Reviewed, UniProtKB/Swiss-Prot P46016 (6PGL_ANASP)

Names and origin

Protein names

Recommended name:
    6-phosphogluconolactonase
      Short name=6PGL
    EC=3.1.1.31

Gene names

Name:	pgl
Synonyms:	devB
Ordered Locus Names:	alr1602

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.
Developmental stage	Developmentally regulated gene in heterocyst development.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
Developmental stage	Heterocyst
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heterocyst differentiation Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	6-phosphogluconolactonase		PRO_0000090087
Experimental info
	Sequence conflict	13 – 16	4	ALIA → RSI in AAA50355. Ref.1
	Sequence conflict	99	1	N → D in AAA50355. Ref.1
	Sequence conflict	235 – 237	3	GAE → RRT in AAA50355. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P46016-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 69DA7B9A72729F96	FASTA	240	26,183
	10 20 30 40 50 60 MKKTVEVLPD QTALIARSLD LILTKLDTAI KQQGRFTIAL SGGSTPKPLY EAIAAQKLPW 70 80 90 100 110 120 DKIHVFWGDE RYVSPDHPDS NELMARTAWL DRVDIPAENI HAVPTLDNNP AVSAAKYEQH 130 140 150 160 170 180 LQTFFNSAPG EFPALDVVLL GMGDDAHTAS LFPHTEALQV RDRLITVGNK DGNPRITFTY 190 200 210 220 230 240 PFINAASSVI FVVAGANKRP ALAQVFAPSA DDLAYPSRFI QPQGELLWLL DAAAGAELSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bacterial subtracted cDNA libraries containing genes involved in the differentiation of vegetative cells to heterocysts allow a new twist on an old method of isolating developmental genes." Bauer C.C., Scappino L., Haselkorn R. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U14553 Genomic DNA. Translation: AAA50355.1. BA000019 Genomic DNA. Translation: BAB77968.1.
PIR	AD2006.
RefSeq	NP_485642.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P46016.
Genome annotation databases
GeneID	1105194.
GenomeReviews	Gene locus alr1602 in contig BA000019_GR.
KEGG	ana:alr1602.
NMPDR	fig|103690.1.peg.1909.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P46016.
OMA	PAICLTG.
Enzyme and pathway databases
BioCyc	NSP103690:ALR1602-MON.
Family and domain databases
InterPro	IPR005900. 6-phosphogluconolactonase. IPR006148. Glc/Gal-6P_isomerase. [Graphical view]
PANTHER	PTHR11054. Phosphogluconlac. 1 hit.
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMs	TIGR01198. pgl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_ANASP

Accession

Primary (citable) accession number: P46016

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2002
Last modified:	November 3, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)