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P46033

- GLNA1_FRAAL

UniProt

P46033 - GLNA1_FRAAL

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Protein
Glutamine synthetase 1
Gene
glnA
Organism
Frankia alni
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Nitrogen fixation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase 1 (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase I
Glutamine synthetase I
Short name:
GSI
Gene namesi
Name:glnA
OrganismiFrankia alni
Taxonomic identifieri1859 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeFrankiaceaeFrankia

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Glutamine synthetase 1
PRO_0000153221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei402 – 4021O-AMP-tyrosine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.

Structurei

3D structure databases

ProteinModelPortaliP46033.
SMRiP46033. Positions 6-474.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46033-1 [UniParc]FASTAAdd to Basket

« Hide

MFTKAEDVLR YIRDEDVQFI DVRFCDLPGI MQHFTIPTQV FAESVFTDGL    50
MFDGSSIRGF QAIHESDMLL LPDPQTAFVD PFREHKTLAM TFFIHDPITK 100
EQYSRDPRNI AKKAETYLRG TSIADTAYFG PEAEFYIFDD VRYDYNPYGS 150
MHHVDSVEAA WNTSRKEEGG NLGYKPRFKG GYFPVPPTDH FTDLRSEMTR 200
VLYETGITVE MQHHEVGTAG QAEIDIRYDT LLKTADNLML YKYVIRNVAR 250
SRGKTVTFMP KPLFEDNGSG MHVHSSLWKD GEPLFYSPNG YGGLSDTARY 300
YIGGLLHHAP ALLAFTNPTT NSYRRLVPGY EAPVNLVYSA RNRSACCRIP 350
LGGDSPKAKR VEFRVPDPSC NPYLAFAAML MAGLDGIRNK IDPPDPIDKD 400
LYELPPDELA AVPQVPGSLE KVLDALEADN DFLREGDVFT TDLIETWLEY 450
KRLNEVDAIR LRPHPYEFTL YYDI 474
Length:474
Mass (Da):53,952
Last modified:November 1, 1995 - v1
Checksum:iFE1DB19AC1735652
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10631 Genomic DNA. No translation available.
PIRiA40598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10631 Genomic DNA. No translation available.
PIRi A40598.

3D structure databases

ProteinModelPortali P46033.
SMRi P46033. Positions 6-474.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Close linkage of genes encoding glutamine synthetases I and II in Frankia alni CpI1."
    Hosted T.J., Rochefort D.A., Benson D.R.
    J. Bacteriol. 175:3679-3684(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CpI1.

Entry informationi

Entry nameiGLNA1_FRAAL
AccessioniPrimary (citable) accession number: P46033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Two forms of glutamine synthetase (GSI and GSII) can be found in this nitrogen fixing bacteria, GSI is a typical prokaryotic glutamine synthetase whereas GSII is similar to the eukaryotic enzyme.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi