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P46059 (S15A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 15 member 1
Alternative name(s):
Intestinal H(+)/peptide cotransporter
Oligopeptide transporter, small intestine isoform
Peptide transporter 1
Gene names
Name:SLC15A1
Synonyms:PEPT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length708 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 708708Solute carrier family 15 member 1
PRO_0000064304

Regions

Transmembrane1 – 2121Helical; Potential
Topological domain22 – 5332Extracellular Potential
Transmembrane54 – 7421Helical; Potential
Topological domain75 – 828Cytoplasmic Potential
Transmembrane83 – 10321Helical; Potential
Topological domain104 – 11815Extracellular Potential
Transmembrane119 – 13921Helical; Potential
Topological domain140 – 16122Cytoplasmic Potential
Transmembrane162 – 18221Helical; Potential
Topological domain183 – 19816Extracellular Potential
Transmembrane199 – 21921Helical; Potential
Topological domain220 – 27657Cytoplasmic Potential
Transmembrane277 – 29721Helical; Potential
Topological domain298 – 32730Extracellular Potential
Transmembrane328 – 34821Helical; Potential
Topological domain349 – 36113Cytoplasmic Potential
Transmembrane362 – 38221Helical; Potential
Topological domain383 – 584202Extracellular Potential
Transmembrane585 – 60521Helical; Potential
Topological domain606 – 61914Cytoplasmic Potential
Transmembrane620 – 64021Helical; Potential
Topological domain641 – 6455Extracellular Potential
Transmembrane646 – 66621Helical; Potential
Topological domain667 – 70842Cytoplasmic Potential

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation4041N-linked (GlcNAc...) Potential
Glycosylation4081N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Potential
Glycosylation5091N-linked (GlcNAc...) Potential
Glycosylation5141N-linked (GlcNAc...) Potential
Glycosylation5621N-linked (GlcNAc...) Potential

Natural variations

Natural variant211V → I. Ref.5
Corresponds to variant rs8187818 [ dbSNP | Ensembl ].
VAR_029321
Natural variant281F → Y. Ref.5
VAR_029322
Natural variant1171S → N. Ref.4 Ref.5
Corresponds to variant rs2297322 [ dbSNP | Ensembl ].
VAR_022147
Natural variant1171S → R. Ref.5
Corresponds to variant rs8187821 [ dbSNP | Ensembl ].
VAR_029323
Natural variant1221V → M. Ref.5
Corresponds to variant rs8187820 [ dbSNP | Ensembl ].
VAR_020456
Natural variant4191G → A. Ref.4 Ref.5
Corresponds to variant rs4646227 [ dbSNP | Ensembl ].
VAR_020457
Natural variant4501V → I. Ref.5
Corresponds to variant rs2274828 [ dbSNP | Ensembl ].
VAR_022148
Natural variant4511T → N. Ref.5
Corresponds to variant rs8187838 [ dbSNP | Ensembl ].
VAR_020458
Natural variant4591R → C.
Corresponds to variant rs2274827 [ dbSNP | Ensembl ].
VAR_022149
Natural variant5371P → S. Ref.5
Corresponds to variant rs8187830 [ dbSNP | Ensembl ].
VAR_029324

Sequences

Sequence LengthMass (Da)Tools
P46059 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A75475789177A907

FASTA70878,806
        10         20         30         40         50         60 
MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN LSTAIYHTFV 

        70         80         90        100        110        120 
ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV SSINDLTDHN HDGTPDSLPV 

       130        140        150        160        170        180 
HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ FEEGQEKQRN RFFSIFYLAI NAGSLLSTII 

       190        200        210        220        230        240 
TPMLRVQQCG IHSKQACYPL AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI 

       250        260        270        280        290        300 
GFAIKNRFRH RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ 

       310        320        330        340        350        360 
GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK CGFNFTSLKK 

       370        380        390        400        410        420 
MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL NIGNNTMNIS LPGEMVTLGP 

       430        440        450        460        470        480 
MSQTNAFMTF DVNKLTRINI SSPGSPVTAV TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK 

       490        500        510        520        530        540 
PEKGENGIRF VNTFNELITI TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ 

       550        560        570        580        590        600 
PNFNTFYLEF GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV 

       610        620        630        640        650        660 
TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI LFAALLLVVC 

       670        680        690        700 
VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS GANSQKQM 

« Hide

References

« Hide 'large scale' references
[1]"Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization."
Liang R., Fei Y.-J., Prasad P.D., Ramamoorthy S., Han H., Yang-Feng T.L., Hediger M.A., Ganapathy V., Leibach F.H.
J. Biol. Chem. 270:6456-6463(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Intestine.
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population."
Saito S., Iida A., Sekine A., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
J. Hum. Genet. 47:576-584(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ASN-117 AND ALA-419.
[5]"Genetic variants of the human dipeptide transporter PEPT1."
Anderle P., Nielsen C.U., Pinsonneault J., Krog P.L., Brodin B., Sadee W.
J. Pharmacol. Exp. Ther. 316:636-646(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ILE-21; TYR-28; ASN-117; ARG-117; MET-122; ALA-419; ILE-450; ASN-451 AND SER-537.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U13173 mRNA. Translation: AAB61693.1.
U21936 mRNA. Translation: AAA63797.1.
AL391670, AL353574 Genomic DNA. Translation: CAH70393.1.
AL353574, AL391670 Genomic DNA. Translation: CAI15619.1.
BC096328 mRNA. Translation: AAH96328.1.
BC096329 mRNA. Translation: AAH96329.1.
PIRA56163.
RefSeqNP_005064.1. NM_005073.3.
UniGeneHs.436893.

3D structure databases

ProteinModelPortalP46059.
SMRP46059. Positions 9-663.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000365686.

Chemistry

BindingDBP46059.
ChEMBLCHEMBL4605.
DrugBankDB01140. Cefadroxil.
DB01415. Ceftibuten.
DB01000. Cyclacillin.
GuidetoPHARMACOLOGY984.

Protein family/group databases

TCDB2.A.17.4.9. the proton-dependent oligopeptide transporter (pot) family.

PTM databases

PhosphoSiteP46059.

Polymorphism databases

DMDM1172435.

Proteomic databases

PaxDbP46059.
PRIDEP46059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376503; ENSP00000365686; ENSG00000088386.
GeneID6564.
KEGGhsa:6564.
UCSCuc001vno.3. human.

Organism-specific databases

CTD6564.
GeneCardsGC13M099336.
HGNCHGNC:10920. SLC15A1.
HPAHPA002827.
MIM600544. gene.
neXtProtNX_P46059.
PharmGKBPA323.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG3104.
HOGENOMHOG000285186.
HOVERGENHBG052962.
InParanoidP46059.
KOK14206.
OMALVWAPNH.
OrthoDBEOG7M3J0R.
PhylomeDBP46059.
TreeFamTF330897.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.

Gene expression databases

ArrayExpressP46059.
BgeeP46059.
CleanExHS_SLC15A1.
GenevestigatorP46059.

Family and domain databases

InterProIPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERPTHR11654. PTHR11654. 1 hit.
PfamPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00926. 2A1704. 1 hit.
PROSITEPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPeptide_transporter_1.
GenomeRNAi6564.
NextBio25539.
PROP46059.
SOURCESearch...

Entry information

Entry nameS15A1_HUMAN
AccessionPrimary (citable) accession number: P46059
Secondary accession number(s): Q5VW82
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM