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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. heterocyst differentiation Source: UniProtKB-KW
  3. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:pgl
Synonyms:devB
Ordered Locus Names:alr1602
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2402406-phosphogluconolactonasePRO_0000090087Add
BLAST

Expressioni

Developmental stagei

Developmentally regulated gene in heterocyst development.

Keywords - Developmental stagei

Heterocyst

Interactioni

Protein-protein interaction databases

STRINGi103690.alr1602.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000256282.
KOiK01057.
OMAiPQGELWW.
OrthoDBiEOG63FW46.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

P46016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTVEVLPD QTALIARSLD LILTKLDTAI KQQGRFTIAL SGGSTPKPLY
60 70 80 90 100
EAIAAQKLPW DKIHVFWGDE RYVSPDHPDS NELMARTAWL DRVDIPAENI
110 120 130 140 150
HAVPTLDNNP AVSAAKYEQH LQTFFNSAPG EFPALDVVLL GMGDDAHTAS
160 170 180 190 200
LFPHTEALQV RDRLITVGNK DGNPRITFTY PFINAASSVI FVVAGANKRP
210 220 230 240
ALAQVFAPSA DDLAYPSRFI QPQGELLWLL DAAAGAELSV
Length:240
Mass (Da):26,183
Last modified:January 23, 2002 - v2
Checksum:i69DA7B9A72729F96
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 164ALIA → RSI in AAA50355 (Ref. 1) Curated
Sequence conflicti99 – 991N → D in AAA50355 (Ref. 1) Curated
Sequence conflicti235 – 2373GAE → RRT in AAA50355 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14553 Genomic DNA. Translation: AAA50355.1.
BA000019 Genomic DNA. Translation: BAB77968.1.
PIRiAD2006.
RefSeqiNP_485642.1. NC_003272.1.
WP_010995771.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB77968; BAB77968; BAB77968.
GeneIDi1105194.
KEGGiana:alr1602.
PATRICi22773236. VBINosSp37423_2098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14553 Genomic DNA. Translation: AAA50355.1.
BA000019 Genomic DNA. Translation: BAB77968.1.
PIRiAD2006.
RefSeqiNP_485642.1. NC_003272.1.
WP_010995771.1. NC_003272.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr1602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB77968; BAB77968; BAB77968.
GeneIDi1105194.
KEGGiana:alr1602.
PATRICi22773236. VBINosSp37423_2098.

Phylogenomic databases

eggNOGiCOG0363.
HOGENOMiHOG000256282.
KOiK01057.
OMAiPQGELWW.
OrthoDBiEOG63FW46.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bacterial subtracted cDNA libraries containing genes involved in the differentiation of vegetative cells to heterocysts allow a new twist on an old method of isolating developmental genes."
    Bauer C.C., Scappino L., Haselkorn R.
    Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry namei6PGL_NOSS1
AccessioniPrimary (citable) accession number: P46016
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2002
Last modified: April 1, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.