P46092 (CCR10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C chemokine receptor type 10
Short name=C-C CKR-10
Short name=CC-CKR-10
Short name=CCR-10

Alternative name(s):
G-protein coupled receptor 2

Gene names

Name:	CCR10
Synonyms:	GPR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells. Ref.6
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Traceable author statement Ref.5. Source: ProtInc
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: Compara G-protein coupled receptor activity Traceable author statement Ref.5. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	C-C chemokine receptor type 10		PRO_0000069293
Regions
	Topological domain	1 – 52	52	Extracellular Potential
	Transmembrane	53 – 68	16	Helical; Name=1; Potential
	Topological domain	69 – 78	10	Cytoplasmic Potential
	Transmembrane	79 – 99	21	Helical; Name=2; Potential
	Topological domain	100 – 114	15	Extracellular Potential
	Transmembrane	115 – 136	22	Helical; Name=3; Potential
	Topological domain	137 – 159	23	Cytoplasmic Potential
	Transmembrane	160 – 179	20	Helical; Name=4; Potential
	Topological domain	180 – 203	24	Extracellular Potential
	Transmembrane	204 – 225	22	Helical; Name=5; Potential
	Topological domain	226 – 247	22	Cytoplasmic Potential
	Transmembrane	248 – 269	22	Helical; Name=6; Potential
	Topological domain	270 – 290	21	Extracellular Potential
	Transmembrane	291 – 313	23	Helical; Name=7; Potential
	Topological domain	314 – 362	49	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	113 ↔ 191		By similarity
Experimental info
	Sequence conflict	51	1	V → L in AAA64593. Ref.5
	Sequence conflict	235	1	Missing in AAF72871. Ref.2
	Sequence conflict	330	1	C → S Ref.1
	Sequence conflict	330	1	C → S Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P46092 [UniParc]. Last modified March 29, 2005. Version 3. Checksum: 736EB9B639AEA99A	FASTA	362	38,416
	10 20 30 40 50 60 MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT VAALGLAGNG 70 80 90 100 110 120 LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA GALQGWSLGS ATCRTISGLY 130 140 150 160 170 180 SASFHAGFLF LACISADRYV AIARALPAGP RPSTPGRAHL VSVIVWLLSL LLALPALLFS 190 200 210 220 230 240 QDGQREGQRR CRLIFPEGLT QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP 250 260 270 280 290 300 ERRRALRVVV ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL 310 320 330 340 350 360 ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS APTETHSLSW DN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine." Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., Clark-Lewis I., Gerard C. J. Immunol. 164:3460-3464(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[2]	"The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)." Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., Lehmann P., Oldham E., Zlotnik A. J. Immunol. 164:3465-3470(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cloning of human genes encoding novel G protein-coupled receptors." Marchese A., Docherty J.M., Nguyen T., Heiber M., Cheng R., Heng H.H.Q., Tsui L.-C., Shi X., George S.R., O'Dowd B.F. Genomics 23:609-618(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-362.
[6]	"Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)." Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D., Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J., Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A. J. Biol. Chem. 275:22313-22323(2000) [PubMed] [Europe PMC] [Abstract] Cited for: LIGAND-BINDING, TISSUE SPECIFICITY.
[7]	"A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues." Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D. J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract] Cited for: LIGAND-BINDING.
+	Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF215981 mRNA. Translation: AAF63709.1. AF208237 mRNA. Translation: AAF72871.1. AY429103 mRNA. Translation: AAR07898.1. BC098132 mRNA. Translation: AAH98132.1. BC098157 mRNA. Translation: AAH98157.1. BC098304 mRNA. Translation: AAH98304.1. BC099840 mRNA. Translation: AAH99840.1. U13667 Genomic DNA. Translation: AAA64593.1.
IPI	IPI00004346.
PIR	B55733.
RefSeq	NP_057686.2. NM_016602.2.
UniGene	Hs.731104.
3D structure databases
ProteinModelPortal	P46092.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5873N.
IntAct	P46092. 4 interactions.
MINT	MINT-123760.
STRING	9606.ENSP00000332504.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P46092.
Polymorphism databases
DMDM	62298314.
Proteomic databases
PaxDb	P46092.
PRIDE	P46092.
Protocols and materials databases
DNASU	2826.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332438; ENSP00000332504; ENSG00000184451.
GeneID	2826.
KEGG	hsa:2826.
UCSC	uc002iax.4. human.
Organism-specific databases
CTD	2826.
GeneCards	GC17M040830.
HGNC	HGNC:4474. CCR10.
HPA	CAB011684.
MIM	600240. gene.
neXtProt	NX_P46092.
PharmGKB	PA28862.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147369.
HOGENOM	HOG000234122.
HOVERGEN	HBG096538.
InParanoid	P46092.
KO	K04185.
OMA	VMAACYA.
OrthoDB	EOG4QNMXD.
PhylomeDB	P46092.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P46092.
CleanEx	HS_CCR10.
Genevestigator	P46092.
GermOnline	ENSG00000184451. Homo sapiens.
Family and domain databases
InterPro	IPR005382. Chemokine_CCR10. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01557. CHEMOKINER10. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2826.
NextBio	11151.
SOURCE	Search...

Entry information

Entry name

CCR10_HUMAN

Accession

Primary (citable) accession number: P46092
Secondary accession number(s): Q4V749, Q6T7X2, Q9NZG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	March 29, 2005
Last modified:	May 1, 2013
This is version 122 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.