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P46092 (CCR10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C chemokine receptor type 10

Short name=C-C CKR-10
Short name=CC-CKR-10
Short name=CCR-10
Alternative name(s):
G-protein coupled receptor 2
Gene names
Name:CCR10
Synonyms:GPR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells. Ref.6

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362C-C chemokine receptor type 10
PRO_0000069293

Regions

Topological domain1 – 5252Extracellular Potential
Transmembrane53 – 6816Helical; Name=1; Potential
Topological domain69 – 7810Cytoplasmic Potential
Transmembrane79 – 9921Helical; Name=2; Potential
Topological domain100 – 11415Extracellular Potential
Transmembrane115 – 13622Helical; Name=3; Potential
Topological domain137 – 15923Cytoplasmic Potential
Transmembrane160 – 17920Helical; Name=4; Potential
Topological domain180 – 20324Extracellular Potential
Transmembrane204 – 22522Helical; Name=5; Potential
Topological domain226 – 24722Cytoplasmic Potential
Transmembrane248 – 26922Helical; Name=6; Potential
Topological domain270 – 29021Extracellular Potential
Transmembrane291 – 31323Helical; Name=7; Potential
Topological domain314 – 36249Cytoplasmic Potential

Amino acid modifications

Disulfide bond113 ↔ 191 By similarity

Experimental info

Sequence conflict511V → L in AAA64593. Ref.5
Sequence conflict2351Missing in AAF72871. Ref.2
Sequence conflict3301C → S Ref.1
Sequence conflict3301C → S Ref.5

Sequences

Sequence LengthMass (Da)Tools
P46092 [UniParc].

Last modified March 29, 2005. Version 3.
Checksum: 736EB9B639AEA99A

FASTA36238,416
        10         20         30         40         50         60 
MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT VAALGLAGNG 

        70         80         90        100        110        120 
LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA GALQGWSLGS ATCRTISGLY 

       130        140        150        160        170        180 
SASFHAGFLF LACISADRYV AIARALPAGP RPSTPGRAHL VSVIVWLLSL LLALPALLFS 

       190        200        210        220        230        240 
QDGQREGQRR CRLIFPEGLT QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP 

       250        260        270        280        290        300 
ERRRALRVVV ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL 

       310        320        330        340        350        360 
ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS APTETHSLSW 


DN 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine."
Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., Clark-Lewis I., Gerard C.
J. Immunol. 164:3460-3464(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[2]"The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)."
Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D., Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T., Lehmann P., Oldham E., Zlotnik A.
J. Immunol. 164:3465-3470(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Cloning of human genes encoding novel G protein-coupled receptors."
Marchese A., Docherty J.M., Nguyen T., Heiber M., Cheng R., Heng H.H.Q., Tsui L.-C., Shi X., George S.R., O'Dowd B.F.
Genomics 23:609-618(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-362.
[6]"Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)."
Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D., Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J., Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A.
J. Biol. Chem. 275:22313-22323(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND-BINDING, TISSUE SPECIFICITY.
[7]"A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues."
Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K., Vierra M.A., Genovese M.C., Butcher E.C., Soler D.
J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND-BINDING.
+Additional computationally mapped references.

Web resources

Wikipedia

CC chemokine receptors entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF215981 mRNA. Translation: AAF63709.1.
AF208237 mRNA. Translation: AAF72871.1.
AY429103 mRNA. Translation: AAR07898.1.
BC098132 mRNA. Translation: AAH98132.1.
BC098157 mRNA. Translation: AAH98157.1.
BC098304 mRNA. Translation: AAH98304.1.
BC099840 mRNA. Translation: AAH99840.1.
U13667 Genomic DNA. Translation: AAA64593.1.
CCDSCCDS11435.1.
PIRB55733.
RefSeqNP_057686.2. NM_016602.2.
UniGeneHs.744542.

3D structure databases

ProteinModelPortalP46092.
SMRP46092. Positions 51-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109087. 5 interactions.
DIPDIP-5873N.
IntActP46092. 4 interactions.
MINTMINT-123760.
STRING9606.ENSP00000332504.

Chemistry

ChEMBLCHEMBL2321628.
GuidetoPHARMACOLOGY67.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP46092.

Polymorphism databases

DMDM62298314.

Proteomic databases

MaxQBP46092.
PaxDbP46092.
PRIDEP46092.

Protocols and materials databases

DNASU2826.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332438; ENSP00000332504; ENSG00000184451.
GeneID2826.
KEGGhsa:2826.
UCSCuc002iax.4. human.

Organism-specific databases

CTD2826.
GeneCardsGC17M040830.
HGNCHGNC:4474. CCR10.
HPACAB011684.
MIM600240. gene.
neXtProtNX_P46092.
PharmGKBPA28862.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147369.
HOGENOMHOG000234122.
HOVERGENHBG096538.
InParanoidP46092.
KOK04185.
OMAVMAACYA.
OrthoDBEOG7SXW4F.
PhylomeDBP46092.
TreeFamTF330966.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP46092.

Gene expression databases

ArrayExpressP46092.
BgeeP46092.
CleanExHS_CCR10.
GenevestigatorP46092.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR005382. Chemokine_CCR10.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01557. CHEMOKINER10.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCCR10.
GenomeRNAi2826.
NextBio11151.
PROP46092.
SOURCESearch...

Entry information

Entry nameCCR10_HUMAN
AccessionPrimary (citable) accession number: P46092
Secondary accession number(s): Q4V749, Q6T7X2, Q9NZG2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 29, 2005
Last modified: July 9, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries