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P46059

- S15A1_HUMAN

UniProt

P46059 - S15A1_HUMAN

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Protein
Solute carrier family 15 member 1
Gene
SLC15A1, PEPT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

GO - Molecular functioni

  1. peptide:proton symporter activity Source: ProtInc
  2. proton-dependent oligopeptide secondary active transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. digestion Source: ProtInc
  2. ion transport Source: Reactome
  3. protein transport Source: UniProtKB-KW
  4. proton transport Source: GOC
  5. transmembrane transport Source: Reactome
  6. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

Protein family/group databases

TCDBi2.A.17.4.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 1
Alternative name(s):
Intestinal H(+)/peptide cotransporter
Oligopeptide transporter, small intestine isoform
Peptide transporter 1
Gene namesi
Name:SLC15A1
Synonyms:PEPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:10920. SLC15A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed prediction
Add
BLAST
Topological domaini22 – 5332Extracellular Reviewed prediction
Add
BLAST
Transmembranei54 – 7421Helical; Reviewed prediction
Add
BLAST
Topological domaini75 – 828Cytoplasmic Reviewed prediction
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Topological domaini104 – 11815Extracellular Reviewed prediction
Add
BLAST
Transmembranei119 – 13921Helical; Reviewed prediction
Add
BLAST
Topological domaini140 – 16122Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei162 – 18221Helical; Reviewed prediction
Add
BLAST
Topological domaini183 – 19816Extracellular Reviewed prediction
Add
BLAST
Transmembranei199 – 21921Helical; Reviewed prediction
Add
BLAST
Topological domaini220 – 27657Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei277 – 29721Helical; Reviewed prediction
Add
BLAST
Topological domaini298 – 32730Extracellular Reviewed prediction
Add
BLAST
Transmembranei328 – 34821Helical; Reviewed prediction
Add
BLAST
Topological domaini349 – 36113Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei362 – 38221Helical; Reviewed prediction
Add
BLAST
Topological domaini383 – 584202Extracellular Reviewed prediction
Add
BLAST
Transmembranei585 – 60521Helical; Reviewed prediction
Add
BLAST
Topological domaini606 – 61914Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei620 – 64021Helical; Reviewed prediction
Add
BLAST
Topological domaini641 – 6455Extracellular Reviewed prediction
Transmembranei646 – 66621Helical; Reviewed prediction
Add
BLAST
Topological domaini667 – 70842Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Solute carrier family 15 member 1
PRO_0000064304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi404 – 4041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi408 – 4081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi439 – 4391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi509 – 5091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi562 – 5621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP46059.
PRIDEiP46059.

PTM databases

PhosphoSiteiP46059.

Expressioni

Gene expression databases

ArrayExpressiP46059.
BgeeiP46059.
CleanExiHS_SLC15A1.
GenevestigatoriP46059.

Organism-specific databases

HPAiHPA002827.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365686.

Structurei

3D structure databases

ProteinModelPortaliP46059.
SMRiP46059. Positions 9-385, 584-635.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3104.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiP46059.
KOiK14206.
OMAiLVWAPNH.
OrthoDBiEOG7M3J0R.
PhylomeDBiP46059.
TreeFamiTF330897.

Family and domain databases

InterProiIPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46059-1 [UniParc]FASTAAdd to Basket

« Hide

MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN    50
LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV 100
SSINDLTDHN HDGTPDSLPV HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ 150
FEEGQEKQRN RFFSIFYLAI NAGSLLSTII TPMLRVQQCG IHSKQACYPL 200
AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI GFAIKNRFRH 250
RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ 300
GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK 350
CGFNFTSLKK MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL 400
NIGNNTMNIS LPGEMVTLGP MSQTNAFMTF DVNKLTRINI SSPGSPVTAV 450
TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK PEKGENGIRF VNTFNELITI 500
TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ PNFNTFYLEF 550
GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV 600
TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI 650
LFAALLLVVC VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS 700
GANSQKQM 708
Length:708
Mass (Da):78,806
Last modified:November 1, 1995 - v1
Checksum:iA75475789177A907
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211V → I.1 Publication
Corresponds to variant rs8187818 [ dbSNP | Ensembl ].
VAR_029321
Natural varianti28 – 281F → Y.1 Publication
VAR_029322
Natural varianti117 – 1171S → N.2 Publications
Corresponds to variant rs2297322 [ dbSNP | Ensembl ].
VAR_022147
Natural varianti117 – 1171S → R.1 Publication
Corresponds to variant rs8187821 [ dbSNP | Ensembl ].
VAR_029323
Natural varianti122 – 1221V → M.1 Publication
Corresponds to variant rs8187820 [ dbSNP | Ensembl ].
VAR_020456
Natural varianti419 – 4191G → A.2 Publications
Corresponds to variant rs4646227 [ dbSNP | Ensembl ].
VAR_020457
Natural varianti450 – 4501V → I.1 Publication
Corresponds to variant rs2274828 [ dbSNP | Ensembl ].
VAR_022148
Natural varianti451 – 4511T → N.1 Publication
Corresponds to variant rs8187838 [ dbSNP | Ensembl ].
VAR_020458
Natural varianti459 – 4591R → C.
Corresponds to variant rs2274827 [ dbSNP | Ensembl ].
VAR_022149
Natural varianti537 – 5371P → S.1 Publication
Corresponds to variant rs8187830 [ dbSNP | Ensembl ].
VAR_029324

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13173 mRNA. Translation: AAB61693.1.
U21936 mRNA. Translation: AAA63797.1.
AL391670, AL353574 Genomic DNA. Translation: CAH70393.1.
AL353574, AL391670 Genomic DNA. Translation: CAI15619.1.
BC096328 mRNA. Translation: AAH96328.1.
BC096329 mRNA. Translation: AAH96329.1.
CCDSiCCDS9489.1.
PIRiA56163.
RefSeqiNP_005064.1. NM_005073.3.
UniGeneiHs.436893.

Genome annotation databases

EnsembliENST00000376503; ENSP00000365686; ENSG00000088386.
GeneIDi6564.
KEGGihsa:6564.
UCSCiuc001vno.3. human.

Polymorphism databases

DMDMi1172435.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13173 mRNA. Translation: AAB61693.1 .
U21936 mRNA. Translation: AAA63797.1 .
AL391670 , AL353574 Genomic DNA. Translation: CAH70393.1 .
AL353574 , AL391670 Genomic DNA. Translation: CAI15619.1 .
BC096328 mRNA. Translation: AAH96328.1 .
BC096329 mRNA. Translation: AAH96329.1 .
CCDSi CCDS9489.1.
PIRi A56163.
RefSeqi NP_005064.1. NM_005073.3.
UniGenei Hs.436893.

3D structure databases

ProteinModelPortali P46059.
SMRi P46059. Positions 9-385, 584-635.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000365686.

Chemistry

BindingDBi P46059.
ChEMBLi CHEMBL4605.
DrugBanki DB01140. Cefadroxil.
DB01415. Ceftibuten.
DB01000. Cyclacillin.
GuidetoPHARMACOLOGYi 984.

Protein family/group databases

TCDBi 2.A.17.4.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

PhosphoSitei P46059.

Polymorphism databases

DMDMi 1172435.

Proteomic databases

PaxDbi P46059.
PRIDEi P46059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376503 ; ENSP00000365686 ; ENSG00000088386 .
GeneIDi 6564.
KEGGi hsa:6564.
UCSCi uc001vno.3. human.

Organism-specific databases

CTDi 6564.
GeneCardsi GC13M099336.
HGNCi HGNC:10920. SLC15A1.
HPAi HPA002827.
MIMi 600544. gene.
neXtProti NX_P46059.
PharmGKBi PA323.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3104.
HOGENOMi HOG000285186.
HOVERGENi HBG052962.
InParanoidi P46059.
KOi K14206.
OMAi LVWAPNH.
OrthoDBi EOG7M3J0R.
PhylomeDBi P46059.
TreeFami TF330897.

Enzyme and pathway databases

Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

Miscellaneous databases

GeneWikii Peptide_transporter_1.
GenomeRNAii 6564.
NextBioi 25539.
PROi P46059.
SOURCEi Search...

Gene expression databases

ArrayExpressi P46059.
Bgeei P46059.
CleanExi HS_SLC15A1.
Genevestigatori P46059.

Family and domain databases

InterProi IPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view ]
PANTHERi PTHR11654. PTHR11654. 1 hit.
Pfami PF00854. PTR2. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00926. 2A1704. 1 hit.
PROSITEi PS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization."
    Liang R., Fei Y.-J., Prasad P.D., Ramamoorthy S., Han H., Yang-Feng T.L., Hediger M.A., Ganapathy V., Leibach F.H.
    J. Biol. Chem. 270:6456-6463(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population."
    Saito S., Iida A., Sekine A., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
    J. Hum. Genet. 47:576-584(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASN-117 AND ALA-419.
  5. Cited for: VARIANTS ILE-21; TYR-28; ASN-117; ARG-117; MET-122; ALA-419; ILE-450; ASN-451 AND SER-537.

Entry informationi

Entry nameiS15A1_HUMAN
AccessioniPrimary (citable) accession number: P46059
Secondary accession number(s): Q5VW82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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