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P46089

- GPR3_HUMAN

UniProt

P46089 - GPR3_HUMAN

Protein

G-protein coupled receptor 3

Gene

GPR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress By similarity, amyloid-beta peptide generation in neurons and neurite outgrowth By similarity. Maintains also meiotic arrest in oocytes By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: ProtInc
    2. regulation of meiosis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 3
    Alternative name(s):
    ACCA orphan receptor
    Gene namesi
    Name:GPR3
    Synonyms:ACCA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4484. GPR3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28872.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330G-protein coupled receptor 3PRO_0000069510Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Lipidationi313 – 3131S-palmitoyl cysteineBy similarity
    Modified residuei324 – 3241PhosphoserineSequence Analysis
    Modified residuei326 – 3261PhosphoserineSequence Analysis
    Modified residuei328 – 3281PhosphoserineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP46089.
    PRIDEiP46089.

    Expressioni

    Tissue specificityi

    Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.

    Inductioni

    Overexpression stimulates amyloid-beta production.

    Gene expression databases

    ArrayExpressiP46089.
    BgeeiP46089.
    CleanExiHS_GPR3.
    GenevestigatoriP46089.

    Organism-specific databases

    HPAiCAB006254.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    APPP05067-42EBI-3909653,EBI-302641

    Protein-protein interaction databases

    BioGridi109088. 4 interactions.
    IntActiP46089. 9 interactions.
    STRINGi9606.ENSP00000363136.

    Structurei

    3D structure databases

    ProteinModelPortaliP46089.
    SMRiP46089. Positions 39-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 7412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini99 – 11012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini133 – 15321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini174 – 19825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 24528CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 2775ExtracellularSequence Analysis
    Topological domaini300 – 33031CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6220Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9824Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei111 – 13222Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17320Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21719Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei246 – 27227Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29922Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320944.
    HOGENOMiHOG000294075.
    HOVERGENiHBG079561.
    InParanoidiP46089.
    KOiK04311.
    OMAiLWAICCC.
    OrthoDBiEOG7966H0.
    PhylomeDBiP46089.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000984. GPR3.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00648. GPR3ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46089-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMWGAGSPLA WLSAGSGNVN VSSVGPAEGP TGPAAPLPSP KAWDVVLCIS    50
    GTLVSCENAL VVAIIVGTPA FRAPMFLLVG SLAVADLLAG LGLVLHFAAV 100
    FCIGSAEMSL VLVGVLAMAF TASIGSLLAI TVDRYLSLYN ALTYYSETTV 150
    TRTYVMLALV WGGALGLGLL PVLAWNCLDG LTTCGVVYPL SKNHLVVLAI 200
    AFFMVFGIML QLYAQICRIV CRHAQQIALQ RHLLPASHYV ATRKGIATLA 250
    VVLGAFAACW LPFTVYCLLG DAHSPPLYTY LTLLPATYNS MINPIIYAFR 300
    NQDVQKVLWA VCCCCSSSKI PFRSRSPSDV 330
    Length:330
    Mass (Da):35,010
    Last modified:November 1, 1995 - v1
    Checksum:i0F82E89200968D1E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti222 – 2221R → H.
    Corresponds to variant rs734852 [ dbSNP | Ensembl ].
    VAR_011859

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18550 Genomic DNA. Translation: AAB60402.1.
    L32831 Genomic DNA. Translation: AAA73560.1.
    X83956 Genomic DNA. Translation: CAA58787.1.
    AK291185 mRNA. Translation: BAF83874.1.
    AK314868 mRNA. Translation: BAG37383.1.
    AL096774 Genomic DNA. Translation: CAC18517.1.
    CH471059 Genomic DNA. Translation: EAX07754.1.
    BC032702 mRNA. Translation: AAH32702.1.
    U13668 Genomic DNA. Translation: AAA64594.1.
    CCDSiCCDS303.1.
    PIRiA55689.
    RefSeqiNP_005272.1. NM_005281.3.
    UniGeneiHs.66542.

    Genome annotation databases

    EnsembliENST00000374024; ENSP00000363136; ENSG00000181773.
    GeneIDi2827.
    KEGGihsa:2827.
    UCSCiuc001bod.4. human.

    Polymorphism databases

    DMDMi1170006.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18550 Genomic DNA. Translation: AAB60402.1 .
    L32831 Genomic DNA. Translation: AAA73560.1 .
    X83956 Genomic DNA. Translation: CAA58787.1 .
    AK291185 mRNA. Translation: BAF83874.1 .
    AK314868 mRNA. Translation: BAG37383.1 .
    AL096774 Genomic DNA. Translation: CAC18517.1 .
    CH471059 Genomic DNA. Translation: EAX07754.1 .
    BC032702 mRNA. Translation: AAH32702.1 .
    U13668 Genomic DNA. Translation: AAA64594.1 .
    CCDSi CCDS303.1.
    PIRi A55689.
    RefSeqi NP_005272.1. NM_005281.3.
    UniGenei Hs.66542.

    3D structure databases

    ProteinModelPortali P46089.
    SMRi P46089. Positions 39-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109088. 4 interactions.
    IntActi P46089. 9 interactions.
    STRINGi 9606.ENSP00000363136.

    Chemistry

    GuidetoPHARMACOLOGYi 83.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 1170006.

    Proteomic databases

    PaxDbi P46089.
    PRIDEi P46089.

    Protocols and materials databases

    DNASUi 2827.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374024 ; ENSP00000363136 ; ENSG00000181773 .
    GeneIDi 2827.
    KEGGi hsa:2827.
    UCSCi uc001bod.4. human.

    Organism-specific databases

    CTDi 2827.
    GeneCardsi GC01P027719.
    H-InvDB HIX0160062.
    HGNCi HGNC:4484. GPR3.
    HPAi CAB006254.
    MIMi 600241. gene.
    neXtProti NX_P46089.
    PharmGKBi PA28872.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320944.
    HOGENOMi HOG000294075.
    HOVERGENi HBG079561.
    InParanoidi P46089.
    KOi K04311.
    OMAi LWAICCC.
    OrthoDBi EOG7966H0.
    PhylomeDBi P46089.
    TreeFami TF330052.

    Miscellaneous databases

    GeneWikii GPR3.
    GenomeRNAii 2827.
    NextBioi 11155.
    PROi P46089.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46089.
    Bgeei P46089.
    CleanExi HS_GPR3.
    Genevestigatori P46089.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000984. GPR3.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00648. GPR3ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors."
      Song Z.-H., Modi W., Bonner T.I.
      Genomics 28:347-349(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system."
      Iismaa T.P., Kiefer J., Liu M.L., Baker E., Sutherland G.R., Shine J.
      Genomics 24:391-394(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase."
      Eggerickx D., Denef J.F., Labbe O., Hayashi Y., Refetoff S., Vassart G., Parmentier M., Libert F.
      Biochem. J. 309:837-843(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-292.
    9. "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors."
      Uhlenbrock K., Gassenhuber J., Kostenis E.
      Cell. Signal. 14:941-953(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY FUNCTION.
    10. "Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay."
      Yin H., Chu A., Li W., Wang B., Shelton F., Otero F., Nguyen D.G., Caldwell J.S., Chen Y.A.
      J. Biol. Chem. 284:12328-12338(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SHOWS THAT IT IS NOT A SPHINGOSINE 1-PHOSPHATE RECEPTOR.
    11. Cited for: FUNCTION.

    Entry informationi

    Entry nameiGPR3_HUMAN
    AccessioniPrimary (citable) accession number: P46089
    Secondary accession number(s): A8K570
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally (PubMed:12220620) thought to be a receptor for sphingosine 1-phosphate. PubMed:19286662 demonstrated that it is not the case.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3