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Protein

G-protein coupled receptor 1

Gene

GPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • neuropeptide binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 1
Gene namesi
Name:GPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4463. GPR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini63 – 7311CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini95 – 11218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini176 – 21035ExtracellularSequence AnalysisAdd
BLAST
Transmembranei211 – 23121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini232 – 24716CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 28618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini308 – 35548CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • neuron projection Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28846.

Polymorphism and mutation databases

BioMutaiGPR1.
DMDMi82654939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355G-protein coupled receptor 1PRO_0000069505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP46091.
PRIDEiP46091.

PTM databases

PhosphoSiteiP46091.

Expressioni

Tissue specificityi

Expressed in hippocampus.

Gene expression databases

BgeeiP46091.
CleanExiHS_GPR1.
ExpressionAtlasiP46091. baseline and differential.
GenevisibleiP46091. HS.

Organism-specific databases

HPAiHPA010525.

Interactioni

Protein-protein interaction databases

BioGridi109086. 1 interaction.
STRINGi9606.ENSP00000384345.

Structurei

3D structure databases

ProteinModelPortaliP46091.
SMRiP46091. Positions 44-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP46091.
KOiK04310.
OMAiWEVSCSG.
OrthoDBiEOG7C5M8T.
PhylomeDBiP46091.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDLEETLFE EFENYSYDLD YYSLESDLEE KVQLGVVHWV SLVLYCLAFV
60 70 80 90 100
LGIPGNAIVI WFTGFKWKKT VTTLWFLNLA IADFIFLLFL PLYISYVAMN
110 120 130 140 150
FHWPFGIWLC KANSFTAQLN MFASVFFLTV ISLDHYIHLI HPVLSHRHRT
160 170 180 190 200
LKNSLIVIIF IWLLASLIGG PALYFRDTVE FNNHTLCYNN FQKHDPDLTL
210 220 230 240 250
IRHHVLTWVK FIIGYLFPLL TMSICYLCLI FKVKKRSILI SSRHFWTILV
260 270 280 290 300
VVVAFVVCWT PYHLFSIWEL TIHHNSYSHH VMQAGIPLST GLAFLNSCLN
310 320 330 340 350
PILYVLISKK FQARFRSSVA EILKYTLWEV SCSGTVSEQL RNSETKNLCL

LETAQ
Length:355
Mass (Da):41,431
Last modified:November 22, 2005 - v2
Checksum:iE25D54CBA59F9C8F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651F → L in AAA64592 (PubMed:7851889).Curated
Sequence conflicti237 – 2382SI → TV in AAA64592 (PubMed:7851889).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti307 – 3071I → V.3 Publications
Corresponds to variant rs3732083 [ dbSNP | Ensembl ].
VAR_023839

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13666 Genomic DNA. Translation: AAA64592.1.
EF577403 mRNA. Translation: ABQ52423.1.
AK290976 mRNA. Translation: BAF83665.1.
AK075130 mRNA. Translation: BAG52070.1.
AC007383 Genomic DNA. Translation: AAY15063.1.
CH471063 Genomic DNA. Translation: EAW70383.1.
BC067833 mRNA. Translation: AAH67833.1.
CCDSiCCDS2368.1.
PIRiA55733.
RefSeqiNP_001091669.1. NM_001098199.1.
NP_001248381.1. NM_001261452.1.
NP_001248382.1. NM_001261453.1.
NP_001248383.1. NM_001261454.1.
NP_001248384.1. NM_001261455.1.
NP_005270.2. NM_005279.3.
XP_005246528.1. XM_005246471.2.
UniGeneiHs.184907.

Genome annotation databases

EnsembliENST00000407325; ENSP00000384345; ENSG00000183671.
ENST00000437420; ENSP00000397535; ENSG00000183671.
ENST00000612892; ENSP00000480405; ENSG00000183671.
ENST00000621141; ENSP00000483003; ENSG00000183671.
GeneIDi2825.
KEGGihsa:2825.
UCSCiuc002vbl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13666 Genomic DNA. Translation: AAA64592.1.
EF577403 mRNA. Translation: ABQ52423.1.
AK290976 mRNA. Translation: BAF83665.1.
AK075130 mRNA. Translation: BAG52070.1.
AC007383 Genomic DNA. Translation: AAY15063.1.
CH471063 Genomic DNA. Translation: EAW70383.1.
BC067833 mRNA. Translation: AAH67833.1.
CCDSiCCDS2368.1.
PIRiA55733.
RefSeqiNP_001091669.1. NM_001098199.1.
NP_001248381.1. NM_001261452.1.
NP_001248382.1. NM_001261453.1.
NP_001248383.1. NM_001261454.1.
NP_001248384.1. NM_001261455.1.
NP_005270.2. NM_005279.3.
XP_005246528.1. XM_005246471.2.
UniGeneiHs.184907.

3D structure databases

ProteinModelPortaliP46091.
SMRiP46091. Positions 44-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109086. 1 interaction.
STRINGi9606.ENSP00000384345.

Chemistry

GuidetoPHARMACOLOGYi82.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP46091.

Polymorphism and mutation databases

BioMutaiGPR1.
DMDMi82654939.

Proteomic databases

PaxDbiP46091.
PRIDEiP46091.

Protocols and materials databases

DNASUi2825.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407325; ENSP00000384345; ENSG00000183671.
ENST00000437420; ENSP00000397535; ENSG00000183671.
ENST00000612892; ENSP00000480405; ENSG00000183671.
ENST00000621141; ENSP00000483003; ENSG00000183671.
GeneIDi2825.
KEGGihsa:2825.
UCSCiuc002vbl.4. human.

Organism-specific databases

CTDi2825.
GeneCardsiGC02M207003.
H-InvDBHIX0029868.
HGNCiHGNC:4463. GPR1.
HPAiHPA010525.
MIMi600239. gene.
neXtProtiNX_P46091.
PharmGKBiPA28846.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP46091.
KOiK04310.
OMAiWEVSCSG.
OrthoDBiEOG7C5M8T.
PhylomeDBiP46091.
TreeFamiTF330976.

Miscellaneous databases

GeneWikiiGPR1.
GenomeRNAii2825.
NextBioi11145.
PROiP46091.
SOURCEiSearch...

Gene expression databases

BgeeiP46091.
CleanExiHS_GPR1.
ExpressionAtlasiP46091. baseline and differential.
GenevisibleiP46091. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Martin A.L., Kaighin V.A., Aronstam R.S.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
    Tissue: Placenta.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
    Tissue: Placenta.
  8. "An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells."
    Shimizu N., Soda Y., Kanbe K., Liu H.Y., Jinno A., Kitamura T., Hoshino H.
    J. Virol. 73:5231-5239(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ITS HIV-1 CORECEPTOR FUNCTION.
  9. "The genetic design of signaling cascades to record receptor activation."
    Barnea G., Strapps W., Herrada G., Berman Y., Ong J., Kloss B., Axel R., Lee K.J.
    Proc. Natl. Acad. Sci. U.S.A. 105:64-69(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING, FUNCTION.

Entry informationi

Entry nameiGPR1_HUMAN
AccessioniPrimary (citable) accession number: P46091
Secondary accession number(s): A5JUU6
, A8K4L1, Q53TR9, Q6NVX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 22, 2005
Last modified: June 24, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.