Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P46091 (GPR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor 1
Gene names
Name:GPR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1. Ref.8 Ref.9

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in hippocampus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionG-protein coupled receptor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355G-protein coupled receptor 1
PRO_0000069505

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6221Helical; Name=1; Potential
Topological domain63 – 7311Cytoplasmic Potential
Transmembrane74 – 9421Helical; Name=2; Potential
Topological domain95 – 11218Extracellular Potential
Transmembrane113 – 13321Helical; Name=3; Potential
Topological domain134 – 15421Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=4; Potential
Topological domain176 – 21035Extracellular Potential
Transmembrane211 – 23121Helical; Name=5; Potential
Topological domain232 – 24716Cytoplasmic Potential
Transmembrane248 – 26821Helical; Name=6; Potential
Topological domain269 – 28618Extracellular Potential
Transmembrane287 – 30721Helical; Name=7; Potential
Topological domain308 – 35548Cytoplasmic Potential

Amino acid modifications

Glycosylation141N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 187 By similarity

Natural variations

Natural variant3071I → V. Ref.3 Ref.4 Ref.7
Corresponds to variant rs3732083 [ dbSNP | Ensembl ].
VAR_023839

Experimental info

Sequence conflict651F → L in AAA64592. Ref.1
Sequence conflict237 – 2382SI → TV in AAA64592. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P46091 [UniParc].

Last modified November 22, 2005. Version 2.
Checksum: E25D54CBA59F9C8F

FASTA35541,431
        10         20         30         40         50         60 
MEDLEETLFE EFENYSYDLD YYSLESDLEE KVQLGVVHWV SLVLYCLAFV LGIPGNAIVI 

        70         80         90        100        110        120 
WFTGFKWKKT VTTLWFLNLA IADFIFLLFL PLYISYVAMN FHWPFGIWLC KANSFTAQLN 

       130        140        150        160        170        180 
MFASVFFLTV ISLDHYIHLI HPVLSHRHRT LKNSLIVIIF IWLLASLIGG PALYFRDTVE 

       190        200        210        220        230        240 
FNNHTLCYNN FQKHDPDLTL IRHHVLTWVK FIIGYLFPLL TMSICYLCLI FKVKKRSILI 

       250        260        270        280        290        300 
SSRHFWTILV VVVAFVVCWT PYHLFSIWEL TIHHNSYSHH VMQAGIPLST GLAFLNSCLN 

       310        320        330        340        350 
PILYVLISKK FQARFRSSVA EILKYTLWEV SCSGTVSEQL RNSETKNLCL LETAQ 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of human genes encoding novel G protein-coupled receptors."
Marchese A., Docherty J.M., Nguyen T., Heiber M., Cheng R., Heng H.H.Q., Tsui L.-C., Shi X., George S.R., O'Dowd B.F.
Genomics 23:609-618(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Martin A.L., Kaighin V.A., Aronstam R.S.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
[4]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
Tissue: Placenta.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-307.
Tissue: Placenta.
[8]"An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells."
Shimizu N., Soda Y., Kanbe K., Liu H.Y., Jinno A., Kitamura T., Hoshino H.
J. Virol. 73:5231-5239(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF ITS HIV-1 CORECEPTOR FUNCTION.
[9]"The genetic design of signaling cascades to record receptor activation."
Barnea G., Strapps W., Herrada G., Berman Y., Ong J., Kloss B., Axel R., Lee K.J.
Proc. Natl. Acad. Sci. U.S.A. 105:64-69(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND-BINDING, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U13666 Genomic DNA. Translation: AAA64592.1.
EF577403 mRNA. Translation: ABQ52423.1.
AK290976 mRNA. Translation: BAF83665.1.
AK075130 mRNA. Translation: BAG52070.1.
AC007383 Genomic DNA. Translation: AAY15063.1.
CH471063 Genomic DNA. Translation: EAW70383.1.
BC067833 mRNA. Translation: AAH67833.1.
PIRA55733.
RefSeqNP_001091669.1. NM_001098199.1.
NP_001248381.1. NM_001261452.1.
NP_001248382.1. NM_001261453.1.
NP_001248383.1. NM_001261454.1.
NP_001248384.1. NM_001261455.1.
NP_005270.2. NM_005279.3.
XP_005246528.1. XM_005246471.1.
UniGeneHs.184907.

3D structure databases

ProteinModelPortalP46091.
SMRP46091. Positions 6-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000351541.

Chemistry

GuidetoPHARMACOLOGY82.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP46091.

Polymorphism databases

DMDM82654939.

Proteomic databases

PaxDbP46091.
PRIDEP46091.

Protocols and materials databases

DNASU2825.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000407325; ENSP00000384345; ENSG00000183671.
ENST00000437420; ENSP00000397535; ENSG00000183671.
GeneID2825.
KEGGhsa:2825.
UCSCuc002vbl.4. human.

Organism-specific databases

CTD2825.
GeneCardsGC02M207003.
H-InvDBHIX0029868.
HGNCHGNC:4463. GPR1.
HPAHPA010525.
MIM600239. gene.
neXtProtNX_P46091.
PharmGKBPA28846.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150376.
HOGENOMHOG000234122.
HOVERGENHBG107927.
InParanoidP46091.
KOK04310.
OMAAQLNMFA.
OrthoDBEOG7C5M8T.
PhylomeDBP46091.
TreeFamTF330976.

Gene expression databases

ArrayExpressP46091.
BgeeP46091.
CleanExHS_GPR1.
GenevestigatorP46091.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR1.
GenomeRNAi2825.
NextBio11145.
PROP46091.
SOURCESearch...

Entry information

Entry nameGPR1_HUMAN
AccessionPrimary (citable) accession number: P46091
Secondary accession number(s): A5JUU6 expand/collapse secondary AC list , A8K4L1, Q53TR9, Q6NVX4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries