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P46092

- CCR10_HUMAN

UniProt

P46092 - CCR10_HUMAN

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Protein

C-C chemokine receptor type 10

Gene
CCR10, GPR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

GO - Molecular functioni

  1. C-C chemokine receptor activity Source: Ensembl
  2. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. chemotaxis Source: Ensembl
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. immune response Source: InterPro
  4. positive regulation of cytosolic calcium ion concentration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.
SignaLinkiP46092.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 10
Short name:
C-C CKR-10
Short name:
CC-CKR-10
Short name:
CCR-10
Alternative name(s):
G-protein coupled receptor 2
Gene namesi
Name:CCR10
Synonyms:GPR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:4474. CCR10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252Extracellular Reviewed predictionAdd
BLAST
Transmembranei53 – 6816Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini69 – 7810Cytoplasmic Reviewed prediction
Transmembranei79 – 9921Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini100 – 11415Extracellular Reviewed predictionAdd
BLAST
Transmembranei115 – 13622Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini137 – 15923Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei160 – 17920Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini180 – 20324Extracellular Reviewed predictionAdd
BLAST
Transmembranei204 – 22522Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini226 – 24722Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei248 – 26922Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini270 – 29021Extracellular Reviewed predictionAdd
BLAST
Transmembranei291 – 31323Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini314 – 36249Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362C-C chemokine receptor type 10PRO_0000069293Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi113 ↔ 191 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP46092.
PaxDbiP46092.
PRIDEiP46092.

PTM databases

PhosphoSiteiP46092.

Expressioni

Tissue specificityi

Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.1 Publication

Gene expression databases

ArrayExpressiP46092.
BgeeiP46092.
CleanExiHS_CCR10.
GenevestigatoriP46092.

Organism-specific databases

HPAiCAB011684.

Interactioni

Protein-protein interaction databases

BioGridi109087. 5 interactions.
DIPiDIP-5873N.
IntActiP46092. 4 interactions.
MINTiMINT-123760.
STRINGi9606.ENSP00000332504.

Structurei

3D structure databases

ProteinModelPortaliP46092.
SMRiP46092. Positions 51-325.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147369.
HOGENOMiHOG000234122.
HOVERGENiHBG096538.
InParanoidiP46092.
KOiK04185.
OMAiVMAACYA.
OrthoDBiEOG7SXW4F.
PhylomeDBiP46092.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR005382. Chemokine_CCR10.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01557. CHEMOKINER10.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46092-1 [UniParc]FASTAAdd to Basket

« Hide

MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT    50
VAALGLAGNG LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA 100
GALQGWSLGS ATCRTISGLY SASFHAGFLF LACISADRYV AIARALPAGP 150
RPSTPGRAHL VSVIVWLLSL LLALPALLFS QDGQREGQRR CRLIFPEGLT 200
QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP ERRRALRVVV 250
ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL 300
ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS 350
APTETHSLSW DN 362
Length:362
Mass (Da):38,416
Last modified:March 29, 2005 - v3
Checksum:i736EB9B639AEA99A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511V → L in AAA64593. 1 Publication
Sequence conflicti235 – 2351Missing in AAF72871. 1 Publication
Sequence conflicti330 – 3301C → S1 Publication
Sequence conflicti330 – 3301C → S1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF215981 mRNA. Translation: AAF63709.1.
AF208237 mRNA. Translation: AAF72871.1.
AY429103 mRNA. Translation: AAR07898.1.
BC098132 mRNA. Translation: AAH98132.1.
BC098157 mRNA. Translation: AAH98157.1.
BC098304 mRNA. Translation: AAH98304.1.
BC099840 mRNA. Translation: AAH99840.1.
U13667 Genomic DNA. Translation: AAA64593.1.
CCDSiCCDS11435.1.
PIRiB55733.
RefSeqiNP_057686.2. NM_016602.2.
UniGeneiHs.744542.

Genome annotation databases

EnsembliENST00000332438; ENSP00000332504; ENSG00000184451.
GeneIDi2826.
KEGGihsa:2826.
UCSCiuc002iax.4. human.

Polymorphism databases

DMDMi62298314.

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF215981 mRNA. Translation: AAF63709.1 .
AF208237 mRNA. Translation: AAF72871.1 .
AY429103 mRNA. Translation: AAR07898.1 .
BC098132 mRNA. Translation: AAH98132.1 .
BC098157 mRNA. Translation: AAH98157.1 .
BC098304 mRNA. Translation: AAH98304.1 .
BC099840 mRNA. Translation: AAH99840.1 .
U13667 Genomic DNA. Translation: AAA64593.1 .
CCDSi CCDS11435.1.
PIRi B55733.
RefSeqi NP_057686.2. NM_016602.2.
UniGenei Hs.744542.

3D structure databases

ProteinModelPortali P46092.
SMRi P46092. Positions 51-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109087. 5 interactions.
DIPi DIP-5873N.
IntActi P46092. 4 interactions.
MINTi MINT-123760.
STRINGi 9606.ENSP00000332504.

Chemistry

ChEMBLi CHEMBL2321628.
GuidetoPHARMACOLOGYi 67.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P46092.

Polymorphism databases

DMDMi 62298314.

Proteomic databases

MaxQBi P46092.
PaxDbi P46092.
PRIDEi P46092.

Protocols and materials databases

DNASUi 2826.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332438 ; ENSP00000332504 ; ENSG00000184451 .
GeneIDi 2826.
KEGGi hsa:2826.
UCSCi uc002iax.4. human.

Organism-specific databases

CTDi 2826.
GeneCardsi GC17M040830.
HGNCi HGNC:4474. CCR10.
HPAi CAB011684.
MIMi 600240. gene.
neXtProti NX_P46092.
PharmGKBi PA28862.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147369.
HOGENOMi HOG000234122.
HOVERGENi HBG096538.
InParanoidi P46092.
KOi K04185.
OMAi VMAACYA.
OrthoDBi EOG7SXW4F.
PhylomeDBi P46092.
TreeFami TF330966.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.
SignaLinki P46092.

Miscellaneous databases

GeneWikii CCR10.
GenomeRNAii 2826.
NextBioi 11151.
PROi P46092.
SOURCEi Search...

Gene expression databases

ArrayExpressi P46092.
Bgeei P46092.
CleanExi HS_CCR10.
Genevestigatori P46092.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR005382. Chemokine_CCR10.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00657. CCCHEMOKINER.
PR01557. CHEMOKINER10.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine."
    Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., Clark-Lewis I., Gerard C.
    J. Immunol. 164:3460-3464(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  2. "The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)."
    Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., Lehmann P., Oldham E., Zlotnik A.
    J. Immunol. 164:3465-3470(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-362.
  6. Cited for: LIGAND-BINDING, TISSUE SPECIFICITY.
  7. "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues."
    Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D.
    J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.

Entry informationi

Entry nameiCCR10_HUMAN
AccessioniPrimary (citable) accession number: P46092
Secondary accession number(s): Q4V749, Q6T7X2, Q9NZG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 29, 2005
Last modified: September 3, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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