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P46059

- S15A1_HUMAN

UniProt

P46059 - S15A1_HUMAN

Protein

Solute carrier family 15 member 1

Gene

SLC15A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

    GO - Molecular functioni

    1. peptide:proton symporter activity Source: ProtInc
    2. proton-dependent oligopeptide secondary active transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. digestion Source: ProtInc
    2. ion transport Source: Reactome
    3. protein transport Source: UniProtKB-KW
    4. proton transport Source: GOC
    5. transmembrane transport Source: Reactome
    6. transport Source: ProtInc

    Keywords - Biological processi

    Peptide transport, Protein transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

    Protein family/group databases

    TCDBi2.A.17.4.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 15 member 1
    Alternative name(s):
    Intestinal H(+)/peptide cotransporter
    Oligopeptide transporter, small intestine isoform
    Peptide transporter 1
    Gene namesi
    Name:SLC15A1
    Synonyms:PEPT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:10920. SLC15A1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA323.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 708708Solute carrier family 15 member 1PRO_0000064304Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP46059.
    PRIDEiP46059.

    PTM databases

    PhosphoSiteiP46059.

    Expressioni

    Gene expression databases

    ArrayExpressiP46059.
    BgeeiP46059.
    CleanExiHS_SLC15A1.
    GenevestigatoriP46059.

    Organism-specific databases

    HPAiHPA002827.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000365686.

    Structurei

    3D structure databases

    ProteinModelPortaliP46059.
    SMRiP46059. Positions 9-385, 584-635.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 5332ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini75 – 828CytoplasmicSequence Analysis
    Topological domaini104 – 11815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini140 – 16122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 19816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 27657CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini298 – 32730ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini349 – 36113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini383 – 584202ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini606 – 61914CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini641 – 6455ExtracellularSequence Analysis
    Topological domaini667 – 70842CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei585 – 60521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei620 – 64021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei646 – 66621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3104.
    HOGENOMiHOG000285186.
    HOVERGENiHBG052962.
    InParanoidiP46059.
    KOiK14206.
    OMAiLVWAPNH.
    OrthoDBiEOG7M3J0R.
    PhylomeDBiP46059.
    TreeFamiTF330897.

    Family and domain databases

    InterProiIPR016196. MFS_dom_general_subst_transpt.
    IPR004768. Oligopep_transport.
    IPR000109. POT_fam.
    IPR018456. PTR2_symporter_CS.
    [Graphical view]
    PANTHERiPTHR11654. PTHR11654. 1 hit.
    PfamiPF00854. PTR2. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00926. 2A1704. 1 hit.
    PROSITEiPS01022. PTR2_1. 1 hit.
    PS01023. PTR2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46059-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN    50
    LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV 100
    SSINDLTDHN HDGTPDSLPV HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ 150
    FEEGQEKQRN RFFSIFYLAI NAGSLLSTII TPMLRVQQCG IHSKQACYPL 200
    AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI GFAIKNRFRH 250
    RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ 300
    GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK 350
    CGFNFTSLKK MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL 400
    NIGNNTMNIS LPGEMVTLGP MSQTNAFMTF DVNKLTRINI SSPGSPVTAV 450
    TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK PEKGENGIRF VNTFNELITI 500
    TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ PNFNTFYLEF 550
    GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV 600
    TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI 650
    LFAALLLVVC VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS 700
    GANSQKQM 708
    Length:708
    Mass (Da):78,806
    Last modified:November 1, 1995 - v1
    Checksum:iA75475789177A907
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211V → I.1 Publication
    Corresponds to variant rs8187818 [ dbSNP | Ensembl ].
    VAR_029321
    Natural varianti28 – 281F → Y.1 Publication
    VAR_029322
    Natural varianti117 – 1171S → N.2 Publications
    Corresponds to variant rs2297322 [ dbSNP | Ensembl ].
    VAR_022147
    Natural varianti117 – 1171S → R.1 Publication
    Corresponds to variant rs8187821 [ dbSNP | Ensembl ].
    VAR_029323
    Natural varianti122 – 1221V → M.1 Publication
    Corresponds to variant rs8187820 [ dbSNP | Ensembl ].
    VAR_020456
    Natural varianti419 – 4191G → A.2 Publications
    Corresponds to variant rs4646227 [ dbSNP | Ensembl ].
    VAR_020457
    Natural varianti450 – 4501V → I.1 Publication
    Corresponds to variant rs2274828 [ dbSNP | Ensembl ].
    VAR_022148
    Natural varianti451 – 4511T → N.1 Publication
    Corresponds to variant rs8187838 [ dbSNP | Ensembl ].
    VAR_020458
    Natural varianti459 – 4591R → C.
    Corresponds to variant rs2274827 [ dbSNP | Ensembl ].
    VAR_022149
    Natural varianti537 – 5371P → S.1 Publication
    Corresponds to variant rs8187830 [ dbSNP | Ensembl ].
    VAR_029324

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13173 mRNA. Translation: AAB61693.1.
    U21936 mRNA. Translation: AAA63797.1.
    AL391670, AL353574 Genomic DNA. Translation: CAH70393.1.
    AL353574, AL391670 Genomic DNA. Translation: CAI15619.1.
    BC096328 mRNA. Translation: AAH96328.1.
    BC096329 mRNA. Translation: AAH96329.1.
    CCDSiCCDS9489.1.
    PIRiA56163.
    RefSeqiNP_005064.1. NM_005073.3.
    UniGeneiHs.436893.

    Genome annotation databases

    EnsembliENST00000376503; ENSP00000365686; ENSG00000088386.
    GeneIDi6564.
    KEGGihsa:6564.
    UCSCiuc001vno.3. human.

    Polymorphism databases

    DMDMi1172435.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13173 mRNA. Translation: AAB61693.1 .
    U21936 mRNA. Translation: AAA63797.1 .
    AL391670 , AL353574 Genomic DNA. Translation: CAH70393.1 .
    AL353574 , AL391670 Genomic DNA. Translation: CAI15619.1 .
    BC096328 mRNA. Translation: AAH96328.1 .
    BC096329 mRNA. Translation: AAH96329.1 .
    CCDSi CCDS9489.1.
    PIRi A56163.
    RefSeqi NP_005064.1. NM_005073.3.
    UniGenei Hs.436893.

    3D structure databases

    ProteinModelPortali P46059.
    SMRi P46059. Positions 9-385, 584-635.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000365686.

    Chemistry

    BindingDBi P46059.
    ChEMBLi CHEMBL4605.
    DrugBanki DB01140. Cefadroxil.
    DB01415. Ceftibuten.
    DB01000. Cyclacillin.
    GuidetoPHARMACOLOGYi 984.

    Protein family/group databases

    TCDBi 2.A.17.4.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

    PTM databases

    PhosphoSitei P46059.

    Polymorphism databases

    DMDMi 1172435.

    Proteomic databases

    PaxDbi P46059.
    PRIDEi P46059.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376503 ; ENSP00000365686 ; ENSG00000088386 .
    GeneIDi 6564.
    KEGGi hsa:6564.
    UCSCi uc001vno.3. human.

    Organism-specific databases

    CTDi 6564.
    GeneCardsi GC13M099336.
    HGNCi HGNC:10920. SLC15A1.
    HPAi HPA002827.
    MIMi 600544. gene.
    neXtProti NX_P46059.
    PharmGKBi PA323.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3104.
    HOGENOMi HOG000285186.
    HOVERGENi HBG052962.
    InParanoidi P46059.
    KOi K14206.
    OMAi LVWAPNH.
    OrthoDBi EOG7M3J0R.
    PhylomeDBi P46059.
    TreeFami TF330897.

    Enzyme and pathway databases

    Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

    Miscellaneous databases

    GeneWikii Peptide_transporter_1.
    GenomeRNAii 6564.
    NextBioi 25539.
    PROi P46059.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46059.
    Bgeei P46059.
    CleanExi HS_SLC15A1.
    Genevestigatori P46059.

    Family and domain databases

    InterProi IPR016196. MFS_dom_general_subst_transpt.
    IPR004768. Oligopep_transport.
    IPR000109. POT_fam.
    IPR018456. PTR2_symporter_CS.
    [Graphical view ]
    PANTHERi PTHR11654. PTHR11654. 1 hit.
    Pfami PF00854. PTR2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00926. 2A1704. 1 hit.
    PROSITEi PS01022. PTR2_1. 1 hit.
    PS01023. PTR2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization."
      Liang R., Fei Y.-J., Prasad P.D., Ramamoorthy S., Han H., Yang-Feng T.L., Hediger M.A., Ganapathy V., Leibach F.H.
      J. Biol. Chem. 270:6456-6463(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population."
      Saito S., Iida A., Sekine A., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
      J. Hum. Genet. 47:576-584(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASN-117 AND ALA-419.
    5. Cited for: VARIANTS ILE-21; TYR-28; ASN-117; ARG-117; MET-122; ALA-419; ILE-450; ASN-451 AND SER-537.

    Entry informationi

    Entry nameiS15A1_HUMAN
    AccessioniPrimary (citable) accession number: P46059
    Secondary accession number(s): Q5VW82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3