Reviewed, UniProtKB/Swiss-Prot P46092 (CCR10_HUMAN)

Names and origin

Protein names

Recommended name:
    C-C chemokine receptor type 10
      Short name=C-C CKR-10
      Short name=CC-CKR-10
      Short name=CCR-10
Alternative name(s):
    G-protein coupled receptor 2

Gene names

Name:	CCR10
Synonyms:	GPR2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells. Ref.6
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Ref.5 Inferred from Experiment. Source: Reactome
Cellular component	integral to plasma membrane Ref.5 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAT2	P48634	1	EBI-348022,EBI-347545
FYN	P06241	1	EBI-348022,EBI-515315
GRB2	P62993	1	EBI-348022,EBI-401755
NCK1	P16333	1	EBI-348022,EBI-389883

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	C-C chemokine receptor type 10		PRO_0000069293
Regions
	Topological domain	1 – 52	52	Extracellular Potential
	Transmembrane	53 – 68	16	1 Potential
	Topological domain	69 – 78	10	Cytoplasmic Potential
	Transmembrane	79 – 99	21	2 Potential
	Topological domain	100 – 114	15	Extracellular Potential
	Transmembrane	115 – 136	22	3 Potential
	Topological domain	137 – 159	23	Cytoplasmic Potential
	Transmembrane	160 – 179	20	4 Potential
	Topological domain	180 – 203	24	Extracellular Potential
	Transmembrane	204 – 225	22	5 Potential
	Topological domain	226 – 247	22	Cytoplasmic Potential
	Transmembrane	248 – 269	22	6 Potential
	Topological domain	270 – 290	21	Extracellular Potential
	Transmembrane	291 – 313	23	7 Potential
	Topological domain	314 – 362	49	Cytoplasmic Potential
Amino acid modifications
	Modified residue	295	1	Phosphothreonine Ref.8
	Modified residue	296	1	Phosphoserine Ref.8
	Disulfide bond	113 ↔ 191		By similarity
Experimental info
	Sequence conflict	51	1	V → L in AAA64593. Ref.5
	Sequence conflict	235	1	Missing in AAF72871. Ref.2
	Sequence conflict	330	1	C → S Ref.1
	Sequence conflict	330	1	C → S Ref.5

Sequences

	Sequence		Length	Mass (Da)
	P46092-1 [UniParc]. Last modified March 29, 2005. Version 3. Checksum: 736EB9B639AEA99A	FASTA	362	38,416
	10 20 30 40 50 60 MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT VAALGLAGNG 70 80 90 100 110 120 LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA GALQGWSLGS ATCRTISGLY 130 140 150 160 170 180 SASFHAGFLF LACISADRYV AIARALPAGP RPSTPGRAHL VSVIVWLLSL LLALPALLFS 190 200 210 220 230 240 QDGQREGQRR CRLIFPEGLT QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP 250 260 270 280 290 300 ERRRALRVVV ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL 310 320 330 340 350 360 ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS APTETHSLSW DN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine." Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., Clark-Lewis I., Gerard C. J. Immunol. 164:3460-3464(2000) [PubMed: 10725696] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[2]	"The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)." Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., Lehmann P., Oldham E., Zlotnik A. J. Immunol. 164:3465-3470(2000) [PubMed: 10725697] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cloning of human genes encoding novel G protein-coupled receptors." Marchese A., Docherty J.M., Nguyen T., Heiber M., Cheng R., Heng H.H.Q., Tsui L.-C., Shi X., George S.R., O'Dowd B.F. Genomics 23:609-618(1994) [PubMed: 7851889] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-362.
[6]	"Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)." Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D., Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J., Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A. J. Biol. Chem. 275:22313-22323(2000) [PubMed: 10781587] [Abstract] Cited for: LIGAND-BINDING, TISSUE SPECIFICITY.
[7]	"A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues." Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D. J. Immunol. 165:2943-2949(2000) [PubMed: 10975800] [Abstract] Cited for: LIGAND-BINDING.
[8]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-295 AND SER-296, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF215981 mRNA. Translation: AAF63709.1. AF208237 mRNA. Translation: AAF72871.1. AY429103 mRNA. Translation: AAR07898.1. BC098132 mRNA. Translation: AAH98132.1. BC098157 mRNA. Translation: AAH98157.1. BC098304 mRNA. Translation: AAH98304.1. BC099840 mRNA. Translation: AAH99840.1. U13667 Genomic DNA. Translation: AAA64593.1.
IPI	IPI00004346.
PIR	B55733.
RefSeq	NP_057686.2.
UniGene	Hs.710983
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5873N.
IntAct	P46092. 4 interactions.
STRING	P46092.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P46092.
Proteomic databases
PRIDE	P46092.
Genome annotation databases
Ensembl	ENST00000332438; ENSP00000332504; ENSG00000184451; Homo sapiens. [Genome view]
GeneID	2826.
KEGG	hsa:2826.
UCSC	uc002iax.2. human.
Organism-specific databases
CTD	2826.
GeneCards	GC17M038086.
H-InvDB	HIX0039075.
HGNC	HGNC:4474. CCR10.
HPA	CAB011684.
MIM	600240. gene.
PharmGKB	PA28862.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P46092.
HOVERGEN	P46092.
OMA	MAACYAL.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P46092.
Bgee	P46092.
CleanEx	HS_CCR10.
Genevestigator	P46092.
GermOnline	ENSG00000184451. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR005382. CC_10_rcpt. IPR000355. Chmkine_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19264:SF249. CC_10_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01557. CHEMOKINER10. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	11151.
SOURCE	Search...

Entry information

Entry name

CCR10_HUMAN

Accession

Primary (citable) accession number: P46092
Secondary accession number(s): Q4V749, Q6T7X2, Q9NZG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	March 29, 2005
Last modified:	November 3, 2009
This is version 87 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.