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Protein

G-protein coupled receptor 1

Gene

Gpr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 1
Gene namesi
Name:Gpr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2728. Gpr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 73CytoplasmicSequence analysisAdd BLAST11
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 112ExtracellularSequence analysisAdd BLAST18
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 154CytoplasmicSequence analysisAdd BLAST21
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 210ExtracellularSequence analysisAdd BLAST35
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini232 – 247CytoplasmicSequence analysisAdd BLAST16
Transmembranei248 – 268Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini269 – 286ExtracellularSequence analysisAdd BLAST18
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 353CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695091 – 353G-protein coupled receptor 1Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP46090.

PTM databases

PhosphoSitePlusiP46090.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067327.

Structurei

3D structure databases

ProteinModelPortaliP46090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGAX. Eukaryota.
ENOG410XQ5U. LUCA.
HOVERGENiHBG107927.
InParanoidiP46090.
KOiK04310.
PhylomeDBiP46090.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSREMLFE ELDNYSYALE YYSQEPDAEE NVYPGIVHWI SLLLYALAFV
60 70 80 90 100
LGIPGNAIVI WFMGFKWKKT VTTLWFLNLA IADFIFVLFL PLYISYVALS
110 120 130 140 150
FHWPFGRWLC KLNSFIAQLN MFSSVFFLTV ISLDRYIHLI HPGLSHPHRT
160 170 180 190 200
LKNSLLVVLF VWLLASLLGG PTLYFRDTVE VNNRIICYNN FQEYELTLMR
210 220 230 240 250
HHVLTWVKFL FGYLLPLLTM SSCYLCLIFK TKKQNILISS KHLWMILSVV
260 270 280 290 300
IAFMVCWTPF HLFSIWELSI HHNSSFQNVL QGGIPLSTGL AFLNSCLNPI
310 320 330 340 350
LYVIISKKFQ ARFRASVAEV LKRSLWEASC SGTVSEQLRS AETKSLSLLE

TAQ
Length:353
Mass (Da):40,901
Last modified:November 1, 1995 - v1
Checksum:i8C526CB53C74087A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74702 Genomic DNA. Translation: AAB32978.1.
PIRiJC2492.
RefSeqiNP_037093.1. NM_012961.1.
UniGeneiRn.81208.

Genome annotation databases

GeneIDi25457.
KEGGirno:25457.
UCSCiRGD:2728. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74702 Genomic DNA. Translation: AAB32978.1.
PIRiJC2492.
RefSeqiNP_037093.1. NM_012961.1.
UniGeneiRn.81208.

3D structure databases

ProteinModelPortaliP46090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067327.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP46090.

Proteomic databases

PaxDbiP46090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25457.
KEGGirno:25457.
UCSCiRGD:2728. rat.

Organism-specific databases

CTDi2825.
RGDi2728. Gpr1.

Phylogenomic databases

eggNOGiENOG410IGAX. Eukaryota.
ENOG410XQ5U. LUCA.
HOVERGENiHBG107927.
InParanoidiP46090.
KOiK04310.
PhylomeDBiP46090.

Miscellaneous databases

PROiP46090.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002275. GPR1_orph_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01146. GPR1ORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR1_RAT
AccessioniPrimary (citable) accession number: P46090
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.