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P46089

- GPR3_HUMAN

UniProt

P46089 - GPR3_HUMAN

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Protein

G-protein coupled receptor 3

Gene

GPR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: ProtInc
  2. regulation of meiosis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 3
Alternative name(s):
ACCA orphan receptor
Gene namesi
Name:GPR3
Synonyms:ACCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:4484. GPR3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330G-protein coupled receptor 3PRO_0000069510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
Lipidationi313 – 3131S-palmitoyl cysteineBy similarity
Modified residuei324 – 3241PhosphoserineSequence Analysis
Modified residuei326 – 3261PhosphoserineSequence Analysis
Modified residuei328 – 3281PhosphoserineSequence Analysis

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP46089.
PRIDEiP46089.

Expressioni

Tissue specificityi

Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.

Inductioni

Overexpression stimulates amyloid-beta production.

Gene expression databases

BgeeiP46089.
CleanExiHS_GPR3.
ExpressionAtlasiP46089. baseline and differential.
GenevestigatoriP46089.

Organism-specific databases

HPAiCAB006254.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPP05067-42EBI-3909653,EBI-302641

Protein-protein interaction databases

BioGridi109088. 5 interactions.
IntActiP46089. 9 interactions.
STRINGi9606.ENSP00000363136.

Structurei

3D structure databases

ProteinModelPortaliP46089.
SMRiP46089. Positions 39-308.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
BLAST
Topological domaini63 – 7412CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini99 – 11012ExtracellularSequence AnalysisAdd
BLAST
Topological domaini133 – 15321CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini174 – 19825ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 24528CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini273 – 2775ExtracellularSequence Analysis
Topological domaini300 – 33031CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6220Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei75 – 9824Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei111 – 13222Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei154 – 17320Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei199 – 21719Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei246 – 27227Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei278 – 29922Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320944.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000294075.
HOVERGENiHBG079561.
InParanoidiP46089.
KOiK04311.
OMAiLWAICCC.
OrthoDBiEOG7966H0.
PhylomeDBiP46089.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000984. GPR3.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00648. GPR3ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46089-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMWGAGSPLA WLSAGSGNVN VSSVGPAEGP TGPAAPLPSP KAWDVVLCIS
60 70 80 90 100
GTLVSCENAL VVAIIVGTPA FRAPMFLLVG SLAVADLLAG LGLVLHFAAV
110 120 130 140 150
FCIGSAEMSL VLVGVLAMAF TASIGSLLAI TVDRYLSLYN ALTYYSETTV
160 170 180 190 200
TRTYVMLALV WGGALGLGLL PVLAWNCLDG LTTCGVVYPL SKNHLVVLAI
210 220 230 240 250
AFFMVFGIML QLYAQICRIV CRHAQQIALQ RHLLPASHYV ATRKGIATLA
260 270 280 290 300
VVLGAFAACW LPFTVYCLLG DAHSPPLYTY LTLLPATYNS MINPIIYAFR
310 320 330
NQDVQKVLWA VCCCCSSSKI PFRSRSPSDV
Length:330
Mass (Da):35,010
Last modified:November 1, 1995 - v1
Checksum:i0F82E89200968D1E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti222 – 2221R → H.
Corresponds to variant rs734852 [ dbSNP | Ensembl ].
VAR_011859

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18550 Genomic DNA. Translation: AAB60402.1.
L32831 Genomic DNA. Translation: AAA73560.1.
X83956 Genomic DNA. Translation: CAA58787.1.
AK291185 mRNA. Translation: BAF83874.1.
AK314868 mRNA. Translation: BAG37383.1.
AL096774 Genomic DNA. Translation: CAC18517.1.
CH471059 Genomic DNA. Translation: EAX07754.1.
BC032702 mRNA. Translation: AAH32702.1.
U13668 Genomic DNA. Translation: AAA64594.1.
CCDSiCCDS303.1.
PIRiA55689.
RefSeqiNP_005272.1. NM_005281.3.
UniGeneiHs.66542.

Genome annotation databases

EnsembliENST00000374024; ENSP00000363136; ENSG00000181773.
GeneIDi2827.
KEGGihsa:2827.
UCSCiuc001bod.4. human.

Polymorphism databases

DMDMi1170006.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18550 Genomic DNA. Translation: AAB60402.1 .
L32831 Genomic DNA. Translation: AAA73560.1 .
X83956 Genomic DNA. Translation: CAA58787.1 .
AK291185 mRNA. Translation: BAF83874.1 .
AK314868 mRNA. Translation: BAG37383.1 .
AL096774 Genomic DNA. Translation: CAC18517.1 .
CH471059 Genomic DNA. Translation: EAX07754.1 .
BC032702 mRNA. Translation: AAH32702.1 .
U13668 Genomic DNA. Translation: AAA64594.1 .
CCDSi CCDS303.1.
PIRi A55689.
RefSeqi NP_005272.1. NM_005281.3.
UniGenei Hs.66542.

3D structure databases

ProteinModelPortali P46089.
SMRi P46089. Positions 39-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109088. 5 interactions.
IntActi P46089. 9 interactions.
STRINGi 9606.ENSP00000363136.

Chemistry

GuidetoPHARMACOLOGYi 83.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 1170006.

Proteomic databases

PaxDbi P46089.
PRIDEi P46089.

Protocols and materials databases

DNASUi 2827.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374024 ; ENSP00000363136 ; ENSG00000181773 .
GeneIDi 2827.
KEGGi hsa:2827.
UCSCi uc001bod.4. human.

Organism-specific databases

CTDi 2827.
GeneCardsi GC01P027719.
H-InvDB HIX0160062.
HGNCi HGNC:4484. GPR3.
HPAi CAB006254.
MIMi 600241. gene.
neXtProti NX_P46089.
PharmGKBi PA28872.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320944.
GeneTreei ENSGT00760000118804.
HOGENOMi HOG000294075.
HOVERGENi HBG079561.
InParanoidi P46089.
KOi K04311.
OMAi LWAICCC.
OrthoDBi EOG7966H0.
PhylomeDBi P46089.
TreeFami TF330052.

Miscellaneous databases

GeneWikii GPR3.
GenomeRNAii 2827.
NextBioi 11155.
PROi P46089.
SOURCEi Search...

Gene expression databases

Bgeei P46089.
CleanExi HS_GPR3.
ExpressionAtlasi P46089. baseline and differential.
Genevestigatori P46089.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000984. GPR3.
IPR000723. GPR_3/6/12_orphan.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00648. GPR3ORPHANR.
PR00644. GPRORPHANR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors."
    Song Z.-H., Modi W., Bonner T.I.
    Genomics 28:347-349(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system."
    Iismaa T.P., Kiefer J., Liu M.L., Baker E., Sutherland G.R., Shine J.
    Genomics 24:391-394(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase."
    Eggerickx D., Denef J.F., Labbe O., Hayashi Y., Refetoff S., Vassart G., Parmentier M., Libert F.
    Biochem. J. 309:837-843(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-292.
  9. "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors."
    Uhlenbrock K., Gassenhuber J., Kostenis E.
    Cell. Signal. 14:941-953(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY FUNCTION.
  10. "Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay."
    Yin H., Chu A., Li W., Wang B., Shelton F., Otero F., Nguyen D.G., Caldwell J.S., Chen Y.A.
    J. Biol. Chem. 284:12328-12338(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SHOWS THAT IT IS NOT A SPHINGOSINE 1-PHOSPHATE RECEPTOR.
  11. Cited for: FUNCTION.

Entry informationi

Entry nameiGPR3_HUMAN
AccessioniPrimary (citable) accession number: P46089
Secondary accession number(s): A8K570
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally (PubMed:12220620) thought to be a receptor for sphingosine 1-phosphate. PubMed:19286662 demonstrated that it is not the case.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3