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Protein

Solute carrier family 15 member 1

Gene

SLC15A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

GO - Molecular functioni

GO - Biological processi

  • digestion Source: ProtInc
  • ion transport Source: Reactome
  • protein transport Source: UniProtKB-KW
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088386-MONOMER.
ReactomeiR-HSA-427975. Proton/oligopeptide cotransporters.

Protein family/group databases

TCDBi2.A.17.4.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 1
Alternative name(s):
Intestinal H(+)/peptide cotransporter
Oligopeptide transporter, small intestine isoform
Peptide transporter 1
Gene namesi
Name:SLC15A1
Synonyms:PEPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:10920. SLC15A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 53ExtracellularSequence analysisAdd BLAST32
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 82CytoplasmicSequence analysis8
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 118ExtracellularSequence analysisAdd BLAST15
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 161CytoplasmicSequence analysisAdd BLAST22
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 198ExtracellularSequence analysisAdd BLAST16
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 276CytoplasmicSequence analysisAdd BLAST57
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 327ExtracellularSequence analysisAdd BLAST30
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 361CytoplasmicSequence analysisAdd BLAST13
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 584ExtracellularSequence analysisAdd BLAST202
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Topological domaini606 – 619CytoplasmicSequence analysisAdd BLAST14
Transmembranei620 – 640HelicalSequence analysisAdd BLAST21
Topological domaini641 – 645ExtracellularSequence analysis5
Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Topological domaini667 – 708CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • brush border Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6564.
OpenTargetsiENSG00000088386.
PharmGKBiPA323.

Chemistry databases

ChEMBLiCHEMBL4605.
DrugBankiDB00855. Aminolevulinic acid.
DB01060. Amoxicillin.
DB00415. Ampicillin.
DB08795. Azidocillin.
DB00542. Benazepril.
DB01053. Benzylpenicillin.
DB01197. Captopril.
DB00833. Cefaclor.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB00535. Cefdinir.
DB01413. Cefepime.
DB00671. Cefixime.
DB00274. Cefmetazole.
DB00493. Cefotaxime.
DB01333. Cefradine.
DB00438. Ceftazidime.
DB01415. Ceftibuten.
DB01332. Ceftizoxime.
DB01212. Ceftriaxone.
DB01112. Cefuroxime.
DB00567. Cephalexin.
DB00672. Chlorpropamide.
DB01340. Cilazapril.
DB01147. Cloxacillin.
DB01000. Cyclacillin.
DB00485. Dicloxacillin.
DB00584. Enalapril.
DB01095. Fluvastatin.
DB00492. Fosinopril.
DB01016. Glyburide.
DB01235. Levodopa.
DB00722. Lisinopril.
DB00968. Methyldopa.
DB00211. Midodrine.
DB00691. Moexipril.
DB00731. Nateglinide.
DB00198. Oseltamivir.
DB00713. Oxacillin.
DB00790. Perindopril.
DB00417. Phenoxymethylpenicillin.
DB00881. Quinapril.
DB00178. Ramipril.
DB01348. Spirapril.
DB01124. Tolbutamide.
DB00519. Trandolapril.
DB00577. Valaciclovir.
DB01610. Valganciclovir.
GuidetoPHARMACOLOGYi984.

Polymorphism and mutation databases

BioMutaiSLC15A1.
DMDMi1172435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643041 – 708Solute carrier family 15 member 1Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi404N-linked (GlcNAc...)Sequence analysis1
Glycosylationi408N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Glycosylationi509N-linked (GlcNAc...)Sequence analysis1
Glycosylationi514N-linked (GlcNAc...)Sequence analysis1
Glycosylationi562N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP46059.
PeptideAtlasiP46059.
PRIDEiP46059.

PTM databases

iPTMnetiP46059.
PhosphoSitePlusiP46059.

Expressioni

Gene expression databases

BgeeiENSG00000088386.
CleanExiHS_SLC15A1.
ExpressionAtlasiP46059. baseline and differential.
GenevisibleiP46059. HS.

Organism-specific databases

HPAiHPA002827.

Interactioni

Protein-protein interaction databases

BioGridi112452. 64 interactors.
STRINGi9606.ENSP00000365686.

Chemistry databases

BindingDBiP46059.

Structurei

3D structure databases

ProteinModelPortaliP46059.
SMRiP46059.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiP46059.
KOiK14206.
OMAiAYTYVIR.
OrthoDBiEOG091G0M1S.
PhylomeDBiP46059.
TreeFamiTF330897.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN
60 70 80 90 100
LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV
110 120 130 140 150
SSINDLTDHN HDGTPDSLPV HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ
160 170 180 190 200
FEEGQEKQRN RFFSIFYLAI NAGSLLSTII TPMLRVQQCG IHSKQACYPL
210 220 230 240 250
AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI GFAIKNRFRH
260 270 280 290 300
RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ
310 320 330 340 350
GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK
360 370 380 390 400
CGFNFTSLKK MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL
410 420 430 440 450
NIGNNTMNIS LPGEMVTLGP MSQTNAFMTF DVNKLTRINI SSPGSPVTAV
460 470 480 490 500
TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK PEKGENGIRF VNTFNELITI
510 520 530 540 550
TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ PNFNTFYLEF
560 570 580 590 600
GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV
610 620 630 640 650
TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI
660 670 680 690 700
LFAALLLVVC VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS

GANSQKQM
Length:708
Mass (Da):78,806
Last modified:November 1, 1995 - v1
Checksum:iA75475789177A907
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02932121V → I.1 PublicationCorresponds to variant rs8187818dbSNPEnsembl.1
Natural variantiVAR_02932228F → Y.1 PublicationCorresponds to variant rs8187817dbSNPEnsembl.1
Natural variantiVAR_022147117S → N.2 PublicationsCorresponds to variant rs2297322dbSNPEnsembl.1
Natural variantiVAR_029323117S → R.1 PublicationCorresponds to variant rs8187821dbSNPEnsembl.1
Natural variantiVAR_020456122V → M.1 PublicationCorresponds to variant rs8187820dbSNPEnsembl.1
Natural variantiVAR_020457419G → A.2 PublicationsCorresponds to variant rs4646227dbSNPEnsembl.1
Natural variantiVAR_022148450V → I.1 PublicationCorresponds to variant rs2274828dbSNPEnsembl.1
Natural variantiVAR_020458451T → N.1 PublicationCorresponds to variant rs8187838dbSNPEnsembl.1
Natural variantiVAR_022149459R → C.Corresponds to variant rs2274827dbSNPEnsembl.1
Natural variantiVAR_029324537P → S.1 PublicationCorresponds to variant rs8187830dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13173 mRNA. Translation: AAB61693.1.
U21936 mRNA. Translation: AAA63797.1.
AL391670, AL353574 Genomic DNA. Translation: CAH70393.1.
AL353574, AL391670 Genomic DNA. Translation: CAI15619.1.
BC096328 mRNA. Translation: AAH96328.1.
BC096329 mRNA. Translation: AAH96329.1.
CCDSiCCDS9489.1.
PIRiA56163.
RefSeqiNP_005064.1. NM_005073.3.
UniGeneiHs.436893.

Genome annotation databases

EnsembliENST00000376503; ENSP00000365686; ENSG00000088386.
GeneIDi6564.
KEGGihsa:6564.
UCSCiuc001vno.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13173 mRNA. Translation: AAB61693.1.
U21936 mRNA. Translation: AAA63797.1.
AL391670, AL353574 Genomic DNA. Translation: CAH70393.1.
AL353574, AL391670 Genomic DNA. Translation: CAI15619.1.
BC096328 mRNA. Translation: AAH96328.1.
BC096329 mRNA. Translation: AAH96329.1.
CCDSiCCDS9489.1.
PIRiA56163.
RefSeqiNP_005064.1. NM_005073.3.
UniGeneiHs.436893.

3D structure databases

ProteinModelPortaliP46059.
SMRiP46059.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112452. 64 interactors.
STRINGi9606.ENSP00000365686.

Chemistry databases

BindingDBiP46059.
ChEMBLiCHEMBL4605.
DrugBankiDB00855. Aminolevulinic acid.
DB01060. Amoxicillin.
DB00415. Ampicillin.
DB08795. Azidocillin.
DB00542. Benazepril.
DB01053. Benzylpenicillin.
DB01197. Captopril.
DB00833. Cefaclor.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB00535. Cefdinir.
DB01413. Cefepime.
DB00671. Cefixime.
DB00274. Cefmetazole.
DB00493. Cefotaxime.
DB01333. Cefradine.
DB00438. Ceftazidime.
DB01415. Ceftibuten.
DB01332. Ceftizoxime.
DB01212. Ceftriaxone.
DB01112. Cefuroxime.
DB00567. Cephalexin.
DB00672. Chlorpropamide.
DB01340. Cilazapril.
DB01147. Cloxacillin.
DB01000. Cyclacillin.
DB00485. Dicloxacillin.
DB00584. Enalapril.
DB01095. Fluvastatin.
DB00492. Fosinopril.
DB01016. Glyburide.
DB01235. Levodopa.
DB00722. Lisinopril.
DB00968. Methyldopa.
DB00211. Midodrine.
DB00691. Moexipril.
DB00731. Nateglinide.
DB00198. Oseltamivir.
DB00713. Oxacillin.
DB00790. Perindopril.
DB00417. Phenoxymethylpenicillin.
DB00881. Quinapril.
DB00178. Ramipril.
DB01348. Spirapril.
DB01124. Tolbutamide.
DB00519. Trandolapril.
DB00577. Valaciclovir.
DB01610. Valganciclovir.
GuidetoPHARMACOLOGYi984.

Protein family/group databases

TCDBi2.A.17.4.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

iPTMnetiP46059.
PhosphoSitePlusiP46059.

Polymorphism and mutation databases

BioMutaiSLC15A1.
DMDMi1172435.

Proteomic databases

PaxDbiP46059.
PeptideAtlasiP46059.
PRIDEiP46059.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376503; ENSP00000365686; ENSG00000088386.
GeneIDi6564.
KEGGihsa:6564.
UCSCiuc001vno.4. human.

Organism-specific databases

CTDi6564.
DisGeNETi6564.
GeneCardsiSLC15A1.
HGNCiHGNC:10920. SLC15A1.
HPAiHPA002827.
MIMi600544. gene.
neXtProtiNX_P46059.
OpenTargetsiENSG00000088386.
PharmGKBiPA323.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiP46059.
KOiK14206.
OMAiAYTYVIR.
OrthoDBiEOG091G0M1S.
PhylomeDBiP46059.
TreeFamiTF330897.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088386-MONOMER.
ReactomeiR-HSA-427975. Proton/oligopeptide cotransporters.

Miscellaneous databases

GeneWikiiPeptide_transporter_1.
GenomeRNAii6564.
PROiP46059.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088386.
CleanExiHS_SLC15A1.
ExpressionAtlasiP46059. baseline and differential.
GenevisibleiP46059. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS15A1_HUMAN
AccessioniPrimary (citable) accession number: P46059
Secondary accession number(s): Q5VW82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.