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Protein

Solute carrier family 15 member 2

Gene

SLC15A2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:8552623). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (PubMed:8552623).By similarity1 Publication

Kineticsi

  1. KM=25.8 µM for cefadroxil (at pH 6.0)1 Publication
  2. KM=23.8 µM for cefadroxil (at pH 6.5)1 Publication
  3. KM=32.5 µM for cefadroxil (at pH 7.4)1 Publication
  4. KM=40.9 µM for cefadroxil (at pH 8.0)1 Publication

    pH dependencei

    Optimum pH is 6.0 or lower.1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Biological processPeptide transport, Protein transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 15 member 2
    Alternative name(s):
    Kidney H(+)/peptide cotransporter
    Oligopeptide transporter, kidney isoform
    Peptide transporter 2
    Gene namesi
    Name:SLC15A2
    Synonyms:PEPT2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    Proteomesi
    • UP000001811 Componenti: Unplaced

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 57CytoplasmicCuratedAdd BLAST57
    Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
    Topological domaini79 – 87ExtracellularCurated9
    Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
    Topological domaini109 – 113CytoplasmicCurated5
    Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
    Topological domaini135 – 139ExtracellularCurated5
    Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
    Topological domaini161 – 183CytoplasmicCuratedAdd BLAST23
    Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
    Topological domaini205 – 217ExtracellularCuratedAdd BLAST13
    Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
    Topological domaini239 – 295CytoplasmicCuratedAdd BLAST57
    Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
    Topological domaini317 – 343ExtracellularCuratedAdd BLAST27
    Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
    Topological domaini365 – 380CytoplasmicCuratedAdd BLAST16
    Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
    Topological domaini402 – 611ExtracellularCuratedAdd BLAST210
    Transmembranei612 – 632HelicalSequence analysisAdd BLAST21
    Topological domaini633 – 643CytoplasmicCuratedAdd BLAST11
    Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
    Topological domaini665 – 674ExtracellularCurated10
    Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
    Topological domaini696 – 729CytoplasmicCuratedAdd BLAST34

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000643101 – 729Solute carrier family 15 member 2Add BLAST729

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei9PhosphoserineBy similarity1
    Modified residuei12PhosphothreonineBy similarity1
    Modified residuei28PhosphoserineBy similarity1
    Glycosylationi435N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi472N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi508N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi528N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi587N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Expressioni

    Tissue specificityi

    Strongly expressed in kidney. Also detected in brain, lung, liver and heart.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000001594

    Structurei

    3D structure databases

    ProteinModelPortaliP46029
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG1237 Eukaryota
    COG3104 LUCA
    HOGENOMiHOG000285186
    HOVERGENiHBG052962
    InParanoidiP46029
    KOiK14637

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR029028 Alpha/beta_knot_MTases
    IPR020846 MFS_dom
    IPR036259 MFS_trans_sf
    IPR004768 Oligopep_transport
    IPR000109 POT_fam
    IPR018456 PTR2_symporter_CS
    PANTHERiPTHR11654 PTHR11654, 1 hit
    PfamiView protein in Pfam
    PF00854 PTR2, 2 hits
    SUPFAMiSSF103473 SSF103473, 2 hits
    SSF75217 SSF75217, 1 hit
    TIGRFAMsiTIGR00926 2A1704, 1 hit
    PROSITEiView protein in PROSITE
    PS01022 PTR2_1, 1 hit
    PS01023 PTR2_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P46029-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MNPFQQNESK ETLFSPVSTE ETPPRLSSPA KKTPPKICGS NYPLSIAFIV
    60 70 80 90 100
    VNEFCERFSY YGMKAVLTLY FLYFLHWNED TSTSVYHAFS SLCYFTPILG
    110 120 130 140 150
    AAIADSWLGK FKTIIYLSLV NVLGHVIKSL SAFPILGGKV VHTVLSLVGL
    160 170 180 190 200
    CLIALGTGGI KPCVAAFGGD QFEEKHAEER TRYFSGFYLA INAGSLISTF
    210 220 230 240 250
    ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK MYKKPPPEGN
    260 270 280 290 300
    IVAQVVKCIW FAISNRFKNR SEDIPKRQHW LDWAAEKYPK QLIMDVKTLT
    310 320 330 340 350
    RVLFLYIPLP MFWALLDQQG SRWTLQATKM NGNLGFFVLQ PDQMQVLNPL
    360 370 380 390 400
    LVLIFIPLFD LVIYRLISKC GINFTSLRKM AVGMVLACLA FAAAATVEIK
    410 420 430 440 450
    INEMAPPQPG SQEILLQVLN LADDEVKLTV LGNNNNSLLA DSIKSFQKTP
    460 470 480 490 500
    HYSKIHLNTK SQDFYFHLKY HNLSIYTEHS VEERNWYSLI IREDGKSISS
    510 520 530 540 550
    IMVKDMENET TYGMTAIRFI NTLQENVNIS LGTDISLNVG ENYGVSAYRT
    560 570 580 590 600
    VQRGEYPAVH CKTEDKDFSL NLGLLDFGAS YLFVITNSTK QGLQAWKMED
    610 620 630 640 650
    IPANKVSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
    660 670 680 690 700
    LTVAIGNIIV LVVAQFSGLV QWAEFVLFSC LLLVVCLIFS IMGYYYIPIK
    710 720
    SEDIQGPEDK QIPHMQGNMI NLETKKTKL
    Length:729
    Mass (Da):81,664
    Last modified:November 1, 1995 - v1
    Checksum:i0D22A35D7E024312
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U32507 mRNA Translation: AAC48495.1
    RefSeqiNP_001076169.1, NM_001082700.1
    UniGeneiOcu.2273

    Genome annotation databases

    GeneIDi100009433
    KEGGiocu:100009433

    Similar proteinsi

    Entry informationi

    Entry nameiS15A2_RABIT
    AccessioniPrimary (citable) accession number: P46029
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: April 25, 2018
    This is version 92 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

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