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Protein

C-C chemokine receptor type 10

Gene

CCR10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

GO - Molecular functioni

  • C-C chemokine receptor activity Source: Ensembl
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP46092.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 10
Short name:
C-C CKR-10
Short name:
CC-CKR-10
Short name:
CCR-10
Alternative name(s):
G-protein coupled receptor 2
Gene namesi
Name:CCR10
Synonyms:GPR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4474. CCR10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
BLAST
Transmembranei53 – 6816Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini69 – 7810CytoplasmicSequence Analysis
Transmembranei79 – 9921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini100 – 11415ExtracellularSequence AnalysisAdd
BLAST
Transmembranei115 – 13622Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15923CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei160 – 17920Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 20324ExtracellularSequence AnalysisAdd
BLAST
Transmembranei204 – 22522Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 24722CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei248 – 26922Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini270 – 29021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei291 – 31323Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini314 – 36249CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28862.

Polymorphism and mutation databases

BioMutaiCCR10.
DMDMi62298314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362C-C chemokine receptor type 10PRO_0000069293Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi113 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP46092.
PaxDbiP46092.
PRIDEiP46092.

PTM databases

PhosphoSiteiP46092.

Expressioni

Tissue specificityi

Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.1 Publication

Gene expression databases

BgeeiP46092.
CleanExiHS_CCR10.
ExpressionAtlasiP46092. baseline and differential.
GenevestigatoriP46092.

Organism-specific databases

HPAiCAB011684.

Interactioni

Protein-protein interaction databases

BioGridi109087. 5 interactions.
DIPiDIP-5873N.
IntActiP46092. 4 interactions.
MINTiMINT-123760.
STRINGi9606.ENSP00000332504.

Structurei

3D structure databases

ProteinModelPortaliP46092.
SMRiP46092. Positions 51-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147369.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG096538.
InParanoidiP46092.
KOiK04185.
OMAiVMAACYA.
OrthoDBiEOG7SXW4F.
PhylomeDBiP46092.
TreeFamiTF330966.

Family and domain databases

InterProiIPR005382. Chemokine_CCR10.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01557. CHEMOKINER10.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT
60 70 80 90 100
VAALGLAGNG LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA
110 120 130 140 150
GALQGWSLGS ATCRTISGLY SASFHAGFLF LACISADRYV AIARALPAGP
160 170 180 190 200
RPSTPGRAHL VSVIVWLLSL LLALPALLFS QDGQREGQRR CRLIFPEGLT
210 220 230 240 250
QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP ERRRALRVVV
260 270 280 290 300
ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL
310 320 330 340 350
ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS
360
APTETHSLSW DN
Length:362
Mass (Da):38,416
Last modified:March 29, 2005 - v3
Checksum:i736EB9B639AEA99A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511V → L in AAA64593 (PubMed:7851889).Curated
Sequence conflicti235 – 2351Missing in AAF72871 (PubMed:10725697).Curated
Sequence conflicti330 – 3301C → S (PubMed:10725696).Curated
Sequence conflicti330 – 3301C → S (PubMed:7851889).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215981 mRNA. Translation: AAF63709.1.
AF208237 mRNA. Translation: AAF72871.1.
AY429103 mRNA. Translation: AAR07898.1.
BC098132 mRNA. Translation: AAH98132.1.
BC098157 mRNA. Translation: AAH98157.1.
BC098304 mRNA. Translation: AAH98304.1.
BC099840 mRNA. Translation: AAH99840.1.
U13667 Genomic DNA. Translation: AAA64593.1.
CCDSiCCDS11435.1.
PIRiB55733.
RefSeqiNP_057686.2. NM_016602.2.
UniGeneiHs.744542.

Genome annotation databases

EnsembliENST00000332438; ENSP00000332504; ENSG00000184451.
GeneIDi2826.
KEGGihsa:2826.
UCSCiuc002iax.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215981 mRNA. Translation: AAF63709.1.
AF208237 mRNA. Translation: AAF72871.1.
AY429103 mRNA. Translation: AAR07898.1.
BC098132 mRNA. Translation: AAH98132.1.
BC098157 mRNA. Translation: AAH98157.1.
BC098304 mRNA. Translation: AAH98304.1.
BC099840 mRNA. Translation: AAH99840.1.
U13667 Genomic DNA. Translation: AAA64593.1.
CCDSiCCDS11435.1.
PIRiB55733.
RefSeqiNP_057686.2. NM_016602.2.
UniGeneiHs.744542.

3D structure databases

ProteinModelPortaliP46092.
SMRiP46092. Positions 51-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109087. 5 interactions.
DIPiDIP-5873N.
IntActiP46092. 4 interactions.
MINTiMINT-123760.
STRINGi9606.ENSP00000332504.

Chemistry

ChEMBLiCHEMBL2321628.
GuidetoPHARMACOLOGYi67.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP46092.

Polymorphism and mutation databases

BioMutaiCCR10.
DMDMi62298314.

Proteomic databases

MaxQBiP46092.
PaxDbiP46092.
PRIDEiP46092.

Protocols and materials databases

DNASUi2826.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332438; ENSP00000332504; ENSG00000184451.
GeneIDi2826.
KEGGihsa:2826.
UCSCiuc002iax.4. human.

Organism-specific databases

CTDi2826.
GeneCardsiGC17M040830.
HGNCiHGNC:4474. CCR10.
HPAiCAB011684.
MIMi600240. gene.
neXtProtiNX_P46092.
PharmGKBiPA28862.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147369.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG096538.
InParanoidiP46092.
KOiK04185.
OMAiVMAACYA.
OrthoDBiEOG7SXW4F.
PhylomeDBiP46092.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP46092.

Miscellaneous databases

GeneWikiiCCR10.
GenomeRNAii2826.
NextBioi11151.
PROiP46092.
SOURCEiSearch...

Gene expression databases

BgeeiP46092.
CleanExiHS_CCR10.
ExpressionAtlasiP46092. baseline and differential.
GenevestigatoriP46092.

Family and domain databases

InterProiIPR005382. Chemokine_CCR10.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01557. CHEMOKINER10.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine."
    Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., Clark-Lewis I., Gerard C.
    J. Immunol. 164:3460-3464(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  2. "The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)."
    Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., Lehmann P., Oldham E., Zlotnik A.
    J. Immunol. 164:3465-3470(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-362.
  6. Cited for: LIGAND-BINDING, TISSUE SPECIFICITY.
  7. "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues."
    Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D.
    J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.

Entry informationi

Entry nameiCCR10_HUMAN
AccessioniPrimary (citable) accession number: P46092
Secondary accession number(s): Q4V749, Q6T7X2, Q9NZG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 29, 2005
Last modified: May 27, 2015
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.