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P46062

- SIPA1_MOUSE

UniProt

P46062 - SIPA1_MOUSE

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Protein

Signal-induced proliferation-associated protein 1

Gene
Sipa1, Spa-1, Spa1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GTPase activator for the nuclear Ras-related regulatory protein Rap1, Rsr1 and Ran in vitro, converting it to the putatively inactive GDP-bound state. Affects cell cycle progression.

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of cell cycle Source: MGI
  2. regulation of small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-induced proliferation-associated protein 1
Short name:
Sipa-1
Alternative name(s):
GTPase-activating protein Spa-1
Gene namesi
Name:Sipa1
Synonyms:Spa-1, Spa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:107576. Sipa1.

Subcellular locationi

Nucleus
Note: Mostly nuclear.

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10371037Signal-induced proliferation-associated protein 1PRO_0000056745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621Phosphothreonine By similarity
Modified residuei65 – 651Phosphoserine By similarity
Modified residuei812 – 8121Phosphoserine By similarity
Modified residuei834 – 8341Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP46062.
PaxDbiP46062.
PRIDEiP46062.

PTM databases

PhosphoSiteiP46062.

Expressioni

Tissue specificityi

Preferentially expressed in both fetal and adult lymphohematopoietic tissues.

Inductioni

By mitogens.

Gene expression databases

CleanExiMM_SIPA1.
GenevestigatoriP46062.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079637.

Structurei

3D structure databases

ProteinModelPortaliP46062.
SMRiP46062. Positions 200-534, 682-753.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini316 – 534219Rap-GAPAdd
BLAST
Domaini682 – 75877PDZAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili968 – 102558 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.
Contains 1 Rap-GAP domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG292441.
HOVERGENiHBG061666.
InParanoidiP46062.
PhylomeDBiP46062.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF02145. Rap_GAP. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46062-1 [UniParc]FASTAAdd to Basket

« Hide

MWAGGVGSPR RGMAPAPTDD LFARKLRQPA RPPLTPNTFE PRPARGPLLR     50
SGSDAGEVRP PTPASPRARA HSHEDASRPA ATPTRLFTDP LALLGLPAEE 100
PEPTFPPVLE PRWFAHYDVQ SLLFDWAPRP RGTGSHTEAN SGTLAEGQTT 150
TSDLLLGAPG FVSELGGEGE LGLGGPISPP VPPALPNAAV SVLEEPQTRT 200
TTYSLEHADL GAGYYRKYFY GKEHQNFFGL DEALGPVAVS LRREEKEGSG 250
GGTLHSYRVI VRTTQLRTLR GTISEDALPP GPPSVSPRKL LEHVAPRLSP 300
TCLRLGSASP KVPRQLLTLD EQVLSFQRKG GILYCRAGQG SEEEMYNNQE 350
AGAAFMQFLT LLGDVVRLKG FESYRAQLDT KTDSTGTHSL YTTYQDHEIM 400
FHVSTMLPYT PNNQQQLLRK RHIGNDIVTI VFQEPGSKPF CPTTIRSHFQ 450
HVFLVVRAHA PCTPHTSYRV AVSRTQDTPA FGPALPEGGG PFAANADFRA 500
FLLAKALNGE QAAGHARQFH AMATRTRQQY LQDLATNEVT TTSLDSASRF 550
GLPSLGGRRR ATPRSPGADV QAAGALMWGV RAAPGARVAA GAETSGPDDA 600
EVPCLLGISA ETLVLVAPRD GRVVFNCACR DVLAWTFSEH QLDLYHGRGE 650
AITLRLDGAP GQAVGEVVAR LQLVSRGCET RELALPRDGQ GRLGFEVDAE 700
GFITHVERFT FAETTGLRPG ARLLRVCGQT LPKLGPETAA QMLRSAPKVC 750
VTVLPPDESG RPRRSFSELY MLSLKEPSRR GGPEPVQDET GKLVILPPTK 800
QLLHFCLKDS SSPPGPGDLT EERTEFLRTH NSLSSGSSLS DEAPVLPNTT 850
PDLLLVTTAN PSAPGTDRET PPSQDQSGSP SSHEDTSDSG PELRASILPR 900
TLSLRNSISK IMSEAGSETL EDEWQSISEI ASTCNTILES LSREGQPISE 950
SGDPKEALKC DSEPEPGSLS EKVSHLESML WKLQEDLQRE KADRAALEEE 1000
VRSLRHNNQR LLAESESAAT RLLLASKHLG APTTDLA 1037
Length:1,037
Mass (Da):112,066
Last modified:May 2, 2002 - v2
Checksum:i2A30592E920A9AA5
GO

Sequence cautioni

The sequence BAA01973.1 differs from that shown. Reason: Frameshift at several positions.
The sequence BAA13469.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti738 – 7381T → A in BAA13469. 1 Publication
Sequence conflicti763 – 7631R → Q in BAA13469. 1 Publication
Sequence conflicti829 – 8291T → S in BAA13469. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D11374 mRNA. Translation: BAA01973.1. Frameshift.
D87849 Genomic DNA. Translation: BAA13469.1. Different initiation.
PIRiI49709.
UniGeneiMm.3072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D11374 mRNA. Translation: BAA01973.1 . Frameshift.
D87849 Genomic DNA. Translation: BAA13469.1 . Different initiation.
PIRi I49709.
UniGenei Mm.3072.

3D structure databases

ProteinModelPortali P46062.
SMRi P46062. Positions 200-534, 682-753.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000079637.

PTM databases

PhosphoSitei P46062.

Proteomic databases

MaxQBi P46062.
PaxDbi P46062.
PRIDEi P46062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:107576. Sipa1.

Phylogenomic databases

eggNOGi NOG292441.
HOVERGENi HBG061666.
InParanoidi P46062.
PhylomeDBi P46062.

Miscellaneous databases

PROi P46062.
SOURCEi Search...

Gene expression databases

CleanExi MM_SIPA1.
Genevestigatori P46062.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
IPR000331. Rap_GAP_dom.
[Graphical view ]
Pfami PF00595. PDZ. 1 hit.
PF02145. Rap_GAP. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression."
    Hattori M., Tsukamoto N., Nur-E-Kamal M.S.A., Rubinfeld B., Iwai K., Kubota H., Maruta H., Minato N.
    Mol. Cell. Biol. 15:552-560(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human."
    Wada Y., Kubota H., Maeda M., Taniwaki M., Hattori M., Imamura S., Iwai K., Minato N.
    Genomics 39:66-73(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 324-1037.
    Strain: DBA/2.
  3. "Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2."
    Kurachi H., Wada Y., Tsukamoto N., Maeda M., Kubota H., Hattori M., Iwai K., Minato N.
    J. Biol. Chem. 272:28081-28088(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF PROBABLE FRAMESHIFTS.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSIPA1_MOUSE
AccessioniPrimary (citable) accession number: P46062
Secondary accession number(s): P70204
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 2, 2002
Last modified: June 11, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi