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Protein

HTH-type transcriptional regulator DsdC

Gene

dsdC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the expression of the dsdX-dsdA operon.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi32 – 51H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00297.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator DsdC
Alternative name(s):
D-serine deaminase activator
Gene namesi
Name:dsdC1 Publication
Ordered Locus Names:b2364, JW2361
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13161. dsdC.

Pathology & Biotechi

Disruption phenotypei

No longer induces the dsdX-dsdA operon.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056211 – 311HTH-type transcriptional regulator DsdCAdd BLAST311

Proteomic databases

PaxDbiP46068.
PRIDEiP46068.

Expressioni

Inductioni

By growth in D-serine.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260553. 4 interactors.
DIPiDIP-9480N.
IntActiP46068. 5 interactors.
STRINGi316385.ECDH10B_2529.

Structurei

3D structure databases

ProteinModelPortaliP46068.
SMRiP46068.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 72HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4105W8I. Bacteria.
COG0583. LUCA.
HOGENOMiHOG000233528.
InParanoidiP46068.
KOiK13636.
PhylomeDBiP46068.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011781. DsdC.
IPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
TIGRFAMsiTIGR02036. dsdC. 1 hit.
PROSITEiView protein in PROSITE
PS50931. HTH_LYSR. 1 hit.

Sequencei

Sequence statusi: Complete.

P46068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLREIRNR LLNGWQLSKM HTFEVAARHQ SFALAAEELS LSPSAVSHRI
60 70 80 90 100
NQLEEELGIQ LFVRSHRKVE LTHEGKRVYW ALKSSLDTLN QEILDIKNQE
110 120 130 140 150
LSGTLTLYSR PSIAQCWLVP ALGDFTRRYP SISLTVLTGN DNVNLQRAGI
160 170 180 190 200
DLAIYFDDAP SAQLTHHFLM DEEILPVCSP EYAQRHALTN TVINLCHCTL
210 220 230 240 250
LHDRQAWSND SGTDEWHSWA QHYAVNLPTS SGIGFDRSDL AVIAAMNHIG
260 270 280 290 300
VAMGRKRLVQ KRLASGELVA PFGDMTVKCH QHYYITTLPG RQWPKIEAFI
310
IWLREQVKTT S
Length:311
Mass (Da):35,332
Last modified:November 1, 1997 - v2
Checksum:i0335B060CF5DB3BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159A → R in CAA62931 (PubMed:7592420).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91821 Genomic DNA. Translation: CAA62931.1.
U00096 Genomic DNA. Translation: AAC75423.1.
AP009048 Genomic DNA. Translation: BAA16224.1.
X86379 Genomic DNA. No translation available.
PIRiA65010.
RefSeqiNP_416865.1. NC_000913.3.
WP_001326971.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75423; AAC75423; b2364.
BAA16224; BAA16224; BAA16224.
GeneIDi948828.
KEGGiecj:JW2361.
eco:b2364.
PATRICifig|1411691.4.peg.4365.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDSDC_ECOLI
AccessioniPrimary (citable) accession number: P46068
Secondary accession number(s): P77443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene