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Protein

G-protein coupled receptor 3

Gene

GPR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).By similarity1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181773-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 3
Alternative name(s):
ACCA orphan receptor
Gene namesi
Name:GPR3
Synonyms:ACCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4484. GPR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 62Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini63 – 74CytoplasmicSequence analysisAdd BLAST12
Transmembranei75 – 98Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini99 – 110ExtracellularSequence analysisAdd BLAST12
Transmembranei111 – 132Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini133 – 153CytoplasmicSequence analysisAdd BLAST21
Transmembranei154 – 173Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini174 – 198ExtracellularSequence analysisAdd BLAST25
Transmembranei199 – 217Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini218 – 245CytoplasmicSequence analysisAdd BLAST28
Transmembranei246 – 272Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini273 – 277ExtracellularSequence analysis5
Transmembranei278 – 299Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini300 – 330CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2827.
OpenTargetsiENSG00000181773.
PharmGKBiPA28872.

Chemistry databases

GuidetoPHARMACOLOGYi83.

Polymorphism and mutation databases

DMDMi1170006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695101 – 330G-protein coupled receptor 3Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Lipidationi313S-palmitoyl cysteineBy similarity1
Modified residuei324PhosphoserineSequence analysis1
Modified residuei326PhosphoserineSequence analysis1
Modified residuei328PhosphoserineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP46089.
PeptideAtlasiP46089.
PRIDEiP46089.

PTM databases

iPTMnetiP46089.
PhosphoSitePlusiP46089.

Expressioni

Tissue specificityi

Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.

Inductioni

Overexpression stimulates amyloid-beta production.

Gene expression databases

BgeeiENSG00000181773.
CleanExiHS_GPR3.
ExpressionAtlasiP46089. baseline and differential.
GenevisibleiP46089. HS.

Organism-specific databases

HPAiCAB006254.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPP05067-42EBI-3909653,EBI-302641

Protein-protein interaction databases

BioGridi109088. 6 interactors.
IntActiP46089. 9 interactors.
STRINGi9606.ENSP00000363136.

Structurei

3D structure databases

ProteinModelPortaliP46089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiP46089.
KOiK04311.
OMAiSPRAWDV.
OrthoDBiEOG091G0CNB.
PhylomeDBiP46089.
TreeFamiTF330052.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000984. GPR3.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00648. GPR3ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWGAGSPLA WLSAGSGNVN VSSVGPAEGP TGPAAPLPSP KAWDVVLCIS
60 70 80 90 100
GTLVSCENAL VVAIIVGTPA FRAPMFLLVG SLAVADLLAG LGLVLHFAAV
110 120 130 140 150
FCIGSAEMSL VLVGVLAMAF TASIGSLLAI TVDRYLSLYN ALTYYSETTV
160 170 180 190 200
TRTYVMLALV WGGALGLGLL PVLAWNCLDG LTTCGVVYPL SKNHLVVLAI
210 220 230 240 250
AFFMVFGIML QLYAQICRIV CRHAQQIALQ RHLLPASHYV ATRKGIATLA
260 270 280 290 300
VVLGAFAACW LPFTVYCLLG DAHSPPLYTY LTLLPATYNS MINPIIYAFR
310 320 330
NQDVQKVLWA VCCCCSSSKI PFRSRSPSDV
Length:330
Mass (Da):35,010
Last modified:November 1, 1995 - v1
Checksum:i0F82E89200968D1E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011859222R → H.Corresponds to variant rs734852dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18550 Genomic DNA. Translation: AAB60402.1.
L32831 Genomic DNA. Translation: AAA73560.1.
X83956 Genomic DNA. Translation: CAA58787.1.
AK291185 mRNA. Translation: BAF83874.1.
AK314868 mRNA. Translation: BAG37383.1.
AL096774 Genomic DNA. Translation: CAC18517.1.
CH471059 Genomic DNA. Translation: EAX07754.1.
BC032702 mRNA. Translation: AAH32702.1.
U13668 Genomic DNA. Translation: AAA64594.1.
CCDSiCCDS303.1.
PIRiA55689.
RefSeqiNP_005272.1. NM_005281.3.
UniGeneiHs.66542.

Genome annotation databases

EnsembliENST00000374024; ENSP00000363136; ENSG00000181773.
GeneIDi2827.
KEGGihsa:2827.
UCSCiuc001bod.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18550 Genomic DNA. Translation: AAB60402.1.
L32831 Genomic DNA. Translation: AAA73560.1.
X83956 Genomic DNA. Translation: CAA58787.1.
AK291185 mRNA. Translation: BAF83874.1.
AK314868 mRNA. Translation: BAG37383.1.
AL096774 Genomic DNA. Translation: CAC18517.1.
CH471059 Genomic DNA. Translation: EAX07754.1.
BC032702 mRNA. Translation: AAH32702.1.
U13668 Genomic DNA. Translation: AAA64594.1.
CCDSiCCDS303.1.
PIRiA55689.
RefSeqiNP_005272.1. NM_005281.3.
UniGeneiHs.66542.

3D structure databases

ProteinModelPortaliP46089.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109088. 6 interactors.
IntActiP46089. 9 interactors.
STRINGi9606.ENSP00000363136.

Chemistry databases

GuidetoPHARMACOLOGYi83.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP46089.
PhosphoSitePlusiP46089.

Polymorphism and mutation databases

DMDMi1170006.

Proteomic databases

PaxDbiP46089.
PeptideAtlasiP46089.
PRIDEiP46089.

Protocols and materials databases

DNASUi2827.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374024; ENSP00000363136; ENSG00000181773.
GeneIDi2827.
KEGGihsa:2827.
UCSCiuc001bod.5. human.

Organism-specific databases

CTDi2827.
DisGeNETi2827.
GeneCardsiGPR3.
H-InvDBHIX0160062.
HGNCiHGNC:4484. GPR3.
HPAiCAB006254.
MIMi600241. gene.
neXtProtiNX_P46089.
OpenTargetsiENSG00000181773.
PharmGKBiPA28872.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiP46089.
KOiK04311.
OMAiSPRAWDV.
OrthoDBiEOG091G0CNB.
PhylomeDBiP46089.
TreeFamiTF330052.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181773-MONOMER.

Miscellaneous databases

GeneWikiiGPR3.
GenomeRNAii2827.
PROiP46089.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181773.
CleanExiHS_GPR3.
ExpressionAtlasiP46089. baseline and differential.
GenevisibleiP46089. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000984. GPR3.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00648. GPR3ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR3_HUMAN
AccessioniPrimary (citable) accession number: P46089
Secondary accession number(s): A8K570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally (PubMed:12220620) thought to be a receptor for sphingosine 1-phosphate. PubMed:19286662 demonstrated that it is not the case.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.