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P46091

- GPR1_HUMAN

UniProt

P46091 - GPR1_HUMAN

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Protein
G-protein coupled receptor 1
Gene
GPR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.2 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 1
Gene namesi
Name:GPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:4463. GPR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141Extracellular Reviewed prediction
Add
BLAST
Transmembranei42 – 6221Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini63 – 7311Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei74 – 9421Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini95 – 11218Extracellular Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini134 – 15421Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei155 – 17521Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini176 – 21035Extracellular Reviewed prediction
Add
BLAST
Transmembranei211 – 23121Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini232 – 24716Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini269 – 28618Extracellular Reviewed prediction
Add
BLAST
Transmembranei287 – 30721Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini308 – 35548Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355G-protein coupled receptor 1
PRO_0000069505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi110 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP46091.
PRIDEiP46091.

PTM databases

PhosphoSiteiP46091.

Expressioni

Tissue specificityi

Expressed in hippocampus.

Gene expression databases

ArrayExpressiP46091.
BgeeiP46091.
CleanExiHS_GPR1.
GenevestigatoriP46091.

Organism-specific databases

HPAiHPA010525.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351541.

Structurei

3D structure databases

ProteinModelPortaliP46091.
SMRiP46091. Positions 39-316.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP46091.
KOiK04310.
OMAiIWELTIH.
OrthoDBiEOG7C5M8T.
PhylomeDBiP46091.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46091-1 [UniParc]FASTAAdd to Basket

« Hide

MEDLEETLFE EFENYSYDLD YYSLESDLEE KVQLGVVHWV SLVLYCLAFV    50
LGIPGNAIVI WFTGFKWKKT VTTLWFLNLA IADFIFLLFL PLYISYVAMN 100
FHWPFGIWLC KANSFTAQLN MFASVFFLTV ISLDHYIHLI HPVLSHRHRT 150
LKNSLIVIIF IWLLASLIGG PALYFRDTVE FNNHTLCYNN FQKHDPDLTL 200
IRHHVLTWVK FIIGYLFPLL TMSICYLCLI FKVKKRSILI SSRHFWTILV 250
VVVAFVVCWT PYHLFSIWEL TIHHNSYSHH VMQAGIPLST GLAFLNSCLN 300
PILYVLISKK FQARFRSSVA EILKYTLWEV SCSGTVSEQL RNSETKNLCL 350
LETAQ 355
Length:355
Mass (Da):41,431
Last modified:November 22, 2005 - v2
Checksum:iE25D54CBA59F9C8F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti307 – 3071I → V.3 Publications
Corresponds to variant rs3732083 [ dbSNP | Ensembl ].
VAR_023839

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651F → L in AAA64592. 1 Publication
Sequence conflicti237 – 2382SI → TV in AAA64592. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13666 Genomic DNA. Translation: AAA64592.1.
EF577403 mRNA. Translation: ABQ52423.1.
AK290976 mRNA. Translation: BAF83665.1.
AK075130 mRNA. Translation: BAG52070.1.
AC007383 Genomic DNA. Translation: AAY15063.1.
CH471063 Genomic DNA. Translation: EAW70383.1.
BC067833 mRNA. Translation: AAH67833.1.
CCDSiCCDS2368.1.
PIRiA55733.
RefSeqiNP_001091669.1. NM_001098199.1.
NP_001248381.1. NM_001261452.1.
NP_001248382.1. NM_001261453.1.
NP_001248383.1. NM_001261454.1.
NP_001248384.1. NM_001261455.1.
NP_005270.2. NM_005279.3.
XP_005246528.1. XM_005246471.1.
XP_006712500.1. XM_006712437.1.
UniGeneiHs.184907.

Genome annotation databases

EnsembliENST00000407325; ENSP00000384345; ENSG00000183671.
ENST00000437420; ENSP00000397535; ENSG00000183671.
GeneIDi2825.
KEGGihsa:2825.
UCSCiuc002vbl.4. human.

Polymorphism databases

DMDMi82654939.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13666 Genomic DNA. Translation: AAA64592.1 .
EF577403 mRNA. Translation: ABQ52423.1 .
AK290976 mRNA. Translation: BAF83665.1 .
AK075130 mRNA. Translation: BAG52070.1 .
AC007383 Genomic DNA. Translation: AAY15063.1 .
CH471063 Genomic DNA. Translation: EAW70383.1 .
BC067833 mRNA. Translation: AAH67833.1 .
CCDSi CCDS2368.1.
PIRi A55733.
RefSeqi NP_001091669.1. NM_001098199.1.
NP_001248381.1. NM_001261452.1.
NP_001248382.1. NM_001261453.1.
NP_001248383.1. NM_001261454.1.
NP_001248384.1. NM_001261455.1.
NP_005270.2. NM_005279.3.
XP_005246528.1. XM_005246471.1.
XP_006712500.1. XM_006712437.1.
UniGenei Hs.184907.

3D structure databases

ProteinModelPortali P46091.
SMRi P46091. Positions 39-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000351541.

Chemistry

GuidetoPHARMACOLOGYi 82.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P46091.

Polymorphism databases

DMDMi 82654939.

Proteomic databases

PaxDbi P46091.
PRIDEi P46091.

Protocols and materials databases

DNASUi 2825.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000407325 ; ENSP00000384345 ; ENSG00000183671 .
ENST00000437420 ; ENSP00000397535 ; ENSG00000183671 .
GeneIDi 2825.
KEGGi hsa:2825.
UCSCi uc002vbl.4. human.

Organism-specific databases

CTDi 2825.
GeneCardsi GC02M207003.
H-InvDB HIX0029868.
HGNCi HGNC:4463. GPR1.
HPAi HPA010525.
MIMi 600239. gene.
neXtProti NX_P46091.
PharmGKBi PA28846.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150376.
HOGENOMi HOG000234122.
HOVERGENi HBG107927.
InParanoidi P46091.
KOi K04310.
OMAi IWELTIH.
OrthoDBi EOG7C5M8T.
PhylomeDBi P46091.
TreeFami TF330976.

Miscellaneous databases

GeneWikii GPR1.
GenomeRNAii 2825.
NextBioi 11145.
PROi P46091.
SOURCEi Search...

Gene expression databases

ArrayExpressi P46091.
Bgeei P46091.
CleanExi HS_GPR1.
Genevestigatori P46091.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Martin A.L., Kaighin V.A., Aronstam R.S.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
    Tissue: Placenta.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
    Tissue: Placenta.
  8. "An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells."
    Shimizu N., Soda Y., Kanbe K., Liu H.Y., Jinno A., Kitamura T., Hoshino H.
    J. Virol. 73:5231-5239(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ITS HIV-1 CORECEPTOR FUNCTION.
  9. "The genetic design of signaling cascades to record receptor activation."
    Barnea G., Strapps W., Herrada G., Berman Y., Ong J., Kloss B., Axel R., Lee K.J.
    Proc. Natl. Acad. Sci. U.S.A. 105:64-69(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING, FUNCTION.

Entry informationi

Entry nameiGPR1_HUMAN
AccessioniPrimary (citable) accession number: P46091
Secondary accession number(s): A5JUU6
, A8K4L1, Q53TR9, Q6NVX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 22, 2005
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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