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P46091

- GPR1_HUMAN

UniProt

P46091 - GPR1_HUMAN

Protein

G-protein coupled receptor 1

Gene

GPR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 1
    Gene namesi
    Name:GPR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4463. GPR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28846.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355G-protein coupled receptor 1PRO_0000069505Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP46091.
    PRIDEiP46091.

    PTM databases

    PhosphoSiteiP46091.

    Expressioni

    Tissue specificityi

    Expressed in hippocampus.

    Gene expression databases

    ArrayExpressiP46091.
    BgeeiP46091.
    CleanExiHS_GPR1.
    GenevestigatoriP46091.

    Organism-specific databases

    HPAiHPA010525.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000351541.

    Structurei

    3D structure databases

    ProteinModelPortaliP46091.
    SMRiP46091. Positions 39-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 7311CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini95 – 11218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 21035ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini232 – 24716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 28618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini308 – 35548CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei211 – 23121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150376.
    HOGENOMiHOG000234122.
    HOVERGENiHBG107927.
    InParanoidiP46091.
    KOiK04310.
    OMAiIWELTIH.
    OrthoDBiEOG7C5M8T.
    PhylomeDBiP46091.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002275. GPR1_orph_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01146. GPR1ORPHANR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46091-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDLEETLFE EFENYSYDLD YYSLESDLEE KVQLGVVHWV SLVLYCLAFV    50
    LGIPGNAIVI WFTGFKWKKT VTTLWFLNLA IADFIFLLFL PLYISYVAMN 100
    FHWPFGIWLC KANSFTAQLN MFASVFFLTV ISLDHYIHLI HPVLSHRHRT 150
    LKNSLIVIIF IWLLASLIGG PALYFRDTVE FNNHTLCYNN FQKHDPDLTL 200
    IRHHVLTWVK FIIGYLFPLL TMSICYLCLI FKVKKRSILI SSRHFWTILV 250
    VVVAFVVCWT PYHLFSIWEL TIHHNSYSHH VMQAGIPLST GLAFLNSCLN 300
    PILYVLISKK FQARFRSSVA EILKYTLWEV SCSGTVSEQL RNSETKNLCL 350
    LETAQ 355
    Length:355
    Mass (Da):41,431
    Last modified:November 22, 2005 - v2
    Checksum:iE25D54CBA59F9C8F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651F → L in AAA64592. (PubMed:7851889)Curated
    Sequence conflicti237 – 2382SI → TV in AAA64592. (PubMed:7851889)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti307 – 3071I → V.3 Publications
    Corresponds to variant rs3732083 [ dbSNP | Ensembl ].
    VAR_023839

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13666 Genomic DNA. Translation: AAA64592.1.
    EF577403 mRNA. Translation: ABQ52423.1.
    AK290976 mRNA. Translation: BAF83665.1.
    AK075130 mRNA. Translation: BAG52070.1.
    AC007383 Genomic DNA. Translation: AAY15063.1.
    CH471063 Genomic DNA. Translation: EAW70383.1.
    BC067833 mRNA. Translation: AAH67833.1.
    CCDSiCCDS2368.1.
    PIRiA55733.
    RefSeqiNP_001091669.1. NM_001098199.1.
    NP_001248381.1. NM_001261452.1.
    NP_001248382.1. NM_001261453.1.
    NP_001248383.1. NM_001261454.1.
    NP_001248384.1. NM_001261455.1.
    NP_005270.2. NM_005279.3.
    XP_005246528.1. XM_005246471.1.
    XP_006712500.1. XM_006712437.1.
    UniGeneiHs.184907.

    Genome annotation databases

    EnsembliENST00000407325; ENSP00000384345; ENSG00000183671.
    ENST00000437420; ENSP00000397535; ENSG00000183671.
    GeneIDi2825.
    KEGGihsa:2825.
    UCSCiuc002vbl.4. human.

    Polymorphism databases

    DMDMi82654939.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13666 Genomic DNA. Translation: AAA64592.1 .
    EF577403 mRNA. Translation: ABQ52423.1 .
    AK290976 mRNA. Translation: BAF83665.1 .
    AK075130 mRNA. Translation: BAG52070.1 .
    AC007383 Genomic DNA. Translation: AAY15063.1 .
    CH471063 Genomic DNA. Translation: EAW70383.1 .
    BC067833 mRNA. Translation: AAH67833.1 .
    CCDSi CCDS2368.1.
    PIRi A55733.
    RefSeqi NP_001091669.1. NM_001098199.1.
    NP_001248381.1. NM_001261452.1.
    NP_001248382.1. NM_001261453.1.
    NP_001248383.1. NM_001261454.1.
    NP_001248384.1. NM_001261455.1.
    NP_005270.2. NM_005279.3.
    XP_005246528.1. XM_005246471.1.
    XP_006712500.1. XM_006712437.1.
    UniGenei Hs.184907.

    3D structure databases

    ProteinModelPortali P46091.
    SMRi P46091. Positions 39-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000351541.

    Chemistry

    GuidetoPHARMACOLOGYi 82.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P46091.

    Polymorphism databases

    DMDMi 82654939.

    Proteomic databases

    PaxDbi P46091.
    PRIDEi P46091.

    Protocols and materials databases

    DNASUi 2825.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000407325 ; ENSP00000384345 ; ENSG00000183671 .
    ENST00000437420 ; ENSP00000397535 ; ENSG00000183671 .
    GeneIDi 2825.
    KEGGi hsa:2825.
    UCSCi uc002vbl.4. human.

    Organism-specific databases

    CTDi 2825.
    GeneCardsi GC02M207003.
    H-InvDB HIX0029868.
    HGNCi HGNC:4463. GPR1.
    HPAi HPA010525.
    MIMi 600239. gene.
    neXtProti NX_P46091.
    PharmGKBi PA28846.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150376.
    HOGENOMi HOG000234122.
    HOVERGENi HBG107927.
    InParanoidi P46091.
    KOi K04310.
    OMAi IWELTIH.
    OrthoDBi EOG7C5M8T.
    PhylomeDBi P46091.
    TreeFami TF330976.

    Miscellaneous databases

    GeneWikii GPR1.
    GenomeRNAii 2825.
    NextBioi 11145.
    PROi P46091.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46091.
    Bgeei P46091.
    CleanExi HS_GPR1.
    Genevestigatori P46091.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002275. GPR1_orph_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01146. GPR1ORPHANR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Martin A.L., Kaighin V.A., Aronstam R.S.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hippocampus.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
      Tissue: Placenta.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
      Tissue: Placenta.
    8. "An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells."
      Shimizu N., Soda Y., Kanbe K., Liu H.Y., Jinno A., Kitamura T., Hoshino H.
      J. Virol. 73:5231-5239(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF ITS HIV-1 CORECEPTOR FUNCTION.
    9. "The genetic design of signaling cascades to record receptor activation."
      Barnea G., Strapps W., Herrada G., Berman Y., Ong J., Kloss B., Axel R., Lee K.J.
      Proc. Natl. Acad. Sci. U.S.A. 105:64-69(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND-BINDING, FUNCTION.

    Entry informationi

    Entry nameiGPR1_HUMAN
    AccessioniPrimary (citable) accession number: P46091
    Secondary accession number(s): A5JUU6
    , A8K4L1, Q53TR9, Q6NVX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3