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Protein

Solute carrier family 15 member 2

Gene

SLC15A2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 2
Alternative name(s):
Kidney H(+)/peptide cotransporter
Oligopeptide transporter, kidney isoform
Peptide transporter 2
Gene namesi
Name:SLC15A2
Synonyms:PEPT2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence analysisAdd
BLAST
Transmembranei568 – 58821HelicalSequence analysisAdd
BLAST
Transmembranei612 – 63221HelicalSequence analysisAdd
BLAST
Transmembranei644 – 66421HelicalSequence analysisAdd
BLAST
Transmembranei675 – 69521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Solute carrier family 15 member 2PRO_0000064310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei12 – 121PhosphothreonineBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence analysis
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence analysis
Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001594.

Structurei

3D structure databases

ProteinModelPortaliP46029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiP46029.
KOiK14637.

Family and domain databases

InterProiIPR029028. Alpha/beta_knot_MTases.
IPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPFQQNESK ETLFSPVSTE ETPPRLSSPA KKTPPKICGS NYPLSIAFIV
60 70 80 90 100
VNEFCERFSY YGMKAVLTLY FLYFLHWNED TSTSVYHAFS SLCYFTPILG
110 120 130 140 150
AAIADSWLGK FKTIIYLSLV NVLGHVIKSL SAFPILGGKV VHTVLSLVGL
160 170 180 190 200
CLIALGTGGI KPCVAAFGGD QFEEKHAEER TRYFSGFYLA INAGSLISTF
210 220 230 240 250
ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK MYKKPPPEGN
260 270 280 290 300
IVAQVVKCIW FAISNRFKNR SEDIPKRQHW LDWAAEKYPK QLIMDVKTLT
310 320 330 340 350
RVLFLYIPLP MFWALLDQQG SRWTLQATKM NGNLGFFVLQ PDQMQVLNPL
360 370 380 390 400
LVLIFIPLFD LVIYRLISKC GINFTSLRKM AVGMVLACLA FAAAATVEIK
410 420 430 440 450
INEMAPPQPG SQEILLQVLN LADDEVKLTV LGNNNNSLLA DSIKSFQKTP
460 470 480 490 500
HYSKIHLNTK SQDFYFHLKY HNLSIYTEHS VEERNWYSLI IREDGKSISS
510 520 530 540 550
IMVKDMENET TYGMTAIRFI NTLQENVNIS LGTDISLNVG ENYGVSAYRT
560 570 580 590 600
VQRGEYPAVH CKTEDKDFSL NLGLLDFGAS YLFVITNSTK QGLQAWKMED
610 620 630 640 650
IPANKVSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL
660 670 680 690 700
LTVAIGNIIV LVVAQFSGLV QWAEFVLFSC LLLVVCLIFS IMGYYYIPIK
710 720
SEDIQGPEDK QIPHMQGNMI NLETKKTKL
Length:729
Mass (Da):81,664
Last modified:November 1, 1995 - v1
Checksum:i0D22A35D7E024312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32507 mRNA. Translation: AAC48495.1.
RefSeqiNP_001076169.1. NM_001082700.1.
UniGeneiOcu.2273.

Genome annotation databases

GeneIDi100009433.
KEGGiocu:100009433.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32507 mRNA. Translation: AAC48495.1.
RefSeqiNP_001076169.1. NM_001082700.1.
UniGeneiOcu.2273.

3D structure databases

ProteinModelPortaliP46029.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001594.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009433.
KEGGiocu:100009433.

Organism-specific databases

CTDi6565.

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiP46029.
KOiK14637.

Family and domain databases

InterProiIPR029028. Alpha/beta_knot_MTases.
IPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter."
    Boll M., Herget M., Wagener M., Weber W., Markovich D., Biber J., Clauss W., Murer H., Daniel H.
    Proc. Natl. Acad. Sci. U.S.A. 93:284-289(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS15A2_RABIT
AccessioniPrimary (citable) accession number: P46029
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 11, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.