTM databases

    PhosphoSiteiP46092.

    Expressioni

    Tissue specificityi

    Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.1 Publication

    Gene expression databases

    ArrayExpressiP46092.
    BgeeiP46092.
    CleanExiHS_CCR10.
    GenevestigatoriP46092.

    Organism-specific databases

    HPAiCAB011684.

    Interactioni

    Protein-protein interaction databases

    BioGridi109087. 5 interactions.
    DIPiDIP-5873N.
    IntActiP46092. 4 interactions.
    MINTiMINT-123760.
    STRINGi9606.ENSP00000332504.

    Structurei

    3D structure databases

    ProteinModelPortaliP46092.
    SMRiP46092. Positions 51-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini69 – 7810CytoplasmicSequence Analysis
    Topological domaini100 – 11415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15923CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 20324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 24722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini270 – 29021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 36249CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 6816Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei115 – 13622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 17920Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22522Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26922Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei291 – 31323Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147369.
    HOGENOMiHOG000234122.
    HOVERGENiHBG096538.
    InParanoidiP46092.
    KOiK04185.
    OMAiVMAACYA.
    OrthoDBiEOG7SXW4F.
    PhylomeDBiP46092.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR005382. Chemokine_CCR10.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01557. CHEMOKINER10.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46092-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT    50
    VAALGLAGNG LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA 100
    GALQGWSLGS ATCRTISGLY SASFHAGFLF LACISADRYV AIARALPAGP 150
    RPSTPGRAHL VSVIVWLLSL LLALPALLFS QDGQREGQRR CRLIFPEGLT 200
    QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP ERRRALRVVV 250
    ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL 300
    ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS 350
    APTETHSLSW DN 362
    Length:362
    Mass (Da):38,416
    Last modified:March 29, 2005 - v3
    Checksum:i736EB9B639AEA99A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti51 – 511V → L in AAA64593. (PubMed:7851889)Curated
    Sequence conflicti235 – 2351Missing in AAF72871. (PubMed:10725697)Curated
    Sequence conflicti330 – 3301C → S(PubMed:10725696)Curated
    Sequence conflicti330 – 3301C → S(PubMed:7851889)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215981 mRNA. Translation: AAF63709.1.
    AF208237 mRNA. Translation: AAF72871.1.
    AY429103 mRNA. Translation: AAR07898.1.
    BC098132 mRNA. Translation: AAH98132.1.
    BC098157 mRNA. Translation: AAH98157.1.
    BC098304 mRNA. Translation: AAH98304.1.
    BC099840 mRNA. Translation: AAH99840.1.
    U13667 Genomic DNA. Translation: AAA64593.1.
    CCDSiCCDS11435.1.
    PIRiB55733.
    RefSeqiNP_057686.2. NM_016602.2.
    UniGeneiHs.744542.

    Genome annotation databases

    EnsembliENST00000332438; ENSP00000332504; ENSG00000184451.
    GeneIDi2826.
    KEGGihsa:2826.
    UCSCiuc002iax.4. human.

    Polymorphism databases

    DMDMi62298314.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CC chemokine receptors entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215981 mRNA. Translation: AAF63709.1 .
    AF208237 mRNA. Translation: AAF72871.1 .
    AY429103 mRNA. Translation: AAR07898.1 .
    BC098132 mRNA. Translation: AAH98132.1 .
    BC098157 mRNA. Translation: AAH98157.1 .
    BC098304 mRNA. Translation: AAH98304.1 .
    BC099840 mRNA. Translation: AAH99840.1 .
    U13667 Genomic DNA. Translation: AAA64593.1 .
    CCDSi CCDS11435.1.
    PIRi B55733.
    RefSeqi NP_057686.2. NM_016602.2.
    UniGenei Hs.744542.

    3D structure databases

    ProteinModelPortali P46092.
    SMRi P46092. Positions 51-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109087. 5 interactions.
    DIPi DIP-5873N.
    IntActi P46092. 4 interactions.
    MINTi MINT-123760.
    STRINGi 9606.ENSP00000332504.

    Chemistry

    ChEMBLi CHEMBL2321628.
    GuidetoPHARMACOLOGYi 67.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P46092.

    Polymorphism databases

    DMDMi 62298314.

    Proteomic databases

    MaxQBi P46092.
    PaxDbi P46092.
    PRIDEi P46092.

    Protocols and materials databases

    DNASUi 2826.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332438 ; ENSP00000332504 ; ENSG00000184451 .
    GeneIDi 2826.
    KEGGi hsa:2826.
    UCSCi uc002iax.4. human.

    Organism-specific databases

    CTDi 2826.
    GeneCardsi GC17M040830.
    HGNCi HGNC:4474. CCR10.
    HPAi CAB011684.
    MIMi 600240. gene.
    neXtProti NX_P46092.
    PharmGKBi PA28862.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147369.
    HOGENOMi HOG000234122.
    HOVERGENi HBG096538.
    InParanoidi P46092.
    KOi K04185.
    OMAi VMAACYA.
    OrthoDBi EOG7SXW4F.
    PhylomeDBi P46092.
    TreeFami TF330966.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.
    SignaLinki P46092.

    Miscellaneous databases

    GeneWikii CCR10.
    GenomeRNAii 2826.
    NextBioi 11151.
    PROi P46092.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46092.
    Bgeei P46092.
    CleanExi HS_CCR10.
    Genevestigatori P46092.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR005382. Chemokine_CCR10.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01557. CHEMOKINER10.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine."
      Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., Clark-Lewis I., Gerard C.
      J. Immunol. 164:3460-3464(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    2. "The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)."
      Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., Lehmann P., Oldham E., Zlotnik A.
      J. Immunol. 164:3465-3470(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-362.
    6. Cited for: LIGAND-BINDING, TISSUE SPECIFICITY.
    7. "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues."
      Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D.
      J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND-BINDING.

    Entry informationi

    Entry nameiCCR10_HUMAN
    AccessioniPrimary (citable) accession number: P46092
    Secondary accession number(s): Q4V749, Q6T7X2, Q9NZG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: March 29, 2005
    Last modified: October 1, 2014
    This is version 137 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3