Reviewed,
UniProtKB/Swiss-Prot P46092 (CCR10_HUMAN)
Last modified
November 3, 2009.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: C-C chemokine receptor type 10 Short name=C-C CKR-10 Short name=CC-CKR-10 Short name=CCR-10 Alternative name(s): G-protein coupled receptor 2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 362 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. |
| Subcellular location | |
| Tissue specificity | Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells. Ref.6 |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Disulfide bond Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | G-protein coupled receptor protein signaling pathway Ref.5 Inferred from Experiment. Source: Reactome |
| Cellular component | integral to plasma membrane Ref.5 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| BAT2 | P48634 | 1 | EBI-348022,EBI-347545 | |
| FYN | P06241 | 1 | EBI-348022,EBI-515315 | |
| GRB2 | P62993 | 1 | EBI-348022,EBI-401755 | |
| NCK1 | P16333 | 1 | EBI-348022,EBI-389883 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 362 | 362 | C-C chemokine receptor type 10 | PRO_0000069293 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 52 | 52 | Extracellular Potential | ||||||||
| Transmembrane | 53 – 68 | 16 | 1 Potential | ||||||||
| Topological domain | 69 – 78 | 10 | Cytoplasmic Potential | ||||||||
| Transmembrane | 79 – 99 | 21 | 2 Potential | ||||||||
| Topological domain | 100 – 114 | 15 | Extracellular Potential | ||||||||
| Transmembrane | 115 – 136 | 22 | 3 Potential | ||||||||
| Topological domain | 137 – 159 | 23 | Cytoplasmic Potential | ||||||||
| Transmembrane | 160 – 179 | 20 | 4 Potential | ||||||||
| Topological domain | 180 – 203 | 24 | Extracellular Potential | ||||||||
| Transmembrane | 204 – 225 | 22 | 5 Potential | ||||||||
| Topological domain | 226 – 247 | 22 | Cytoplasmic Potential | ||||||||
| Transmembrane | 248 – 269 | 22 | 6 Potential | ||||||||
| Topological domain | 270 – 290 | 21 | Extracellular Potential | ||||||||
| Transmembrane | 291 – 313 | 23 | 7 Potential | ||||||||
| Topological domain | 314 – 362 | 49 | Cytoplasmic Potential | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 295 | 1 | Phosphothreonine Ref.8 | ||||||||
| Modified residue | 296 | 1 | Phosphoserine Ref.8 | ||||||||
| Disulfide bond | 113 ↔ 191 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 51 | 1 | V → L in AAA64593. Ref.5 | ||||||||
| Sequence conflict | 235 | 1 | Missing in AAF72871. Ref.2 | ||||||||
| Sequence conflict | 330 | 1 | C → S Ref.1 | ||||||||
| Sequence conflict | 330 | 1 | C → S Ref.5 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine." Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., Clark-Lewis I., Gerard C. J. Immunol. 164:3460-3464(2000) [PubMed: 10725696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. |
| [2] | "The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)." Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., Lehmann P., Oldham E., Zlotnik A. J. Immunol. 164:3465-3470(2000) [PubMed: 10725697] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. |
| [3] | "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "Cloning of human genes encoding novel G protein-coupled receptors." Marchese A., Docherty J.M., Nguyen T., Heiber M., Cheng R., Heng H.H.Q., Tsui L.-C., Shi X., George S.R., O'Dowd B.F. Genomics 23:609-618(1994) [PubMed: 7851889] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-362. |
| [6] | "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)." Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D., Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J., Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A. J. Biol. Chem. 275:22313-22323(2000) [PubMed: 10781587] [Abstract] Cited for: LIGAND-BINDING, TISSUE SPECIFICITY. |
| [7] | "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues." Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D. J. Immunol. 165:2943-2949(2000) [PubMed: 10975800] [Abstract] Cited for: LIGAND-BINDING. |
| [8] | "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-295 AND SER-296, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF215981 mRNA. Translation: AAF63709.1. AF208237 mRNA. Translation: AAF72871.1. AY429103 mRNA. Translation: AAR07898.1. BC098132 mRNA. Translation: AAH98132.1. BC098157 mRNA. Translation: AAH98157.1. BC098304 mRNA. Translation: AAH98304.1. BC099840 mRNA. Translation: AAH99840.1. U13667 Genomic DNA. Translation: AAA64593.1. | |
| IPI | IPI00004346. |
| PIR | B55733. |
| RefSeq | NP_057686.2. |
| UniGene | Hs.710983 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:5873N. |
| IntAct | P46092. 4 interactions. |
| STRING | P46092. |
Protein family/group databases | |
| GPCRDB | Search... |
PTM databases | |
| PhosphoSite | P46092. |
Proteomic databases | |
| PRIDE | P46092. |
Genome annotation databases | |
| Ensembl | ENST00000332438; ENSP00000332504; ENSG00000184451; Homo sapiens. [Genome view] |
| GeneID | 2826. |
| KEGG | hsa:2826. |
| UCSC | uc002iax.2. human. |
Organism-specific databases | |
| CTD | 2826. |
| GeneCards | GC17M038086. |
| H-InvDB | HIX0039075. |
| HGNC | HGNC:4474. CCR10. |
| HPA | CAB011684. |
| MIM | 600240. gene. |
| PharmGKB | PA28862. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P46092. |
| HOVERGEN | P46092. |
| OMA | MAACYAL. |
Enzyme and pathway databases | |
| Reactome | REACT_14797. Signaling by GPCR. |
Gene expression databases | |
| ArrayExpress | P46092. |
| Bgee | P46092. |
| CleanEx | HS_CCR10. |
| Genevestigator | P46092. |
| GermOnline | ENSG00000184451. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000276. 7TM_GPCR_Rhodpsn. IPR005382. CC_10_rcpt. IPR000355. Chmkine_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view] |
| PANTHER | PTHR19264:SF249. CC_10_rcpt. 1 hit. |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR00657. CCCHEMOKINER. PR01557. CHEMOKINER10. PR00237. GPCRRHODOPSN. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 11151. |
| SOURCE | Search... |
Entry information
| Entry name | CCR10_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P46092 Secondary accession number(s): Q4V749, Q6T7X2, Q9NZG2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


