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Protein

G-protein coupled receptor 1

Gene

GPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • neuropeptide binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-32666-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 1
Gene namesi
Name:GPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4463. GPR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 73CytoplasmicSequence analysisAdd BLAST11
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 112ExtracellularSequence analysisAdd BLAST18
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 154CytoplasmicSequence analysisAdd BLAST21
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 210ExtracellularSequence analysisAdd BLAST35
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini232 – 247CytoplasmicSequence analysisAdd BLAST16
Transmembranei248 – 268Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini269 – 286ExtracellularSequence analysisAdd BLAST18
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 355CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • neuron projection Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2825.
OpenTargetsiENSG00000183671.
ENSG00000283448.
PharmGKBiPA28846.

Chemistry databases

GuidetoPHARMACOLOGYi82.

Polymorphism and mutation databases

BioMutaiGPR1.
DMDMi82654939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695051 – 355G-protein coupled receptor 1Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP46091.
PeptideAtlasiP46091.
PRIDEiP46091.

PTM databases

iPTMnetiP46091.
PhosphoSitePlusiP46091.

Expressioni

Tissue specificityi

Expressed in hippocampus.

Gene expression databases

BgeeiENSG00000183671.
CleanExiHS_GPR1.
ExpressionAtlasiP46091. baseline and differential.
GenevisibleiP46091. HS.

Organism-specific databases

HPAiHPA010525.

Interactioni

Protein-protein interaction databases

IntActiP46091. 1 interactor.
STRINGi9606.ENSP00000384345.

Structurei

3D structure databases

ProteinModelPortaliP46091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGAX. Eukaryota.
ENOG410XQ5U. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP46091.
KOiK04310.
OMAiNNFHEHD.
OrthoDBiEOG091G09DC.
PhylomeDBiP46091.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDLEETLFE EFENYSYDLD YYSLESDLEE KVQLGVVHWV SLVLYCLAFV
60 70 80 90 100
LGIPGNAIVI WFTGFKWKKT VTTLWFLNLA IADFIFLLFL PLYISYVAMN
110 120 130 140 150
FHWPFGIWLC KANSFTAQLN MFASVFFLTV ISLDHYIHLI HPVLSHRHRT
160 170 180 190 200
LKNSLIVIIF IWLLASLIGG PALYFRDTVE FNNHTLCYNN FQKHDPDLTL
210 220 230 240 250
IRHHVLTWVK FIIGYLFPLL TMSICYLCLI FKVKKRSILI SSRHFWTILV
260 270 280 290 300
VVVAFVVCWT PYHLFSIWEL TIHHNSYSHH VMQAGIPLST GLAFLNSCLN
310 320 330 340 350
PILYVLISKK FQARFRSSVA EILKYTLWEV SCSGTVSEQL RNSETKNLCL

LETAQ
Length:355
Mass (Da):41,431
Last modified:November 22, 2005 - v2
Checksum:iE25D54CBA59F9C8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65F → L in AAA64592 (PubMed:7851889).Curated1
Sequence conflicti237 – 238SI → TV in AAA64592 (PubMed:7851889).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023839307I → V.3 PublicationsCorresponds to variant rs3732083dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13666 Genomic DNA. Translation: AAA64592.1.
EF577403 mRNA. Translation: ABQ52423.1.
AK290976 mRNA. Translation: BAF83665.1.
AK075130 mRNA. Translation: BAG52070.1.
AC007383 Genomic DNA. Translation: AAY15063.1.
CH471063 Genomic DNA. Translation: EAW70383.1.
BC067833 mRNA. Translation: AAH67833.1.
CCDSiCCDS2368.1.
PIRiA55733.
RefSeqiNP_001091669.1. NM_001098199.1.
NP_001248381.1. NM_001261452.1.
NP_001248382.1. NM_001261453.1.
NP_001248383.1. NM_001261454.1.
NP_001248384.1. NM_001261455.1.
NP_005270.2. NM_005279.3.
XP_005246528.1. XM_005246471.2.
XP_016859321.1. XM_017003832.1.
UniGeneiHs.184907.

Genome annotation databases

EnsembliENST00000407325; ENSP00000384345; ENSG00000183671.
ENST00000437420; ENSP00000397535; ENSG00000183671.
ENST00000612892; ENSP00000480405; ENSG00000183671.
ENST00000621141; ENSP00000483003; ENSG00000183671.
ENST00000636848; ENSP00000490642; ENSG00000283448.
ENST00000637075; ENSP00000490813; ENSG00000283448.
ENST00000638097; ENSP00000490453; ENSG00000283448.
ENST00000638116; ENSP00000489673; ENSG00000283448.
GeneIDi2825.
KEGGihsa:2825.
UCSCiuc002vbl.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13666 Genomic DNA. Translation: AAA64592.1.
EF577403 mRNA. Translation: ABQ52423.1.
AK290976 mRNA. Translation: BAF83665.1.
AK075130 mRNA. Translation: BAG52070.1.
AC007383 Genomic DNA. Translation: AAY15063.1.
CH471063 Genomic DNA. Translation: EAW70383.1.
BC067833 mRNA. Translation: AAH67833.1.
CCDSiCCDS2368.1.
PIRiA55733.
RefSeqiNP_001091669.1. NM_001098199.1.
NP_001248381.1. NM_001261452.1.
NP_001248382.1. NM_001261453.1.
NP_001248383.1. NM_001261454.1.
NP_001248384.1. NM_001261455.1.
NP_005270.2. NM_005279.3.
XP_005246528.1. XM_005246471.2.
XP_016859321.1. XM_017003832.1.
UniGeneiHs.184907.

3D structure databases

ProteinModelPortaliP46091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP46091. 1 interactor.
STRINGi9606.ENSP00000384345.

Chemistry databases

GuidetoPHARMACOLOGYi82.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP46091.
PhosphoSitePlusiP46091.

Polymorphism and mutation databases

BioMutaiGPR1.
DMDMi82654939.

Proteomic databases

PaxDbiP46091.
PeptideAtlasiP46091.
PRIDEiP46091.

Protocols and materials databases

DNASUi2825.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407325; ENSP00000384345; ENSG00000183671.
ENST00000437420; ENSP00000397535; ENSG00000183671.
ENST00000612892; ENSP00000480405; ENSG00000183671.
ENST00000621141; ENSP00000483003; ENSG00000183671.
ENST00000636848; ENSP00000490642; ENSG00000283448.
ENST00000637075; ENSP00000490813; ENSG00000283448.
ENST00000638097; ENSP00000490453; ENSG00000283448.
ENST00000638116; ENSP00000489673; ENSG00000283448.
GeneIDi2825.
KEGGihsa:2825.
UCSCiuc002vbl.6. human.

Organism-specific databases

CTDi2825.
DisGeNETi2825.
GeneCardsiGPR1.
H-InvDBHIX0029868.
HGNCiHGNC:4463. GPR1.
HPAiHPA010525.
MIMi600239. gene.
neXtProtiNX_P46091.
OpenTargetsiENSG00000183671.
ENSG00000283448.
PharmGKBiPA28846.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGAX. Eukaryota.
ENOG410XQ5U. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP46091.
KOiK04310.
OMAiNNFHEHD.
OrthoDBiEOG091G09DC.
PhylomeDBiP46091.
TreeFamiTF330976.

Enzyme and pathway databases

BioCyciZFISH:G66-32666-MONOMER.

Miscellaneous databases

GeneWikiiGPR1.
GenomeRNAii2825.
PROiP46091.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183671.
CleanExiHS_GPR1.
ExpressionAtlasiP46091. baseline and differential.
GenevisibleiP46091. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR1_HUMAN
AccessioniPrimary (citable) accession number: P46091
Secondary accession number(s): A5JUU6
, A8K4L1, Q53TR9, Q6NVX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.