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P46059

- S15A1_HUMAN

UniProt

P46059 - S15A1_HUMAN

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Protein

Solute carrier family 15 member 1

Gene

SLC15A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

GO - Molecular functioni

  1. peptide:proton symporter activity Source: ProtInc
  2. proton-dependent oligopeptide secondary active transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. digestion Source: ProtInc
  2. ion transport Source: Reactome
  3. protein transport Source: UniProtKB-KW
  4. proton transport Source: GOC
  5. transmembrane transport Source: Reactome
  6. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

Protein family/group databases

TCDBi2.A.17.4.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 1
Alternative name(s):
Intestinal H(+)/peptide cotransporter
Oligopeptide transporter, small intestine isoform
Peptide transporter 1
Gene namesi
Name:SLC15A1
Synonyms:PEPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:10920. SLC15A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Topological domaini22 – 5332ExtracellularSequence AnalysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Topological domaini75 – 828CytoplasmicSequence Analysis
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST
Topological domaini104 – 11815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Topological domaini140 – 16122CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 19816ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Topological domaini220 – 27657CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei277 – 29721HelicalSequence AnalysisAdd
BLAST
Topological domaini298 – 32730ExtracellularSequence AnalysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence AnalysisAdd
BLAST
Topological domaini349 – 36113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence AnalysisAdd
BLAST
Topological domaini383 – 584202ExtracellularSequence AnalysisAdd
BLAST
Transmembranei585 – 60521HelicalSequence AnalysisAdd
BLAST
Topological domaini606 – 61914CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei620 – 64021HelicalSequence AnalysisAdd
BLAST
Topological domaini641 – 6455ExtracellularSequence Analysis
Transmembranei646 – 66621HelicalSequence AnalysisAdd
BLAST
Topological domaini667 – 70842CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Solute carrier family 15 member 1PRO_0000064304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP46059.
PRIDEiP46059.

PTM databases

PhosphoSiteiP46059.

Expressioni

Gene expression databases

BgeeiP46059.
CleanExiHS_SLC15A1.
ExpressionAtlasiP46059. baseline and differential.
GenevestigatoriP46059.

Organism-specific databases

HPAiHPA002827.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365686.

Structurei

3D structure databases

ProteinModelPortaliP46059.
SMRiP46059. Positions 9-374, 584-635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3104.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiP46059.
KOiK14206.
OMAiLVWAPNH.
OrthoDBiEOG7M3J0R.
PhylomeDBiP46059.
TreeFamiTF330897.

Family and domain databases

InterProiIPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46059-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN
60 70 80 90 100
LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV
110 120 130 140 150
SSINDLTDHN HDGTPDSLPV HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ
160 170 180 190 200
FEEGQEKQRN RFFSIFYLAI NAGSLLSTII TPMLRVQQCG IHSKQACYPL
210 220 230 240 250
AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI GFAIKNRFRH
260 270 280 290 300
RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ
310 320 330 340 350
GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK
360 370 380 390 400
CGFNFTSLKK MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL
410 420 430 440 450
NIGNNTMNIS LPGEMVTLGP MSQTNAFMTF DVNKLTRINI SSPGSPVTAV
460 470 480 490 500
TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK PEKGENGIRF VNTFNELITI
510 520 530 540 550
TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ PNFNTFYLEF
560 570 580 590 600
GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV
610 620 630 640 650
TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI
660 670 680 690 700
LFAALLLVVC VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS

GANSQKQM
Length:708
Mass (Da):78,806
Last modified:November 1, 1995 - v1
Checksum:iA75475789177A907
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211V → I.1 Publication
Corresponds to variant rs8187818 [ dbSNP | Ensembl ].
VAR_029321
Natural varianti28 – 281F → Y.1 Publication
VAR_029322
Natural varianti117 – 1171S → N.2 Publications
Corresponds to variant rs2297322 [ dbSNP | Ensembl ].
VAR_022147
Natural varianti117 – 1171S → R.1 Publication
Corresponds to variant rs8187821 [ dbSNP | Ensembl ].
VAR_029323
Natural varianti122 – 1221V → M.1 Publication
Corresponds to variant rs8187820 [ dbSNP | Ensembl ].
VAR_020456
Natural varianti419 – 4191G → A.2 Publications
Corresponds to variant rs4646227 [ dbSNP | Ensembl ].
VAR_020457
Natural varianti450 – 4501V → I.1 Publication
Corresponds to variant rs2274828 [ dbSNP | Ensembl ].
VAR_022148
Natural varianti451 – 4511T → N.1 Publication
Corresponds to variant rs8187838 [ dbSNP | Ensembl ].
VAR_020458
Natural varianti459 – 4591R → C.
Corresponds to variant rs2274827 [ dbSNP | Ensembl ].
VAR_022149
Natural varianti537 – 5371P → S.1 Publication
Corresponds to variant rs8187830 [ dbSNP | Ensembl ].
VAR_029324

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13173 mRNA. Translation: AAB61693.1.
U21936 mRNA. Translation: AAA63797.1.
AL391670, AL353574 Genomic DNA. Translation: CAH70393.1.
AL353574, AL391670 Genomic DNA. Translation: CAI15619.1.
BC096328 mRNA. Translation: AAH96328.1.
BC096329 mRNA. Translation: AAH96329.1.
CCDSiCCDS9489.1.
PIRiA56163.
RefSeqiNP_005064.1. NM_005073.3.
UniGeneiHs.436893.

Genome annotation databases

EnsembliENST00000376503; ENSP00000365686; ENSG00000088386.
GeneIDi6564.
KEGGihsa:6564.
UCSCiuc001vno.3. human.

Polymorphism databases

DMDMi1172435.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13173 mRNA. Translation: AAB61693.1 .
U21936 mRNA. Translation: AAA63797.1 .
AL391670 , AL353574 Genomic DNA. Translation: CAH70393.1 .
AL353574 , AL391670 Genomic DNA. Translation: CAI15619.1 .
BC096328 mRNA. Translation: AAH96328.1 .
BC096329 mRNA. Translation: AAH96329.1 .
CCDSi CCDS9489.1.
PIRi A56163.
RefSeqi NP_005064.1. NM_005073.3.
UniGenei Hs.436893.

3D structure databases

ProteinModelPortali P46059.
SMRi P46059. Positions 9-374, 584-635.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000365686.

Chemistry

BindingDBi P46059.
ChEMBLi CHEMBL4605.
DrugBanki DB00855. Aminolevulinic acid.
DB01060. Amoxicillin.
DB00415. Ampicillin.
DB08795. Azidocillin.
DB00542. Benazepril.
DB01053. Benzylpenicillin.
DB01197. Captopril.
DB00833. Cefaclor.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB00535. Cefdinir.
DB01413. Cefepime.
DB00671. Cefixime.
DB00274. Cefmetazole.
DB00493. Cefotaxime.
DB01333. Cefradine.
DB00438. Ceftazidime.
DB01415. Ceftibuten.
DB01332. Ceftizoxime.
DB01212. Ceftriaxone.
DB01112. Cefuroxime.
DB00567. Cephalexin.
DB00672. Chlorpropamide.
DB01340. Cilazapril.
DB01147. Cloxacillin.
DB01000. Cyclacillin.
DB00485. Dicloxacillin.
DB00584. Enalapril.
DB01095. Fluvastatin.
DB00492. Fosinopril.
DB01016. Glyburide.
DB01235. L-DOPA.
DB00722. Lisinopril.
DB00968. Methyldopa.
DB00211. Midodrine.
DB00691. Moexipril.
DB00731. Nateglinide.
DB00198. Oseltamivir.
DB00713. Oxacillin.
DB00790. Perindopril.
DB00881. Quinapril.
DB00178. Ramipril.
DB01348. Spirapril.
DB01124. Tolbutamide.
DB00519. Trandolapril.
DB00577. Valaciclovir.
DB01610. Valganciclovir.
GuidetoPHARMACOLOGYi 984.

Protein family/group databases

TCDBi 2.A.17.4.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

PhosphoSitei P46059.

Polymorphism databases

DMDMi 1172435.

Proteomic databases

PaxDbi P46059.
PRIDEi P46059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376503 ; ENSP00000365686 ; ENSG00000088386 .
GeneIDi 6564.
KEGGi hsa:6564.
UCSCi uc001vno.3. human.

Organism-specific databases

CTDi 6564.
GeneCardsi GC13M099336.
HGNCi HGNC:10920. SLC15A1.
HPAi HPA002827.
MIMi 600544. gene.
neXtProti NX_P46059.
PharmGKBi PA323.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3104.
GeneTreei ENSGT00530000062961.
HOGENOMi HOG000285186.
HOVERGENi HBG052962.
InParanoidi P46059.
KOi K14206.
OMAi LVWAPNH.
OrthoDBi EOG7M3J0R.
PhylomeDBi P46059.
TreeFami TF330897.

Enzyme and pathway databases

Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

Miscellaneous databases

GeneWikii Peptide_transporter_1.
GenomeRNAii 6564.
NextBioi 25539.
PROi P46059.
SOURCEi Search...

Gene expression databases

Bgeei P46059.
CleanExi HS_SLC15A1.
ExpressionAtlasi P46059. baseline and differential.
Genevestigatori P46059.

Family and domain databases

InterProi IPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view ]
PANTHERi PTHR11654. PTHR11654. 1 hit.
Pfami PF00854. PTR2. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00926. 2A1704. 1 hit.
PROSITEi PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization."
    Liang R., Fei Y.-J., Prasad P.D., Ramamoorthy S., Han H., Yang-Feng T.L., Hediger M.A., Ganapathy V., Leibach F.H.
    J. Biol. Chem. 270:6456-6463(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population."
    Saito S., Iida A., Sekine A., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
    J. Hum. Genet. 47:576-584(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASN-117 AND ALA-419.
  5. Cited for: VARIANTS ILE-21; TYR-28; ASN-117; ARG-117; MET-122; ALA-419; ILE-450; ASN-451 AND SER-537.

Entry informationi

Entry nameiS15A1_HUMAN
AccessioniPrimary (citable) accession number: P46059
Secondary accession number(s): Q5VW82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3