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Protein

HTH-type transcriptional regulator DsdC

Gene

dsdC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulates the expression of the dsd operon for D-serine deaminase (dsdA).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi32 – 5120H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00297.
ECOL316407:JW2361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator DsdC
Alternative name(s):
D-serine deaminase activator
Gene namesi
Name:dsdC
Ordered Locus Names:b2364, JW2361
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13161. dsdC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311HTH-type transcriptional regulator DsdCPRO_0000105621Add
BLAST

Proteomic databases

PaxDbiP46068.

Interactioni

Protein-protein interaction databases

BioGridi4260553. 4 interactions.
DIPiDIP-9480N.
IntActiP46068. 5 interactions.
STRINGi511145.b2364.

Structurei

3D structure databases

ProteinModelPortaliP46068.
SMRiP46068. Positions 16-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 7258HTH lysR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105W8I. Bacteria.
COG0583. LUCA.
HOGENOMiHOG000233528.
InParanoidiP46068.
KOiK13636.
OMAiNHVGVAM.
OrthoDBiEOG6G4VSC.
PhylomeDBiP46068.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011781. DsdC.
IPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
TIGRFAMsiTIGR02036. dsdC. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLREIRNR LLNGWQLSKM HTFEVAARHQ SFALAAEELS LSPSAVSHRI
60 70 80 90 100
NQLEEELGIQ LFVRSHRKVE LTHEGKRVYW ALKSSLDTLN QEILDIKNQE
110 120 130 140 150
LSGTLTLYSR PSIAQCWLVP ALGDFTRRYP SISLTVLTGN DNVNLQRAGI
160 170 180 190 200
DLAIYFDDAP SAQLTHHFLM DEEILPVCSP EYAQRHALTN TVINLCHCTL
210 220 230 240 250
LHDRQAWSND SGTDEWHSWA QHYAVNLPTS SGIGFDRSDL AVIAAMNHIG
260 270 280 290 300
VAMGRKRLVQ KRLASGELVA PFGDMTVKCH QHYYITTLPG RQWPKIEAFI
310
IWLREQVKTT S
Length:311
Mass (Da):35,332
Last modified:November 1, 1997 - v2
Checksum:i0335B060CF5DB3BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591A → R in CAA62931 (PubMed:7592420).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91821 Genomic DNA. Translation: CAA62931.1.
U00096 Genomic DNA. Translation: AAC75423.1.
AP009048 Genomic DNA. Translation: BAA16224.1.
X86379 Genomic DNA. No translation available.
PIRiA65010.
RefSeqiNP_416865.1. NC_000913.3.
WP_001326971.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75423; AAC75423; b2364.
BAA16224; BAA16224; BAA16224.
GeneIDi948828.
KEGGiecj:JW2361.
eco:b2364.
PATRICi32120107. VBIEscCol129921_2462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91821 Genomic DNA. Translation: CAA62931.1.
U00096 Genomic DNA. Translation: AAC75423.1.
AP009048 Genomic DNA. Translation: BAA16224.1.
X86379 Genomic DNA. No translation available.
PIRiA65010.
RefSeqiNP_416865.1. NC_000913.3.
WP_001326971.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP46068.
SMRiP46068. Positions 16-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260553. 4 interactions.
DIPiDIP-9480N.
IntActiP46068. 5 interactions.
STRINGi511145.b2364.

Proteomic databases

PaxDbiP46068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75423; AAC75423; b2364.
BAA16224; BAA16224; BAA16224.
GeneIDi948828.
KEGGiecj:JW2361.
eco:b2364.
PATRICi32120107. VBIEscCol129921_2462.

Organism-specific databases

EchoBASEiEB2953.
EcoGeneiEG13161. dsdC.

Phylogenomic databases

eggNOGiENOG4105W8I. Bacteria.
COG0583. LUCA.
HOGENOMiHOG000233528.
InParanoidiP46068.
KOiK13636.
OMAiNHVGVAM.
OrthoDBiEOG6G4VSC.
PhylomeDBiP46068.

Enzyme and pathway databases

BioCyciEcoCyc:PD00297.
ECOL316407:JW2361-MONOMER.

Miscellaneous databases

PROiP46068.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011781. DsdC.
IPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
TIGRFAMsiTIGR02036. dsdC. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization and transcriptional regulation of the Escherichia coli K-12 D-serine tolerance locus."
    Noerregaard-Madsen M., McFall E., Valentin-Hansen P.
    J. Bacteriol. 177:6456-6461(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: K12.
  2. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. Brannigan J.A.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-53.
    Strain: K12.

Entry informationi

Entry nameiDSDC_ECOLI
AccessioniPrimary (citable) accession number: P46068
Secondary accession number(s): P77443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.